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A0A143ZVB3 A0A143ZVB3 PF3D7_0710400 PF3D7_0710400 PF3D7_1371700 PF3D7_1371700 PF3D7_1037000 PF3D7_1037000 PF3D7_1238700 PF3D7_1238700 PF3D7_1334100 PF3D7_1334100 PF3D7_1338900 PF3D7_1338900 PF3D7_0102600 PF3D7_0102600 PF3D7_0408400 PF3D7_0408400 PF3D7_0706700 PF3D7_0706700 PF3D7_0902000 PF3D7_0902000 PF3D7_0910900 PF3D7_0910900 PF3D7_1304000 PF3D7_1304000 PF3D7_1316000 PF3D7_1316000 PF3D7_1335500 PF3D7_1335500 PF3D7_1368300 PF3D7_1368300 PFF0285c PFF0285c PF3D7_0607600 PF3D7_0607600 PF3D7_0623900 PF3D7_0623900 PF3D7_0630300 PF3D7_0630300 PF3D7_1403100 PF3D7_1403100 PF3D7_1442100 PF3D7_1442100 PF3D7_0308000 PF3D7_0308000 PF3D7_0308100 PF3D7_0308100 PF3D7_0317400 PF3D7_0317400 PF3D7_0203300 PF3D7_0203300 PF3D7_0204000 PF3D7_0204000 PF3D7_0206000 PF3D7_0206000 PF3D7_0214600 PF3D7_0214600 PF3D7_0215800 PF3D7_0215800 PF3D7_0218000 PF3D7_0218000 PF3D7_0219600 PF3D7_0219600 PCNA PCNA CRK2 CRK2 FEN1 FEN1 PF3D7_1226600 PF3D7_1226600 PF3D7_1017000 PF3D7_1017000 PF14_0366 PF14_0366 PF3D7_0213400 PF3D7_0213400 PF3D7_1223300 PF3D7_1223300 PF3D7_0419300 PF3D7_0419300 PF3D7_0416300 PF3D7_0416300 PFD0685c PFD0685c PF3D7_0111300 PF3D7_0111300 PF3D7_0105900 PF3D7_0105900 PF3D7_0924600 PF3D7_0924600 PF3D7_0918600 PF3D7_0918600 PF3D7_0910500 PF3D7_0910500 PF3D7_0904800 PF3D7_0904800 PF3D7_0527000 PF3D7_0527000 PF3D7_0525200 PF3D7_0525200 PF3D7_0514100 PF3D7_0514100 PF3D7_0510500 PF3D7_0510500 PF3D7_0509100 PF3D7_0509100 PF3D7_0505500 PF3D7_0505500 PF3D7_0503200 PF3D7_0503200 PF3D7_0500900 PF3D7_0500900 PF3D7_1241700 PF3D7_1241700 PF3D7_1239500 PF3D7_1239500 PF3D7_1234300 PF3D7_1234300 PF3D7_1222400 PF3D7_1222400 PF3D7_1211700 PF3D7_1211700 PF3D7_1211300 PF3D7_1211300 orc1 orc1 PF3D7_0803400 PF3D7_0803400 PF3D7_0816800 PF3D7_0816800 PF3D7_0726300 PF3D7_0726300 PF3D7_0725000 PF3D7_0725000 MCM7 MCM7 PF3D7_0705300 PF3D7_0705300 PF3D7_1368800 PF3D7_1368800 PF3D7_1355100 PF3D7_1355100 PF3D7_1347100 PF3D7_1347100 MAL13P1.96 MAL13P1.96 PF3D7_1317100 PF3D7_1317100 PF3D7_1305000 PF3D7_1305000 PF3D7_1304100 PF3D7_1304100 PF3D7_1135600 PF3D7_1135600 PF3D7_1130700 PF3D7_1130700 PF3D7_1123800 PF3D7_1123800 PF3D7_1117800 PF3D7_1117800 PF3D7_1111100 PF3D7_1111100 PF3D7_1107400 PF3D7_1107400 PF3D7_1039000 PF3D7_1039000 PF3D7_1023400 PF3D7_1023400 PF3D7_1008200 PF3D7_1008200 PF3D7_1463300 PF3D7_1463300 PF3D7_1463200 PF3D7_1463200 PF3D7_1456500 PF3D7_1456500 PF3D7_1451300 PF3D7_1451300 PF3D7_1449400 PF3D7_1449400 PF3D7_1448200 PF3D7_1448200 PF3D7_1429900 PF3D7_1429900 PF3D7_1427500 PF3D7_1427500 PF3D7_1417800 PF3D7_1417800 PF3D7_1412100 PF3D7_1412100 PF3D7_1405400 PF3D7_1405400 PF3D7_0411900 PF3D7_0411900 PF3D7_0409600 PF3D7_0409600
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A143ZVB3Serine/threonine protein kinase, FIKK family. (617 aa)
PF3D7_0710400DNA repair protein RAD14, putative. (365 aa)
PF3D7_1371700Serine/threonine protein kinase, FIKK family. (561 aa)
PF3D7_1037000DNA polymerase zeta catalytic subunit, putative. (2226 aa)
PF3D7_1238700BTB/POZ domain-containing protein, putative. (505 aa)
PF3D7_1334100Uncharacterized protein. (983 aa)
PF3D7_1338900Serine/threonine protein kinase, putative. (931 aa)
PF3D7_0102600Serine/threonine protein kinase, FIKK family. (630 aa)
PF3D7_0408400Uncharacterized protein. (471 aa)
PF3D7_0706700DNA mismatch repair protein MSH2, putative. (873 aa)
PF3D7_0902000Serine/threonine protein kinase, FIKK family. (542 aa)
PF3D7_0910900DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (539 aa)
PF3D7_1304000Condensin complex subunit 2, putative. (1024 aa)
PF3D7_1316000Protein kinase, putative; Belongs to the protein kinase superfamily. (328 aa)
PF3D7_1335500DNA replication complex GINS protein, putative. (493 aa)
PF3D7_1368300Uncharacterized protein. (230 aa)
PFF0285cProbable DNA repair protein RAD50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity (By similarity). Belongs to the SMC family. RAD50 subfamily. (2236 aa)
PF3D7_0607600Spindle assembly abnormal protein 6, putative. (861 aa)
PF3D7_0623900Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (288 aa)
PF3D7_0630300DNA polymerase epsilon catalytic subunit A, putative. (2907 aa)
PF3D7_1403100Condensin complex subunit 1, putative. (1955 aa)
PF3D7_1442100Replication factor A protein 3, putative. (109 aa)
PF3D7_0308000DNA polymerase delta small subunit, putative. (498 aa)
PF3D7_0308100Zinc finger protein, putative. (1711 aa)
PF3D7_0317400DNA replication complex GINS protein, putative. (518 aa)
PF3D7_0203300ERCC1 nucleotide excision repair protein, putative. (242 aa)
PF3D7_0204000Condensin-2 complex subunit H2, putative. (797 aa)
PF3D7_0206000DNA repair protein RAD2, putative. (1516 aa)
PF3D7_0214600Serine/threonine protein kinase, putative. (1714 aa)
PF3D7_0215800Origin recognition complex subunit 5. (899 aa)
PF3D7_0218000Replication factor C subunit 2, putative. (330 aa)
PF3D7_0219600Replication factor C subunit 1. (904 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. (274 aa)
CRK2Cell division control protein 2 homolog; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II (By similarity). (288 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (672 aa)
PF3D7_1226600Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
PF3D7_1017000DNA polymerase. (1094 aa)
PF14_0366DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (452 aa)
PF3D7_0213400Protein kinase 7. (343 aa)
PF3D7_1223300DNA gyrase subunit A. (1222 aa)
PF3D7_0419300Rad51 domain-containing protein. (346 aa)
PF3D7_0416300DNA helicase MCM9, putative; Belongs to the MCM family. (1465 aa)
PFD0685cStructural maintenance of chromosomes protein 3 homolog; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity); Belongs to the SMC fami [...] (1193 aa)
PF3D7_0111300P-loop containing nucleoside triphosphate hydrolase, putative. (1167 aa)
PF3D7_01059003'-5' exonuclease, putative. (448 aa)
PF3D7_0924600Uncharacterized protein. (2082 aa)
PF3D7_0918600ATP-dependent DNA helicase Q1. (728 aa)
PF3D7_0910500DNA repair protein REV1, putative. (1697 aa)
PF3D7_0904800Replication protein A1, small. (484 aa)
PF3D7_0527000DNA replication licensing factor MCM3, putative; Belongs to the MCM family. (962 aa)
PF3D7_0525200Structural maintenance of chromosomes protein 6, putative. (1849 aa)
PF3D7_0514100ATP-dependent DNA helicase UvrD. (1441 aa)
PF3D7_0510500Topoisomerase I. (839 aa)
PF3D7_0509100Structural maintenance of chromosomes protein 4, putative. (1708 aa)
PF3D7_0505500DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1350 aa)
PF3D7_0503200ATPase_AAA_core domain-containing protein. (979 aa)
PF3D7_0500900Serine/threonine protein kinase, FIKK family. (600 aa)
PF3D7_1241700Replication factor C subunit 4, putative. (336 aa)
PF3D7_1239500DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1006 aa)
PF3D7_1234300DNA polymerase epsilon subunit B, putative. (624 aa)
PF3D7_1222400AP2 domain transcription factor. (2558 aa)
PF3D7_1211700DNA replication licensing factor MCM5, putative; Belongs to the MCM family. (758 aa)
PF3D7_1211300DNA helicase MCM8, putative; Belongs to the MCM family. (1135 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (1189 aa)
PF3D7_0803400DNA repair and recombination protein RAD54, putative. (1239 aa)
PF3D7_0816800Meiotic recombination protein DMC1, putative; Belongs to the RecA family. (347 aa)
PF3D7_0726300DNA mismatch repair protein PMS1, putative. (1330 aa)
PF3D7_0725000Exonuclease I, putative. (1347 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (821 aa)
PF3D7_0705300Origin recognition complex subunit 2. (825 aa)
PF3D7_1368800DNA repair endonuclease XPF, putative. (1700 aa)
PF3D7_1355100DNA helicase; Belongs to the MCM family. (929 aa)
PF3D7_1347100DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (710 aa)
MAL13P1.96Structural maintenance of chromosomes protein 2; May play a role in the conversion of interphase chromatin into condensed chromosomes; Belongs to the SMC family. SMC2 subfamily. (1218 aa)
PF3D7_1317100DNA replication licensing factor MCM4; Belongs to the MCM family. (1005 aa)
PF3D7_1305000MCL1 domain-containing protein, putative. (1479 aa)
PF3D7_1304100DNA ligase. (912 aa)
PF3D7_1135600Condensin-2 complex subunit. (1818 aa)
PF3D7_1130700Structural maintenance of chromosomes protein 1, putative. (1818 aa)
PF3D7_1123800Structural maintenance of chromosomes protein 5, putative. (1268 aa)
PF3D7_1117800DNA mismatch repair protein MLH. (1016 aa)
PF3D7_1111100Replication factor C subunit 5, putative. (349 aa)
PF3D7_1107400DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (350 aa)
PF3D7_1039000Serine/threonine protein kinase, FIKK family. (913 aa)
PF3D7_1023400HORMA domain protein, putative. (195 aa)
PF3D7_1008200Endonuclease, putative. (388 aa)
PF3D7_1463300DNA polymerase alpha subunit B, putative. (539 aa)
PF3D7_1463200Replication factor C subunit 3, putative. (344 aa)
PF3D7_1456500SCD domain-containing protein. (2391 aa)
PF3D7_1451300E3 SUMO-protein ligase NSE2, putative. (229 aa)
PF3D7_1449400Crossover junction endonuclease MUS81, putative. (1271 aa)
PF3D7_1448200Condensin-2 complex subunit G2, putative. (1206 aa)
PF3D7_1429900ADP-dependent DNA helicase RecQ. (1440 aa)
PF3D7_1427500DNA mismatch repair protein MSH2, putative. (811 aa)
PF3D7_1417800DNA helicase. (971 aa)
PF3D7_1412100Mini-chromosome maintenance complex-binding protein, putative. (956 aa)
PF3D7_1405400DNA mismatch repair protein, putative. (1515 aa)
PF3D7_0411900DNA polymerase. (1912 aa)
PF3D7_0409600Replication protein A1, large subunit. (1145 aa)
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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