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PF14_0358 PF14_0358 PF14_0076 PF14_0076 PF3D7_1247800 PF3D7_1247800 PF3D7_1222300 PF3D7_1222300 PF3D7_0416800 PF3D7_0416800 PF3D7_0415400 PF3D7_0415400 PF3D7_0106800 PF3D7_0106800 PF3D7_0103900 PF3D7_0103900 PF3D7_0103100 PF3D7_0103100 PF3D7_0935200 PF3D7_0935200 PF3D7_0926500 PF3D7_0926500 PF3D7_0906100 PF3D7_0906100 PF3D7_0905900 PF3D7_0905900 PF3D7_0904100 PF3D7_0904100 PF3D7_0529700 PF3D7_0529700 PF3D7_1311400 PF3D7_1311400 PF3D7_1309700 PF3D7_1309700 RH5 RH5 CyRPA CyRPA PF3D7_0422100 PF3D7_0422100 PF3D7_1145100 PF3D7_1145100 PF3D7_1140500 PF3D7_1140500 PF3D7_1134800 PF3D7_1134800 PF3D7_1119500 PF3D7_1119500 PF11_0174 PF11_0174 PF3D7_1111300 PF3D7_1111300 PF3D7_1110500 PF3D7_1110500 PF3D7_1107200 PF3D7_1107200 PF3D7_1025400 PF3D7_1025400 PF3D7_1019900 PF3D7_1019900 ENO ENO PF3D7_1466600 PF3D7_1466600 PF3D7_1459600 PF3D7_1459600 PF3D7_1457500 PF3D7_1457500 PF3D7_1455600 PF3D7_1455600 PF3D7_1455500 PF3D7_1455500 PF3D7_1452600 PF3D7_1452600 HDP HDP PF14_0397 PF14_0397 PF3D7_1441600 PF3D7_1441600 PF3D7_1440700 PF3D7_1440700 PF3D7_1429800 PF3D7_1429800 PF3D7_1408100 PF3D7_1408100 PF3D7_1407800 PF3D7_1407800 PF3D7_1406700 PF3D7_1406700 PF3D7_0528100 PF3D7_0528100 PF3D7_0515300 PF3D7_0515300 TCTP TCTP PF3D7_0505100 PF3D7_0505100 PFE0100w PFE0100w PFL2415w PFL2415w PF3D7_1246300 PF3D7_1246300 PF3D7_1245800 PF3D7_1245800 PF3D7_1239900 PF3D7_1239900 PF3D7_1236000 PF3D7_1236000 PF3D7_1230700 PF3D7_1230700 PF3D7_1226400 PF3D7_1226400 PF3D7_1225700 PF3D7_1225700 PF3D7_1219100 PF3D7_1219100 PF3D7_1218300 PF3D7_1218300 PF3D7_1215800 PF3D7_1215800 PF3D7_1314500 PF3D7_1314500 PF3D7_1408000 PF3D7_1408000 PF3D7_0820500 PF3D7_0820500 pfsec23 pfsec23 PF3D7_0823000 PF3D7_0823000 PF3D7_0730200 PF3D7_0730200 PF3D7_0727000 PF3D7_0727000 PF3D7_0720700 PF3D7_0720700 PF3D7_0719100 PF3D7_0719100 CG10 CG10 PF3D7_1352800 PF3D7_1352800 PF3D7_1348100 PF3D7_1348100 A0A143ZVA4 A0A143ZVA4 A0A143ZX23 A0A143ZX23 A0A143ZX45 A0A143ZX45 A0A143ZXE1 A0A143ZXE1 A0A143ZY06 A0A143ZY06 PF3D7_1243500 PF3D7_1243500 PF3D7_1323800 PF3D7_1323800 PF3D7_0103000 PF3D7_0103000 PF3D7_0402300 PF3D7_0402300 PF3D7_0405100 PF3D7_0405100 PF3D7_0806300 PF3D7_0806300 PF3D7_0808100 PF3D7_0808100 PF3D7_0808400 PF3D7_0808400 Rh2b Rh2b PF3D7_1361100 PF3D7_1361100 PF3D7_1367200 PF3D7_1367200 PF3D7_0606700 PF3D7_0606700 PF3D7_0613700 PF3D7_0613700 PF3D7_0617100 PF3D7_0617100 C6KT30_PLAF7 C6KT30_PLAF7 PF3D7_0310700 PF3D7_0310700 PF3D7_0211200 PF3D7_0211200 PF13_0198 PF13_0198 PF3D7_0214100 PF3D7_0214100 PF3D7_0217300 PF3D7_0217300 PFC0245c PFC0245c RIPR RIPR PFD0110w PFD0110w vapA vapA PF3D7_1310600 PF3D7_1310600
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PF14_0358Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily. (184 aa)
PF14_0076Plasmepsin-1; Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation (By similarity); Belongs to the peptidase A1 family. (452 aa)
PF3D7_1247800Dipeptidyl aminopeptidase 2; Belongs to the peptidase C1 family. (590 aa)
PF3D7_1222300Endoplasmin, putative. (821 aa)
PF3D7_0416800Small GTP-binding protein sar1; Belongs to the small GTPase superfamily. SAR1 family. (192 aa)
PF3D7_0415400Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (208 aa)
PF3D7_0106800Ras-related protein Rab-5C. (214 aa)
PF3D7_0103900Parasite-infected erythrocyte surface protein. (575 aa)
PF3D7_0103100Vacuolar protein sorting-associated protein 51, putative. (1634 aa)
PF3D7_0935200Vacuolar protein sorting-associated protein 33, putative; Belongs to the STXBP/unc-18/SEC1 family. (1147 aa)
PF3D7_0926500Tetratricopeptide repeat protein, putative. (1922 aa)
PF3D7_0906100Vacuolar protein sorting-associated protein 46, putative. (195 aa)
PF3D7_0905900Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (1010 aa)
PF3D7_0904100AP-4 complex subunit epsilon, putative. (1388 aa)
PF3D7_0529700Heptatricopeptide repeat-containing protein, putative. (986 aa)
PF3D7_1311400AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (437 aa)
PF3D7_1309700Vacuolar protein sorting-associated protein 18, putative. (1672 aa)
RH5Reticulocyte-binding protein homolog 5; Essential for the invasion of host erythrocytes by blood stage merozoites. By binding P113 at the surface of the merozoite and human BSG/basigin on the erythrocyte membrane, leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes. In addition, the interaction with BSG results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte. This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion. (526 aa)
CyRPACysteine-rich protective antigen; Essential for the invasion of host erythrocytes by blood stage merozoites. Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes. This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte. (362 aa)
PF3D7_0422100Transmembrane emp24 domain-containing protein, putative. (385 aa)
PF3D7_1145100Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (1068 aa)
PF3D7_1140500Myosin K, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1738 aa)
PF3D7_1134800Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (487 aa)
PF3D7_1119500AP-4 complex subunit mu, putative; Belongs to the adaptor complexes medium subunit family. (436 aa)
PF11_0174Probable cathepsin C; Thiol protease. Has a role as a digestive enzyme. (700 aa)
PF3D7_1111300Protein transport protein BOS1, putative. (289 aa)
PF3D7_1110500Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (1050 aa)
PF3D7_1107200Uncharacterized protein. (713 aa)
PF3D7_1025400Uncharacterized protein. (1358 aa)
PF3D7_1019900Autophagy-related protein; Belongs to the ATG8 family. (124 aa)
ENOEnolase. (446 aa)
PF3D7_1466600Enkurin domain-containing protein, putative. (280 aa)
PF3D7_1459600Uncharacterized protein. (801 aa)
PF3D7_1457500Vacuolar protein sorting-associated protein 4; Belongs to the AAA ATPase family. (419 aa)
PF3D7_1455600Ferlin, putative. (1904 aa)
PF3D7_1455500AP-1 complex subunit gamma, putative. (1081 aa)
PF3D7_1452600DCB domain-containing protein. (3347 aa)
HDPHeme ligase; Heme detoxifying enzyme that converts heme to crystalline hemozoin (beta-hematin) to protect the organism from the toxic effects of heme. During its development, P.falciparum proteolyzes vast amounts of host hemoglobin, leading to heme release. (205 aa)
PF14_0397Uncharacterized protein PF14_0397. (229 aa)
PF3D7_1441600Acid cluster protein 33 homologue, putative. (569 aa)
PF3D7_1440700AP-3 complex subunit mu, putative; Belongs to the adaptor complexes medium subunit family. (733 aa)
PF3D7_1429800Coatomer subunit beta, putative. (1370 aa)
PF3D7_1408100Plasmepsin III; Belongs to the peptidase A1 family. (451 aa)
PF3D7_1407800Plasmepsin IV; Belongs to the peptidase A1 family. (449 aa)
PF3D7_1406700Vacuolar protein sorting-associated protein 29; Belongs to the VPS29 family. (194 aa)
PF3D7_0528100AP complex subunit beta. (929 aa)
PF3D7_0515300Phosphatidylinositol 3-kinase. (2133 aa)
TCTPTranslationally-controlled tumor protein homolog; Involved in calcium binding and microtubule stabilization. Belongs to the TCTP family. (171 aa)
PF3D7_0505100Trafficking protein particle complex subunit 8, putative. (2754 aa)
PFE0100wRING finger protein PFE0100w. (1272 aa)
PFL2415wVacuolar protein sorting-associated protein 26; May play a role in vesicular protein sorting, similar to the yeast retromer proteins. (297 aa)
PF3D7_1246300Clathrin adaptor domain-containing protein, putative. (888 aa)
PF3D7_1245800Epsin-like protein, putative. (431 aa)
PF3D7_1239900Vacuolar protein sorting-associated protein 16, putative. (1032 aa)
PF3D7_1236000Vesicle transport v-SNARE protein VTI1, putative. (410 aa)
PF3D7_1230700Protein transport protein SEC13; Belongs to the WD repeat SEC13 family. (822 aa)
PF3D7_1226400Mic1 domain-containing protein. (856 aa)
PF3D7_1225700VAC14 domain-containing protein, putative. (1501 aa)
PF3D7_1219100Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1997 aa)
PF3D7_1218300AP-2 complex subunit mu, putative; Belongs to the adaptor complexes medium subunit family. (621 aa)
PF3D7_1215800Radial spoke head protein 9, putative. (366 aa)
PF3D7_1314500Transmembrane emp24 domain-containing protein, putative; Belongs to the EMP24/GP25L family. (206 aa)
PF3D7_1408000Plasmepsin II; Belongs to the peptidase A1 family. (453 aa)
PF3D7_0820500Protein transport protein YIF1, putative. (852 aa)
pfsec23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (759 aa)
PF3D7_0823000Serine/threonine protein kinase VPS15, putative. (1332 aa)
PF3D7_0730200AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (858 aa)
PF3D7_0727000Vacuolar protein sorting-associated protein 53, putative. (1162 aa)
PF3D7_0720700Phosphoinositide-binding protein, putative. (2166 aa)
PF3D7_0719100ATP synthase F0 subunit a-like protein, putative. (179 aa)
CG10Putative chloroquine resistance transporter; May regulate endogenous transporter; Belongs to the CRT-like transporter family. (424 aa)
PF3D7_1352800Vacuolar fusion protein MON1, putative. (884 aa)
PF3D7_1348100GTPase, putative. (224 aa)
A0A143ZVA4Uncharacterized protein. (1502 aa)
A0A143ZX23Vesicle transport v-SNARE protein, putative. (198 aa)
A0A143ZX45FPL domain-containing protein. (1797 aa)
A0A143ZXE1Uncharacterized protein. (1582 aa)
A0A143ZY06Vesicle transport v-SNARE protein, putative. (70 aa)
PF3D7_1243500Vacuolar-sorting protein SNF7, putative. (226 aa)
PF3D7_1323800Vacuolar protein sorting-associated protein 52, putative. (1353 aa)
PF3D7_0103000Vacuolar protein sorting-associated protein VTA1, putative. (259 aa)
PF3D7_0402300Reticulocyte binding protein homologue 1. (2971 aa)
PF3D7_0405100Protein transport protein Sec24B, putative. (1350 aa)
PF3D7_0806300Ferlin-like protein, putative. (1704 aa)
PF3D7_0808100AP-3 complex subunit delta, putative. (1609 aa)
PF3D7_0808400Coatomer subunit epsilon, putative. (278 aa)
Rh2bReticulocyte binding protein 2 homolog b; Involved in reticulocyte adhesion. (3179 aa)
PF3D7_1361100Protein transport protein Sec24A. (940 aa)
PF3D7_1367200CLAMP domain-containing protein, putative. (367 aa)
PF3D7_0606700Coatomer alpha subunit, putative. (1512 aa)
PF3D7_0613700Syntaxin-binding protein, putative; Belongs to the STXBP/unc-18/SEC1 family. (703 aa)
PF3D7_0617100AP-2 complex subunit alpha, putative. (1236 aa)
C6KT30_PLAF7FPL domain-containing protein. (1796 aa)
PF3D7_0310700Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
PF3D7_0211200Ras-related protein Rab-5A. (235 aa)
PF13_0198Reticulocyte-binding protein 2 homolog a; Involved in reticulocyte adhesion. (3130 aa)
PF3D7_0214100Protein transport protein SEC31. (1471 aa)
PF3D7_0217300AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (141 aa)
PFC0245cProtein dopey homolog PFC0245c; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family. (3933 aa)
RIPRRh5-interacting protein; Essential for the invasion of host erythrocytes by blood stage merozoites. As part of the PfRH5 adhesion complex, facilitates the interaction of RH5 and human BSG required for the Ca(2+) release into the erythrocyte. (1086 aa)
PFD0110wReticulocyte-binding protein PFD0110w; Involved in reticulocyte adhesion. (2971 aa)
vapAV-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (611 aa)
PF3D7_1310600Ras-related protein Rab-5B. (207 aa)
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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