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| | HQ_1271A | Pantoate kinase. (304 aa) |
| | purO | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (195 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (226 aa) |
| | pyrD | Dihydroorotate dehydrogenase (quinone). (357 aa) |
| | pncB1 | Nicotinate phosphoribosyltransferase. (386 aa) |
| | pyrC1 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (434 aa) |
| | HQ_1085A | Bis-gamma-glutamylcystine reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (468 aa) |
| | nadE1 | NAD synthase, ammonia-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | nadM | Nicotinamide-nucleotide adenylyltransferase. (211 aa) |
| | HQ_1238A | Nicotinamide mononucleotide deamidase. (172 aa) |
| | gptA2 | Probable phosphoribosyltransferase. (254 aa) |
| | HQ_1272A | 4-phosphopantoate--beta-alanine ligase. (269 aa) |
| | dcd | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (206 aa) |
| | guaAa1 | GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (184 aa) |
| | HQ_1319A | Thioesterase domain protein; Product: IS1341-type transposase (nonfunctional); gene has an in-frame stop codon. (146 aa) |
| | HQ_1339A | UPF0218 family protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (186 aa) |
| | gap1 | Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (357 aa) |
| | gap2 | Glyceraldehyde-3-phosphate dehydrogenase (NAD) (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (355 aa) |
| | pgk | Phosphoglycerate kinase. (411 aa) |
| | HQ_1399A | Thioesterase domain protein; The underlying mobile genetic element is noncoding but has a region of high similarity to the C-terminal region of transposons with an IS1341-type transposase gene; pseudocoding frame (HqIRS71 element) (nonfunctional). (150 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase. (453 aa) |
| | adkA | Adenylate kinase (ATP-AMP transphosphorylase),archaeal-type; Belongs to the archaeal adenylate kinase family. (184 aa) |
| | HQ_1457A | NUDIX family hydrolase. (172 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (401 aa) |
| | acs1 | acyl-CoA synthetase. (659 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (586 aa) |
| | ribL | FAD synthase. (179 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (401 aa) |
| | purE1 | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (218 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa) |
| | purNH | Phosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase. (534 aa) |
| | purB | Adenylosuccinate lyase. (474 aa) |
| | pyrE1 | Homolog to orotate phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (221 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. (385 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (725 aa) |
| | tdk | Thymidine kinase. (225 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (178 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit. (304 aa) |
| | pyrC2 | Metal-dependent hydrolase (homolog to dihydroorotase / allantoinase). (474 aa) |
| | aldH2 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa) |
| | purE2 | PurE family protein. (249 aa) |
| | pncB2 | Nicotinate phosphoribosyltransferase. (390 aa) |
| | HQ_1998A | Homolog to dUTP diphosphatase. (138 aa) |
| | gap3 | Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (330 aa) |
| | HQ_2043A | ADP-ribose pyrophosphatase. (251 aa) |
| | nnrDE | Bifunctional NAD(P)H-hydrate repair enzyme Nnr; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to al [...] (500 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (499 aa) |
| | acd | acyl-CoA dehydrogenase. (384 aa) |
| | HQ_2391A | NUDIX family hydrolase. (153 aa) |
| | mce | Methylmalonyl-CoA epimerase; The underlying mobile genetic element is noncoding but has a region of high similarity to the C-terminal region of transposons with an IS1341-type transposase gene; pseudocoding frame (HqIRS72 element) (nonfunctional). (129 aa) |
| | hts | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (336 aa) |
| | HQ_2488A | ADP-ribose pyrophosphatase. (235 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (434 aa) |
| | coaD | Phosphopantetheine adenylyltransferase. (170 aa) |
| | nadE2 | NAD synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (561 aa) |
| | HQ_2585A | Adenylate cyclase domain protein. (191 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (342 aa) |
| | fba1 | Fructose-bisphosphate aldolase, class 2. (330 aa) |
| | ushA | 5'-nucleotidase family hydrolase. (473 aa) |
| | cmk1 | Cytidylate kinase. (204 aa) |
| | HQ_2747A | Homolog to NAD kinase. (366 aa) |
| | cmk2 | Cytidylate kinase. (192 aa) |
| | adk1 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa) |
| | carA | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. (366 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (504 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa) |
| | hmgB | Hydroxymethylglutaryl-CoA synthase; Product: IS200-type transposase HqIRS115 (nonfunctional); gene has an in-frame stop codon and is truncated at the N-terminus. (447 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (158 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (659 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (338 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (401 aa) |
| | HQ_3011A | HD family hydrolase. (411 aa) |
| | pgi | Glucose-6-phosphate isomerase. (430 aa) |
| | dut | dUTP diphosphatase. (157 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (359 aa) |
| | purU | Formyltetrahydrofolate deformylase. (327 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (91 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (228 aa) |
| | tmk | Thymidylate kinase. (203 aa) |
| | guaAb | GMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP. (305 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (555 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (219 aa) |
| | hit1 | Histidine triad family protein (homolog to bis(5'-nucleosyl)-tetraphosphatase). (223 aa) |
| | hmgA | hydroxymethylglutaryl-CoA reductase (NADPH); Belongs to the HMG-CoA reductase family. (406 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (383 aa) |
| | nadB | L-aspartate oxidase. (513 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (271 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (275 aa) |
| | apt3 | Purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase). (239 aa) |
| | pyrE2 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa) |
| | ribK | Riboflavin kinase, CTP-dependent; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (234 aa) |
| | atpD | A-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (232 aa) |
| | atpB | A-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (475 aa) |
| | atpA | A-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (585 aa) |
| | atpF | A-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (109 aa) |
| | atpC | A-type ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (347 aa) |
| | atpE | A-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (193 aa) |
| | carB | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. (1088 aa) |
| | surE1 | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (265 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (214 aa) |
| | adk2 | Probable adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (170 aa) |
| | HQ_3483A | NUDIX family hydrolase. (163 aa) |
| | HQ_3517A | CobC/GpmA family phosphatase; Product: ISH3-type transposase HqIRS25 (nonfunctional); gene is interrupted (frameshift,in-frame stop). (196 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (290 aa) |
| | hit2 | Histidine triad family protein (homolog to bis(5'-nucleosyl)-tetraphosphatase). (144 aa) |
| | HQ_3655A | Histidine phosphatase family protein. (166 aa) |
| | surE2 | 5'-nucleotidase SurE. (283 aa) |
