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LOC107927582 LOC107927582 LOC107927137 LOC107927137 LOC107943981 LOC107943981 LOC107946806 LOC107946806 LOC107924650 LOC107924650 LOC107925060 LOC107925060 LOC107947091 LOC107947091 LOC107924261 LOC107924261 LOC107922452 LOC107922452 LOC107920673 LOC107920673 LOC107920789 LOC107920789 LOC107913539 LOC107913539 LOC107912765 LOC107912765 LOC107947115 LOC107947115 LOC107912324 LOC107912324 LOC107911801 LOC107911801 LOC107913234 LOC107913234 LOC107947368 LOC107947368 LOC107949785 LOC107949785 LOC107950594 LOC107950594 LOC107950214 LOC107950214 LOC107959376 LOC107959376 LOC107918535 LOC107918535 LOC107894311 LOC107894311 LOC107942638 LOC107942638 LOC107940962 LOC107940962 LOC107940281 LOC107940281 LOC107916254 LOC107916254 LOC107937982 LOC107937982 LOC107935920 LOC107935920 LOC107935704 LOC107935704 LOC107935553 LOC107935553 LOC107887093 LOC107887093 LOC107888453 LOC107888453 LOC107888519 LOC107888519 LOC107892362 LOC107892362 LOC107916232 LOC107916232 LOC107894587 LOC107894587 LOC107896560 LOC107896560 LOC107892338 LOC107892338 LOC107893417 LOC107893417 LOC107890889 LOC107890889 LOC107913776 LOC107913776 LOC107914874 LOC107914874 LOC107897934 LOC107897934 LOC107896602 LOC107896602 LOC107898021 LOC107898021 LOC107900442 LOC107900442 LOC107903900 LOC107903900 LOC107905873 LOC107905873 LOC107906483 LOC107906483 LOC107907498 LOC107907498 LOC107908531 LOC107908531 LOC107907353 LOC107907353 LOC107909874 LOC107909874 LOC107934367 LOC107934367 LOC107910656 LOC107910656 LOC107911799 LOC107911799 LOC107893906 LOC107893906 LOC107893529 LOC107893529
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC107927582Replication factor C subunit 1. (992 aa)
LOC107927137DNA ligase. (796 aa)
LOC107943981DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1324 aa)
LOC107946806Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (858 aa)
LOC107924650DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
LOC107925060Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
LOC107947091DNA primase; Belongs to the eukaryotic-type primase small subunit family. (452 aa)
LOC107924261FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (647 aa)
LOC107922452Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
LOC107920673DNA polymerase. (1097 aa)
LOC107920789DNA helicase; Belongs to the MCM family. (839 aa)
LOC107913539DNA helicase; Belongs to the MCM family. (839 aa)
LOC107912765DNA ligase. (1409 aa)
LOC107947115DNA primase; Belongs to the eukaryotic-type primase small subunit family. (452 aa)
LOC107912324DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
LOC107911801FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (647 aa)
LOC107913234DNA polymerase. (1531 aa)
LOC107947368Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (861 aa)
LOC107949785Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (626 aa)
LOC107950594Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
LOC107950214Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (266 aa)
LOC107959376DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2204 aa)
LOC107918535Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (414 aa)
LOC107894311DNA polymerase. (1960 aa)
LOC107942638DNA helicase; Belongs to the MCM family. (790 aa)
LOC107940962Probable DNA replication complex GINS protein PSF1. (151 aa)
LOC107940281DNA ligase. (1168 aa)
LOC107916254Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (383 aa)
LOC107937982DNA helicase; Belongs to the MCM family. (734 aa)
LOC107935920DNA helicase; Belongs to the MCM family. (758 aa)
LOC107935704Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (266 aa)
LOC107935553Origin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (421 aa)
LOC107887093Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (626 aa)
LOC107888453DNA helicase; Belongs to the MCM family. (935 aa)
LOC107888519DNA helicase; Belongs to the MCM family. (935 aa)
LOC107892362FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (639 aa)
LOC107916232DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (231 aa)
LOC107894587FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (101 aa)
LOC107896560Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (383 aa)
LOC107892338FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (639 aa)
LOC107893417DNA helicase; Belongs to the MCM family. (734 aa)
LOC107890889Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
LOC107913776DNA helicase; Belongs to the MCM family. (758 aa)
LOC107914874DNA replication complex GINS protein PSF1. (200 aa)
LOC107897934DNA polymerase. (1531 aa)
LOC107896602DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (231 aa)
LOC107898021DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (623 aa)
LOC107900442DNA replication complex GINS protein PSF3-like isoform X1. (185 aa)
LOC107903900DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (623 aa)
LOC107905873DNA helicase; Belongs to the MCM family. (758 aa)
LOC107906483Probable DNA replication complex GINS protein PSF1 isoform X1. (204 aa)
LOC107907498DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
LOC107908531DNA helicase; Belongs to the MCM family. (822 aa)
LOC107907353DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
LOC107909874DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (326 aa)
LOC107934367DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (209 aa)
LOC107910656DNA helicase; Belongs to the MCM family. (840 aa)
LOC107911799FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (540 aa)
LOC107893906FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (99 aa)
LOC107893529DNA polymerase. (1097 aa)
Your Current Organism:
Gossypium hirsutum
NCBI taxonomy Id: 3635
Other names: American cotton, American upland cotton, G. hirsutum, Gossypium hirsutum L., Gossypium hirsutum subsp. mexicanum, Gossypium hirsutum subsp. mexicanum (Tod.) Mauer, Gossypium lanceolatum, Gossypium lanceolatum Tod., Gossypium purpurascens, Gossypium purpurascens Poir., cotton
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