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upp upp pyrD pyrD pyrC1 pyrC1 pyrH pyrH dcd dcd guaAa1 guaAa1 ham1 ham1 purT purT purK purK purE1 purE1 purA purA purNH purNH purB purB apt1 apt1 purL purL HQ_1756A HQ_1756A fhs fhs tdk tdk folA2 folA2 HQ_1856A HQ_1856A pyrI pyrI pyrB pyrB pyrC2 pyrC2 apt2 apt2 uraA2 uraA2 guaB guaB folA1 folA1 hts hts HQ_2498A HQ_2498A purD purD cdd cdd udp2 udp2 purM purM carA carA folD folD glyA glyA purF purF HQ_2947A HQ_2947A HQ_3112A HQ_3112A dut dut purC purC purU purU purS purS purQ purQ tmk tmk guaAb guaAb udp3 udp3 pyrF pyrF uraA3 uraA3 apt3 apt3 pyrE2 pyrE2 carB carB surE1 surE1 guaAa2 guaAa2 surE2 surE2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (226 aa)
pyrDDihydroorotate dehydrogenase (quinone). (357 aa)
pyrC1Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (434 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
dcddCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (206 aa)
guaAa1GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (184 aa)
ham1Non-canonical purine NTP pyrophosphatase. (226 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (401 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (401 aa)
purE1N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (218 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa)
purNHPhosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase. (534 aa)
purBAdenylosuccinate lyase. (474 aa)
apt1HGPRTase-like protein 1; May catalyze a purine salvage reaction, the substrate is unknown. (188 aa)
purLPhosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (725 aa)
HQ_1756AHomolog to 5,10-methylenetetrahydrofolate reductase. (285 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (580 aa)
tdkThymidine kinase. (225 aa)
folA2Dihydrofolate reductase. (160 aa)
HQ_1856AHomolog to glycine cleavage system protein T. (458 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (178 aa)
pyrBAspartate carbamoyltransferase catalytic subunit. (304 aa)
pyrC2Metal-dependent hydrolase (homolog to dihydroorotase / allantoinase). (474 aa)
apt2HGPRTase-like protein 2; May catalyze a purine salvage reaction, the substrate is unknown. (181 aa)
uraA2Xanthine/uracil permease family transport protein. (458 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (499 aa)
folA1Dihydrofolate reductase. (195 aa)
htsThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (336 aa)
HQ_2498AProbable nucleoside hydrolase. (328 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (434 aa)
cddCytidine deaminase. (138 aa)
udp2Uridine phosphorylase. (274 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (342 aa)
carACarbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. (366 aa)
folDMethylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (659 aa)
HQ_2947AGlutamine amidotransferase (Homolog to GMP synthase subunit A); Product: uncharacterized protein (nonfunctional); gene: tot; gene has two in-frame stop codons. (234 aa)
HQ_3112AHomolog to glycine cleavage system protein T. (373 aa)
dutdUTP diphosphatase. (157 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (359 aa)
purUFormyltetrahydrofolate deformylase. (327 aa)
purSPhosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (91 aa)
purQPhosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (228 aa)
tmkThymidylate kinase. (203 aa)
guaAbGMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP. (305 aa)
udp3Uridine phosphorylase. (245 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (275 aa)
uraA3Xanthine/uracil permease family transport protein. (470 aa)
apt3Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). (239 aa)
pyrE2Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa)
carBCarbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. (1088 aa)
surE15'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (265 aa)
guaAa2Glutamine amidotransferase (homolog to GMP synthase subunit A). (245 aa)
surE25'-nucleotidase SurE. (283 aa)
Your Current Organism:
Haloquadratum walsbyi DSM 16790
NCBI taxonomy Id: 362976
Other names: H. walsbyi DSM 16790, Haloquadratum walsbyi str. DSM 16790, Haloquadratum walsbyi strain DSM 16790
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