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PF3D7_1439400 PF3D7_1439400 PF3D7_1438900 PF3D7_1438900 PF3D7_1437200 PF3D7_1437200 PF3D7_1435300 PF3D7_1435300 PF3D7_1435000 PF3D7_1435000 PF3D7_1430700 PF3D7_1430700 PF3D7_1419200 PF3D7_1419200 PF3D7_1416500 PF3D7_1416500 PF3D7_1409100 PF3D7_1409100 PF3D7_1408900 PF3D7_1408900 PF3D7_1405600 PF3D7_1405600 PF3D7_1404100 PF3D7_1404100 PF3D7_0306300 PF3D7_0306300 A0A143ZVU1 A0A143ZVU1 PF3D7_1014000 PF3D7_1014000 A0A144A3W0 A0A144A3W0 PF3D7_1316400 PF3D7_1316400 PF3D7_1325500 PF3D7_1325500 PF3D7_1361700 PF3D7_1361700 PF3D7_0409500 PF3D7_0409500 PF3D7_0422000 PF3D7_0422000 MAL8P1.31 MAL8P1.31 PF3D7_0918100 PF3D7_0918100 PF3D7_0923200 PF3D7_0923200 PF3D7_0925500 PF3D7_0925500 PF3D7_0602800 PF3D7_0602800 PF3D7_0606900 PF3D7_0606900 PF3D7_0612200 PF3D7_0612200 PF3D7_0615100 PF3D7_0615100 PF3D7_0616800 PF3D7_0616800 PF3D7_0618500 PF3D7_0618500 PF3D7_0623200 PF3D7_0623200 PF3D7_0623500 PF3D7_0623500 PF3D7_0630700 PF3D7_0630700 PF3D7_1455900 PF3D7_1455900 GR3 GR3 PF3D7_0219100 PF3D7_0219100 PF3D7_0304500 PF3D7_0304500 PF3D7_0306400 PF3D7_0306400 trxr2 trxr2 PFF0160c PFF0160c prx prx PF3D7_1324900 PF3D7_1324900 coxI coxI coI coI coxIII coxIII PF14_0545 PF14_0545 PF3D7_0511200 PF3D7_0511200 PF3D7_0504600 PF3D7_0504600 PF3D7_0303600 PF3D7_0303600 PF3D7_0110200 PF3D7_0110200 PF3D7_0104400 PF3D7_0104400 PF3D7_0930000 PF3D7_0930000 PF3D7_0920800 PF3D7_0920800 PF3D7_0919300 PF3D7_0919300 PF3D7_0918800 PF3D7_0918800 PF3D7_0915000 PF3D7_0915000 PF3D7_1242000 PF3D7_1242000 PF3D7_1232200 PF3D7_1232200 PF3D7_1216200 PF3D7_1216200 PF3D7_1215000 PF3D7_1215000 PF3D7_1214600 PF3D7_1214600 PF3D7_1212800 PF3D7_1212800 PF3D7_1212000 PF3D7_1212000 PF3D7_0820700 PF3D7_0820700 PF3D7_1345700 PF3D7_1345700 PF3D7_1311700 PF3D7_1311700 PF3D7_1462700 PF3D7_1462700 PF3D7_1430900 PF3D7_1430900 PF3D7_1302600 PF3D7_1302600 PF3D7_0802000 PF3D7_0802000 PF3D7_0802200 PF3D7_0802200 PF3D7_0809900 PF3D7_0809900 SODB SODB PF3D7_0815900 PF3D7_0815900 PF3D7_0720400 PF3D7_0720400 PF3D7_0709200 PF3D7_0709200 PF3D7_1364600 PF3D7_1364600 PF3D7_1357900 PF3D7_1357900 trx2 trx2 PF3D7_1332100 PF3D7_1332100 PF3D7_1325200 PF3D7_1325200 PF3D7_1318100 PF3D7_1318100 PF3D7_1312600 PF3D7_1312600 PF3D7_1310400 PF3D7_1310400 PF3D7_1142400 PF3D7_1142400 PF3D7_1140700 PF3D7_1140700 PF3D7_1139700 PF3D7_1139700 PF3D7_1135900 PF3D7_1135900 PF3D7_1124500 PF3D7_1124500 PF3D7_1124000 PF3D7_1124000 PF3D7_1122200 PF3D7_1122200 PF3D7_1114800 PF3D7_1114800 PF3D7_1034400 PF3D7_1034400 PF3D7_1028100 PF3D7_1028100 PF3D7_1027300 PF3D7_1027300 PF3D7_1022800 PF3D7_1022800 PF3D7_1015800 PF3D7_1015800 PF3D7_1002500 PF3D7_1002500 DXR DXR PF3D7_1462800 PF3D7_1462800 PF3D7_1454700 PF3D7_1454700 PF14_0511 PF14_0511 PF3D7_1450300 PF3D7_1450300 HDP HDP PF3D7_1446400 PF3D7_1446400 PF3D7_1445000 PF3D7_1445000
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PF3D7_1439400Cytochrome b-c1 complex subunit Rieske, putative. (355 aa)
PF3D7_1438900Thioredoxin peroxidase 1. (195 aa)
PF3D7_1437200Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (847 aa)
PF3D7_1435300Glutamate synthase [NADH], putative. (3106 aa)
PF3D7_1435000Cytochrome c oxidase assembly protein COX15, putative. (430 aa)
PF3D7_1430700Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (510 aa)
PF3D7_1419200Thioredoxin-like protein, putative. (671 aa)
PF3D7_1416500Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (470 aa)
PF3D7_1409100Aldo-keto reductase, putative. (1212 aa)
PF3D7_1408900tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (340 aa)
PF3D7_1405600Ribonucleoside-diphosphate reductase small chain, putative. (349 aa)
PF3D7_1404100Cytochrome c, putative; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (115 aa)
PF3D7_0306300Glutaredoxin 1. (111 aa)
A0A143ZVU1Thioredoxin reductase. (541 aa)
PF3D7_1014000GDP-L-fucose synthase. (344 aa)
A0A144A3W0Glutathione reductase. (546 aa)
PF3D7_1316400SAS6-like protein, putative. (228 aa)
PF3D7_1325500PUA_3 domain-containing protein. (667 aa)
PF3D7_1361700Cytochrome c oxidase subunit 2, putative. (228 aa)
PF3D7_0409500NAD(P)-binding protein, putative. (398 aa)
PF3D7_0422000Steroid dehydrogenase, putative. (321 aa)
MAL8P1.31Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...] (266 aa)
PF3D7_0918100Cytochrome b5-like heme/steroid binding protein, putative; Belongs to the cytochrome b5 family. (130 aa)
PF3D7_0923200Nitric oxide synthase, putative. (780 aa)
PF3D7_0925500Thioredoxin; Belongs to the thioredoxin family. (128 aa)
PF3D7_0602800JmjC domain-containing protein, putative. (646 aa)
PF3D7_0606900Glutaredoxin-like protein. (219 aa)
PF3D7_0612200Leucine-rich repeat protein. (1864 aa)
PF3D7_0615100Enoyl-acyl carrier reductase. (432 aa)
PF3D7_0616800Malate:quinone oxidoreductase. (521 aa)
PF3D7_0618500Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (313 aa)
PF3D7_0623200Ferredoxin--NADP reductase, apicoplast; Belongs to the ferredoxin--NADP reductase type 1 family. (371 aa)
PF3D7_0623500Superoxide dismutase [Fe]. (266 aa)
PF3D7_0630700Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, putative. (657 aa)
PF3D7_1455900Polyprenol reductase, putative. (285 aa)
GR3Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. (500 aa)
PF3D7_0219100Saccharopine dehydrogenase, putative. (426 aa)
PF3D7_03045001-cys-glutaredoxin-like protein-1. (171 aa)
PF3D7_0306400Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (653 aa)
trxr2Thioredoxin reductase 2. (617 aa)
PFF0160cDihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. (569 aa)
prxPeroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (240 aa)
PF3D7_1324900L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (316 aa)
coxICytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (376 aa)
coICytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (512 aa)
coxIIICytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (279 aa)
PF14_0545Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (104 aa)
PF3D7_0511200Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (949 aa)
PF3D7_05046002-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative. (381 aa)
PF3D7_0303600Plasmoredoxin. (179 aa)
PF3D7_0110200Sulfhydryl oxidase. (143 aa)
PF3D7_01044004-hydroxy-3-methylbut-2-enyl diphosphate reductase. (535 aa)
PF3D7_0930000Procollagen lysine 5-dioxygenase, putative. (558 aa)
PF3D7_0920800Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (510 aa)
PF3D7_0919300Thioredoxin-like protein 1, putative. (207 aa)
PF3D7_0918800Dihydrouridine synthase, putative. (577 aa)
PF3D7_0915000Type II NADH:ubiquinone oxidoreductase. (533 aa)
PF3D7_1242000Sulfhydryl oxidase. (531 aa)
PF3D7_1232200Dihydrolipoyl dehydrogenase. (512 aa)
PF3D7_1216200Glycerol-3-phosphate dehydrogenase [NAD(+)]. (367 aa)
PF3D7_1215000Thioredoxin peroxidase 2. (216 aa)
PF3D7_1214600Adrenodoxin-type ferredoxin, putative. (158 aa)
PF3D7_1212800Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (321 aa)
PF3D7_1212000Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
PF3D7_08207002-oxoglutarate dehydrogenase E1 component. (1038 aa)
PF3D7_1345700Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (468 aa)
PF3D7_1311700Cytochrome c, putative; Belongs to the cytochrome c family. (159 aa)
PF3D7_1462700Cytochrome c1, putative. (394 aa)
PF3D7_1430900Cytochrome c oxidase subunit 2, putative. (172 aa)
PF3D7_1302600Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (411 aa)
PF3D7_0802000Glutamate dehydrogenase, putative. (1397 aa)
PF3D7_08022001-cys peroxiredoxin. (220 aa)
PF3D7_0809900JmjC domain-containing protein, putative. (1259 aa)
SODBSuperoxide dismutase [Fe]; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (198 aa)
PF3D7_0815900Dihydrolipoyl dehydrogenase, apicoplast; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (666 aa)
PF3D7_0720400Apoptosis-inducing factor, putative. (642 aa)
PF3D7_0709200Glutaredoxin-like protein. (272 aa)
PF3D7_1364600Aldehyde reductase, putative. (880 aa)
PF3D7_1357900Pyrroline-5-carboxylate reductase, putative. (262 aa)
trx2Thioredoxin 2. (157 aa)
PF3D7_1332100Uncharacterized protein. (522 aa)
PF3D7_1325200Lactate dehydrogenase, putative; Belongs to the LDH/MDH superfamily. (334 aa)
PF3D7_1318100Ferredoxin, apicoplast; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the 2Fe2S plant-type ferredoxin family. (194 aa)
PF3D7_13126002-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (429 aa)
PF3D7_1310400Uncharacterized protein. (1135 aa)
PF3D7_1142400Coproporphyrinogen-III oxidase. (470 aa)
PF3D7_1140700Chromo domain-containing protein. (2275 aa)
PF3D7_1139700NADPH:adrenodoxin oxidoreductase, mitochondrial. (505 aa)
PF3D7_11359003-oxo-5-alpha-steroid 4-dehydrogenase, putative. (296 aa)
PF3D7_1124500Pyruvate dehydrogenase E1 component subunit alpha. (608 aa)
PF3D7_1124000Endoplasmic reticulum oxidoreductin, putative. (465 aa)
PF3D7_1122200JmjC domain-containing protein, putative. (446 aa)
PF3D7_1114800Glycerol-3-phosphate dehydrogenase [NAD(+)]. (394 aa)
PF3D7_1034400Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (631 aa)
PF3D7_1028100Protoporphyrinogen oxidase. (609 aa)
PF3D7_1027300Peroxiredoxin. (393 aa)
PF3D7_10228004-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (Ferredoxin), putative. (824 aa)
PF3D7_1015800Ribonucleoside-diphosphate reductase small chain, putative. (335 aa)
PF3D7_1002500Uncharacterized protein. (187 aa)
DXR1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (488 aa)
PF3D7_1462800Glyceraldehyde-3-phosphate dehydrogenase. (337 aa)
PF3D7_14547006-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
PF14_0511Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase; Bifunctional enzyme which catalyzes the first two steps of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. In the N-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily. (910 aa)
PF3D7_1450300NADPH--cytochrome P450 reductase, putative. (865 aa)
HDPHeme ligase; Heme detoxifying enzyme that converts heme to crystalline hemozoin (beta-hematin) to protect the organism from the toxic effects of heme. During its development, P.falciparum proteolyzes vast amounts of host hemoglobin, leading to heme release. (205 aa)
PF3D7_1446400Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (415 aa)
PF3D7_1445000Prolyl hydroxylase-like protein, putative. (406 aa)
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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