(11 nodes) Displacement of DNA glycosylase by APEX1, and DNA-(apurinic or apyrimidinic site) endonuclease activity network (Plasmodium falciparum)

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Your Input:
	PF3D7_1129500	A/G-specific adenine glycosylase, putative. (611 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (437 aa)
	PF3D7_0305600	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (617 aa)
	PF3D7_0917100	N-glycosylase/DNA lyase, putative. (757 aa)
	PF3D7_1250800	DNA repair protein rhp16, putative. (1647 aa)
	PF3D7_1363200	Bifunctional polynucleotide phosphatase/kinase. (462 aa)
	PF3D7_1332600	DNA-(Apurinic or apyrimidinic site) lyase 1, putative. (597 aa)
	PF3D7_1028000	Methyltransferase, putative. (593 aa)
	PF3D7_1467100	DNA-3-methyladenine glycosylase, putative. (501 aa)
	PF3D7_1430600	Endonuclease/exonuclease/phosphatase family protein, putative. (876 aa)
	PF3D7_1415000	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (322 aa)

Your Current Organism:

Plasmodium falciparum

NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NTH1	PF3D7_0305600	C6KSY9	O97240	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.833
NTH1	PF3D7_0917100	C6KSY9	Q8I2Y2	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	N-glycosylase/DNA lyase, putative.	0.680
NTH1	PF3D7_1129500	C6KSY9	A0A143ZYC4	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	A/G-specific adenine glycosylase, putative.	0.701
NTH1	PF3D7_1332600	C6KSY9	Q8IE02	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	DNA-(Apurinic or apyrimidinic site) lyase 1, putative.	0.890
NTH1	PF3D7_1363200	C6KSY9	Q8ID74	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	Bifunctional polynucleotide phosphatase/kinase.	0.487
NTH1	PF3D7_1415000	C6KSY9	Q8ILU6	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.624
NTH1	PF3D7_1430600	C6KSY9	Q8ILF8	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	Endonuclease/exonuclease/phosphatase family protein, putative.	0.680
NTH1	PF3D7_1467100	C6KSY9	Q8IKG6	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	DNA-3-methyladenine glycosylase, putative.	0.635
PF3D7_0305600	NTH1	O97240	C6KSY9	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.833
PF3D7_0305600	PF3D7_0917100	O97240	Q8I2Y2	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	N-glycosylase/DNA lyase, putative.	0.748
PF3D7_0305600	PF3D7_1129500	O97240	A0A143ZYC4	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	A/G-specific adenine glycosylase, putative.	0.797
PF3D7_0305600	PF3D7_1332600	O97240	Q8IE02	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	DNA-(Apurinic or apyrimidinic site) lyase 1, putative.	0.855
PF3D7_0305600	PF3D7_1363200	O97240	Q8ID74	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	Bifunctional polynucleotide phosphatase/kinase.	0.571
PF3D7_0305600	PF3D7_1415000	O97240	Q8ILU6	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.747
PF3D7_0305600	PF3D7_1467100	O97240	Q8IKG6	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	DNA-3-methyladenine glycosylase, putative.	0.660
PF3D7_0917100	NTH1	Q8I2Y2	C6KSY9	N-glycosylase/DNA lyase, putative.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.680
PF3D7_0917100	PF3D7_0305600	Q8I2Y2	O97240	N-glycosylase/DNA lyase, putative.	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.748
PF3D7_0917100	PF3D7_1028000	Q8I2Y2	Q8IJC4	N-glycosylase/DNA lyase, putative.	Methyltransferase, putative.	0.696
PF3D7_0917100	PF3D7_1129500	Q8I2Y2	A0A143ZYC4	N-glycosylase/DNA lyase, putative.	A/G-specific adenine glycosylase, putative.	0.628
PF3D7_0917100	PF3D7_1332600	Q8I2Y2	Q8IE02	N-glycosylase/DNA lyase, putative.	DNA-(Apurinic or apyrimidinic site) lyase 1, putative.	0.728