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| | ftsW | Candidate cell division protein (division cell wall cluster); Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa) |
| | rpmH | Candidate 50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | Rta_37910 | Conserved hypothetical protein. (373 aa) |
| | Rta_37830 | Candidate membrane protein. (451 aa) |
| | Rta_37330 | Candidate membrane protein. (583 aa) |
| | def-2 | Candidate peptide deformylase (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (170 aa) |
| | fmt | Candidate methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (353 aa) |
| | rplN | Candidate 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | Candidate 50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (105 aa) |
| | rplE | Candidate 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rpsN | Candidate 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rpsH | Candidate 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa) |
| | rplF | Candidate 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (171 aa) |
| | rplR | Candidate 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (122 aa) |
| | rpsE | Candidate 30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (173 aa) |
| | rpmD | Candidate 50S ribosomal protein L30. (60 aa) |
| | rplO | Candidate 50S ribosomal subunit protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (143 aa) |
| | infA-3 | Candidate translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | rpmJ | Candidate 50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | Candidate 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa) |
| | rpsK | Candidate 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa) |
| | rpsD | Candidate 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (207 aa) |
| | rplQ | Candidate 50S ribosomal protein L17. (134 aa) |
| | tuf-2 | Candidate elongation factor Tu. (396 aa) |
| | rplK | Candidate 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (143 aa) |
| | rplA | Candidate 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa) |
| | rplJ | Candidate 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (170 aa) |
| | rplL | Candidate 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (125 aa) |
| | Rta_34440 | Candidate b-glucosyltransferase MdoH, Glycosyltransferase Family 2. (659 aa) |
| | mdoG | Candidate glucans biosynthesis protein G; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (526 aa) |
| | Rta_33590 | A-glycosyltransferase, Glycosyltransferase Family 4-like protein. (333 aa) |
| | pth | Candidate peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (203 aa) |
| | rplY | 50S ribosomal protein L25-like protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (235 aa) |
| | Rta_32800 | A-glycosyltransferase, Glycosyltransferase Family 4-like protein. (400 aa) |
| | Rta_32410 | Animal glycogenin, Glycosyltransferase Family 8-like protein. (283 aa) |
| | ileS | Candidate isoleucyl-tRNA synthetase (Isoleucine--tRNA ligase); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 sub [...] (956 aa) |
| | rpmG | Candidate 50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (56 aa) |
| | rpmB | Candidate 50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (77 aa) |
| | valS | Candidate valyl-tRNA synthetase (Valine--tRNA ligase); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (964 aa) |
| | aspS | Candidate aspartyl-tRNA synthetase (Aspartate--tRNA ligase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (600 aa) |
| | metG | Candidate methionyl-tRNA synthetase (Methionine--tRNA ligase); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (690 aa) |
| | serS | Candidate seryl-tRNA synthetase (Serine--tRNA ligase); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | Rta_29340 | Amidase-like protein; Belongs to the amidase family. (466 aa) |
| | rplU | Candidate 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | rpmA | Candidate 50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (86 aa) |
| | proS | Global RNA synthesis factor; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involve [...] (581 aa) |
| | prfA | Candidate peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (336 aa) |
| | rpmF | Candidate 50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (60 aa) |
| | lepA | Candidate GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (603 aa) |
| | nagZ | Candidate b-N-acetylhexosaminidase, Glycoside Hydrolase Family 3; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (360 aa) |
| | lysU | Candidate lysyl-tRNA synthetase (Lysine--tRNA ligase); Belongs to the class-II aminoacyl-tRNA synthetase family. (509 aa) |
| | Rta_28320 | Conserved hypothetical protein. (309 aa) |
| | Rta_28310 | A-glycosyltransferase, Glycosyltransferase Family 4-like protein. (340 aa) |
| | Rta_28280 | A-glycosyltransferase, Glycosyltransferase Family 4-like protein. (374 aa) |
| | rpsT | Candidate Ribosomal protein S20; Binds directly to 16S ribosomal RNA. (105 aa) |
| | murJ | Candidate virulence factor; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (521 aa) |
| | Rta_27750 | A-glycosyltransferase, Glycosyltransferase Family 4-like protein. (328 aa) |
| | Rta_27660 | Conserved hypothetical protein. (238 aa) |
| | Rta_27650 | Conserved hypothetical protein. (207 aa) |
| | infA-2 | Candidate translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (81 aa) |
| | Rta_27510 | Conserved hypothetical protein. (232 aa) |
| | Rta_26990 | Candidate membrane protein GlpM. (116 aa) |
| | glnS | Candidate glutaminyl-tRNA synthetase (Glutamine--tRNA ligase). (596 aa) |
| | uppP | Candidate undecaprenol kinase (Bacitracin resistance protein); Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa) |
| | rpsU | Candidate 30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (70 aa) |
| | Rta_26670 | Conserved hypothetical protein. (405 aa) |
| | rpsO | Candidate 30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (87 aa) |
| | Rta_26190 | A-glycosyltransferase, Glycosyltransferase Family 4-like protein. (360 aa) |
| | kdsA | Candidate 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (285 aa) |
| | Rta_25520 | Conserved hypothetical protein. (357 aa) |
| | Rta_25100 | Candidate membrane protein. (190 aa) |
| | efp | Candidate elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (163 aa) |
| | rpsF | Candidate 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (121 aa) |
| | rpsR | Candidate ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (93 aa) |
| | rplI | 50S ribosomal protein L9; Binds to the 23S rRNA. (150 aa) |
| | Rta_23460 | Candidate membrane protein. (558 aa) |
| | rpmE | 50S ribosomal protein L31 type B; Belongs to the bacterial ribosomal protein bL31 family. (85 aa) |
| | Rta_23390 | Conserved hypothetical protein. (406 aa) |
| | pbpG | Candidate penicillin-binding protein 5 precursor (D-alanyl-D-alanine carboxypeptidase); Belongs to the peptidase S11 family. (310 aa) |
| | Rta_22110 | Acyltransferase, membrane protein-like protein. (646 aa) |
| | kdsB | Candidate 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa) |
| | Rta_21280 | Conserved hypothetical protein. (276 aa) |
| | Rta_21120 | Candidate membrane protein. (422 aa) |
| | def | Candidate peptide deformylase (Polypeptide deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (196 aa) |
| | mltG | Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (331 aa) |
| | smpB | Candidate small protein B (SsrA-binding protein); Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. T [...] (157 aa) |
| | infB | Candidate translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (954 aa) |
| | Rta_19560 | Conserved hypothetical protein. (136 aa) |
| | hisS | Candidate histidyl-tRNA synthetase (Histidine--tRNA ligase). (439 aa) |
| | pheT | Candidate phenylalanyl-tRNA synthetase beta subunit(Phenylalanine--tRNA ligase alpha subuniit); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (806 aa) |
| | pheS | Candidate phenylalanyl-tRNA synthetase alpha subunit(Phenylalanine--tRNA ligase alpha subunit); Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (376 aa) |
| | rplT | Candidate 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa) |
| | rpmI | Candidate 50S ribosomal protein L35 (ribosomal subunit protein A); Belongs to the bacterial ribosomal protein bL35 family. (67 aa) |
| | infC | Candidate translation initiation factor 3 (IF-3); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (174 aa) |
| | thrS | Candidate threonyl-tRNA synthetase (Threonine--tRNA ligase); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (616 aa) |
| | frr | Candidate ribosome recycling factor (Ribosome releasing factor); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (187 aa) |
| | tsf | Candidate elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (297 aa) |
| | rpsB | Candidate 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (250 aa) |
| | Rta_17420 | Amidase-like protein; Belongs to the amidase family. (453 aa) |
| | Rta_17110 | Penicillin-binding protein 1A; Candidate bifunctional family GT51 b-glycosyltransferase/PBP transpeptidase (candidate murein polymerase), Glycosyltransferase Family 51. (801 aa) |
| | lgt | Candidate prolipoprotein diacylglyceryl transferase, membrane protein; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (273 aa) |
| | Rta_16080 | Hypothetical protein. (356 aa) |
| | cysS | Candidate cysteinyl-tRNA synthetase (Cysteine--tRNA ligase); Belongs to the class-I aminoacyl-tRNA synthetase family. (458 aa) |
| | Rta_15040 | glutamyl-tRNA synthetase (Glutamate--tRNA ligase)-like protein. (275 aa) |
| | alaS | Candidate alanyl-tRNA synthetase (Alanine--tRNA ligase); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (876 aa) |
| | rpsA | Candidate 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (558 aa) |
| | bacA | Candidate bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (275 aa) |
| | rplS | Candidate 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (125 aa) |
| | rpsP | Candidate 30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (88 aa) |
| | Rta_11580 | Candidate ABC transporter, ATP-binding component with duplicated domains. (548 aa) |
| | Rta_10980 | Candidate KDO transferase, Glycosyltransferase Family 30; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (436 aa) |
| | Rta_10970 | Candidate LPS heptosyltransferase, Glycosyltransferase Family 9. (347 aa) |
| | Rta_10900 | Candidate succinoglycan transport protein. (497 aa) |
| | Rta_10890 | Candidate membrane protein. (451 aa) |
| | Rta_10870 | Candidate b-glycosyltransferase, Glycosyltransferase Family 2. (363 aa) |
| | Rta_10850 | A-glycosyltransferase, Glycosyltransferase Family 4-like protein. (444 aa) |
| | Rta_10820 | B-glycosyltransferase, Glycosyltransferase Family 26-like protein; Belongs to the glycosyltransferase 26 family. (264 aa) |
| | Rta_10810 | Conserved hypothetical protein. (300 aa) |
| | Rta_10800 | Conserved hypothetical protein. (467 aa) |
| | gltX | Candidate glutamyl-tRNA synthetase (Glutamate--tRNA ligase); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (460 aa) |
| | murB | Candidate UDP-N-acetylenolpyruvoylglucosamine reductase (UDP-N-acetylmuramate dehydrogenase); Cell wall formation. (354 aa) |
| | Rta_10460 | Conserved hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (163 aa) |
| | prfB | Candidate peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (300 aa) |
| | trpS | Candidate tryptophanyl-tRNA synthetase (Tryptophan--tRNA ligase); Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (431 aa) |
| | mpl | UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (457 aa) |
| | rodA | Candidate rod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (384 aa) |
| | mtgA | Candidate monofunctional peptidoglycan glycosyltransferase, Glycosyltransferase Family 51; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (242 aa) |
| | ddlA | Candidate D-alanine-D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (323 aa) |
| | murC | Candidate UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (470 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (357 aa) |
| | murD | Candidate UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase (D-glutamic acid adding enzyme); Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (510 aa) |
| | mraY | Candidate phospho-N-acetylmuramoyl-pentapeptide-transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (372 aa) |
| | murF | Candidate UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (497 aa) |
| | murE | Candidate UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (494 aa) |
| | ftsI | Candidate cell division penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (578 aa) |
| | Rta_08900 | Candidate b-glycosyltransferase, Glycosyltransferase Family 2. (277 aa) |
| | Rta_08840 | Conserved hypothetical protein. (349 aa) |
| | Rta_08830 | Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (UDP-GlcNAc:undecaprenyl-P GlcNAc 1-P transferase)-like protein. (369 aa) |
| | Rta_08820 | Candidate b-glycosyltransferase, Glycosyltransferase Family 2. (233 aa) |
| | Rta_08790 | Candidate membrane protein. (118 aa) |
| | Rta_08780 | Candidate b-glycosyltransferase, Glycosyltransferase Family 2. (341 aa) |
| | Rta_08760 | Glycosyltransferase, Glycosyltransferase Family 46-like protein. (417 aa) |
| | rmlA1 | dTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (295 aa) |
| | murA | Candidate UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | Rta_07950 | Penicillin-binding protein 1A; Candidate bifunctional family GT51 b-glycosyltransferase/PBP transpeptidase (candidate murein polymerase), Glycosyltransferase Family 51. (800 aa) |
| | glmU | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (467 aa) |
| | tyrS | Candidate Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (372 aa) |
| | rpsI | Candidate 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | rplM | Candidate 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | prfC | Candidate peptide chain release factor; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (543 aa) |
| | Rta_06120 | Transcription elongation factor-like protein. (136 aa) |
| | glyS | Candidate glycine--tRNA ligase beta chain (Glycyl-tRNA synthetase beta chain). (703 aa) |
| | glyQ | Candidate Glycine--tRNA ligase alpha chain (Glycyl-tRNA synthetase alpha chain). (306 aa) |
| | lnt | Candidate apolipoprotein N-acyltransferase (ALP N-acyltransferase), membrane protein; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (532 aa) |
| | Rta_05090 | Conserved hypothetical protein. (275 aa) |
| | glf | Candidate UDP-galactopyranose mutase. (401 aa) |
| | infA | Candidate Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (88 aa) |
| | gatB | Candidate Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (482 aa) |
| | gatA | Candidate Glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (487 aa) |
| | gatC | Candidate Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (115 aa) |
| | pbp2 | Candidate cell division penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. (686 aa) |
| | rpsQ | Candidate 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (89 aa) |
| | rpmC | Candidate 50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (69 aa) |
| | rplP | Candidate 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa) |
| | rpsC | Candidate 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (310 aa) |
| | rplV | Candidate 50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (109 aa) |
| | rpsS | Candidate 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rplB | Candidate 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa) |
| | rplW | Candidate 50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (111 aa) |
| | rplD | Candidate 50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (206 aa) |
| | rplC | Candidate 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (231 aa) |
| | rpsJ | Candidate 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (105 aa) |
| | tuf | Candidate Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa) |
| | fusA | Candidate Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 sub [...] (700 aa) |
| | rpsG | Candidate 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (157 aa) |
| | rpsL | Candidate 30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (125 aa) |
| | dac | Candidate penicillin-binding protein precursor (D-alanyl-D-alanine carboxypeptidase); Belongs to the peptidase S11 family. (374 aa) |
| | Rta_02900 | Candidate membrane protein. (367 aa) |
| | argS | Candidate Arginyl-tRNA synthetase. (557 aa) |
| | Rta_02660 | Candidate dolichyl-phosphate b-D-mannosyltransferase, Glycosyltransferase Family 2. (219 aa) |
| | leuS | Candidate Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (891 aa) |
| | Rta_01890 | Candidate LPS heptosyltransferase, Glycosyltransferase Family 9. (334 aa) |
| | Rta_01850 | Conserved hypothetical protein. (156 aa) |
| | Rta_01580 | Candidate membrane protein. (396 aa) |
| | Rta_00530 | Monofunctional peptidoglycan glycosyltransferase, Glycosyltransferase Family 51-like protein; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. Belongs to the glycosyltransferase 51 family. (425 aa) |
