STRINGSTRING
ackA ackA LSL_1141 LSL_1141 hpf hpf LSL_1191 LSL_1191 LSL_1193 LSL_1193 LSL_1201 LSL_1201 LSL_1202 LSL_1202 LSL_1210 LSL_1210 LSL_1225 LSL_1225 recR recR LSL_1227 LSL_1227 tadA tadA rplL rplL rplJ rplJ rplA rplA rplK rplK rpmG-2 rpmG-2 mrnC mrnC wecD-7 wecD-7 LSL_1273 LSL_1273 srmB-4 srmB-4 LSL_1296 LSL_1296 mgtE mgtE topB topB ackA-2 ackA-2 wecD-11 wecD-11 LSL_1352 LSL_1352 LSL_1356 LSL_1356 LSL_1363 LSL_1363 tyrS tyrS sbcD sbcD LSL_1387 LSL_1387 rnmV2 rnmV2 rpsI rpsI rplM rplM truA truA rplQ rplQ rpsK rpsK rpsM rpsM rpmJ rpmJ adk adk rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ LSL_1441 LSL_1441 LSL_1460 LSL_1460 LSL_1467 LSL_1467 trxA-3 trxA-3 treB treB LSL_1529 LSL_1529 rfbB rfbB ychF ychF parB parB LSL_1602 LSL_1602 LSL_1642 LSL_1642 LSL_1649 LSL_1649 LSL_1657 LSL_1657 LSL_1658 LSL_1658 LSL_1721 LSL_1721 rpmH rpmH dnaB-2 dnaB-2 recF recF gyrB gyrB rpsF rpsF rpsR rpsR gldA gldA phnP phnP LSL_0046 LSL_0046 scrA scrA serC serC LSL_0128 LSL_0128 LSL_0133 LSL_0133 LSL_0136 LSL_0136 acoB acoB LSL_0179 LSL_0179 rpsL rpsL rpsG rpsG sir2 sir2 czcD czcD LSL_0224 LSL_0224 rnmV1 rnmV1 ispE ispE LSL_0257 LSL_0257 mcrA mcrA LSL_0324 LSL_0324 LSL_0338 LSL_0338 rpmE rpmE srmB srmB srmB-2 srmB-2 LSL_0409 LSL_0409 LSL_0410 LSL_0410 LSL_0440 LSL_0440 fabB fabB LSL_0469 LSL_0469 trxA trxA dnaB dnaB dnaI dnaI rpmI rpmI rplT rplT LSL_0500 LSL_0500 nadD nadD rpmF rpmF rpsB rpsB LSL_0514 LSL_0514 LSL_0526 LSL_0526 ispA ispA recN recN rpmG rpmG LSL_0550 LSL_0550 ada ada rPL rPL ribF ribF murE-2 murE-2 LSL_0610 LSL_0610 priA priA rpmB rpmB smc smc rpsP rpsP rplS rplS rpsT rpsT rpsO rpsO purF purF purD purD comEB comEB fni fni LSL_0690 LSL_0690 nth nth rpsU rpsU LSL_0717 LSL_0717 topA topA LSL_0733 LSL_0733 LSL_0742 LSL_0742 LSL_0752 LSL_0752 LSL_0758 LSL_0758 LSL_0759 LSL_0759 LSL_0760 LSL_0760 mcrA-2 mcrA-2 udk udk dtd dtd LSL_0840 LSL_0840 fhs fhs nifS nifS gyrB-2 gyrB-2 LSL_0885 LSL_0885 rpsA rpsA recO recO dgkA dgkA ybeY ybeY recQ recQ LSL_0905 LSL_0905 dnaG dnaG rpmA rpmA rplU rplU gAlE gAlE LSL_0967 LSL_0967 qor qor LSL_0980 LSL_0980 lysA lysA LSL_1006 LSL_1006 LSL_1018 LSL_1018 draG draG LSL_1044 LSL_1044 radC radC nifS-2 nifS-2 ezrA ezrA rpsD rpsD LSL_1079 LSL_1079 LSL_1092 LSL_1092 rnz rnz trxA-2 trxA-2 LSL_1109 LSL_1109 srmB-3 srmB-3 LSL_1113 LSL_1113
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
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ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
LSL_1141Copper homeostasis protein cutC. (187 aa)
hpfRibosome-associated factor Y; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (184 aa)
LSL_1191Phage transcriptional regulator, Cro/CI family; COG0640 [K] Predicted transcriptional regulators. (165 aa)
LSL_1193Phage immunity repressor. (126 aa)
LSL_1201Hypothetical protein, phage associated. (256 aa)
LSL_1202DNA primase; COG0433 [R] Predicted ATPase. (516 aa)
LSL_1210COG0474 [P] Cation transport ATPase. (800 aa)
LSL_1225Conserved hypothetical protein. (79 aa)
recRRecombination protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
LSL_1227Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (104 aa)
tadACytosine/adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (166 aa)
rplLLSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rplJLSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (167 aa)
rplALSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa)
rplKLSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rpmG-2COG0267 [J] Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (50 aa)
mrnCConserved hypothetical protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (135 aa)
wecD-7Acetyltransferase. (92 aa)
LSL_1273COG2423 [E] Predicted ornithine cyclodeaminase, mu-crystallin homolog. (328 aa)
srmB-4COG0513 [LKJ] Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (426 aa)
LSL_1296Conserved hypothetical protein. (347 aa)
mgtEMg2+ transporter; Acts as a magnesium transporter. (455 aa)
topBDNA topoisomerase III; COG0550 [L] Topoisomerase IA. (691 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
wecD-11Acetyltransferase; COG2388 [R] Predicted acetyltransferase. (207 aa)
LSL_1352tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (330 aa)
LSL_1356S1-type RNA-binding domain; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (154 aa)
LSL_1363Conserved hypothetical protein; COG1787 [V] Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes. (757 aa)
tyrSTyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (416 aa)
sbcDExonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (371 aa)
LSL_1387Conserved hypothetical protein; COG2020 [O] Putative protein-S-isoprenylcysteine methyltransferase. (187 aa)
rnmV2Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (189 aa)
rpsICOG0103 [J] Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplMLSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (256 aa)
rplQCOG0203 [J] Ribosomal protein L17. (127 aa)
rpsKSSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (128 aa)
rpsMSSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpmJCOG0257 [J] Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
adkAdenylate kinase / Nucleoside-diphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (219 aa)
rplOLSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmDCOG1841 [J] Ribosomal protein L30/L7E. (60 aa)
rpsESSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (166 aa)
rplRLSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rplFLSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rpsHSSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsNSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplELSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rplXLSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (101 aa)
rplNLSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQSSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa)
rpmCCOG0255 [J] Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (64 aa)
rplPLSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa)
rpsCSSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa)
rplVLSU ribosomal protein L22P; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (115 aa)
rpsSSSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplBLSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rplWLSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (94 aa)
rplDLSU ribosomal protein L1E; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (207 aa)
rplCLSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (207 aa)
rpsJSSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
LSL_1441Hypothetical protein. (130 aa)
LSL_1460Conserved hypothetical protein; COG0845 [M] Membrane-fusion protein. (357 aa)
LSL_1467COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (378 aa)
trxA-3Thioredoxin; COG0526 [OC] Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family. (107 aa)
treBPTS system, trehalose-specific IIBC component; COG1263 [G] Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (640 aa)
LSL_1529Hypothetical membrane spanning protein. (186 aa)
rfbBCOG1088 [M] dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (343 aa)
ychFGTP-binding protein, probable translation factor; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
parBChromosome partitioning protein, DNA-binding protein; COG0640 [K] Predicted transcriptional regulators; Belongs to the ParB family. (291 aa)
LSL_1602COG0474 [P] Cation transport ATPase. (881 aa)
LSL_1642COG1428 [F] Deoxynucleoside kinases. (245 aa)
LSL_1649Transcriptional regulator, Cro/CI family; COG0583 [K] Transcriptional regulator. (267 aa)
LSL_1657Hypothetical protein, phage associated. (256 aa)
LSL_1658DNA primase; COG0433 [R] Predicted ATPase. (464 aa)
LSL_1721COG1607 [I] Acyl-CoA hydrolase. (169 aa)
rpmHCOG0230 [J] Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
dnaB-2Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (463 aa)
recFDNA replication and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (379 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (652 aa)
rpsFSSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpsRSSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
gldACOG0371 [C] Glycerol dehydrogenase and related enzymes. (363 aa)
phnPCOG1235 [R] Metal-dependent hydrolases of the beta-lactamase superfamily I. (267 aa)
LSL_0046Short chain dehydrogenase; COG1028 [IQR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (282 aa)
scrAPTS system, sucrose-specific IIABC component; COG1263 [G] Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific. (644 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa)
LSL_0128COG1791 [S] Uncharacterized conserved protein, contains double-stranded beta-helix domain. (136 aa)
LSL_0133COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (382 aa)
LSL_0136COG1250 [I] 3-hydroxyacyl-CoA dehydrogenase. (293 aa)
acoBCOG0022 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (325 aa)
LSL_0179COG4690 [E] Dipeptidase. (472 aa)
rpsLSSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. (137 aa)
rpsGSSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
sir2SIR2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (243 aa)
czcDCobalt-zinc-cadmium resistance protein; COG0053 [P] Predicted Co/Zn/Cd cation transporters; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (341 aa)
LSL_0224COG1257 [I] Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (421 aa)
rnmV1Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (185 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (289 aa)
LSL_0257Replisome organizer, phage associated. (327 aa)
mcrACOG1403 [V] Restriction endonuclease. (176 aa)
LSL_0324Metallo-beta-lactamase family protein; COG2220 [R] Predicted Zn-dependent hydrolases of the beta-lactamase fold; Belongs to the UPF0173 family. (219 aa)
LSL_0338Hydrolase; COG1078 [R] HD superfamily phosphohydrolases. (451 aa)
rpmECOG0254 [J] Ribosomal protein L31. (82 aa)
srmBSuperfamily II DNA and RNA helicase; COG1199 [KL] Rad3-related DNA helicases. (788 aa)
srmB-2ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (492 aa)
LSL_0409COG0700 [S] Uncharacterized membrane protein. (230 aa)
LSL_0410COG0700 [S] Uncharacterized membrane protein. (229 aa)
LSL_0440Polyribonucleotide nucleotidyltransferase; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (136 aa)
fabB3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa)
LSL_0469N-acetyldiaminopimelate deacetylase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (381 aa)
trxAThioredoxin; COG0526 [OC] Thiol-disulfide isomerase and thioredoxins. (105 aa)
dnaBCOG3611 [L] Replication initiation/membrane attachment protein. (448 aa)
dnaICOG1484 [L] DNA replication protein. (309 aa)
rpmICOG0291 [J] Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rplTLSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (120 aa)
LSL_0500GTP-binding protein; COG1160 [R] Predicted GTPases. (373 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa)
rpmFCOG0333 [J] Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (58 aa)
rpsBCOG0052 [J] Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (265 aa)
LSL_0514COG1428 [F] Deoxynucleoside kinases. (240 aa)
LSL_0526COG3425 [I] 3-hydroxy-3-methylglutaryl CoA synthase. (387 aa)
ispAGeranyltranstransferase; COG0142 [H] Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (297 aa)
recNDNA repair protein; May be involved in recombinational repair of damaged DNA. (555 aa)
rpmGCOG0267 [J] Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
LSL_0550Integral membrane protein, Rhomboid family; COG0705 [R] Uncharacterized membrane protein (homolog of Drosophila rhomboid). (220 aa)
adaCOG0350 [L] Methylated DNA-protein cysteine methyltransferase. (153 aa)
rPLCOG1358 [J] Ribosomal protein HS6-type (S12/L30/L7a). (101 aa)
ribFRiboflavin kinase / FMN adenylyltransferase; COG0196 [H] FAD synthase; Belongs to the ribF family. (318 aa)
murE-2UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; COG0769 [M] UDP-N-acetylmuramyl tripeptide synthase. (449 aa)
LSL_0610Hypothetical protein. (284 aa)
priAPrimosomal protein n-prim; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (792 aa)
rpmBCOG0227 [J] Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (61 aa)
smcChromosome partition protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1178 aa)
rpsPCOG0228 [J] Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (91 aa)
rplSLSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (118 aa)
rpsTSSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (84 aa)
rpsOSSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (483 aa)
purDCOG0151 [F] Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (418 aa)
comEBComE operon protein 2; COG2131 [F] Deoxycytidylate deaminase. (158 aa)
fniIsopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (348 aa)
LSL_0690DNA replication protein dnaD; COG3935 [L] Putative primosome component and related proteins. (235 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)
rpsUCOG0828 [J] Ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (61 aa)
LSL_0717GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (285 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (703 aa)
LSL_0733Transposase ISLasa9a, IS200-IS605 family; COG0675 [L] Transposase and inactivated derivatives. (425 aa)
LSL_0742Phage transcriptional regulator, Cro/CI family; COG0640 [K] Predicted transcriptional regulators. (131 aa)
LSL_0752Phage helicase; COG0553 [KL] Superfamily II DNA/RNA helicases, SNF2 family. (407 aa)
LSL_0758Phage DNA polymerase. (565 aa)
LSL_0759Phage primase. (343 aa)
LSL_0760Phage DNA primase; COG0433 [R] Predicted ATPase. (289 aa)
mcrA-2COG1403 [V] Restriction endonuclease. (108 aa)
udkCOG0572 [F] Uridine kinase. (213 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa)
LSL_0840Ribonuclease HI / Cell wall enzyme EBSB. (128 aa)
fhsFormate--tetrahydrofolate ligase; COG2759 [F] Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. (552 aa)
nifSCOG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (380 aa)
gyrB-2Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (673 aa)
LSL_0885DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa)
rpsACOG0539 [J] Ribosomal protein S1. (399 aa)
recODNA repair protein; Involved in DNA repair and RecF pathway recombination. (260 aa)
dgkACOG0818 [M] Diacylglycerol kinase. (138 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (159 aa)
recQCOG0514 [L] Superfamily II DNA helicase. (481 aa)
LSL_0905COG0720 [H] 6-pyruvoyl-tetrahydropterin synthase. (122 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa)
rpmACOG0211 [J] Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (93 aa)
rplULSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
gAlEUDP-glucose 4-epimerase; COG0451 [MG] Nucleoside-diphosphate-sugar epimerases. (319 aa)
LSL_0967Hypothetical protein. (269 aa)
qorCOG0604 [CR] NADPH:quinone reductase and related Zn-dependent oxidoreductases. (334 aa)
LSL_0980UDP-glucuronate 4-epimerase; COG0451 [MG] Nucleoside-diphosphate-sugar epimerases. (359 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
LSL_1006COG4690 [E] Dipeptidase. (474 aa)
LSL_1018Cellulose synthase catalytic subunit; UDP-forming. (690 aa)
draGCOG1397 [O] ADP-ribosylglycohydrolase. (328 aa)
LSL_1044RNA binding protein; COG2302 [S] Uncharacterized conserved protein, contains S4-like domain. (262 aa)
radCCOG2003 [L] DNA repair proteins; Belongs to the UPF0758 family. (225 aa)
nifS-2COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (382 aa)
ezrASeptation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (570 aa)
rpsDSSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (201 aa)
LSL_1079ATPase, AAA family; COG2256 [L] ATPase related to the helicase subunit of the Holliday junction resolvase. (423 aa)
LSL_1092COG0300 [R] Short-chain dehydrogenases of various substrate specificities; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (269 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (317 aa)
trxA-2Thioredoxin; COG0526 [OC] Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family. (103 aa)
LSL_1109Endonuclease involved in recombination; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (143 aa)
srmB-3ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (440 aa)
LSL_1113Phosphoesterase, DHH family protein; COG0618 [R] Exopolyphosphatase-related proteins. (324 aa)
Your Current Organism:
Lactobacillus salivarius
NCBI taxonomy Id: 362948
Other names: L. salivarius UCC118, Lactobacillus salivarius UCC118, Lactobacillus salivarius str. UCC118, Lactobacillus salivarius strain UCC118, Lactobacillus salivarius subsp. salivarius UCC118
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