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| | cobS | Cobalamin synthase-like protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (265 aa) |
| | cobQ | Candidate cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (478 aa) |
| | cobD-2 | Cobalamin biosynthesis protein, membrane protein-like protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (314 aa) |
| | Rta_16420 | Candidate COB(I)alamin adenosyltransferase (Corrinoid adenosyltransferase); Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (189 aa) |
| | Rta_16380 | Obyrinic acid A,C-diamide synthase-like protein. (441 aa) |
| | Rta_16370 | Bifunctional cobalamin biosynthesis protein : Cobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (200 aa) |
| | ugd | Candidate UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase). (496 aa) |
| | acsA | Candidate acetyl-coenzyme A synthetase(Acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (661 aa) |
| | Rta_15900 | 4-phospho-D-threonate 3-dehydrogenase / 4-phospho-D-erythronate 3-dehydrogenase; 4-hydroxythreonine-4-phosphate dehydrogenase (4- (phosphohydroxy)-L-threonine dehydrogenase)-like protein; Belongs to the PdxA family. (342 aa) |
| | hemH | Heme synthetase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (367 aa) |
| | accA | Candidate Acetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | nusB | Candidate N utilization substance protein B (Transcription termination factor); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (177 aa) |
| | dnaE1 | Candidate DNA polymerase III alpha subunit, DnaE subfamily. (1174 aa) |
| | dnaE2 | Candidate DNA polymerase III alpha subunit, DnaE subfamily; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1113 aa) |
| | aroC | Candidate chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | thyA | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | folA | Candidate dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | Rta_14410 | Conserved hypothetical protein. (271 aa) |
| | Rta_13940 | D-3-phosphoglycerate dehydrogenase (phosphoglycerate dehydrogenase)-like protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (311 aa) |
| | Rta_13850 | Conserved hypothetical protein. (168 aa) |
| | Rta_13670 | Candidate bifunctional protein: chorismate mutase; prephenate dehydratase. (360 aa) |
| | Rta_13660 | Prephenate dehydrogenase-like protein. (288 aa) |
| | cmk | Deoxycytidine kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (663 aa) |
| | hldD | Candidate ADP-L-glycero-D-manno-heptose-6-epimerase (ADP- glyceromanno-heptose 6-epimerase); Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (344 aa) |
| | Rta_13380 | Candidate carbon monoxide dehydrogenase large chain. (789 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (628 aa) |
| | polA | Candidate DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (954 aa) |
| | dnaN | Candidate DNA polymerase III sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required [...] (368 aa) |
| | Rta_00070 | Hypothetical protein. (55 aa) |
| | Rta_00110 | Exonuclease protein-like protein. (204 aa) |
| | queC | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (205 aa) |
| | Rta_00250 | Xanthine dehydrogenase-like protein. (795 aa) |
| | Rta_00890 | Conserved hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. (188 aa) |
| | Rta_00980 | Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase). (701 aa) |
| | Rta_01170 | Candidate Carbon monoxide dehydrogenase large chain. (780 aa) |
| | pyrF | Candidate Orotidine 5 -phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (291 aa) |
| | holA | Candidate DNA polymerase III, delta subunit. (362 aa) |
| | rpoN | Candidate RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (521 aa) |
| | hemB | Candidate Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa) |
| | Rta_03160 | Candidate membrane protein. (142 aa) |
| | atpB | Candidate F-ATPase, A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (305 aa) |
| | atpE | Candidate F-ATPase, C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa) |
| | atpF | Candidate F-ATPase, B chain; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | Candidate F-ATPase, delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (176 aa) |
| | atpA | Candidate F-ATPase, alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (517 aa) |
| | atpG | Candidate F-ATPase, gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpD | Candidate F-ATPase, beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (469 aa) |
| | atpC | Candidate F-ATPase, epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa) |
| | Rta_03670 | Candidate Xanthine dehydrogenase. (739 aa) |
| | pyrE | Candidate Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (226 aa) |
| | yagR | Candidate Xanthine dehydrogenase yagR, molybdenum binding subunit. (738 aa) |
| | priA | Candidate primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (682 aa) |
| | hemE | Candidate Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (377 aa) |
| | Rta_05485 | Adenylate cyclase-like protein. (194 aa) |
| | phhA | Candidate phenylalanine 4-monooxygenase (Phenylalanine-4-hydroxylase). (286 aa) |
| | Rta_05530 | Mg2+/Co2+ transporter CorC-like protein. (296 aa) |
| | Rta_06100 | RNA polymerase sigma-24 factor-like protein; Belongs to the sigma-70 factor family. (291 aa) |
| | Rta_06820 | Eukaryotic-type DNA primase-like protein. (410 aa) |
| | Rta_07330 | Hypothetical protein. (76 aa) |
| | Rta_07440 | Conserved hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (194 aa) |
| | glmU | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (467 aa) |
| | Rta_07780 | ATP-dependent DNA ligase-like protein. (819 aa) |
| | aroK | Candidate shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | aroB | Candidate 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (322 aa) |
| | Rta_08070 | Conserved hypothetical protein. (289 aa) |
| | murA | Candidate UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | pdxA | Candidate 4-hydroxythreonine-4-phosphate dehydrogenase 2; Belongs to the PdxA family. (343 aa) |
| | coaX | Bvg accessory factor-like protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (265 aa) |
| | rfbD | Candidate dTDP-4-dehydrorhamnose reductase (dTDP-4-keto-L- rhamnose reductase); Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (296 aa) |
| | rfbC | dTDP-L-rhamnose synthetase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | Rta_09240 | RNA polymerase sigma-24 factor-like protein; Belongs to the sigma-70 factor family. (427 aa) |
| | aroD | Candidate 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (240 aa) |
| | pyrC | Candidate Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | murD | Candidate UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase (D-glutamic acid adding enzyme); Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (510 aa) |
| | aroE | Candidate shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | aroG | Candidate phospho-2-dehydro-3-deoxyheptonate aldolase (phospho-2-keto-3-deoxyheptonate aldolase); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (373 aa) |
| | accC | Candidate Biotin carboxylase (subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | rpoN-2 | Candidate RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (462 aa) |
| | Rta_10430 | Acetyl-CoA synthase (Acetate thiokinase). (603 aa) |
| | Rta_10620 | RNA polymerase sigma-24 factor-like protein; Belongs to the sigma-70 factor family. ECF subfamily. (212 aa) |
| | folC | Tetrahydrofolylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (432 aa) |
| | purF | Candidate amidophosphoribosyltransferase (Glutamine phosphoribosylpyrophosphate amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (508 aa) |
| | pdxH | Candidate pyridoxamine 5'-phosphate oxidase (Pyridoxamine-phosphate oxidase); Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa) |
| | Rta_11230 | D-3-phosphoglycerate dehydrogenase (Phosphoglycerate dehydrogenase)-like protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa) |
| | Rta_11300 | Conserved hypothetical protein. (182 aa) |
| | Rta_11900 | Hypothetical protein. (136 aa) |
| | cobD | Candidate membrane protein, distantly related to cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (334 aa) |
| | Rta_12170 | Pterin carbinolamine dehydratase. (110 aa) |
| | Rta_37550 | Conserved hypothetical protein. (105 aa) |
| | purB | Candidate adenylosuccinate lyase (Adenylosuccinase); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (466 aa) |
| | purC | Candidate phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (302 aa) |
| | purE | Candidate phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa) |
| | purK | Candidate phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa) |
| | purU | Candidate formyltetrahydrofolate deformylase (Formyl-FH(4) hydrolase); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa) |
| | tgt | Guanine insertion enzyme; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the prod [...] (386 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (348 aa) |
| | rpoA | RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | Rta_36010 | Conserved hypothetical protein; Belongs to the CinA family. (173 aa) |
| | thiL | Candidate thiamine-monophosphate kinase (Thiamine-phosphate kinase); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa) |
| | apaG | Candidate ApaG protein. (126 aa) |
| | trpE | Candidate anthranilate synthase component I. (506 aa) |
| | trpD1 | Candidate anthranilate phosphoribosyltransferase 1; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (343 aa) |
| | trpC | Candidate indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (263 aa) |
| | nusG | Candidate transcription antitermination protein; Participates in transcription elongation, termination and antitermination. (199 aa) |
| | rpoB | Candidate DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1370 aa) |
| | rpoC | Candidate DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1408 aa) |
| | cobS-2 | Cobalamin synthase-like protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (277 aa) |
| | Rta_35050 | Candidate 2-aminobenzoate-CoA ligase. (536 aa) |
| | amn | Candidate AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (504 aa) |
| | nrdB | Candidate ribonucleoside reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (406 aa) |
| | nrdA | Candidate ribonucleoside-diphosphate reductase, alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (968 aa) |
| | purH | Candidate bifunctional purine biosynthesis protein : Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase. (523 aa) |
| | hemL | Candidate glutamate-1-semialdehyde 2,1-aminomutase (Glutamate-1-semialdehyde aminotransferase). (432 aa) |
| | Rta_34180 | Phosphomethylpyrimidine kinase (HMP-phosphate kinase)-like protein. (321 aa) |
| | Rta_34110 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. (199 aa) |
| | pyrB | Candidate aspartate carbamoyltransferase (Aspartate transcarbamylase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | pyrC-2 | Candidate dihydroorotase. (437 aa) |
| | Rta_33670 | Cytochrome AA3 controlling protein, membrane protein-like protein. (397 aa) |
| | ctaB | Candidate protoheme IX farnesyltransferase (Heme O synthase), membrane protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (289 aa) |
| | rpoH | Candidate RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (310 aa) |
| | coaD | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (167 aa) |
| | prs | Candidate ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa) |
| | ppnK | Candidate inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (298 aa) |
| | Rta_33170 | Conserved hypothetical protein. (503 aa) |
| | rpoZ | DNA-directed RNA polymerase omega chain (RNAP omega subunit); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (67 aa) |
| | gmk | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | Rta_32910 | Candidate oxygen-independent coproporphyrinogen III oxidase-like protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (395 aa) |
| | add | Candidate adenosine deaminase (Adenosine aminohydrolase); Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (351 aa) |
| | dcd | Candidate deoxycytidine triphosphate deaminase (dCTP deaminase); Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | ribF | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. (332 aa) |
| | purN | 5 -phosphoribosylglycinamide transformylase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (196 aa) |
| | Rta_31420 | Guanylate kinase (GMP kinase)-like protein. (255 aa) |
| | Rta_31410 | Hypothetical protein. (331 aa) |
| | nudB | Candidate dATP pyrophosphohydrolase. (160 aa) |
| | Rta_31080 | ATP-dependent DNA ligase-like protein. (590 aa) |
| | Rta_31070 | GTP cyclohydrolase I-like protein. (245 aa) |
| | nadC | Candidate nicotinate-nucleotide pyrophosphorylase [carboxylating] (Quinolinate phosphoribosyltransferase [decarboxylating]); Belongs to the NadC/ModD family. (287 aa) |
| | nadA | Candidate quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (371 aa) |
| | nadB | Candidate L-aspartate oxidase (Quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate. (529 aa) |
| | serS | Candidate seryl-tRNA synthetase (Serine--tRNA ligase); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | Rta_29820 | Flagellar biosynthesis/type III secretory pathway ATPase-like protein. (439 aa) |
| | Rta_29550 | Conserved hypothetical protein. (206 aa) |
| | coaE | Candidate dephospho-CoA kinase (Dephosphocoenzyme A kinase); Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa) |
| | hemA | Candidate glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (423 aa) |
| | queF | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (283 aa) |
| | dinP | Candidate DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (409 aa) |
| | hemC | Pre-uroporphyrinogen synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (318 aa) |
| | Rta_28670 | Hydroxymethylbilane hydrolyase (cyclizing); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (255 aa) |
| | Rta_28650 | HemY protein-like protein. (416 aa) |
| | rpoE | Candidate RNA polymerase sigma-24 factor; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | pdxJ | Candidate pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (251 aa) |
| | accD | Candidate Acetyl-CoA carboxylase carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | trpA | Candidate tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | trpB | Candidate tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (415 aa) |
| | trpF | Candidate N-(5 -phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (248 aa) |
| | serC | Candidate phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (335 aa) |
| | kynU | Kynureninase (L-kynurenine hydrolase)-like protein; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (448 aa) |
| | purM | Candidate phosphoribosylformylglycinamidine cyclo-ligase(Phosphoribosyl-aminoimidazole synthetase). (344 aa) |
| | folK | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. (164 aa) |
| | atpE-2 | ATP synthase C chain-like protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (80 aa) |
| | Rta_27720 | Conserved hypothetical protein. (3962 aa) |
| | Rta_27535 | CrtK protein, membrane protein-like protein. (132 aa) |
| | Rta_27410 | PhnB protein-like protein. (141 aa) |
| | pncB | Candidate nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa) |
| | Rta_26650 | Uroporphyrinogen III methylase; Belongs to the precorrin methyltransferase family. (258 aa) |
| | Rta_26640 | Similar to anthranilate phosphoribosyltransferase 2 of Ralstonia solanacearum (Pseudomonas solanacearum)-like protein. (301 aa) |
| | Rta_26150 | Conserved hypothetical protein. (344 aa) |
| | queG | Conserved hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (351 aa) |
| | Rta_25840 | Conserved hypothetical protein. (209 aa) |
| | pyrG | Candidate CTP synthase (UTP--ammonia ligase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (409 aa) |
| | dut | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa) |
| | Rta_25120 | Candidate response regulator, CyC-C. (393 aa) |
| | rfbC-2 | dTDP-L-rhamnose synthetase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (179 aa) |
| | rpoD | Candidate RNA polymerase sigma-70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (792 aa) |
| | dnaG | Candidate DNA primase protein DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (595 aa) |
| | rpoS | Candidate RNA polymerase sigma-38 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (305 aa) |
| | Rta_24380 | Lactoylglutathione lyase (Methylglyoxalase)-like protein; (Aldoketomutase) (Glyoxalase I). (142 aa) |
| | glcG | Candidate protein glcG. (135 aa) |
| | priB | Candidate primosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (95 aa) |
| | dnaB | Candidate replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (467 aa) |
| | Rta_23850 | Conserved hypothetical protein. (153 aa) |
| | rho | Candidate transcription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (428 aa) |
| | dnaX | Candidate DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (635 aa) |
| | nadE | Candidate NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (538 aa) |
| | Rta_22970 | RNA polymerase sigma-24 factor-like protein; Belongs to the sigma-70 factor family. ECF subfamily. (188 aa) |
| | thiD | Candidate phosphomethylpyrimidine kinase (HMP-phosphate kinase). (286 aa) |
| | thiE | Thiamine-phosphate synthase. (347 aa) |
| | thiS | Candidate ThiS protein. (67 aa) |
| | thiG | Candidate thiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa) |
| | Rta_22340 | Candidate benzoate-CoA ligase. (524 aa) |
| | Rta_22020 | D-3-phosphoglycerate dehydrogenase (phosphoglycerate dehydrogenase)-like protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa) |
| | adk | Candidate adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | kdsB | Candidate 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa) |
| | Rta_21540 | D-3-phosphoglycerate dehydrogenase (phosphoglycerate dehydrogenase)-like protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (361 aa) |
| | Rta_21330 | Conserved hypothetical protein. (124 aa) |
| | upp | Candidate uracil phosphoribosyltransferase (UMP pyrophosphorylase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | purD | Phosphoribosylglycinamide synthetase; Belongs to the GARS family. (426 aa) |
| | hemF | Coprogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (306 aa) |
| | nadD | Candidate nicotinate-nucleotide adenylyltransferase (Deamido-NAD(+) pyrophosphorylase); Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (203 aa) |
| | Rta_20800 | RNA polymerase sigma-24 factor-like protein; Belongs to the sigma-70 factor family. (412 aa) |
| | Rta_20680 | Adenylate cyclase-like protein. (203 aa) |
| | purL | Candidate phosphoribosylformylglycinamidine synthase (FGAM synthase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa) |
| | Rta_20200 | BolA protein-like protein; Belongs to the BolA/IbaG family. (89 aa) |
| | Rta_19910 | Hypothetical protein. (266 aa) |
| | Rta_19870 | Conserved hypothetical protein. (292 aa) |
| | tmk | Candidate thymidylate kinase (dTMP kinase); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa) |
| | holB | Candidate DNA polymerase III, delta prime subunit. (329 aa) |
| | guaA | Candidate GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (537 aa) |
| | guaB | Candidate Inosine-5 -monophosphate dehydrogenase (IMP dehydrogenase); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa) |
| | nusA | L factor; Participates in both transcription termination and antitermination. (498 aa) |
| | holC | Candidate DNA polymerase III, chi subunit. (143 aa) |
| | Rta_19390 | Conserved hypothetical protein. (127 aa) |
| | Rta_19060 | Xanthine phosphoribosyltransferase-like protein. (174 aa) |
| | purA | Candidate adenylosuccinate synthetase (IMP--aspartate ligase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa) |
| | ndk | Candidate nucleoside diphosphate kinase (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | prpE | Candidate propionate--CoA ligase (Propionyl-CoA synthetase). (630 aa) |
| | folD | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | pyrD | Candidate dihydroorotate dehydrogenase (Dihydroorotate oxidase); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (354 aa) |
| | dnaQ | Candidate DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (243 aa) |
| | Rta_18440 | Allantoinase-like protein. (491 aa) |
| | Rta_17850 | Adenylyl cyclase. (296 aa) |
| | folP | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (294 aa) |
| | carB | Candidate carbamoyl-phosphate synthase large chain (Carbamoyl-phosphate synthase (ammonia)); Belongs to the CarB family. (1084 aa) |
| | carA | Candidate carbamoyl-phosphate synthase small chain (Carbamoyl-phosphate synthase (glutamine-hydrolyzing)); Belongs to the CarA family. (387 aa) |
| | pyrH | Uridylate kinase (Uridine monophosphate kinase)-like protein; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | Rta_16890 | Hypothetical protein. (139 aa) |
| | serA | Candidate D-3-phosphoglycerate dehydrogenase (phosphoglycerate dehydrogenase); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (412 aa) |
| | Rta_16850 | Conserved hypothetical protein. (75 aa) |
| | Rta_16730 | 4-hydroxythreonine-4-phosphate dehydrogenase (4- (phosphohydroxy)-L-threonine dehydrogenase)-like protein; Belongs to the PdxA family. (312 aa) |
| | cobT | Candidate Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (348 aa) |
