STRINGSTRING
AJF67257.1 AJF67257.1 mqnE mqnE fbiC fbiC murA murA AJF65104.1 AJF65104.1 nadA nadA AJF69651.1 AJF69651.1 thiE thiE trpA trpA ctaB ctaB AJF64536.1 AJF64536.1 metK-2 metK-2 AJF63741.1 AJF63741.1 AJF64130.1 AJF64130.1 ribH ribH AJF63991.1 AJF63991.1 ubiA ubiA hemC hemC AJF65826.1 AJF65826.1 speE speE AJF66067.1 AJF66067.1 AJF66195.1 AJF66195.1 AJF66351.1 AJF66351.1 AJF66461.1 AJF66461.1 AJF66498.1 AJF66498.1 metK-3 metK-3 mqnC mqnC AJF69922.1 AJF69922.1 AJF66984.1 AJF66984.1 AJF67054.1 AJF67054.1 AJF67126.1 AJF67126.1 aroA aroA AJF67223.1 AJF67223.1 metK metK AJF69183.1 AJF69183.1 AJF68943.1 AJF68943.1 AJF68241.1 AJF68241.1 AJF68240.1 AJF68240.1 AJF68239.1 AJF68239.1 AJF68051.1 AJF68051.1 AJF70055.1 AJF70055.1 AJF67749.1 AJF67749.1 miaA miaA aroA-2 aroA-2 AJF67304.1 AJF67304.1 ubiX ubiX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJF67257.1Spermidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
mqnERadical SAM protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
fbiCFO synthase; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (861 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (446 aa)
AJF65104.1UDP pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (274 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (392 aa)
AJF69651.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II DAHP synthase family. (448 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (217 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (273 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (315 aa)
AJF64536.1Cobinamide adenolsyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
metK-2S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
AJF63741.1Glutathione S-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AJF64130.1Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (161 aa)
AJF63991.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
ubiAUbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (328 aa)
AJF65826.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (287 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (568 aa)
AJF66067.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
AJF66195.1Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AJF66351.1Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
AJF66461.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
AJF66498.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
metK-3S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
mqnCHypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa)
AJF69922.1Phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UbiA prenyltransferase family. (307 aa)
AJF66984.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
AJF67054.1UDP pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (253 aa)
AJF67126.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (286 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa)
AJF67223.1Polyprenyl synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (349 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
AJF69183.1Glutathione S-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
AJF68943.1Polyketide cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
AJF68241.1Dimethylallyltranstransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (352 aa)
AJF68240.1Phytoene synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
AJF68239.1Squalene synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
AJF68051.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
AJF70055.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
AJF67749.1UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (312 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (411 aa)
AJF67304.1Cob(I)yrinic acid a,c-diamide adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
ubiXAromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (222 aa)
Your Current Organism:
Streptomyces vietnamensis
NCBI taxonomy Id: 362257
Other names: CCTCC M 205143, CCTCC:M:205143, IAM 15340, JCM 21785, S. vietnamensis, Streptomyces vietnamensis Zhu et al. 2007, strain GIMV4.0001
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.