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PF3D7_0107800 PF3D7_0107800 PF3D7_1129500 PF3D7_1129500 PF3D7_1037000 PF3D7_1037000 PFF0285c PFF0285c NTH1 NTH1 PF3D7_0619400 PF3D7_0619400 PF3D7_0630300 PF3D7_0630300 PF3D7_1442100 PF3D7_1442100 PF3D7_0303300 PF3D7_0303300 PF3D7_0318200 PF3D7_0318200 PF3D7_0203300 PF3D7_0203300 PF3D7_0205500 PF3D7_0205500 PF3D7_0215700 PF3D7_0215700 PF3D7_0218000 PF3D7_0218000 PF3D7_0219600 PF3D7_0219600 PF3D7_0305600 PF3D7_0305600 PCNA PCNA FEN1 FEN1 PF3D7_1211800 PF3D7_1211800 PF3D7_0419300 PF3D7_0419300 PF3D7_0403500 PF3D7_0403500 PF3D7_0110400 PF3D7_0110400 Q8I272_PLAF7 Q8I272_PLAF7 PF3D7_0934100 PF3D7_0934100 PF3D7_0923000 PF3D7_0923000 PF3D7_0917100 PF3D7_0917100 PF3D7_0910500 PF3D7_0910500 PF3D7_0516700 PF3D7_0516700 PF3D7_0512300 PF3D7_0512300 PF3D7_0507700 PF3D7_0507700 PF3D7_0505500 PF3D7_0505500 PF3D7_1244200 PF3D7_1244200 PF3D7_1241700 PF3D7_1241700 PF3D7_1234300 PF3D7_1234300 PF3D7_1213700 PF3D7_1213700 PF3D7_1204200 PF3D7_1204200 PF3D7_0819600 PF3D7_0819600 PF3D7_0726300 PF3D7_0726300 PF3D7_0725000 PF3D7_0725000 PF3D7_0708100 PF3D7_0708100 PF3D7_1368800 PF3D7_1368800 PF3D7_1365900 PF3D7_1365900 PF3D7_1364800 PF3D7_1364800 PF3D7_1353500 PF3D7_1353500 PF3D7_1342700 PF3D7_1342700 PF3D7_1338400 PF3D7_1338400 PF3D7_1314900 PF3D7_1314900 PF3D7_1313000 PF3D7_1313000 PF3D7_1308100 PF3D7_1308100 PF3D7_1304100 PF3D7_1304100 PF3D7_1132300 PF3D7_1132300 PF3D7_1117800 PF3D7_1117800 PF3D7_1111100 PF3D7_1111100 PF3D7_1107400 PF3D7_1107400 PF3D7_1039000 PF3D7_1039000 PF3D7_1037600 PF3D7_1037600 PF3D7_1027400 PF3D7_1027400 PF3D7_1023400 PF3D7_1023400 PF3D7_1011700 PF3D7_1011700 PF3D7_1467100 PF3D7_1467100 PF3D7_1463700 PF3D7_1463700 PF3D7_1463200 PF3D7_1463200 PF3D7_1441900 PF3D7_1441900 PF3D7_1432600 PF3D7_1432600 PF3D7_1427500 PF3D7_1427500 PF3D7_1423600 PF3D7_1423600 PF3D7_1418000 PF3D7_1418000 PF3D7_1415000 PF3D7_1415000
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PF3D7_0107800Double-strand break repair protein MRE11. (1233 aa)
PF3D7_1129500A/G-specific adenine glycosylase, putative. (611 aa)
PF3D7_1037000DNA polymerase zeta catalytic subunit, putative. (2226 aa)
PFF0285cProbable DNA repair protein RAD50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity (By similarity). Belongs to the SMC family. RAD50 subfamily. (2236 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (437 aa)
PF3D7_0619400Cell division cycle protein 48 homologue, putative. (828 aa)
PF3D7_0630300DNA polymerase epsilon catalytic subunit A, putative. (2907 aa)
PF3D7_1442100Replication factor A protein 3, putative. (109 aa)
PF3D7_0303300DNA-directed RNA polymerases I, II, and III subunit RPABC2, putative. (153 aa)
PF3D7_0318200DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2457 aa)
PF3D7_0203300ERCC1 nucleotide excision repair protein, putative. (242 aa)
PF3D7_0205500DNA-directed RNA polymerase II 16 kDa subunit, putative. (132 aa)
PF3D7_0215700DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1340 aa)
PF3D7_0218000Replication factor C subunit 2, putative. (330 aa)
PF3D7_0219600Replication factor C subunit 1. (904 aa)
PF3D7_0305600DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (617 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. (274 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (672 aa)
PF3D7_1211800Polyubiquitin. (381 aa)
PF3D7_0419300Rad51 domain-containing protein. (346 aa)
PF3D7_0403500Ubiquitin specific protease, putative. (400 aa)
PF3D7_0110400DNA-directed RNA polymerase II subunit RPB9, putative. (249 aa)
Q8I272_PLAF7Centrin-1. (168 aa)
PF3D7_0934100TFIIH basal transcription factor complex helicase XPD subunit. (1056 aa)
PF3D7_0923000DNA-directed RNA polymerase II subunit RPB3, putative. (335 aa)
PF3D7_0917100N-glycosylase/DNA lyase, putative. (757 aa)
PF3D7_0910500DNA repair protein REV1, putative. (1697 aa)
PF3D7_0516700Ubiquitin carboxyl-terminal hydrolase 2, putative; Belongs to the peptidase C19 family. (1332 aa)
PF3D7_0512300CDK-activating kinase assembly factor MAT1. (260 aa)
PF3D7_0507700Nuclear protein localization protein 4, putative. (531 aa)
PF3D7_0505500DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1350 aa)
PF3D7_1244200General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (945 aa)
PF3D7_1241700Replication factor C subunit 4, putative. (336 aa)
PF3D7_1234300DNA polymerase epsilon subunit B, putative. (624 aa)
PF3D7_1213700DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
PF3D7_1204200Uncharacterized protein. (629 aa)
PF3D7_0819600Ubiquitin-like domain-containing protein. (277 aa)
PF3D7_0726300DNA mismatch repair protein PMS1, putative. (1330 aa)
PF3D7_0725000Exonuclease I, putative. (1347 aa)
PF3D7_0708100DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative. (69 aa)
PF3D7_1368800DNA repair endonuclease XPF, putative. (1700 aa)
PF3D7_1365900Ubiquitin-60S ribosomal protein L40. (128 aa)
PF3D7_1364800DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative. (205 aa)
PF3D7_1353500RNA polymerase II transcription factor B subunit 4, putative. (326 aa)
PF3D7_1342700DNA-directed RNA polymerases I, II, and III subunit RPABC4, putative. (58 aa)
PF3D7_1338400SprT-like domain-containing protein, putative. (443 aa)
PF3D7_1314900General transcription factor IIH subunit. (401 aa)
PF3D7_1313000Ubiquitin-like protein nedd8 homologue, putative. (76 aa)
PF3D7_1308100CCAAT-binding transcription factor, putative. (152 aa)
PF3D7_1304100DNA ligase. (912 aa)
PF3D7_1132300Nucleic acid binding protein, putative. (273 aa)
PF3D7_1117800DNA mismatch repair protein MLH. (1016 aa)
PF3D7_1111100Replication factor C subunit 5, putative. (349 aa)
PF3D7_1107400DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (350 aa)
PF3D7_1039000Serine/threonine protein kinase, FIKK family. (913 aa)
PF3D7_1037600TFIIH basal transcription factor complex helicase XPB subunit, putative. (886 aa)
PF3D7_1027400DNA-directed RNA polymerase II subunit RPB7, putative. (177 aa)
PF3D7_1023400HORMA domain protein, putative. (195 aa)
PF3D7_1011700DNA repair protein RAD23, putative. (389 aa)
PF3D7_1467100DNA-3-methyladenine glycosylase, putative. (501 aa)
PF3D7_1463700Cyclin 1; Belongs to the cyclin family. (326 aa)
PF3D7_1463200Replication factor C subunit 3, putative. (344 aa)
PF3D7_1441900RNA polymerase II transcription factor B subunit 5, putative. (67 aa)
PF3D7_1432600BHD_1 domain-containing protein. (1195 aa)
PF3D7_1427500DNA mismatch repair protein MSH2, putative. (811 aa)
PF3D7_1423600Calcium-dependent protein kinase, putative; Belongs to the protein kinase superfamily. (284 aa)
PF3D7_1418000Ubiquitin fusion degradation protein 1, putative. (282 aa)
PF3D7_1415000Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (322 aa)
Your Current Organism:
Plasmodium falciparum
NCBI taxonomy Id: 36329
Other names: P. falciparum 3D7, Plasmodium falciparum (isolate 3D7), Plasmodium falciparum 3D7
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