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A0A143ZZR0 A0A143ZZR0 A0A144A1V5 A0A144A1V5 PF3D7_1334100 PF3D7_1334100 PF3D7_1328200 PF3D7_1328200 PF3D7_1322200 PF3D7_1322200 PF3D7_0416400 PF3D7_0416400 PF08_0048 PF08_0048 PF3D7_0910900 PF3D7_0910900 PF3D7_1304000 PF3D7_1304000 PF3D7_1335500 PF3D7_1335500 PF3D7_1368300 PF3D7_1368300 PF3D7_0603600 PF3D7_0603600 PF3D7_0604600 PF3D7_0604600 PFF0285c PFF0285c PF3D7_0610400 PF3D7_0610400 PF3D7_0611400 PF3D7_0611400 PF3D7_0617800 PF3D7_0617800 PF3D7_0617900 PF3D7_0617900 PF3D7_0624600 PF3D7_0624600 PF3D7_0628600 PF3D7_0628600 PF3D7_0630300 PF3D7_0630300 PF3D7_0205800 PF3D7_0205800 PF3D7_1027600 PF3D7_1027600 PF3D7_1403100 PF3D7_1403100 PF3D7_0308000 PF3D7_0308000 PF3D7_0317400 PF3D7_0317400 PF3D7_0316500 PF3D7_0316500 PF3D7_0319300 PF3D7_0319300 PF3D7_0204000 PF3D7_0204000 PF3D7_0209700 PF3D7_0209700 PF3D7_0215800 PF3D7_0215800 PF3D7_0218000 PF3D7_0218000 PF3D7_0219600 PF3D7_0219600 PF3D7_0320900 PF3D7_0320900 PCNA PCNA PF3D7_1226600 PF3D7_1226600 PF3D7_1017000 PF3D7_1017000 PF14_0366 PF14_0366 PFD0685c PFD0685c PF3D7_0403900 PF3D7_0403900 PF3D7_0111300 PF3D7_0111300 PF3D7_0919000 PF3D7_0919000 PF3D7_0918600 PF3D7_0918600 PF3D7_0904700 PF3D7_0904700 PF3D7_0525200 PF3D7_0525200 PF3D7_0517400 PF3D7_0517400 PF3D7_0510500 PF3D7_0510500 PF3D7_0509100 PF3D7_0509100 PF3D7_0505200 PF3D7_0505200 PF3D7_1241700 PF3D7_1241700 PF3D7_1234300 PF3D7_1234300 PF3D7_1220900 PF3D7_1220900 Q8I5N7_PLAF7 Q8I5N7_PLAF7 PF3D7_1211700 PF3D7_1211700 PF3D7_1206500 PF3D7_1206500 PF3D7_1203700 PF3D7_1203700 orc1 orc1 Q8I624_PLAF7 Q8I624_PLAF7 PF3D7_0809700 PF3D7_0809700 PF3D7_0812600 PF3D7_0812600 PF3D7_0816800 PF3D7_0816800 PF3D7_0817900 PF3D7_0817900 PF3D7_0719300 PF3D7_0719300 PF3D7_0714000 PF3D7_0714000 MCM7 MCM7 PF3D7_0705300 PF3D7_0705300 PF3D7_1362200 PF3D7_1362200 PF3D7_1357500 PF3D7_1357500 PF3D7_1347100 PF3D7_1347100 PF3D7_1338400 PF3D7_1338400 PF3D7_1334000 PF3D7_1334000 PF3D7_1333700 PF3D7_1333700 Sir2A Sir2A SETVS SETVS MAL13P1.96 MAL13P1.96 PF3D7_1317100 PF3D7_1317100 PF3D7_1314200 PF3D7_1314200 PF3D7_1309400 PF3D7_1309400 PF3D7_1305000 PF3D7_1305000 PF3D7_1149000 PF3D7_1149000 Q8IHX1_PLAF7 Q8IHX1_PLAF7 PF3D7_1135600 PF3D7_1135600 PF3D7_1130700 PF3D7_1130700 PF3D7_1123800 PF3D7_1123800 PF3D7_1118600 PF3D7_1118600 PF3D7_1112100 PF3D7_1112100 PF3D7_1111100 PF3D7_1111100 PF3D7_1107500 PF3D7_1107500 PF3D7_1106000 PF3D7_1106000 PF3D7_1105100 PF3D7_1105100 PF3D7_1105000 PF3D7_1105000 PF3D7_1103600 PF3D7_1103600 PF3D7_1033500 PF3D7_1033500 PF3D7_1027000 PF3D7_1027000 PF3D7_1009400 PF3D7_1009400 PF3D7_1463300 PF3D7_1463300 PF3D7_1463200 PF3D7_1463200 PF3D7_1456500 PF3D7_1456500 PF3D7_1451300 PF3D7_1451300 PF3D7_1448200 PF3D7_1448200 PF3D7_1441400 PF3D7_1441400 PF3D7_1429900 PF3D7_1429900 PF3D7_1422800 PF3D7_1422800 PF3D7_1418100 PF3D7_1418100 PF3D7_0411900 PF3D7_0411900
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A143ZZR0Meiotic recombination protein SPO11, putative. (307 aa)
A0A144A1V5SRAP domain-containing protein, putative. (400 aa)
PF3D7_1334100Uncharacterized protein. (983 aa)
PF3D7_1328200Uncharacterized protein. (2668 aa)
PF3D7_1322200Uncharacterized protein. (3438 aa)
PF3D7_0416400Histone acetyltransferase, putative. (1259 aa)
PF08_0048Probable ATP-dependent helicase PF08_0048; Catalytic component of a chromatin remodeling complex. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (2082 aa)
PF3D7_0910900DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (539 aa)
PF3D7_1304000Condensin complex subunit 2, putative. (1024 aa)
PF3D7_1335500DNA replication complex GINS protein, putative. (493 aa)
PF3D7_1368300Uncharacterized protein. (230 aa)
PF3D7_0603600AT-rich interactive domain-containing protein, putative. (2368 aa)
PF3D7_0604600DNA helicase, putative. (1712 aa)
PFF0285cProbable DNA repair protein RAD50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity (By similarity). Belongs to the SMC family. RAD50 subfamily. (2236 aa)
PF3D7_0610400Histone H3; Belongs to the histone H3 family. (136 aa)
PF3D7_0611400SWIB/MDM2 domain-containing protein. (830 aa)
PF3D7_0617800Histone H2A; Belongs to the histone H2A family. (132 aa)
PF3D7_0617900Histone H3; Belongs to the histone H3 family. (136 aa)
PF3D7_0624600SNF2 helicase, putative. (2719 aa)
PF3D7_0628600DNA methyltransferase 1-associated protein 1, putative. (385 aa)
PF3D7_0630300DNA polymerase epsilon catalytic subunit A, putative. (2907 aa)
PF3D7_0205800PH domain-containing protein, putative. (120 aa)
PF3D7_1027600Meiotic recombination protein SPO11-2, putative. (336 aa)
PF3D7_1403100Condensin complex subunit 1, putative. (1955 aa)
PF3D7_0308000DNA polymerase delta small subunit, putative. (498 aa)
PF3D7_0317400DNA replication complex GINS protein, putative. (518 aa)
PF3D7_0316500Kinetochore protein NUF2, putative. (461 aa)
PF3D7_0319300Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (160 aa)
PF3D7_0204000Condensin-2 complex subunit H2, putative. (797 aa)
PF3D7_0209700RING zinc finger protein, putative. (568 aa)
PF3D7_0215800Origin recognition complex subunit 5. (899 aa)
PF3D7_0218000Replication factor C subunit 2, putative. (330 aa)
PF3D7_0219600Replication factor C subunit 1. (904 aa)
PF3D7_0320900Histone H2A; Belongs to the histone H2A family. (158 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. (274 aa)
PF3D7_1226600Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
PF3D7_1017000DNA polymerase. (1094 aa)
PF14_0366DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (452 aa)
PFD0685cStructural maintenance of chromosomes protein 3 homolog; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity); Belongs to the SMC fami [...] (1193 aa)
PF3D7_0403900SET domain protein, putative. (1186 aa)
PF3D7_0111300P-loop containing nucleoside triphosphate hydrolase, putative. (1167 aa)
PF3D7_0919000Nucleosome assembly protein; Belongs to the nucleosome assembly protein (NAP) family. (269 aa)
PF3D7_0918600ATP-dependent DNA helicase Q1. (728 aa)
PF3D7_0904700Bacterial histone-like protein; Belongs to the bacterial histone-like protein family. (189 aa)
PF3D7_0525200Structural maintenance of chromosomes protein 6, putative. (1849 aa)
PF3D7_0517400FACT complex subunit SPT16, putative. (1141 aa)
PF3D7_0510500Topoisomerase I. (839 aa)
PF3D7_0509100Structural maintenance of chromosomes protein 4, putative. (1708 aa)
PF3D7_0505200Actin-like protein, putative; Belongs to the actin family. (565 aa)
PF3D7_1241700Replication factor C subunit 4, putative. (336 aa)
PF3D7_1234300DNA polymerase epsilon subunit B, putative. (624 aa)
PF3D7_1220900Heterochromatin protein 1. (266 aa)
Q8I5N7_PLAF7Meiotic recombination protein SPO11, putative. (327 aa)
PF3D7_1211700DNA replication licensing factor MCM5, putative; Belongs to the MCM family. (758 aa)
PF3D7_1206500Tat binding protein 1(TBP-1)-interacting protein, putative. (651 aa)
PF3D7_1203700Nucleosome assembly protein; Belongs to the nucleosome assembly protein (NAP) family. (347 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (1189 aa)
Q8I624_PLAF7SRAP domain-containing protein, putative. (401 aa)
PF3D7_0809700RuvB-like helicase; Belongs to the RuvB family. (520 aa)
PF3D7_0812600Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
PF3D7_0816800Meiotic recombination protein DMC1, putative; Belongs to the RecA family. (347 aa)
PF3D7_0817900High mobility group protein B2. (99 aa)
PF3D7_0719300Actin-related protein, putative; Belongs to the actin family. (1032 aa)
PF3D7_0714000Histone H2B; Belongs to the histone H2B family. (123 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (821 aa)
PF3D7_0705300Origin recognition complex subunit 2. (825 aa)
PF3D7_1362200RuvB-like helicase; Belongs to the RuvB family. (483 aa)
PF3D7_1357500DNA helicase, putative. (906 aa)
PF3D7_1347100DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (710 aa)
PF3D7_1338400SprT-like domain-containing protein, putative. (443 aa)
PF3D7_1334000RING zinc finger protein, putative. (445 aa)
PF3D7_1333700Histone H3-like centromeric protein CSE4. (170 aa)
Sir2ANAD-dependent protein deacylase Sir2A; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versio [...] (273 aa)
SETVSVariant-silencing SET domain-containing protein; Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes. SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein. During infection, the clonal parasite population expresses only 1 gene at a time, while the 59 other var genes are silenced. The parasite then switches to t [...] (2548 aa)
MAL13P1.96Structural maintenance of chromosomes protein 2; May play a role in the conversion of interphase chromatin into condensed chromosomes; Belongs to the SMC family. SMC2 subfamily. (1218 aa)
PF3D7_1317100DNA replication licensing factor MCM4; Belongs to the MCM family. (1005 aa)
PF3D7_1314200Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (2518 aa)
PF3D7_1309400HORMA domain protein, putative. (1327 aa)
PF3D7_1305000MCL1 domain-containing protein, putative. (1479 aa)
PF3D7_1149000Antigen 332, DBL-like protein. (6093 aa)
Q8IHX1_PLAF7AAA family ATPase, putative; Belongs to the AAA ATPase family. (645 aa)
PF3D7_1135600Condensin-2 complex subunit. (1818 aa)
PF3D7_1130700Structural maintenance of chromosomes protein 1, putative. (1818 aa)
PF3D7_1123800Structural maintenance of chromosomes protein 5, putative. (1268 aa)
PF3D7_1118600Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (608 aa)
PF3D7_1112100Protein kinase domain-containing protein. (2460 aa)
PF3D7_1111100Replication factor C subunit 5, putative. (349 aa)
PF3D7_1107500Prefoldin, putative. (155 aa)
PF3D7_1106000RuvB-like helicase; Belongs to the RuvB family. (475 aa)
PF3D7_1105100Histone H2B; Belongs to the histone H2B family. (117 aa)
PF3D7_1105000Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
PF3D7_1103600Actin-like protein, putative; Belongs to the actin family. (499 aa)
PF3D7_1033500WD repeat-containing protein 70, putative. (709 aa)
PF3D7_1027000Uncharacterized protein. (1811 aa)
PF3D7_1009400Zinc finger protein, putative. (362 aa)
PF3D7_1463300DNA polymerase alpha subunit B, putative. (539 aa)
PF3D7_1463200Replication factor C subunit 3, putative. (344 aa)
PF3D7_1456500SCD domain-containing protein. (2391 aa)
PF3D7_1451300E3 SUMO-protein ligase NSE2, putative. (229 aa)
PF3D7_1448200Condensin-2 complex subunit G2, putative. (1206 aa)
PF3D7_1441400FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (506 aa)
PF3D7_1429900ADP-dependent DNA helicase RecQ. (1440 aa)
PF3D7_1422800Actin-related protein, putative; Belongs to the actin family. (522 aa)
PF3D7_1418100Liver specific protein 1, putative. (3597 aa)
PF3D7_0411900DNA polymerase. (1912 aa)
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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