STRINGSTRING
lipA lipA lipB lipB Rta_03520 Rta_03520 aceE aceE Rta_07340 Rta_07340 Rta_08280 Rta_08280 fbp fbp bkdA1 bkdA1 bkdA2 bkdA2 bkdB bkdB lpd lpd folC folC edd edd eda eda folA folA thyA thyA gcvP gcvP gcvH gcvH gcvT gcvT glyA glyA Rta_16260 Rta_16260 Rta_17720 Rta_17720 rpiA rpiA folD folD aceE-2 aceE-2 aceF aceF Rta_18700 Rta_18700 sucA sucA sucB sucB Rta_18810 Rta_18810 eno eno tpiA tpiA pdhB pdhB pdhA pdhA Rta_31430 Rta_31430 tkt tkt prs prs pgi pgi tal tal zwf zwf hexR hexR rpe rpe purU purU fba fba pykA pykA pgk pgk gapA gapA Rta_37770 Rta_37770
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lipACandidate lipoic acid synthetase (Lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (327 aa)
lipBCandidate lipoate-protein ligase B (Lipoate biosynthesis protein B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (226 aa)
Rta_03520Conserved hypothetical protein; Belongs to the UPF0250 family. (98 aa)
aceECandidate pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (877 aa)
Rta_07340N-acetylmannosamine kinase(ManNAc kinase)-like protein. (315 aa)
Rta_08280Conserved hypothetical protein; Belongs to the glucose-6-phosphate 1-epimerase family. (276 aa)
fbpD-fructose-1,6-bisphosphate 1-phosphohydrolase. (338 aa)
bkdA1Candidate 2-oxoisovalerate dehydrogenase, alpha subunit. (412 aa)
bkdA2Candidate 2-oxoisovalerate dehydrogenase, beta subunit. (357 aa)
bkdBCandidate Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (435 aa)
lpdDihydrolipoamide dehydrogenase. (464 aa)
folCTetrahydrofolylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (432 aa)
eddCandidate phosphogluconate dehydratase (6-phosphogluconate dehydratase); Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (624 aa)
eda2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase; Candidate bifunctional protein: 4-hydroxy-2-oxoglutarate aldolase (2-keto-4-hydroxyglutarate aldolase); 2- dehydro-3-deoxyphosphogluconate aldolase (Phospho-2- dehydro-3-deoxygluconate aldolase). (214 aa)
folACandidate dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa)
thyACandidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
gcvPGlycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa)
gcvHCandidate glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTCandidate aminomethyltransferase (Glycine cleavage system T protein). (378 aa)
glyACandidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa)
Rta_16260Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). (395 aa)
Rta_17720Conserved hypothetical protein. (309 aa)
rpiACandidate ribose 5-phosphate isomerase A (Phosphoriboisomerase A); Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
folDCandidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
aceE-2Candidate pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (901 aa)
aceFDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (567 aa)
Rta_18700Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). (598 aa)
sucACandidate 2-oxoglutarate dehydrogenase E1 component (Alpha- ketoglutarate dehydrogenase). (956 aa)
sucBDihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (427 aa)
Rta_18810Dihydrolipoamide dehydrogenase. (476 aa)
eno2-phospho-D- glycerate hydro-lyase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
tpiATriose-phosphate isomerase (Triosephosphate isomerase)-like protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
pdhBCandidate pyruvate dehydrogenase E1 component, beta subunit. (321 aa)
pdhACandidate pyruvate dehydrogenase E1 component, alpha subunit. (337 aa)
Rta_314301-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating). (322 aa)
tktConserved hypothetical protein. (302 aa)
prsCandidate ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)
pgiPhosphohexose isomerase; Belongs to the GPI family. (536 aa)
talCandidate transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (340 aa)
zwfCandidate glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (492 aa)
hexRCandidate transcriptional regulator HexR (Hex regulon repressor), RpiR family. (282 aa)
rpeCandidate ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3- epimerase). (227 aa)
purUCandidate formyltetrahydrofolate deformylase (Formyl-FH(4) hydrolase); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa)
fbaCandidate fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
pykACandidate pyruvate kinase II; Belongs to the pyruvate kinase family. (477 aa)
pgkCandidate phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (397 aa)
gapACandidate glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
Rta_37770Candidate transketolase; Belongs to the transketolase family. (676 aa)
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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