STRINGSTRING
Rta_19350 Rta_19350 infB infB typA typA smc smc clpA clpA cysN cysN clpB clpB Rta_25220 Rta_25220 mutL mutL Rta_27040 Rta_27040 era era lepA lepA Rta_28890 Rta_28890 Rta_29040 Rta_29040 obg obg pilB pilB Rta_29820 Rta_29820 Rta_30610 Rta_30610 Rta_31620 Rta_31620 Rta_31940 Rta_31940 Rta_31990 Rta_31990 Rta_32180 Rta_32180 ureG ureG Rta_32920 Rta_32920 Rta_33170 Rta_33170 Rta_33230 Rta_33230 ftsY ftsY Rta_33950 Rta_33950 engD engD ffh ffh htpG htpG gspE-2 gspE-2 tuf-2 tuf-2 recG recG trmE trmE Rta_00075 Rta_00075 minD minD Rta_01300 Rta_01300 uvrA1 uvrA1 nudJ nudJ fusA fusA tuf tuf rep rep hflB1 hflB1 uvrA2 uvrA2 prfC prfC paaD paaD ruvA ruvA ruvB ruvB hslU hslU ftsZ ftsZ icmF icmF Rta_11580 Rta_11580 Rta_11585 Rta_11585 rsgA rsgA gspE gspE Rta_12670 Rta_12670 uvrD uvrD Rta_13400 Rta_13400 Rta_14610 Rta_14610 clpX clpX lonA lonA mfd mfd hflB2 hflB2 Rta_18240 Rta_18240 uvrB uvrB hscA hscA Rta_18820 Rta_18820 scpB scpB hflX hflX
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rta_19350AAA-metalloprotease-like protein. (712 aa)
infBCandidate translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (954 aa)
typACandidate GTP-binding elongation factor. (610 aa)
smcCandidate chromosome segregation protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1234 aa)
clpACandidate ATP-dependent Clp protease ATP-binding subunit clpA; Belongs to the ClpA/ClpB family. (773 aa)
cysNATP-sulfurylase large subunit. (415 aa)
clpBCandidate heat shock protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (874 aa)
Rta_25220MoxR protein-like protein. (290 aa)
mutLCandidate DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (597 aa)
Rta_27040Candidate membrane protein. (452 aa)
eraCandidate GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (320 aa)
lepACandidate GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (603 aa)
Rta_28890Candidate cation transport ATPase. (806 aa)
Rta_29040ATP-dependent protease La-like protein. (332 aa)
obgCandidate Spo0B-associated GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (364 aa)
pilBCandidate type 4 fimbrial assembly protein pilB, putative traffic ATPase. (581 aa)
Rta_29820Flagellar biosynthesis/type III secretory pathway ATPase-like protein. (439 aa)
Rta_30610ATP-binding protein-like protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (362 aa)
Rta_31620ATPase protein, AAA family-like protein. (440 aa)
Rta_31940Type IV pilus assembly protein tapB-like protein. (597 aa)
Rta_31990ATPases-like protein. (340 aa)
Rta_32180MoxR ATPases-like protein. (330 aa)
ureGCandidate urease accessory protein; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. (191 aa)
Rta_32920Candidate HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (206 aa)
Rta_33170Conserved hypothetical protein. (503 aa)
Rta_33230Conserved hypothetical protein. (652 aa)
ftsYCandidate Cell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (339 aa)
Rta_33950MoxR ATPases-like protein. (265 aa)
engDCandidate GTP-dependent nucleic acid-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (362 aa)
ffhCandidate signal recognition particle protein SR54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the indi [...] (454 aa)
htpGCandidate heat shock protein, HSP90 family; Molecular chaperone. Has ATPase activity. (641 aa)
gspE-2Candidate general secretion pathway protein E (Type II traffic warden ATPase), component of type II secretion system. (463 aa)
tuf-2Candidate elongation factor Tu. (396 aa)
recGCandidate ATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (696 aa)
trmECandidate tRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (439 aa)
Rta_000755-methylcytosine-specific restriction enzyme B-like protein. (938 aa)
minDCandidate septum formation inhibitor-activating ATPase. (271 aa)
Rta_01300ATPase protein, AAA family-like protein. (765 aa)
uvrA1Candidate excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (989 aa)
nudJConserved hypothetical protein; Belongs to the Nudix hydrolase family. NudJ subfamily. (162 aa)
fusACandidate Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 sub [...] (700 aa)
tufCandidate Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa)
repCandidate ATP-dependent DNA helicase. (681 aa)
hflB1Candidate ATP-dependent Zn protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (672 aa)
uvrA2Candidate excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1915 aa)
prfCCandidate peptide chain release factor; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (543 aa)
paaDCandidate Phenylacetic acid degradation protein. (171 aa)
ruvACandidate Holliday junction resolvasome, DNA-binding subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (193 aa)
ruvBCandidate Holliday junction resolvasome, helicase subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (351 aa)
hslUCandidate ATP-dependent hsl protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (436 aa)
ftsZCandidate cell division tubulin-like GTPase; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (407 aa)
icmFCandidate methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1097 aa)
Rta_11580Candidate ABC transporter, ATP-binding component with duplicated domains. (548 aa)
Rta_11585Hypothetical protein. (503 aa)
rsgACandidate GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (308 aa)
gspECandidate general secretion pathway protein E (Type II traffic warden ATPase). (480 aa)
Rta_12670ATPases-like protein. (258 aa)
uvrDCandidate DNA helicase II. (809 aa)
Rta_13400Conserved hypothetical protein. (328 aa)
Rta_14610Conserved hypothetical protein. (155 aa)
clpXCandidate ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa)
lonACandidate ATP-dependent LA protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (814 aa)
mfdCandidate transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1163 aa)
hflB2Candidate ATP-dependent Zn protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (636 aa)
Rta_18240Candidate LAO/AO transport system kinase. (332 aa)
uvrBCandidate excinuclease ABC, helicase subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA su [...] (701 aa)
hscACandidate chaperone, Hsp70 (DnaK) family; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (619 aa)
Rta_18820Conserved hypothetical protein. (332 aa)
scpBCandidate segregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (227 aa)
hflXCandidate GTP-binding protein hflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (399 aa)
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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