(42 nodes) Endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5-phosphomonoesters network (Theobroma cacao)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	TCM_030497	Uncharacterized protein. (245 aa)
	TCM_016820	Polynucleotidyl transferase, ribonuclease H-like superfamily protein, putative isoform 4. (305 aa)
	TCM_000758	Ribonuclease III family protein. (540 aa)
	TCM_002265	Metallo-hydrolase/oxidoreductase superfamily protein. (353 aa)
	TCM_004832	Ribonucleases P/MRP protein subunit POP1, putative. (860 aa)
	TCM_005432	5'-3' exonuclease family protein, putative isoform 1. (611 aa)
	TCM_002131	Ribonuclease 3-like protein 3, putative. (301 aa)
	TCM_042266	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (460 aa)
	TCM_041460	Aceous RNase P 3 isoform 1. (616 aa)
	TCM_041093	RBR-type E3 ubiquitin transferase. (601 aa)
	TCM_041092	RBR-type E3 ubiquitin transferase. (545 aa)
	TCM_037118	Dicer-like protein, putative isoform 1; Belongs to the helicase family. Dicer subfamily. (1690 aa)
	TCM_037856	Aceous RNase P 1, putative isoform 1. (872 aa)
	TCM_037410	Ribonuclease III, putative isoform 1; Belongs to the helicase family. Dicer subfamily. (1639 aa)
	TCM_036886	Debranching enzyme 1 isoform 1. (414 aa)
	TCM_036757	Endonuclease V family protein, putative isoform 1. (269 aa)
	TCM_029587	5'-3' exonuclease family protein isoform 2. (677 aa)
	TCM_029352	RBR-type E3 ubiquitin transferase. (520 aa)
	TCM_029029	RNA binding protein, putative. (267 aa)
	TCM_028839	tRNAse Z4 isoform 1. (967 aa)
	TCM_027389	RNAse THREE protein 1, putative isoform 1. (223 aa)
	TCM_015751	Pentatricopeptide (PPR) repeat-containing protein. (711 aa)
	TCM_015153	Single-stranded DNA endonuclease family protein. (589 aa)
	TCM_012569	5'-3' exonuclease family protein, putative isoform 1. (532 aa)
	TCM_012025	Ribonuclease III family protein, putative. (189 aa)
	TCM_042782	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (225 aa)
	TCM_044005	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (298 aa)
	TCM_042345	DNA replication helicase, putative isoform 1. (1384 aa)
	TCM_031646	Polynucleotidyl transferase, ribonuclease H-like superfamily protein, putative. (332 aa)
	TCM_031111	tRNAse Z1 isoform 1. (300 aa)
	TCM_026595	DNA excision repair protein ERCC-1 isoform 1. (409 aa)
	TCM_030826	Ribonuclease 3-like protein 2. (379 aa)
	TCM_030825	RNAse THREE-like protein 2 isoform 1. (371 aa)
	TCM_005016	Dicer-like 1 isoform 1; Belongs to the helicase family. Dicer subfamily. (2007 aa)
	TCM_010030	Tetratricopeptide repeat (TPR)-like superfamily protein isoform 2. (470 aa)
	TCM_016845	DNA-repair protein UVH3, putative isoform 1. (1670 aa)
	TCM_010210	RNase H family protein, putative isoform 1. (420 aa)
	TCM_020135	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (953 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa)
	TCM_025106	Dicer-like protein isoform 1; Belongs to the helicase family. Dicer subfamily. (1418 aa)
	TCM_020284	Ribonuclease P family protein / Rpp14 family protein isoform 1. (154 aa)
	TCM_017033	Multidrug resistance pump, putative isoform 1. (574 aa)

Your Current Organism:

Theobroma cacao

NCBI taxonomy Id: 3641
Other names: T. cacao, Theobroma cacao L., cacao, chocolate, cocoa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	TCM_012569	A0A061F433	A0A061FWG9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	5'-3' exonuclease family protein, putative isoform 1.	0.709
FEN1	TCM_016845	A0A061F433	A0A061ECG6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA-repair protein UVH3, putative isoform 1.	0.429
FEN1	TCM_026595	A0A061F433	A0A061FA79	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA excision repair protein ERCC-1 isoform 1.	0.658
FEN1	TCM_029587	A0A061F433	A0A061GFB8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	5'-3' exonuclease family protein isoform 2.	0.709
FEN1	TCM_030497	A0A061F433	A0A061FBF2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.831
FEN1	TCM_042345	A0A061F433	A0A061FLH1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication helicase, putative isoform 1.	0.831
FEN1	TCM_044005	A0A061F433	A0A061FQ66	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.525
TCM_002265	TCM_028839	A0A061DMU1	A0A061GAG6	Metallo-hydrolase/oxidoreductase superfamily protein.	tRNAse Z4 isoform 1.	0.919
TCM_002265	TCM_029029	A0A061DMU1	A0A061GB34	Metallo-hydrolase/oxidoreductase superfamily protein.	RNA binding protein, putative.	0.430
TCM_002265	TCM_031111	A0A061DMU1	A0A061FDP0	Metallo-hydrolase/oxidoreductase superfamily protein.	tRNAse Z1 isoform 1.	0.902
TCM_004832	TCM_017033	A0A061DRG1	A0A061EJX9	Ribonucleases P/MRP protein subunit POP1, putative.	Multidrug resistance pump, putative isoform 1.	0.934
TCM_004832	TCM_020284	A0A061DRG1	A0A061ESH1	Ribonucleases P/MRP protein subunit POP1, putative.	Ribonuclease P family protein / Rpp14 family protein isoform 1.	0.953
TCM_004832	TCM_041460	A0A061DRG1	A0A061GWB5	Ribonucleases P/MRP protein subunit POP1, putative.	Aceous RNase P 3 isoform 1.	0.934
TCM_005432	TCM_012569	A0A061DTH5	A0A061FWG9	5'-3' exonuclease family protein, putative isoform 1.	5'-3' exonuclease family protein, putative isoform 1.	0.709
TCM_005432	TCM_016845	A0A061DTH5	A0A061ECG6	5'-3' exonuclease family protein, putative isoform 1.	DNA-repair protein UVH3, putative isoform 1.	0.429
TCM_005432	TCM_026595	A0A061DTH5	A0A061FA79	5'-3' exonuclease family protein, putative isoform 1.	DNA excision repair protein ERCC-1 isoform 1.	0.658
TCM_005432	TCM_029587	A0A061DTH5	A0A061GFB8	5'-3' exonuclease family protein, putative isoform 1.	5'-3' exonuclease family protein isoform 2.	0.709
TCM_005432	TCM_030497	A0A061DTH5	A0A061FBF2	5'-3' exonuclease family protein, putative isoform 1.	Uncharacterized protein.	0.831
TCM_005432	TCM_042345	A0A061DTH5	A0A061FLH1	5'-3' exonuclease family protein, putative isoform 1.	DNA replication helicase, putative isoform 1.	0.831
TCM_005432	TCM_044005	A0A061DTH5	A0A061FQ66	5'-3' exonuclease family protein, putative isoform 1.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.525