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AJF63620.1 AJF63620.1 AJF63746.1 AJF63746.1 AJF63757.1 AJF63757.1 AJF69551.1 AJF69551.1 AJF69553.1 AJF69553.1 pfkA pfkA AJF64148.1 AJF64148.1 AJF64351.1 AJF64351.1 AJF64590.1 AJF64590.1 tal tal zwf zwf AJF64593.1 AJF64593.1 pgl pgl pgi pgi tpiA tpiA pgk pgk AJF64602.1 AJF64602.1 AJF64629.1 AJF64629.1 AJF64652.1 AJF64652.1 rbsK rbsK AJF64817.1 AJF64817.1 AJF64818.1 AJF64818.1 AJF64820.1 AJF64820.1 lipB lipB lipA lipA AJF65015.1 AJF65015.1 AJF65202.1 AJF65202.1 AJF65289.1 AJF65289.1 AJF65445.1 AJF65445.1 eno eno prs prs ppc ppc AJF65806.1 AJF65806.1 AJF65950.1 AJF65950.1 AJF66077.1 AJF66077.1 AJF66078.1 AJF66078.1 AJF66079.1 AJF66079.1 AJF66093.1 AJF66093.1 AJF66094.1 AJF66094.1 AJF66095.1 AJF66095.1 AJF66152.1 AJF66152.1 AJF66227.1 AJF66227.1 AJF66614.1 AJF66614.1 AJF66717.1 AJF66717.1 AJF66718.1 AJF66718.1 gabD2 gabD2 sucC sucC sucD sucD mdh mdh AJF66912.1 AJF66912.1 AJF66913.1 AJF66913.1 AJF66914.1 AJF66914.1 AJF66915.1 AJF66915.1 pckG pckG AJF67029.1 AJF67029.1 aspA-2 aspA-2 AJF69946.1 AJF69946.1 AJF67071.1 AJF67071.1 AJF67097.1 AJF67097.1 sdhA sdhA AJF67099.1 AJF67099.1 AJF67119.1 AJF67119.1 AJF67244.1 AJF67244.1 kgd kgd AJF67336.1 AJF67336.1 pfkA-2 pfkA-2 gcvH-2 gcvH-2 AJF67775.1 AJF67775.1 AJF67776.1 AJF67776.1 acnA acnA AJF68077.1 AJF68077.1 AJF68346.1 AJF68346.1 AJF68376.1 AJF68376.1 AJF68502.1 AJF68502.1 sdhA-2 sdhA-2 AJF68504.1 AJF68504.1 AJF68626.1 AJF68626.1 AJF70147.1 AJF70147.1 eno-2 eno-2 AJF68974.1 AJF68974.1 AJF69263.1 AJF69263.1 AJF69269.1 AJF69269.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJF63620.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AJF63746.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (739 aa)
AJF63757.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa)
AJF69551.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AJF69553.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (387 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJF64148.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
AJF64351.1Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
AJF64590.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (695 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (510 aa)
AJF64593.1OpcA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (259 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (550 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (403 aa)
AJF64602.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
AJF64629.1Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
AJF64652.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (306 aa)
AJF64817.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AJF64818.1Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (601 aa)
AJF64820.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (901 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (273 aa)
lipARadical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa)
AJF65015.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (910 aa)
AJF65202.1Catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
AJF65289.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
AJF65445.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (909 aa)
AJF65806.1N-acetylglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. (172 aa)
AJF65950.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
AJF66077.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AJF66078.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AJF66079.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
AJF66093.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
AJF66094.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
AJF66095.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AJF66152.16-phosphogluconate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AJF66227.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
AJF66614.1Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (366 aa)
AJF66717.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AJF66718.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (560 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AJF66912.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
AJF66913.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
AJF66914.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
AJF66915.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (605 aa)
AJF67029.1Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
aspA-2Aspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
AJF69946.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (556 aa)
AJF67071.1Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
AJF67097.1Catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
AJF67099.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
AJF67119.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AJF67244.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1269 aa)
AJF67336.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
gcvH-2Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
AJF67775.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AJF67776.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (621 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (906 aa)
AJF68077.1Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
AJF68346.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AJF68376.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
AJF68502.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
sdhA-2Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (646 aa)
AJF68504.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AJF68626.1Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family. (121 aa)
AJF70147.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
eno-2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (435 aa)
AJF68974.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
AJF69263.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AJF69269.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
Your Current Organism:
Streptomyces vietnamensis
NCBI taxonomy Id: 362257
Other names: CCTCC M 205143, CCTCC:M:205143, IAM 15340, JCM 21785, S. vietnamensis, Streptomyces vietnamensis Zhu et al. 2007, strain GIMV4.0001
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