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| | rfaG-8 | COG0438 [M] Glycosyltransferase. (385 aa) |
| | ugd | COG1004 [M] Predicted UDP-glucose 6-dehydrogenase. (416 aa) |
| | rfaG-9 | COG0438 [M] Glycosyltransferase. (353 aa) |
| | rfaG-14 | COG0438 [M] Glycosyltransferase. (368 aa) |
| | rfaG-15 | COG0438 [M] Glycosyltransferase. (382 aa) |
| | rfaG-16 | COG0438 [M] Glycosyltransferase. (382 aa) |
| | rfaG-17 | COG0438 [M] Glycosyltransferase. (365 aa) |
| | LSL_1006 | COG4690 [E] Dipeptidase. (474 aa) |
| | LSL_1007 | Conserved hypothetical protein. (298 aa) |
| | cydC | Transport ATP-binding protein; COG4987 [CO] ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components. (586 aa) |
| | cydD | Transport ATP-binding protein; COG4988 [CO] ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components. (574 aa) |
| | cydB | COG1294 [C] Cytochrome bd-type quinol oxidase, subunit 2. (338 aa) |
| | cydA | COG1271 [C] Cytochrome bd-type quinol oxidase, subunit 1. (472 aa) |
| | LSL_1037 | Conserved hypothetical protein; COG0639 [T] Diadenosine tetraphosphatase and related serine/threonine protein phosphatases. (285 aa) |
| | LSL_1044 | RNA binding protein; COG2302 [S] Uncharacterized conserved protein, contains S4-like domain. (262 aa) |
| | radC | COG2003 [L] DNA repair proteins; Belongs to the UPF0758 family. (225 aa) |
| | nifS-2 | COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (382 aa) |
| | LSL_1086 | COG0344 [S] Predicted membrane protein. (183 aa) |
| | uvrC | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (590 aa) |
| | serA-2 | COG1052 [CHR] Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | LSL_1101 | Phosphoesterase; COG0622 [R] Predicted phosphoesterase. (172 aa) |
| | mutS | DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (786 aa) |
| | LSL_1108 | COG0718 [S] Uncharacterized protein conserved in bacteria; Belongs to the UPF0473 family. (98 aa) |
| | LSL_1113 | Phosphoesterase, DHH family protein; COG0618 [R] Exopolyphosphatase-related proteins. (324 aa) |
| | ruvB | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa) |
| | ruvA | Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa) |
| | mutL | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (659 aa) |
| | mutS-2 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (876 aa) |
| | guaC | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (325 aa) |
| | dnaQ | COG0847 [L] DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (177 aa) |
| | pta | Phosphate acetyltransferase; COG0280 [C] Phosphotransacetylase. (325 aa) |
| | eriC | COG0038 [P] Chloride channel protein EriC. (512 aa) |
| | LSL_1161 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (239 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (441 aa) |
| | LSL_1171 | ATP-binding protein; Displays ATPase and GTPase activities. (295 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (944 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (666 aa) |
| | secA | Protein translocase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (787 aa) |
| | hpf | Ribosome-associated factor Y; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (184 aa) |
| | LSL_1201 | Hypothetical protein, phage associated. (256 aa) |
| | LSL_1202 | DNA primase; COG0433 [R] Predicted ATPase. (516 aa) |
| | groL | 60 kDa chaperonin GROEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (540 aa) |
| | LSL_1218 | Glycoprotein endopeptidase; COG1214 [O] Inactive homolog of metal-dependent proteases, putative molecular chaperone. (243 aa) |
| | holB | DNA polymerase III, delta' subunit; COG0470 [L] ATPase involved in DNA replication. (330 aa) |
| | dnaX | DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (579 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (723 aa) |
| | nrdB | COG0208 [F] Ribonucleotide reductase, beta subunit. (326 aa) |
| | rplA | LSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa) |
| | rplK | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (178 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa) |
| | LSL_1279 | Beta-phosphoglucomutase / Glucose-1-phosphate phosphodismutase; COG0637 [R] Predicted phosphatase/phosphohexomutase. (223 aa) |
| | malR | Maltose operon transcriptional repressor; COG1522 [K] Transcriptional regulators. (331 aa) |
| | LSL_1285 | Hypothetical protein. (137 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase regulatory subunit; COG0448 [G] ADP-glucose pyrophosphorylase. (390 aa) |
| | glgC-2 | Glucose-1-phosphate adenylyltransferase catalytic subunit; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (380 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (649 aa) |
| | LSL_1300 | Conserved hypothetical protein. (104 aa) |
| | mgtE | Mg2+ transporter; Acts as a magnesium transporter. (455 aa) |
| | wecD-9 | COG0110 [R] Acetyltransferase (isoleucine patch superfamily). (178 aa) |
| | wecD-10 | COG0110 [R] Acetyltransferase (isoleucine patch superfamily). (189 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (460 aa) |
| | nrdD | COG1328 [F] Oxygen-sensitive ribonucleoside-triphosphate reductase. (725 aa) |
| | gatB | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (477 aa) |
| | gatA | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (487 aa) |
| | pcrA | COG0210 [L] Superfamily I DNA and RNA helicases. (744 aa) |
| | LSL_1356 | S1-type RNA-binding domain; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (154 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1174 aa) |
| | fur | COG0735 [P] Fe2+/Zn2+ uptake regulation proteins; Belongs to the Fur family. (147 aa) |
| | sbcC | Exonuclease; COG0419 [L] ATPase involved in DNA repair. (1033 aa) |
| | sbcD | Exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (371 aa) |
| | LSL_1372 | Pyruvate oxidase; COG0028 [EH] Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (602 aa) |
| | LSL_1374 | ABC transporter permease protein; COG0577 [V] ABC-type antimicrobial peptide transport system, permease component. (353 aa) |
| | rep-2 | COG0210 [L] Superfamily I DNA and RNA helicases. (763 aa) |
| | napA | Na+/H+ antiporter; COG0475 [P] Kef-type K+ transport systems, membrane components. (618 aa) |
| | rnmV2 | Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (189 aa) |
| | rpsI | COG0103 [J] Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | cbiO-2 | Cobalt transport ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (282 aa) |
| | rpoA | DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa) |
| | rpsK | SSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (128 aa) |
| | secY | Protein translocase subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (432 aa) |
| | rplO | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | rpmD | COG1841 [J] Ribosomal protein L30/L7E. (60 aa) |
| | rpsE | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (166 aa) |
| | rpsH | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rplE | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa) |
| | rplN | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rpsC | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa) |
| | rpsS | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa) |
| | rplB | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa) |
| | rplC | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (207 aa) |
| | LSL_1438 | Transcriptional regulator, RpiR family; COG1522 [K] Transcriptional regulators. (278 aa) |
| | fur-2 | COG0735 [P] Fe2+/Zn2+ uptake regulation proteins; Belongs to the Fur family. (143 aa) |
| | nagA | COG1820 [G] N-acetylglucosamine-6-phosphate deacetylase. (378 aa) |
| | LSL_1492 | Conserved hypothetical protein. (263 aa) |
| | LSL_1500 | Conserved hypothetical protein; COG0628 [R] Predicted permease. (351 aa) |
| | LSL_1523 | Hypothetical membrane spanning protein. (541 aa) |
| | rfaG-18 | COG0438 [M] Glycosyltransferase. (350 aa) |
| | rfaG-19 | COG0438 [M] Glycosyltransferase. (407 aa) |
| | rfaG-20 | COG0438 [M] Glycosyltransferase. (370 aa) |
| | rfaG-22 | COG0438 [M] Glycosyltransferase. (364 aa) |
| | LSL_1564 | DNA helicase; COG0210 [L] Superfamily I DNA and RNA helicases. (563 aa) |
| | LSL_1566 | Conserved hypothetical protein; COG0344 [S] Predicted membrane protein. (465 aa) |
| | LSL_1576 | COG0011 [S] Uncharacterized conserved protein. (214 aa) |
| | LSL_1577 | Hydrolase, HAD superfamily; COG0637 [R] Predicted phosphatase/phosphohexomutase. (221 aa) |
| | LSL_1582 | NADPH-dependent FMN reductase. (259 aa) |
| | LSL_1585 | COG1108 [P] ABC-type Mn2+/Zn2+ transport systems, permease components. (266 aa) |
| | LSL_1586 | ABC transporter, ATP-binding protein; COG1121 [P] ABC-type Mn/Zn transport systems, ATPase component. (222 aa) |
| | LSL_1592 | Hypothetical membrane spanning protein. (589 aa) |
| | addA | ATP-dependent nuclease subunit A; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1248 aa) |
| | rexB | ATP-dependent nuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1193 aa) |
| | prsA-2 | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa) |
| | LSL_1640 | Transcriptional regulator, ArsR family; COG0640 [K] Predicted transcriptional regulators. (116 aa) |
| | LSL_1642 | COG1428 [F] Deoxynucleoside kinases. (245 aa) |
| | LSL_1657 | Hypothetical protein, phage associated. (256 aa) |
| | LSL_1658 | DNA primase; COG0433 [R] Predicted ATPase. (464 aa) |
| | LSL_1675 | ABC transporter permease protein; COG0577 [V] ABC-type antimicrobial peptide transport system, permease component. (856 aa) |
| | oppC | COG0601 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, permease components. (342 aa) |
| | LSL_1708 | Transcriptional regulator, ArsR family; COG0583 [K] Transcriptional regulator. (119 aa) |
| | LSL_1711 | Transcriptional regulator, LacI family; COG1522 [K] Transcriptional regulators. (330 aa) |
| | cysK-2 | COG0031 [E] Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa) |
| | dnaB-2 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (463 aa) |
| | rnpA | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (113 aa) |
| | LSL_1525 | Hypothetical membrane spanning protein. (392 aa) |
| | dnaN | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (379 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (850 aa) |
| | LSL_0014 | Pyruvate oxidase; COG0028 [EH] Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (628 aa) |
| | cysK | COG0031 [E] Cysteine synthase. (305 aa) |
| | LSL_0035 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (236 aa) |
| | phnP | COG1235 [R] Metal-dependent hydrolases of the beta-lactamase superfamily I. (267 aa) |
| | LSL_0049 | Transposase ISLasa1a, IS1223 family; COG0675 [L] Transposase and inactivated derivatives. (172 aa) |
| | scrR | Sucrose operon repressor; COG1522 [K] Transcriptional regulators. (330 aa) |
| | ktrA | Potassium uptake protein; COG0569 [P] K+ transport systems, NAD-binding component. (212 aa) |
| | glpO | Alpha-glycerophosphate oxidase; COG0240 [C] Glycerol-3-phosphate dehydrogenase. (609 aa) |
| | potA | Spermidine/putrescine transport ATP-binding protein potA; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (362 aa) |
| | aceF | COG0508 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (426 aa) |
| | LSL_0166 | Hypothetical membrane spanning protein. (400 aa) |
| | LSL_0179 | COG4690 [E] Dipeptidase. (472 aa) |
| | LSL_0186 | Acetolactate synthase; COG0028 [EH] Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (561 aa) |
| | pyrB | COG0540 [F] Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (316 aa) |
| | carA | COG0505 [EF] Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (362 aa) |
| | rpoB | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1199 aa) |
| | rpoC | DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1221 aa) |
| | rpsG | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | LSL_0205 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (229 aa) |
| | rep | COG0210 [L] Superfamily I DNA and RNA helicases. (755 aa) |
| | rnmV1 | Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (185 aa) |
| | LSL_0257 | Replisome organizer, phage associated. (327 aa) |
| | mcrA | COG1403 [V] Restriction endonuclease. (176 aa) |
| | argH | COG0165 [E] Argininosuccinate lyase. (460 aa) |
| | ldhA | COG1052 [CHR] Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa) |
| | udp | Phosphorylase, Pnp/Udp family; COG2820 [F] Uridine phosphorylase. (256 aa) |
| | birA | Biotin operon repressor / Biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (321 aa) |
| | spoVK | COG0464 [O] ATPases of the AAA+ class. (535 aa) |
| | LSL_0330 | Hypothetical protein. (294 aa) |
| | LSL_0332 | Conserved hypothetical protein. (666 aa) |
| | rpoE | DNA-directed RNA polymerase delta chain; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (196 aa) |
| | LSL_0359 | Hypothetical protein. (82 aa) |
| | LSL_0367 | Sigma-70 factor family protein. (192 aa) |
| | LSL_0371 | Hypothetical membrane spanning protein; COG0628 [R] Predicted permease. (376 aa) |
| | gpsA | COG0240 [C] Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa) |
| | lacZ | COG3250 [G] Beta-galactosidase/beta-glucuronidase. (1007 aa) |
| | galR | Galactose operon repressor; COG1522 [K] Transcriptional regulators. (332 aa) |
| | rfaG-3 | COG0438 [M] Glycosyltransferase. (399 aa) |
| | rfaG-4 | COG0438 [M] Glycosyltransferase. (336 aa) |
| | LSL_0413 | Transcriptional regulator, ArsR family; COG0583 [K] Transcriptional regulator. (111 aa) |
| | ccpA | Catabolite control protein A; COG1522 [K] Transcriptional regulators. (335 aa) |
| | LSL_0424 | ComG operon protein 1; COG2804 [NU] Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB. (327 aa) |
| | LSL_0426 | ComG operon protein 3. (100 aa) |
| | LSL_0440 | Polyribonucleotide nucleotidyltransferase; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (136 aa) |
| | fabD | Malonyl-CoA-[acyl-carrier-protein] transacylase; COG0331 [I] (acyl-carrier-protein) S-malonyltransferase. (312 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (149 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (459 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | accA | COG0825 [I] Acetyl-CoA carboxylase alpha subunit. (262 aa) |
| | fabI | COG0623 [I] Enoyl-[acyl-carrier-protein] reductase (NADH). (252 aa) |
| | LSL_0471 | Transcription regulator, Crp family; COG0583 [K] Transcriptional regulator. (221 aa) |
| | trmB | tRNA (m(7)G46) methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (212 aa) |
| | LSL_0484 | tRNA binding domain protein; COG0073 [R] EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (216 aa) |
| | maoC | Dehydrogenase with MaoC-like domain; COG2030 [I] Acyl dehydratase. (146 aa) |
| | dnaB | COG3611 [L] Replication initiation/membrane attachment protein. (448 aa) |
| | dnaI | COG1484 [L] DNA replication protein. (309 aa) |
| | rpmF | COG0333 [J] Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (58 aa) |
| | rpsB | COG0052 [J] Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (265 aa) |
| | LSL_0514 | COG1428 [F] Deoxynucleoside kinases. (240 aa) |
| | LSL_0522 | COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (228 aa) |
| | nusB | N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (131 aa) |
| | xseA | Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (446 aa) |
| | xseB | Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (75 aa) |
| | lexA | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (206 aa) |
| | LSL_0546 | Transposase ISLasa5a, IS3 family; COG0675 [L] Transposase and inactivated derivatives. (459 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (571 aa) |
| | rPL | COG1358 [J] Ribosomal protein HS6-type (S12/L30/L7a). (101 aa) |
| | LSL_0586 | Transposase ISLasa7, IS3 family; COG0675 [L] Transposase and inactivated derivatives. (222 aa) |
| | murE-2 | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; COG0769 [M] UDP-N-acetylmuramyl tripeptide synthase. (449 aa) |
| | atpB | ATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (237 aa) |
| | atpE | ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa) |
| | atpF | ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (175 aa) |
| | atpH | ATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa) |
| | atpA | ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (503 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (309 aa) |
| | atpD | ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa) |
| | rpoZ | DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (65 aa) |
| | LSL_0613 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa) |
| | priA | Primosomal protein n-prim; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (792 aa) |
| | LSL_0615 | 16S rRNA m(5)C 967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (445 aa) |
| | recG | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (676 aa) |
| | ffh | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (482 aa) |
| | rpsT | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (84 aa) |
| | rpsO | SSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | rnj | Metallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (565 aa) |
| | clpX | ATP-dependent clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (408 aa) |
| | rnj-2 | Metallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (558 aa) |
| | LSL_0647 | COG5428 [S] Uncharacterized conserved small protein. (71 aa) |
| | typA | GTP-binding protein; COG1217 [T] Predicted membrane GTPase involved in stress response. (613 aa) |
| | comEA | COG1555 [L] DNA uptake protein and related DNA-binding proteins. (229 aa) |
| | holA | COG1466 [L] DNA polymerase III, delta subunit. (340 aa) |
| | LSL_0690 | DNA replication protein dnaD; COG3935 [L] Putative primosome component and related proteins. (235 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (255 aa) |
| | recD | Exodeoxyribonuclease V alpha chain; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (824 aa) |
| | LSL_0733 | Transposase ISLasa9a, IS200-IS605 family; COG0675 [L] Transposase and inactivated derivatives. (425 aa) |
| | LSL_0746 | Phage antirepressor. (143 aa) |
| | LSL_0752 | Phage helicase; COG0553 [KL] Superfamily II DNA/RNA helicases, SNF2 family. (407 aa) |
| | LSL_0755 | Hypothetical protein, phage associated. (137 aa) |
| | LSL_0756 | Phage NTP-binding protein. (526 aa) |
| | LSL_0758 | Phage DNA polymerase. (565 aa) |
| | LSL_0759 | Phage primase. (343 aa) |
| | LSL_0760 | Phage DNA primase; COG0433 [R] Predicted ATPase. (289 aa) |
| | LSL_0767 | Hypothetical protein, phage associated; COG0286 [V] Type I restriction-modification system methyltransferase subunit. (217 aa) |
| | mcrA-2 | COG1403 [V] Restriction endonuclease. (108 aa) |
| | LSL_0797 | Phage lysin; COG3757 [M] Lyzozyme M1 (1,4-beta-N-acetylmuramidase). (252 aa) |
| | carA-2 | COG0505 [EF] Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (366 aa) |
| | nifS | COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (380 aa) |
| | dnaE-2 | COG0587 [L] DNA polymerase III, alpha subunit. (1097 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | LSL_0873 | Fibronectin-binding protein / Fibrinogen-binding protein; COG1293 [K] Predicted RNA-binding protein homologous to eukaryotic snRNP. (562 aa) |
| | rpsA | COG0539 [J] Ribosomal protein S1. (399 aa) |
| | dltA | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] (508 aa) |
| | dgkA | COG0818 [M] Diacylglycerol kinase. (138 aa) |
| | recQ | COG0514 [L] Superfamily II DNA helicase. (481 aa) |
| | rpoD | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (372 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa) |
| | glyS | COG0751 [J] Glycyl-tRNA synthetase, beta subunit. (693 aa) |
| | glyQ | COG0752 [J] Glycyl-tRNA synthetase, alpha subunit. (305 aa) |
| | hsdS-2 | Type I restriction-modification system specificity subunit; COG0732 [V] Restriction endonuclease S subunits. (372 aa) |
| | hsdS-3 | Type I restriction-modification system specificity subunit; COG0732 [V] Restriction endonuclease S subunits. (384 aa) |
| | hsdM | COG0286 [V] Type I restriction-modification system methyltransferase subunit. (529 aa) |
| | LSL_0924 | Maltose O-acetyltransferase; COG0110 [R] Acetyltransferase (isoleucine patch superfamily). (210 aa) |
| | hslU | ATP-dependent hsl protease ATP-binding subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (467 aa) |
| | hslV | ATP-dependent protease hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (175 aa) |
| | LSL_0962 | Hypothetical protein. (173 aa) |
| | LSL_0967 | Hypothetical protein. (269 aa) |
| | rfaG-7 | Glycosyltransferase. (379 aa) |
