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| | uraA | Candidate xanthine/uracil permease. (440 aa) |
| | pyrF | Candidate Orotidine 5 -phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (291 aa) |
| | dapB | Candidate Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (279 aa) |
| | proA | Candidate Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | pyrE | Candidate Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (226 aa) |
| | putA | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1019 aa) |
| | Rta_07240 | Dihydroneopterin aldolase-like protein. (122 aa) |
| | dapA | Candidate dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | lysA | Candidate Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (423 aa) |
| | aroK | Candidate shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | aroB | Candidate 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (322 aa) |
| | argE | Candidate Acetylornithine deacetylase. (373 aa) |
| | argB | Candidate Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (311 aa) |
| | aroD | Candidate 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (240 aa) |
| | pyrC | Candidate Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | dapF | Candidate Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa) |
| | aroE | Candidate shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | argJ | Ornithine transacetylase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argG | Candidate argininosuccinate synthase (Citrulline--aspartate ligase); Belongs to the argininosuccinate synthase family. Type 2 subfamily. (448 aa) |
| | purF | Candidate amidophosphoribosyltransferase (Glutamine phosphoribosylpyrophosphate amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (508 aa) |
| | guaC | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (325 aa) |
| | cmk | Deoxycytidine kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (663 aa) |
| | Rta_13660 | Prephenate dehydrogenase-like protein. (288 aa) |
| | Rta_13670 | Candidate bifunctional protein: chorismate mutase; prephenate dehydratase. (360 aa) |
| | aroC | Candidate chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | tolA | Candidate tolA protein. (280 aa) |
| | exbD-2 | Candidate biopolymer transport protein. (141 aa) |
| | tolQ-2 | Candidate biopolymer transport protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (257 aa) |
| | Rta_15170 | Conserved hypothetical protein. (127 aa) |
| | Rta_15180 | Aspartate transaminase. (397 aa) |
| | nusB | Candidate N utilization substance protein B (Transcription termination factor); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (177 aa) |
| | ribH | Candidate riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribAB | Candidate riboflavin biosynthesis bifunctional protein : GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (375 aa) |
| | ribE | Candidate riboflavin synthase, alpha chain. (207 aa) |
| | ribD | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (385 aa) |
| | nrdR | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa) |
| | lysC | Candidate aspartokinase (Aspartate kinase); Belongs to the aspartokinase family. (410 aa) |
| | Rta_15710 | Hydrolases (HAD superfamily)-like protein. (231 aa) |
| | carA | Candidate carbamoyl-phosphate synthase small chain (Carbamoyl-phosphate synthase (glutamine-hydrolyzing)); Belongs to the CarA family. (387 aa) |
| | carB | Candidate carbamoyl-phosphate synthase large chain (Carbamoyl-phosphate synthase (ammonia)); Belongs to the CarB family. (1084 aa) |
| | folP | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (294 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (319 aa) |
| | pyrD | Candidate dihydroorotate dehydrogenase (Dihydroorotate oxidase); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (354 aa) |
| | ndk | Candidate nucleoside diphosphate kinase (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | purA | Candidate adenylosuccinate synthetase (IMP--aspartate ligase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa) |
| | guaB | Candidate Inosine-5 -monophosphate dehydrogenase (IMP dehydrogenase); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa) |
| | guaA | Candidate GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (537 aa) |
| | tmk | Candidate thymidylate kinase (dTMP kinase); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa) |
| | purL | Candidate phosphoribosylformylglycinamidine synthase (FGAM synthase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa) |
| | argA | Candidate amino-acid acetyltransferase (N-acetylglutamate synthase); Belongs to the acetyltransferase family. ArgA subfamily. (469 aa) |
| | Rta_20980 | Aminotransferases-like protein. (398 aa) |
| | dapD | Tetrahydropicolinate succinylase; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | Rta_21000 | Twitching mobility protein-like protein. (384 aa) |
| | dapE | Candidate succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (389 aa) |
| | Rta_21020 | Site-specific DNA-methyltransferase (adenine-specific)-like protein; Belongs to the protein N5-glutamine methyltransferase family. (285 aa) |
| | Rta_21030 | Candidate ABC transporter, ATP-binding component with duplicated domains. (642 aa) |
| | purD | Phosphoribosylglycinamide synthetase; Belongs to the GARS family. (426 aa) |
| | Rta_21560 | Dihydrodipicolinate synthase-like protein; Belongs to the DapA family. (310 aa) |
| | adk | Candidate adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | surE | Candidate acid phosphatase (Stationary-phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa) |
| | dapA-2 | Candidate dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (281 aa) |
| | dut | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa) |
| | pyrG | Candidate CTP synthase (UTP--ammonia ligase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | Rta_26640 | Similar to anthranilate phosphoribosyltransferase 2 of Ralstonia solanacearum (Pseudomonas solanacearum)-like protein. (301 aa) |
| | folK | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. (164 aa) |
| | pcnB | Candidate polynucleotide adenylyltransferase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (527 aa) |
| | Rta_27790 | Conserved hypothetical protein. (225 aa) |
| | Rta_27800 | DnaA ATPase protein-like protein; Belongs to the DnaA family. (233 aa) |
| | purM | Candidate phosphoribosylformylglycinamidine cyclo-ligase(Phosphoribosyl-aminoimidazole synthetase). (344 aa) |
| | Rta_27820 | Chromosome partitioning protein-like protein. (280 aa) |
| | argD | Candidate acetylornithine aminotransferase (acetylornithine transaminase); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | arcB | Candidate ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (315 aa) |
| | asd | Candidate aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (382 aa) |
| | Rta_28190 | Conserved hypothetical protein. (899 aa) |
| | truA | Candidate tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (260 aa) |
| | trpF | Candidate N-(5 -phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (248 aa) |
| | trpB | Candidate tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (415 aa) |
| | trpA | Candidate tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | argH | Candidate argininosuccinate lyase (Arginosuccinase). (471 aa) |
| | Rta_28970 | Conserved hypothetical protein. (286 aa) |
| | proB | Candidate glutamate 5-kinase (Gamma-glutamyl kinase); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (389 aa) |
| | Rta_31420 | Guanylate kinase (GMP kinase)-like protein. (255 aa) |
| | purN | 5 -phosphoribosylglycinamide transformylase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (196 aa) |
| | ribF | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. (332 aa) |
| | Rta_32100 | Ornithine cyclodeaminase-like protein. (302 aa) |
| | dcd | Candidate deoxycytidine triphosphate deaminase (dCTP deaminase); Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | Rta_32670 | N-acetylornithinase. (408 aa) |
| | gmk | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | relA-2 | Candidate GTP pyrophosphokinase (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (753 aa) |
| | pyrC-2 | Candidate dihydroorotase. (437 aa) |
| | pyrB | Candidate aspartate carbamoyltransferase (Aspartate transcarbamylase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | pyrR | Candidate bifunctional protein : Pyrimidine operon attenuation regulatory protein; Uracil phosphoribosyltransferase. (167 aa) |
| | Rta_34100 | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (136 aa) |
| | Rta_34110 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. (199 aa) |
| | purH | Candidate bifunctional purine biosynthesis protein : Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase. (523 aa) |
| | nrdA | Candidate ribonucleoside-diphosphate reductase, alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (968 aa) |
| | nrdB | Candidate ribonucleoside reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (406 aa) |
| | ribB | Candidate 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (221 aa) |
| | trpC | Candidate indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (263 aa) |
| | trpD1 | Candidate anthranilate phosphoribosyltransferase 1; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (343 aa) |
| | rhtB-4 | Candidate threonine efflux protein. (216 aa) |
| | trpG | Candidate anthranilate synthase component II (Glutamine amido- transferase). (190 aa) |
| | trpE | Candidate anthranilate synthase component I. (506 aa) |
| | proC | Candidate pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | purK | Candidate phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa) |
| | purE | Candidate phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa) |
| | purC | Candidate phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (302 aa) |
| | purB | Candidate adenylosuccinate lyase (Adenylosuccinase); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (466 aa) |
| | argC-2 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (305 aa) |
