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| | LSL_1649 | Transcriptional regulator, Cro/CI family; COG0583 [K] Transcriptional regulator. (267 aa) |
| | LSL_1657 | Hypothetical protein, phage associated. (256 aa) |
| | LSL_1658 | DNA primase; COG0433 [R] Predicted ATPase. (464 aa) |
| | dnaB-2 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (463 aa) |
| | rpmH | COG0230 [J] Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | gAlE | UDP-glucose 4-epimerase; COG0451 [MG] Nucleoside-diphosphate-sugar epimerases. (319 aa) |
| | rplU | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa) |
| | rpmA | COG0211 [J] Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (93 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa) |
| | recQ | COG0514 [L] Superfamily II DNA helicase. (481 aa) |
| | dgkA | COG0818 [M] Diacylglycerol kinase. (138 aa) |
| | recO | DNA repair protein; Involved in DNA repair and RecF pathway recombination. (260 aa) |
| | rpsA | COG0539 [J] Ribosomal protein S1. (399 aa) |
| | LSL_0885 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa) |
| | gyrB-2 | Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (673 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | udk | COG0572 [F] Uridine kinase. (213 aa) |
| | LSL_0760 | Phage DNA primase; COG0433 [R] Predicted ATPase. (289 aa) |
| | LSL_0759 | Phage primase. (343 aa) |
| | LSL_0752 | Phage helicase; COG0553 [KL] Superfamily II DNA/RNA helicases, SNF2 family. (407 aa) |
| | LSL_0742 | Phage transcriptional regulator, Cro/CI family; COG0640 [K] Predicted transcriptional regulators. (131 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (703 aa) |
| | rpsU | COG0828 [J] Ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (61 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa) |
| | LSL_0690 | DNA replication protein dnaD; COG3935 [L] Putative primosome component and related proteins. (235 aa) |
| | comEB | ComE operon protein 2; COG2131 [F] Deoxycytidylate deaminase. (158 aa) |
| | rpsO | SSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | rpsT | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (84 aa) |
| | rpsP | COG0228 [J] Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (91 aa) |
| | smc | Chromosome partition protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1178 aa) |
| | rpmB | COG0227 [J] Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (61 aa) |
| | priA | Primosomal protein n-prim; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (792 aa) |
| | rPL | COG1358 [J] Ribosomal protein HS6-type (S12/L30/L7a). (101 aa) |
| | rpmG | COG0267 [J] Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa) |
| | recN | DNA repair protein; May be involved in recombinational repair of damaged DNA. (555 aa) |
| | rpsB | COG0052 [J] Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (265 aa) |
| | rpmI | COG0291 [J] Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa) |
| | dnaI | COG1484 [L] DNA replication protein. (309 aa) |
| | dnaB | COG3611 [L] Replication initiation/membrane attachment protein. (448 aa) |
| | LSL_0440 | Polyribonucleotide nucleotidyltransferase; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (136 aa) |
| | srmB-2 | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (492 aa) |
| | rpmE | COG0254 [J] Ribosomal protein L31. (82 aa) |
| | LSL_0338 | Hydrolase; COG1078 [R] HD superfamily phosphohydrolases. (451 aa) |
| | LSL_0257 | Replisome organizer, phage associated. (327 aa) |
| | rnmV1 | Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (185 aa) |
| | sir2 | SIR2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (243 aa) |
| | rpsG | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | LSL_0179 | COG4690 [E] Dipeptidase. (472 aa) |
| | LSL_0133 | COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (382 aa) |
| | rpsR | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa) |
| | rpsF | SSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (96 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (652 aa) |
| | recF | DNA replication and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (379 aa) |
| | rpmF | COG0333 [J] Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (58 aa) |
| | rplW | LSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (94 aa) |
| | rplB | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa) |
| | rpsS | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa) |
| | rpsC | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa) |
| | rpmC | COG0255 [J] Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (64 aa) |
| | rpsQ | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa) |
| | rplN | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplE | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa) |
| | rpsN | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rplR | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa) |
| | rpsE | SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (166 aa) |
| | rpmD | COG1841 [J] Ribosomal protein L30/L7E. (60 aa) |
| | rplO | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | rpmJ | COG0257 [J] Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsK | SSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (128 aa) |
| | rplQ | COG0203 [J] Ribosomal protein L17. (127 aa) |
| | rplM | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa) |
| | rpsI | COG0103 [J] Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | rnmV2 | Ribonuclease M5; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (189 aa) |
| | LSL_1363 | Conserved hypothetical protein; COG1787 [V] Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes. (757 aa) |
| | LSL_1356 | S1-type RNA-binding domain; COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain). (154 aa) |
| | LSL_1352 | tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (330 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | topB | DNA topoisomerase III; COG0550 [L] Topoisomerase IA. (691 aa) |
| | LSL_1296 | Conserved hypothetical protein. (347 aa) |
| | srmB-4 | COG0513 [LKJ] Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (426 aa) |
| | rpmG-2 | COG0267 [J] Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (50 aa) |
| | rplK | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | rplA | LSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa) |
| | rplJ | LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (167 aa) |
| | rplL | LSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa) |
| | LSL_1227 | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (104 aa) |
| | recR | Recombination protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa) |
| | LSL_1225 | Conserved hypothetical protein. (79 aa) |
| | LSL_1202 | DNA primase; COG0433 [R] Predicted ATPase. (516 aa) |
| | LSL_1201 | Hypothetical protein, phage associated. (256 aa) |
| | LSL_1193 | Phage immunity repressor. (126 aa) |
| | LSL_1191 | Phage transcriptional regulator, Cro/CI family; COG0640 [K] Predicted transcriptional regulators. (165 aa) |
| | hpf | Ribosome-associated factor Y; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (184 aa) |
| | LSL_1141 | Copper homeostasis protein cutC. (187 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | LSL_1113 | Phosphoesterase, DHH family protein; COG0618 [R] Exopolyphosphatase-related proteins. (324 aa) |
| | srmB-3 | ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (440 aa) |
| | trxA-2 | Thioredoxin; COG0526 [OC] Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family. (103 aa) |
| | LSL_1079 | ATPase, AAA family; COG2256 [L] ATPase related to the helicase subunit of the Holliday junction resolvase. (423 aa) |
| | ezrA | Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (570 aa) |
| | radC | COG2003 [L] DNA repair proteins; Belongs to the UPF0758 family. (225 aa) |
| | LSL_1044 | RNA binding protein; COG2302 [S] Uncharacterized conserved protein, contains S4-like domain. (262 aa) |
| | draG | COG1397 [O] ADP-ribosylglycohydrolase. (328 aa) |
| | LSL_1018 | Cellulose synthase catalytic subunit; UDP-forming. (690 aa) |
| | LSL_1006 | COG4690 [E] Dipeptidase. (474 aa) |
| | LSL_0980 | UDP-glucuronate 4-epimerase; COG0451 [MG] Nucleoside-diphosphate-sugar epimerases. (359 aa) |
| | LSL_0967 | Hypothetical protein. (269 aa) |
| | rplC | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (207 aa) |
| | rpsJ | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | LSL_1460 | Conserved hypothetical protein; COG0845 [M] Membrane-fusion protein. (357 aa) |
| | LSL_1467 | COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (378 aa) |
| | trxA-3 | Thioredoxin; COG0526 [OC] Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family. (107 aa) |
| | LSL_1529 | Hypothetical membrane spanning protein. (186 aa) |
| | rfbB | COG1088 [M] dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (343 aa) |
| | parB | Chromosome partitioning protein, DNA-binding protein; COG0640 [K] Predicted transcriptional regulators; Belongs to the ParB family. (291 aa) |
