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PF3D7_1406200 PF3D7_1406200 PF3D7_1309400 PF3D7_1309400 PF3D7_1314200 PF3D7_1314200 PF3D7_1317100 PF3D7_1317100 MAL13P1.96 MAL13P1.96 SETVS SETVS PF3D7_1324500 PF3D7_1324500 PF3D7_1329300 PF3D7_1329300 Sir2A Sir2A PF3D7_1343400 PF3D7_1343400 PF3D7_1347100 PF3D7_1347100 PF3D7_1349800 PF3D7_1349800 PF3D7_1355100 PF3D7_1355100 PF3D7_1357500 PF3D7_1357500 PF3D7_1362200 PF3D7_1362200 MCM7 MCM7 PF3D7_0714000 PF3D7_0714000 PF3D7_0719300 PF3D7_0719300 PF07_0086 PF07_0086 PF3D7_0823300 PF3D7_0823300 PF3D7_0816800 PF3D7_0816800 PF3D7_0809900 PF3D7_0809900 PF3D7_0809700 PF3D7_0809700 PF3D7_0803400 PF3D7_0803400 PF3D7_1203700 PF3D7_1203700 PF3D7_1205600 PF3D7_1205600 PF3D7_1206500 PF3D7_1206500 PF3D7_1211300 PF3D7_1211300 PF3D7_1211700 PF3D7_1211700 PF3D7_1217700 PF3D7_1217700 PF3D7_1220900 PF3D7_1220900 PF3D7_1224500 PF3D7_1224500 PF3D7_1225200 PF3D7_1225200 PF3D7_1234100 PF3D7_1234100 PF3D7_1239500 PF3D7_1239500 PF3D7_1240400 PF3D7_1240400 PF3D7_1250800 PF3D7_1250800 PF3D7_0501800 PF3D7_0501800 PF3D7_0505200 PF3D7_0505200 PF3D7_0505600 PF3D7_0505600 PF3D7_0509100 PF3D7_0509100 PF3D7_0510500 PF3D7_0510500 PF3D7_0511700 PF3D7_0511700 PF3D7_0514100 PF3D7_0514100 PF3D7_0517400 PF3D7_0517400 PF3D7_0521700 PF3D7_0521700 PF3D7_0527000 PF3D7_0527000 PF3D7_0530600 PF3D7_0530600 PF3D7_0918600 PF3D7_0918600 PF3D7_0919000 PF3D7_0919000 PF3D7_0934100 PF3D7_0934100 PF3D7_0110700 PF3D7_0110700 PF3D7_0403900 PF3D7_0403900 PFD0685c PFD0685c PF3D7_0416300 PF3D7_0416300 PF3D7_0419300 PF3D7_0419300 PF3D7_0420000 PF3D7_0420000 PF3D7_1223300 PF3D7_1223300 PF3D7_0925700 PF3D7_0925700 PF3D7_0205400 PF3D7_0205400 PF3D7_0204000 PF3D7_0204000 PF3D7_0317500 PF3D7_0317500 PF3D7_0313000 PF3D7_0313000 PF3D7_1403100 PF3D7_1403100 SET1 SET1 PF3D7_0628600 PF3D7_0628600 PF3D7_0624600 PF3D7_0624600 PF3D7_0611400 PF3D7_0611400 PFF0285c PFF0285c PF3D7_0604600 PF3D7_0604600 PF3D7_0603600 PF3D7_0603600 PF3D7_1304000 PF3D7_1304000 PF08_0048 PF08_0048 PF3D7_0818700 PF3D7_0818700 PF3D7_0416400 PF3D7_0416400 PF3D7_1319400 PF3D7_1319400 PF3D7_1472200 PF3D7_1472200 PF3D7_0721000 PF3D7_0721000 PF3D7_0710400 PF3D7_0710400 PF3D7_1408400 PF3D7_1408400 PF3D7_1411400 PF3D7_1411400 PF3D7_1412100 PF3D7_1412100 PF3D7_1415900 PF3D7_1415900 PF3D7_1417800 PF3D7_1417800 PF3D7_1418100 PF3D7_1418100 PF3D7_1422800 PF3D7_1422800 PF3D7_1429900 PF3D7_1429900 PF3D7_1433300 PF3D7_1433300 PF3D7_1433500 PF3D7_1433500 PF3D7_1439100 PF3D7_1439100 PF3D7_1448200 PF3D7_1448200 PF3D7_1456500 PF3D7_1456500 PF3D7_1464000 PF3D7_1464000 PF3D7_1474300 PF3D7_1474300 PF3D7_1008000 PF3D7_1008000 PF3D7_1014600 PF3D7_1014600 PF3D7_1027000 PF3D7_1027000 PF3D7_1030000 PF3D7_1030000 PF3D7_1037600 PF3D7_1037600 PF3D7_1103600 PF3D7_1103600 PF3D7_1104200 PF3D7_1104200 PF3D7_1105000 PF3D7_1105000 PF3D7_1105100 PF3D7_1105100 PF3D7_1105200 PF3D7_1105200 PF3D7_1106000 PF3D7_1106000 PF3D7_1106700 PF3D7_1106700 PF3D7_1112100 PF3D7_1112100 PF3D7_1112600 PF3D7_1112600 PF3D7_1117100 PF3D7_1117100 PF3D7_1118600 PF3D7_1118600 PF3D7_1130700 PF3D7_1130700 PF3D7_1135600 PF3D7_1135600 PF3D7_1141800 PF3D7_1141800 PF3D7_1149000 PF3D7_1149000
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PF3D7_1406200Transcription elongation factor SPT6, putative. (2820 aa)
PF3D7_1309400HORMA domain protein, putative. (1327 aa)
PF3D7_1314200Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (2518 aa)
PF3D7_1317100DNA replication licensing factor MCM4; Belongs to the MCM family. (1005 aa)
MAL13P1.96Structural maintenance of chromosomes protein 2; May play a role in the conversion of interphase chromatin into condensed chromosomes; Belongs to the SMC family. SMC2 subfamily. (1218 aa)
SETVSVariant-silencing SET domain-containing protein; Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes. SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein. During infection, the clonal parasite population expresses only 1 gene at a time, while the 59 other var genes are silenced. The parasite then switches to t [...] (2548 aa)
PF3D7_1324500DEAD box helicase, putative. (1099 aa)
PF3D7_1329300Chromatin assembly factor 1 subunit B, putative. (582 aa)
Sir2ANAD-dependent protein deacylase Sir2A; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versio [...] (273 aa)
PF3D7_1343400DNA repair protein RAD5, putative. (1452 aa)
PF3D7_1347100DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (710 aa)
PF3D7_1349800GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (439 aa)
PF3D7_1355100DNA helicase; Belongs to the MCM family. (929 aa)
PF3D7_1357500DNA helicase, putative. (906 aa)
PF3D7_1362200RuvB-like helicase; Belongs to the RuvB family. (483 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (821 aa)
PF3D7_0714000Histone H2B; Belongs to the histone H2B family. (123 aa)
PF3D7_0719300Actin-related protein, putative; Belongs to the actin family. (1032 aa)
PF07_0086Uncharacterized protein PF07_0086. (3429 aa)
PF3D7_0823300Histone acetyltransferase GCN5. (1465 aa)
PF3D7_0816800Meiotic recombination protein DMC1, putative; Belongs to the RecA family. (347 aa)
PF3D7_0809900JmjC domain-containing protein, putative. (1259 aa)
PF3D7_0809700RuvB-like helicase; Belongs to the RuvB family. (520 aa)
PF3D7_0803400DNA repair and recombination protein RAD54, putative. (1239 aa)
PF3D7_1203700Nucleosome assembly protein; Belongs to the nucleosome assembly protein (NAP) family. (347 aa)
PF3D7_1205600Tetratricopeptide repeat protein, putative. (333 aa)
PF3D7_1206500Tat binding protein 1(TBP-1)-interacting protein, putative. (651 aa)
PF3D7_1211300DNA helicase MCM8, putative; Belongs to the MCM family. (1135 aa)
PF3D7_1211700DNA replication licensing factor MCM5, putative; Belongs to the MCM family. (758 aa)
PF3D7_1217700Uncharacterized protein. (520 aa)
PF3D7_1220900Heterochromatin protein 1. (266 aa)
PF3D7_1224500Histone chaperone ASF1, putative. (273 aa)
PF3D7_1225200Uncharacterized protein. (1187 aa)
PF3D7_1234100Bromodomain protein, putative. (3896 aa)
PF3D7_1239500DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1006 aa)
PF3D7_1240400Erythrocyte membrane protein 1, PfEMP1. (2287 aa)
PF3D7_1250800DNA repair protein rhp16, putative. (1647 aa)
PF3D7_0501800Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1076 aa)
PF3D7_0505200Actin-like protein, putative; Belongs to the actin family. (565 aa)
PF3D7_0505600BCNT-C domain-containing protein. (333 aa)
PF3D7_0509100Structural maintenance of chromosomes protein 4, putative. (1708 aa)
PF3D7_0510500Topoisomerase I. (839 aa)
PF3D7_0511700EKC/KEOPS complex subunit CGI121; Belongs to the CGI121/TPRKB family. (179 aa)
PF3D7_0514100ATP-dependent DNA helicase UvrD. (1441 aa)
PF3D7_0517400FACT complex subunit SPT16, putative. (1141 aa)
PF3D7_0521700ATP-dependent RNA helicase DDX1, putative. (841 aa)
PF3D7_0527000DNA replication licensing factor MCM3, putative; Belongs to the MCM family. (962 aa)
PF3D7_0530600XAP-5 DNA binding protein, putative. (447 aa)
PF3D7_0918600ATP-dependent DNA helicase Q1. (728 aa)
PF3D7_0919000Nucleosome assembly protein; Belongs to the nucleosome assembly protein (NAP) family. (269 aa)
PF3D7_0934100TFIIH basal transcription factor complex helicase XPD subunit. (1056 aa)
PF3D7_0110700Chromatin assembly factor 1 protein WD40 domain, putative. (446 aa)
PF3D7_0403900SET domain protein, putative. (1186 aa)
PFD0685cStructural maintenance of chromosomes protein 3 homolog; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity); Belongs to the SMC fami [...] (1193 aa)
PF3D7_0416300DNA helicase MCM9, putative; Belongs to the MCM family. (1465 aa)
PF3D7_0419300Rad51 domain-containing protein. (346 aa)
PF3D7_0420000Zinc finger protein, putative. (3370 aa)
PF3D7_1223300DNA gyrase subunit A. (1222 aa)
PF3D7_0925700Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (449 aa)
PF3D7_0205400PCI domain-containing protein, putative. (457 aa)
PF3D7_0204000Condensin-2 complex subunit H2, putative. (797 aa)
PF3D7_0317500Kinesin-5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1619 aa)
PF3D7_0313000Uncharacterized protein. (346 aa)
PF3D7_1403100Condensin complex subunit 1, putative. (1955 aa)
SET1Putative histone-lysine N-methyltransferase 1; Probable histone methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. (6753 aa)
PF3D7_0628600DNA methyltransferase 1-associated protein 1, putative. (385 aa)
PF3D7_0624600SNF2 helicase, putative. (2719 aa)
PF3D7_0611400SWIB/MDM2 domain-containing protein. (830 aa)
PFF0285cProbable DNA repair protein RAD50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity (By similarity). Belongs to the SMC family. RAD50 subfamily. (2236 aa)
PF3D7_0604600DNA helicase, putative. (1712 aa)
PF3D7_0603600AT-rich interactive domain-containing protein, putative. (2368 aa)
PF3D7_1304000Condensin complex subunit 2, putative. (1024 aa)
PF08_0048Probable ATP-dependent helicase PF08_0048; Catalytic component of a chromatin remodeling complex. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (2082 aa)
PF3D7_0818700DNA helicase, putative. (1223 aa)
PF3D7_0416400Histone acetyltransferase, putative. (1259 aa)
PF3D7_1319400Uncharacterized protein. (1070 aa)
PF3D7_1472200Histone deacetylase, putative. (2251 aa)
PF3D7_0721000Uncharacterized protein. (3459 aa)
PF3D7_0710400DNA repair protein RAD14, putative. (365 aa)
PF3D7_1408400FANCJ-like helicase, putative. (1160 aa)
PF3D7_1411400Plastid replication-repair enzyme. (2016 aa)
PF3D7_1412100Mini-chromosome maintenance complex-binding protein, putative. (956 aa)
PF3D7_1415900Zinc finger protein, putative. (146 aa)
PF3D7_1417800DNA helicase. (971 aa)
PF3D7_1418100Liver specific protein 1, putative. (3597 aa)
PF3D7_1422800Actin-related protein, putative; Belongs to the actin family. (522 aa)
PF3D7_1429900ADP-dependent DNA helicase RecQ. (1440 aa)
PF3D7_1433300Chromatin assembly factor 1 P55 subunit, putative. (428 aa)
PF3D7_1433500DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1472 aa)
PF3D7_1439100DEAD/DEAH box helicase, putative. (2472 aa)
PF3D7_1448200Condensin-2 complex subunit G2, putative. (1206 aa)
PF3D7_1456500SCD domain-containing protein. (2391 aa)
PF3D7_1464000YL1 nuclear protein, putative. (705 aa)
PF3D7_1474300DNA repair metallo-beta-lactamase protein, putative. (860 aa)
PF3D7_1008000Histone deacetylase 2. (2379 aa)
PF3D7_1014600Transcriptional coactivator ADA2. (2578 aa)
PF3D7_1027000Uncharacterized protein. (1811 aa)
PF3D7_1030000Transcription elongation factor SPT4, putative. (133 aa)
PF3D7_1037600TFIIH basal transcription factor complex helicase XPB subunit, putative. (886 aa)
PF3D7_1103600Actin-like protein, putative; Belongs to the actin family. (499 aa)
PF3D7_1104200Chromatin remodeling protein. (1426 aa)
PF3D7_1105000Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
PF3D7_1105100Histone H2B; Belongs to the histone H2B family. (117 aa)
PF3D7_1105200WD repeat-containing protein WRAP73, putative. (463 aa)
PF3D7_1106000RuvB-like helicase; Belongs to the RuvB family. (475 aa)
PF3D7_1106700DNA replication ATP-dependent helicase/nuclease DNA2, putative. (1024 aa)
PF3D7_1112100Protein kinase domain-containing protein. (2460 aa)
PF3D7_1112600ATPase, putative. (707 aa)
PF3D7_1117100Ubiquitin carboxyl-terminal hydrolase UCH54. (465 aa)
PF3D7_1118600Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (608 aa)
PF3D7_1130700Structural maintenance of chromosomes protein 1, putative. (1818 aa)
PF3D7_1135600Condensin-2 complex subunit. (1818 aa)
PF3D7_1141800EELM2 domain-containing protein, putative. (394 aa)
PF3D7_1149000Antigen 332, DBL-like protein. (6093 aa)
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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