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| | LSL_1207 | ComF operon protein 1; COG4098 [L] Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein). (445 aa) |
| | rex | Redox-sensitive transcriptional regulator Rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (213 aa) |
| | LSL_1215 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. (649 aa) |
| | recR | Recombination protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa) |
| | LSL_1227 | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (104 aa) |
| | dnaX | DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (579 aa) |
| | rplJ | LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (167 aa) |
| | rplA | LSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa) |
| | rplK | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | spoU-2 | TRNA/rRNA methyltransferase; COG0566 [J] rRNA methylases; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (248 aa) |
| | mrnC | Conserved hypothetical protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (135 aa) |
| | glnS | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (495 aa) |
| | radA | DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (457 aa) |
| | LSL_1259 | COG2183 [K] Transcriptional accessory protein; contains S1 RNA binding domain. (723 aa) |
| | LSL_1263 | Transcriptional regulator, GntR family; COG1522 [K] Transcriptional regulators. (232 aa) |
| | LSL_1136 | 23S rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (170 aa) |
| | malR | Maltose operon transcriptional repressor; COG1522 [K] Transcriptional regulators. (331 aa) |
| | srmB-4 | COG0513 [LKJ] Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (426 aa) |
| | rluD-2 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (295 aa) |
| | topB | DNA topoisomerase III; COG0550 [L] Topoisomerase IA. (691 aa) |
| | LSL_1316 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (177 aa) |
| | LSL_1318 | CopAB ATPases metal-fist type repressor; COG1395 [K] Predicted transcriptional regulator. (148 aa) |
| | LSL_1338 | DNA-binding protein. (203 aa) |
| | pcrA | COG0210 [L] Superfamily I DNA and RNA helicases. (744 aa) |
| | lysS | COG1190 [J] Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (495 aa) |
| | LSL_1352 | tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (330 aa) |
| | LSL_1356 | S1-type RNA-binding domain; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (154 aa) |
| | LSL_1358 | COG1188 [J] Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). (89 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1174 aa) |
| | LSL_1363 | Conserved hypothetical protein; COG1787 [V] Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes. (757 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (416 aa) |
| | rep-2 | COG0210 [L] Superfamily I DNA and RNA helicases. (763 aa) |
| | rnmV2 | Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (189 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (256 aa) |
| | rpoA | DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa) |
| | rpsK | SSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (128 aa) |
| | rpsM | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa) |
| | infA | Bacterial Protein Translation Initiation Factor 1 (IF-1); One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | rplO | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | rpsE | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (166 aa) |
| | rplR | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa) |
| | rplF | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa) |
| | rpsH | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rpsN | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rplE | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa) |
| | rplX | LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (101 aa) |
| | rplN | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rpsQ | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa) |
| | rplP | LSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa) |
| | rpsC | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa) |
| | rplV | LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (115 aa) |
| | rpsS | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa) |
| | rplB | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa) |
| | rplW | LSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (94 aa) |
| | rplD | LSU ribosomal protein L1E; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (207 aa) |
| | rplC | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (207 aa) |
| | rpsJ | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | ssl-2 | DNA/RNA helicase, DEAD/DEAH box family; COG1061 [KL] DNA or RNA helicases of superfamily II. (951 aa) |
| | rluD-3 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (304 aa) |
| | cspC-2 | COG1278 [K] Cold shock proteins. (66 aa) |
| | troR | Iron-dependent repressor; COG1321 [K] Mn-dependent transcriptional regulator. (215 aa) |
| | rluD-4 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (296 aa) |
| | xthA | COG0708 [L] Exonuclease III. (275 aa) |
| | LSL_1508 | Transcription regulator, GntR family; COG1522 [K] Transcriptional regulators. (241 aa) |
| | treR | Trehalose operon transcriptional repressor; COG1522 [K] Transcriptional regulators. (237 aa) |
| | LSL_1564 | DNA helicase; COG0210 [L] Superfamily I DNA and RNA helicases. (563 aa) |
| | LSL_1581 | Transcriptional regulator, MerR family; COG0640 [K] Predicted transcriptional regulators. (129 aa) |
| | parB | Chromosome partitioning protein, DNA-binding protein; COG0640 [K] Predicted transcriptional regulators; Belongs to the ParB family. (291 aa) |
| | parB-2 | Chromosome partitioning protein; COG0640 [K] Predicted transcriptional regulators; Belongs to the ParB family. (280 aa) |
| | addA | ATP-dependent nuclease subunit A; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1248 aa) |
| | rexB | ATP-dependent nuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1193 aa) |
| | LSL_1622 | Transcriptional regulator, Cro/CI family; COG0583 [K] Transcriptional regulator. (136 aa) |
| | LSL_1638 | DNA-entry nuclease. (276 aa) |
| | LSL_1647 | Hypothetical protein; COG1491 [J] Predicted RNA-binding protein. (259 aa) |
| | xerC-6 | COG0582 [L] Integrase; Belongs to the 'phage' integrase family. (381 aa) |
| | LSL_1649 | Transcriptional regulator, Cro/CI family; COG0583 [K] Transcriptional regulator. (267 aa) |
| | LSL_1650 | Antirepressor. (271 aa) |
| | LSL_1667 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (204 aa) |
| | LSL_1677 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (185 aa) |
| | LSL_1688 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (197 aa) |
| | LSL_1691 | Conserved hypothetical protein; COG3279 [KT] Response regulator of the LytR/AlgR family. (144 aa) |
| | efp-2 | Protein Translation Elongation Factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | LSL_1711 | Transcriptional regulator, LacI family; COG1522 [K] Transcriptional regulators. (330 aa) |
| | dnaB-2 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (463 aa) |
| | rplI | LSU ribosomal protein L9P; Binds to the 23S rRNA. (149 aa) |
| | LSL_1728 | Phosphoesterase, DHH family protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. (677 aa) |
| | rnpA | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (113 aa) |
| | dnaQ | COG0847 [L] DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (177 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (155 aa) |
| | rnr | Ribonuclease R 1; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (799 aa) |
| | ftsK | Cell division protein; COG1674 [D] DNA segregation ATPase FtsK/SpoIIIE and related proteins; Belongs to the FtsK/SpoIIIE/SftA family. (759 aa) |
| | LSL_1132 | Transcriptional regulator; COG0718 [S] Uncharacterized protein conserved in bacteria. (308 aa) |
| | recA | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (381 aa) |
| | rny | Hydrolase, HAD superfamily; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (521 aa) |
| | mutS-2 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (876 aa) |
| | mutL | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (659 aa) |
| | ruvA | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa) |
| | ruvB | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa) |
| | LSL_1113 | Phosphoesterase, DHH family protein; COG0618 [R] Exopolyphosphatase-related proteins. (324 aa) |
| | srmB-3 | ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (440 aa) |
| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (880 aa) |
| | mutS | DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (786 aa) |
| | uvrC | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (590 aa) |
| | recJ | COG0608 [L] Single-stranded DNA-specific exonuclease. (777 aa) |
| | LSL_1079 | ATPase, AAA family; COG2256 [L] ATPase related to the helicase subunit of the Holliday junction resolvase. (423 aa) |
| | rpsD | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa) |
| | thiI | Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (405 aa) |
| | cspC | COG1278 [K] Cold shock proteins. (69 aa) |
| | mraZ | Cell division protein mraZ; COG0718 [S] Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. (143 aa) |
| | LSL_1044 | RNA binding protein; COG2302 [S] Uncharacterized conserved protein, contains S4-like domain. (262 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (931 aa) |
| | ssl | DNA/RNA helicase, DEAD/DEAH box family; COG1061 [KL] DNA or RNA helicases of superfamily II. (986 aa) |
| | LSL_1008 | Transcriptional regulator, AraC family; COG2207 [K] AraC-type DNA-binding domain-containing proteins. (278 aa) |
| | LSL_0999 | Putative 23S rRNA m(5)C methyltransferase; COG0144 [J] tRNA and rRNA cytosine-C5-methylases. (456 aa) |
| | rplU | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa) |
| | xerC-7 | Integrase/recombinase, XerC/CodV family; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (298 aa) |
| | rluB | Ribosomal large subunit pseudouridine synthase B; COG1187 [J] 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (242 aa) |
| | LSL_0935 | COG0718 [S] Uncharacterized protein conserved in bacteria; Belongs to the CvfB family. (288 aa) |
| | xerD | Integrase/recombinase, XerD/RipX family; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (297 aa) |
| | recU | Recombination protein; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (213 aa) |
| | hsdR | Type I restriction-modification system restriction subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1004 aa) |
| | hsdM | COG0286 [V] Type I restriction-modification system methyltransferase subunit. (529 aa) |
| | hsdS-3 | Type I restriction-modification system specificity subunit; COG0732 [V] Restriction endonuclease S subunits. (384 aa) |
| | xerC-4 | DNA integration/recombination/inversion protein; COG0582 [L] Integrase; Belongs to the 'phage' integrase family. (305 aa) |
| | hsdS-2 | Type I restriction-modification system specificity subunit; COG0732 [V] Restriction endonuclease S subunits. (372 aa) |
| | hsdS | Type I restriction-modification system specificity subunit; COG0732 [V] Restriction endonuclease S subunits. (401 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa) |
| | recQ | COG0514 [L] Superfamily II DNA helicase. (481 aa) |
| | rpoD | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (372 aa) |
| | era | GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (300 aa) |
| | rpsA | COG0539 [J] Ribosomal protein S1. (399 aa) |
| | LSL_0885 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa) |
| | LSL_0873 | Fibronectin-binding protein / Fibrinogen-binding protein; COG1293 [K] Predicted RNA-binding protein homologous to eukaryotic snRNP. (562 aa) |
| | gyrA-2 | Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (808 aa) |
| | gyrB-2 | Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (673 aa) |
| | dnaE-2 | COG0587 [L] DNA polymerase III, alpha subunit. (1097 aa) |
| | trmU | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (375 aa) |
| | aspS | Aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa) |
| | LSL_0840 | Ribonuclease HI / Cell wall enzyme EBSB. (128 aa) |
| | LSL_0839 | Conserved hypothetical protein; COG0116 [L] Predicted N6-adenine-specific DNA methylase; Belongs to the methyltransferase superfamily. (376 aa) |
| | LSL_0834 | Transcriptional regulator, DeoR family; COG1349 [KG] Transcriptional regulators of sugar metabolism. (250 aa) |
| | pyrR | Uracil phosphoribosyltransferase / Pyrimidine operon regulatory protein pyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (178 aa) |
| | rluD | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (298 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | greA-2 | Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (156 aa) |
| | pheT | COG0072 [J] Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (805 aa) |
| | pheS | COG0016 [J] Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (348 aa) |
| | spoU | 23S rRNA methyltransferase; COG0566 [J] rRNA methylases; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (253 aa) |
| | mcrA-2 | COG1403 [V] Restriction endonuclease. (108 aa) |
| | LSL_0767 | Hypothetical protein, phage associated; COG0286 [V] Type I restriction-modification system methyltransferase subunit. (217 aa) |
| | xerC-3 | COG0582 [L] Integrase; Belongs to the 'phage' integrase family. (315 aa) |
| | LSL_0755 | Hypothetical protein, phage associated. (137 aa) |
| | LSL_0742 | Phage transcriptional regulator, Cro/CI family; COG0640 [K] Predicted transcriptional regulators. (131 aa) |
| | LSL_0733 | Transposase ISLasa9a, IS200-IS605 family; COG0675 [L] Transposase and inactivated derivatives. (425 aa) |
| | LSL_0732 | Transposase ISLasa8a, IS200-IS605 family; COG0675 [L] Transposase and inactivated derivatives. (143 aa) |
| | xerC-2 | COG0582 [L] Integrase; Belongs to the 'phage' integrase family. (373 aa) |
| | recD | Exodeoxyribonuclease V alpha chain; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (824 aa) |
| | LSL_0723 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (205 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (703 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (255 aa) |
| | LSL_0711 | Transcriptional regulator, MerR family; COG0640 [K] Predicted transcriptional regulators. (153 aa) |
| | LSL_0707 | ABC transporter, ATP-binding protein; COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains. (635 aa) |
| | pcnB | Poly(A) polymerase / tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (404 aa) |
| | LSL_0703 | Integrase/recombinase xerD. (276 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa) |
| | asnS | COG0017 [J] Aspartyl/asparaginyl-tRNA synthetases. (433 aa) |
| | dinG | ATP-dependent helicase, DinG family; 3'-5' exonuclease. (929 aa) |
| | holA | COG1466 [L] DNA polymerase III, delta subunit. (340 aa) |
| | comEA | COG1555 [L] DNA uptake protein and related DNA-binding proteins. (229 aa) |
| | LSL_0660 | Methyltransferase; COG0742 [L] N6-adenine-specific methylase. (186 aa) |
| | typA | GTP-binding protein; COG1217 [T] Predicted membrane GTPase involved in stress response. (613 aa) |
| | rnj-2 | Metallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (558 aa) |
| | tufB | Protein Translation Elongation Factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa) |
| | rnj | Metallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (565 aa) |
| | rpsO | SSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | rpsT | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (84 aa) |
| | LSL_0631 | COG1837 [R] Predicted RNA-binding protein (contains KH domain); Belongs to the UPF0109 family. (81 aa) |
| | ffh | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (482 aa) |
| | smc | Chromosome partition protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1178 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (232 aa) |
| | recG | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (676 aa) |
| | rsgA | GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (296 aa) |
| | LSL_0615 | 16S rRNA m(5)C 967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (445 aa) |
| | priA | Primosomal protein n-prim; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (792 aa) |
| | rpoZ | DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (65 aa) |
| | LSL_0592 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (336 aa) |
| | prmC | Peptide release factor-glutamine N5-methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (279 aa) |
| | prfA | Bacterial Peptide Chain Release Factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (360 aa) |
| | LSL_0586 | Transposase ISLasa7, IS3 family; COG0675 [L] Transposase and inactivated derivatives. (222 aa) |
| | LSL_0585 | Transposase ISLasa6a, IS3 family; COG0675 [L] Transposase and inactivated derivatives. (265 aa) |
| | lepA | GTP-binding translation elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (609 aa) |
| | hrcA | Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (350 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (302 aa) |
| | infB | Bacterial Protein Translation Initiation Factor 2 (IF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (737 aa) |
| | nusA | N utilization substance protein A; Participates in both transcription termination and antitermination. (375 aa) |
| | dnaE | DNA polymerase III alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1444 aa) |
| | glnR | Glutamine synthetase repressor; COG0640 [K] Predicted transcriptional regulators. (128 aa) |
| | LSL_0546 | Transposase ISLasa5a, IS3 family; COG0675 [L] Transposase and inactivated derivatives. (459 aa) |
| | lexA | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (206 aa) |
| | recN | DNA repair protein; May be involved in recombinational repair of damaged DNA. (555 aa) |
| | argR-2 | Arginine repressor; Regulates arginine biosynthesis genes. (152 aa) |
| | LSL_0537 | Hemolysin; COG1189 [J] Predicted rRNA methylase. (275 aa) |
| | xseA | Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (446 aa) |
| | nusB | N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (131 aa) |
| | efp | Protein Translation Elongation Factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | LSL_0522 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (228 aa) |
| | tsf | Protein Translation Elongation Factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (291 aa) |
| | LSL_0509 | Methyltransferase; COG4122 [R] Predicted O-methyltransferase; Belongs to the methyltransferase superfamily. (252 aa) |
| | tmcAL | Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (380 aa) |
| | LSL_0501 | Conserved hypothetical protein; COG1534 [J] Predicted RNA-binding protein containing KH domain, possibly ribosomal protein. (106 aa) |
| | rplT | LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (120 aa) |
| | infC | Bacterial Protein Translation Initiation Factor 3 (IF-3); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (174 aa) |
| | thrS | Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (649 aa) |
| | nrdR | Putative regulatory protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (157 aa) |
| | nei | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (276 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (892 aa) |
| | dnaA | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (454 aa) |
| | dnaN | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (379 aa) |
| | LSL_0003 | COG0011 [S] Uncharacterized conserved protein. (73 aa) |
| | recF | DNA replication and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (379 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (652 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (850 aa) |
| | rpsF | SSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (96 aa) |
| | ssb | Single-strand DNA binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (183 aa) |
| | rpsR | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa) |
| | LSL_0020 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (188 aa) |
| | LSL_0035 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (236 aa) |
| | LSL_0049 | Transposase ISLasa1a, IS1223 family; COG0675 [L] Transposase and inactivated derivatives. (172 aa) |
| | LSL_0050 | Transposase ISLasa3a, IS200 family; COG0675 [L] Transposase and inactivated derivatives. (155 aa) |
| | LSL_0054 | Hypothetical protein. (139 aa) |
| | scrR | Sucrose operon repressor; COG1522 [K] Transcriptional regulators. (330 aa) |
| | LSL_0076 | Transcriptional regulator, DeoR family; COG1349 [KG] Transcriptional regulators of sugar metabolism. (258 aa) |
| | LSL_0079 | Transcriptional regulator, MerR family; COG0583 [K] Transcriptional regulator. (148 aa) |
| | LSL_0083 | COG2197 [TK] Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (218 aa) |
| | cas9 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. [...] (1149 aa) |
| | cas1 | CRISPR-associated protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (301 aa) |
| | greA | Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (157 aa) |
| | LSL_0195 | Transcriptional regulator ctsR; COG4463 [K] Transcriptional repressor of class III stress genes; Belongs to the CtsR family. (155 aa) |
| | rpoB | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1199 aa) |
| | rpoC | DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1221 aa) |
| | rpsL | SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. (137 aa) |
| | rpsG | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | efg | Protein Translation Elongation Factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF- [...] (697 aa) |
| | LSL_0205 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (229 aa) |
| | LSL_0211 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (216 aa) |
| | rep | COG0210 [L] Superfamily I DNA and RNA helicases. (755 aa) |
| | LSL_0222 | Transcriptional regulator, TetR family; COG0583 [K] Transcriptional regulator. (215 aa) |
| | metG | Methionyl-tRNA synthetase / Protein secretion chaperonin CsaA; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (675 aa) |
| | rnmV1 | Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (185 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (296 aa) |
| | argR | Arginine repressor, argR; Regulates arginine biosynthesis genes. (156 aa) |
| | xerC | COG0582 [L] Integrase; Belongs to the 'phage' integrase family. (381 aa) |
| | LSL_0242 | cI-like repressor, phage associated; COG0640 [K] Predicted transcriptional regulators. (258 aa) |
| | LSL_0247 | Dna binding protein, phage associated. (63 aa) |
| | cro | Cro-like protein, phage associated; COG0640 [K] Predicted transcriptional regulators. (63 aa) |
| | LSL_0251 | COG3645 [S] Uncharacterized phage-encoded protein. (242 aa) |
| | mcrA | COG1403 [V] Restriction endonuclease. (176 aa) |
| | LSL_0314 | Transcriptional regulator, MerR family; COG0640 [K] Predicted transcriptional regulators. (132 aa) |
| | purR | Pur operon repressor; COG0503 [F] Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. (279 aa) |
| | birA | Biotin operon repressor / Biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (321 aa) |
| | rho | Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (427 aa) |
| | srmB | Superfamily II DNA and RNA helicase; COG1199 [KL] Rad3-related DNA helicases. (788 aa) |
| | srmB-2 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (492 aa) |
| | LSL_0360 | Transcriptional regulator, PemK family; Toxic component of a type II toxin-antitoxin (TA) system. (122 aa) |
| | prfC | Bacterial Peptide Chain Release Factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (525 aa) |
| | galR | Galactose operon repressor; COG1522 [K] Transcriptional regulators. (332 aa) |
| | rnhA | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (219 aa) |
| | ccpA | Catabolite control protein A; COG1522 [K] Transcriptional regulators. (335 aa) |
| | LSL_0422 | COG0011 [S] Uncharacterized conserved protein. (242 aa) |
| | LSL_0432 | COG0827 [L] Adenine-specific DNA methylase. (346 aa) |
| | LSL_0440 | Polyribonucleotide nucleotidyltransferase; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (136 aa) |
| | rsuA | Ribosomal small subunit pseudouridine synthase A; COG1187 [J] 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (240 aa) |
| | LSL_0471 | Transcription regulator, Crp family; COG0583 [K] Transcriptional regulator. (221 aa) |
| | LSL_0474 | CMP-binding factor; COG3481 [R] Predicted HD-superfamily hydrolase. (315 aa) |
| | LSL_0484 | tRNA binding domain protein; COG0073 [R] EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (216 aa) |
| | LSL_1161 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (239 aa) |
| | dinP | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (357 aa) |
| | whiA | Conserved hypothetical protein; Involved in cell division and chromosome segregation. (315 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (944 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (666 aa) |
| | LSL_1182 | Alkaline phosphatase synthesis two-component response regulator phoP; COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (233 aa) |
| | prfB | Bacterial Peptide Chain Release Factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (355 aa) |
| | xerC-5 | COG0582 [L] Integrase; Belongs to the 'phage' integrase family. (381 aa) |
| | LSL_1191 | Phage transcriptional regulator, Cro/CI family; COG0640 [K] Predicted transcriptional regulators. (165 aa) |
| | LSL_1192 | Phage repressor proteins. (62 aa) |
| | LSL_1193 | Phage immunity repressor. (126 aa) |
