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hflB1 hflB1 clpP clpP cyaY cyaY hslV hslV hslU hslU hslR hslR clpP-2 clpP-2 clpX clpX lonA lonA Rta_16570 Rta_16570 hflB2 hflB2 iscR iscR iscS iscS iscU iscU iscA iscA hscB hscB hscA hscA fdx fdx Rta_18690 Rta_18690 hfq hfq hflX hflX hflK hflK Rta_19020 Rta_19020 Rta_19350 Rta_19350 Rta_19480 Rta_19480 Rta_19490 Rta_19490 clpA clpA clpS clpS clpB clpB grpE grpE dnaK dnaK dnaJ dnaJ Rta_25860 Rta_25860 Rta_28350 Rta_28350 Rta_29040 Rta_29040 hrcA hrcA recN recN Rta_33210 Rta_33210 htpG htpG groS groS groL groL Rta_36760 Rta_36760
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hflB1Candidate ATP-dependent Zn protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (672 aa)
clpPCandidate ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp). (198 aa)
cyaYCandidate iron binding protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (111 aa)
hslVCandidate ATP-dependent protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (186 aa)
hslUCandidate ATP-dependent hsl protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (436 aa)
hslRCandidate heat shock protein, HSP15 family. (137 aa)
clpP-2Candidate ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (202 aa)
clpXCandidate ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa)
lonACandidate ATP-dependent LA protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (814 aa)
Rta_16570Hypothetical protein. (168 aa)
hflB2Candidate ATP-dependent Zn protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (636 aa)
iscRCandidate transcriptional regulator IscR (Fe-S cluster-containing transcription factor), Rrf2 family. (178 aa)
iscSCandidate cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (408 aa)
iscUCandidate Fe-S cluster assembly protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
iscACandidate Fe-S cluster assembly protein; Belongs to the HesB/IscA family. (105 aa)
hscBCandidate co-chaperone, DnaJ family; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (172 aa)
hscACandidate chaperone, Hsp70 (DnaK) family; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (619 aa)
fdxCandidate ferredoxin. (112 aa)
Rta_18690Conserved hypothetical protein. (200 aa)
hfqCandidate host factor I protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (82 aa)
hflXCandidate GTP-binding protein hflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (399 aa)
hflKCandidate HflK protein; HflC and HflK could encode or regulate a protease. (425 aa)
Rta_19020HflC protein-like protein; HflC and HflK could regulate a protease. (305 aa)
Rta_19350AAA-metalloprotease-like protein. (712 aa)
Rta_19480Conserved hypothetical protein. (304 aa)
Rta_19490Conserved hypothetical protein. (141 aa)
clpACandidate ATP-dependent Clp protease ATP-binding subunit clpA; Belongs to the ClpA/ClpB family. (773 aa)
clpSCandidate ATP-dependent Clp protease adaptor protein clpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (143 aa)
clpBCandidate heat shock protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (874 aa)
grpECandidate heat shock protein, HSP70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. S [...] (197 aa)
dnaKCandidate heat shock protein, HSP70 family; Acts as a chaperone; Belongs to the heat shock protein 70 family. (652 aa)
dnaJCandidate heat shock protein J; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] (382 aa)
Rta_25860Chaperone protein, HSP33 family-like protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. (325 aa)
Rta_28350Chaperone protein-like protein. (422 aa)
Rta_29040ATP-dependent protease La-like protein. (332 aa)
hrcACandidate transcriptional regulator HrcA (Heat-inducible transcription repressor hrcA), HrcA family; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (333 aa)
recNCandidate DNA repair ATPase; May be involved in recombinational repair of damaged DNA. (557 aa)
Rta_33210P-loop-containing kinase-like protein; Displays ATPase and GTPase activities. (300 aa)
htpGCandidate heat shock protein, HSP90 family; Molecular chaperone. Has ATPase activity. (641 aa)
groSgroES protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (117 aa)
groLgroEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
Rta_36760Thioredoxin-like protein. (300 aa)
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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