83 items (Theobroma cacao) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TCM_000067	Nucleoside-triphosphatase C1orf57 isoform 1. (203 aa)
	TCM_000794	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (288 aa)
	TCM_001302	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
	TCM_002855	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity; Belongs to the adenylate kinase family. AK6 subfamily. (177 aa)
	TCM_004233	Pyruvate kinase; Belongs to the pyruvate kinase family. (576 aa)
	TCM_004705	RELA/SPOT isoform 1. (907 aa)
	TCM_004771	Phosphoribosylformylglycinamidine cyclo-ligase. (416 aa)
	TCM_006004	Allantoate amidohydrolase isoform 1. (490 aa)
	TCM_006154	Glycinamide ribonucleotide (GAR) synthetase isoform 2. (530 aa)
	TCM_006764	GLN phosphoribosyl pyrophosphate amidotransferase 1. (594 aa)
	TCM_005727	Nucleoside diphosphate kinase. (148 aa)
	TCM_006021	AICARFT/IMPCHase bienzyme family protein isoform 1. (615 aa)
	TCM_008874	Uncharacterized protein. (120 aa)
	TCM_010776	Urease; In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (837 aa)
	TCM_010779	Adenylate kinase 1 isoform 1; Belongs to the adenylate kinase family. (250 aa)
	TCM_010981	Phosphoglucomutase/phosphomannomutase family protein isoform 2; Belongs to the phosphohexose mutase family. (583 aa)
	TCM_007642	Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
	TCM_011708	GDA1/CD39 nucleoside phosphatase family protein, putative isoform 1; Belongs to the GDA1/CD39 NTPase family. (546 aa)
	TCM_017121	P-loop containing nucleoside triphosphate hydrolases superfamily protein, putative; Belongs to the adenylate kinase family. (268 aa)
	TCM_010011	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (909 aa)
	TCM_020482	P-loop containing nucleoside triphosphate hydrolases superfamily protein isoform 1. (281 aa)
	TCM_017203	Ferritin/ribonucleotide reductase-like family protein. (329 aa)
	TCM_020727	Pseudouridine synthase/archaeosine transglycosylase-like family protein. (574 aa)
	TCM_020402	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (203 aa)
	TCM_020615	Survival protein SurE-like phosphatase/nucleotidase. (309 aa)
	TCM_020614	Survival protein SurE-like phosphatase/nucleotidase, putative isoform 2. (317 aa)
	TCM_020739	Pyruvate kinase; Belongs to the pyruvate kinase family. (591 aa)
	TCM_020797	N-carbamyl-L-amino acid amidohydrolase protein isoform 1. (473 aa)
	TCM_021497	Ca2+-activated RelA/spot isoform 1. (577 aa)
	TCM_021668	AMP deaminase / myoadenylate deaminase, putative isoform 1. (842 aa)
	TCM_020494	Ribonucleoside-diphosphate reductase small chain A isoform 1. (470 aa)
	TCM_022183	Adenosine kinase 2. (341 aa)
	TCM_022396	Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
	TCM_022068	Adenosine kinase; Belongs to the adenylate kinase family. (288 aa)
	TCM_024730	Guanylate kinase isoform 1. (402 aa)
	TCM_024362	Pyruvate kinase; Belongs to the pyruvate kinase family. (522 aa)
	TCM_024914	Nudix hydrolase isoform 1. (290 aa)
	TCM_022107	Purine biosynthesis 4. (1412 aa)
	TCM_025975	Pyruvate kinase; Belongs to the pyruvate kinase family. (500 aa)
	TCM_026470	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (208 aa)
	TCM_026264	Phosphoribosylaminoimidazole carboxylase atpase-subunit isoform 1. (653 aa)
	PURA	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (489 aa)
	TCM_026034	Apyrase 1; Belongs to the GDA1/CD39 NTPase family. (557 aa)
	TCM_034204	Pseudouridine synthase/archaeosine transglycosylase-like family protein isoform 1. (483 aa)
	TCM_034455	Purin 7 isoform 1. (403 aa)
	TCM_034718	Adenine phosphoribosyl transferase 1 isoform 1. (256 aa)
	TCM_035853	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (187 aa)
	TCM_036205	Adenosine monophosphate kinase isoform 1; Belongs to the adenylate kinase family. (300 aa)
	TCM_042341	Phosphoribosyltransferase family protein isoform 1. (394 aa)
	TCM_042608	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (547 aa)
	TCM_043040	Adenosine kinase; Belongs to the adenylate kinase family. (300 aa)
	TCM_043508	Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
	TCM_043180	Adenosine kinase 2. (341 aa)
	TCM_044299	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (309 aa)
	TCM_014573	Nucleoside diphosphate kinase. (237 aa)
	TCM_014607	P-loop containing nucleoside triphosphate hydrolases superfamily protein isoform 1. (269 aa)
	TCM_014822	Nucleoside diphosphate kinase. (148 aa)
	TCM_014604	Adenylate kinase 1 isoform 1; Belongs to the adenylate kinase family. (244 aa)
	TCM_014490	Calcineurin-like metallo-phosphoesterase superfamily protein. (322 aa)
	TCM_011950	Transthyretin-like protein isoform 3. (335 aa)
	TCM_015365	Pyruvate kinase family protein isoform 1. (751 aa)
	TCM_015766	Pyruvate kinase; Belongs to the pyruvate kinase family. (571 aa)
	TCM_016011	Adenine phosphoribosyl transferase 4. (182 aa)
	TCM_047022	Nudix hydrolase. (313 aa)
	TCM_016472	Pleckstrin (PH) domain-containing protein isoform 1. (245 aa)
	TCM_015041	Phosphoglucomutase isoform 1. (639 aa)
	TCM_027085	DHHA2 domain-containing protein. (606 aa)
	TCM_015300	Pyruvate kinase; Belongs to the pyruvate kinase family. (589 aa)
	TCM_027245	Adenine phosphoribosyl transferase 2 isoform 2. (216 aa)
	TCM_015773	Phosphoribosyltransferase family protein. (404 aa)
	TCM_015847	Ureidoglycine aminohydrolase isoform 1. (308 aa)
	TCM_029141	RELA/SPOT. (724 aa)
	TCM_030190	Adenosine/AMP deaminase family protein isoform 1. (358 aa)
	TCM_029892	Allantoinase, putative isoform 1. (501 aa)
	TCM_036938	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family. (493 aa)
	TCM_036979	Adenine phosphoribosyl transferase 2 isoform 2. (247 aa)
	TCM_029062	Acid phosphatase. (388 aa)
	TCM_037673	Alkaline-phosphatase-like family protein isoform 1. (492 aa)
	TCM_037637	Acid phosphatase, putative isoform 1. (389 aa)
	TCM_030344	Formyl transferase. (427 aa)
	TCM_038629	Pyruvate kinase; Belongs to the pyruvate kinase family. (506 aa)
	TCM_040658	Xanthine dehydrogenase 1 isoform 1. (1368 aa)
	TCM_038279	Adenylate kinase family protein isoform 1. (603 aa)

Your Current Organism:

Theobroma cacao

NCBI taxonomy Id: 3641
Other names: T. cacao, Theobroma cacao L., cacao, chocolate, cocoa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PURA	TCM_004771	A0A061F482	A0A061DT32	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Phosphoribosylformylglycinamidine cyclo-ligase.	0.853
PURA	TCM_005727	A0A061F482	A0A061E2I2	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Nucleoside diphosphate kinase.	0.421
PURA	TCM_006021	A0A061F482	A0A061E3M3	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	AICARFT/IMPCHase bienzyme family protein isoform 1.	0.994
PURA	TCM_006154	A0A061F482	A0A061DW46	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Glycinamide ribonucleotide (GAR) synthetase isoform 2.	0.853
PURA	TCM_006764	A0A061F482	A0A061DZL3	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	GLN phosphoribosyl pyrophosphate amidotransferase 1.	0.790
PURA	TCM_010011	A0A061F482	A0A061ED95	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.959
PURA	TCM_011708	A0A061F482	A0A061EAG1	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	GDA1/CD39 nucleoside phosphatase family protein, putative isoform 1; Belongs to the GDA1/CD39 NTPase family.	0.902
PURA	TCM_014573	A0A061F482	A0A061FYQ0	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Nucleoside diphosphate kinase.	0.401
PURA	TCM_014822	A0A061F482	A0A061FZ11	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Nucleoside diphosphate kinase.	0.421
PURA	TCM_015773	A0A061F482	A0A061GAJ9	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Phosphoribosyltransferase family protein.	0.567
PURA	TCM_016011	A0A061F482	A0A061G4R7	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenine phosphoribosyl transferase 4.	0.584
PURA	TCM_016472	A0A061F482	A0A061G775	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Pleckstrin (PH) domain-containing protein isoform 1.	0.401
PURA	TCM_020402	A0A061F482	A0A061ELY9	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.965
PURA	TCM_020482	A0A061F482	A0A061EKC4	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	P-loop containing nucleoside triphosphate hydrolases superfamily protein isoform 1.	0.579
PURA	TCM_020614	A0A061F482	A0A061EMV0	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Survival protein SurE-like phosphatase/nucleotidase, putative isoform 2.	0.900
PURA	TCM_020615	A0A061F482	A0A061EM36	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Survival protein SurE-like phosphatase/nucleotidase.	0.900
PURA	TCM_021668	A0A061F482	A0A061ERB2	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	AMP deaminase / myoadenylate deaminase, putative isoform 1.	0.959
PURA	TCM_022107	A0A061F482	A0A061EZV3	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Purine biosynthesis 4.	0.911
PURA	TCM_022183	A0A061F482	A0A061ET81	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenosine kinase 2.	0.610
PURA	TCM_024730	A0A061F482	A0A061EWX9	Adenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Guanylate kinase isoform 1.	0.579