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| | argE | Candidate Acetylornithine deacetylase. (373 aa) |
| | argB | Candidate Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (311 aa) |
| | aroD | Candidate 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (240 aa) |
| | dapF | Candidate Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa) |
| | aroE | Candidate shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | aroG | Candidate phospho-2-dehydro-3-deoxyheptonate aldolase (phospho-2-keto-3-deoxyheptonate aldolase); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (373 aa) |
| | accB | Candidate Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (148 aa) |
| | accC | Candidate Biotin carboxylase (subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | argJ | Ornithine transacetylase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argG | Candidate argininosuccinate synthase (Citrulline--aspartate ligase); Belongs to the argininosuccinate synthase family. Type 2 subfamily. (448 aa) |
| | folC | Tetrahydrofolylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (432 aa) |
| | metZ | Cystathionine gamma-synthase (O-succinylhomoserine (Thiol)-lyase)-like protein; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa) |
| | ilvD-2 | Candidate dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (580 aa) |
| | thrB | Candidate homoserine kinase; Belongs to the pseudomonas-type ThrB family. (327 aa) |
| | cmk | Deoxycytidine kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (663 aa) |
| | Rta_13660 | Prephenate dehydrogenase-like protein. (288 aa) |
| | Rta_13670 | Candidate bifunctional protein: chorismate mutase; prephenate dehydratase. (360 aa) |
| | Rta_14300 | Acetolactate synthase large subunit (Acetohydroxy-acid synthase large subunit)-like protein; Belongs to the TPP enzyme family. (564 aa) |
| | glnA | Candidate glutamine synthetase (Glutamate--ammonia ligase). (472 aa) |
| | folA | Candidate dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | aroC | Candidate chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | glyA | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | accA | Candidate Acetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | lysC | Candidate aspartokinase (Aspartate kinase); Belongs to the aspartokinase family. (410 aa) |
| | leuD | Alpha-IPM isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (193 aa) |
| | leuC | Alpha-IPM isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (464 aa) |
| | Rta_15910 | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase)-like protein. (356 aa) |
| | ugd | Candidate UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase). (496 aa) |
| | ilvD-3 | Candidate dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (564 aa) |
| | hisI | Candidate Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (113 aa) |
| | Rta_16180 | malonyl-CoA decarboxylase (Malonyl-CoA carboxy-lyase)-like protein. (494 aa) |
| | Rta_16440 | Imidazole acetol- phosphate transaminase. (318 aa) |
| | Rta_16710 | Acetohydroxy-acid synthase small subunit; Belongs to the TPP enzyme family. (554 aa) |
| | Rta_17240 | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). (236 aa) |
| | fabZ | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases-like protein; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (156 aa) |
| | carA | Candidate carbamoyl-phosphate synthase small chain (Carbamoyl-phosphate synthase (glutamine-hydrolyzing)); Belongs to the CarA family. (387 aa) |
| | carB | Candidate carbamoyl-phosphate synthase large chain (Carbamoyl-phosphate synthase (ammonia)); Belongs to the CarB family. (1084 aa) |
| | folP | Dihydropteroate pyrophosphorylase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (294 aa) |
| | Rta_17930 | Gentisate 1,2-dioxygenase-like protein. (353 aa) |
| | Rta_17990 | Glutamine synthetase (Glutamate--ammonia ligase)-like protein. (493 aa) |
| | Rta_18250 | Candidate propionyl-CoA carboxylase. (510 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (319 aa) |
| | Rta_18420 | Candidate carboxyvinyl-carboxyphosphonate phosphorylmutase (Carboxyphosphonoenolpyruvate phosphonomutase). (287 aa) |
| | leuD-2 | Alpha-IPM isomerase; Belongs to the LeuD family. (171 aa) |
| | leuC-2 | Alpha-IPM isomerase. (420 aa) |
| | folD | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | hisZ | Candidate ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (382 aa) |
| | fabI | Candidate Enoyl-[acyl-carrier-protein] reductase (NADH). (277 aa) |
| | argA | Candidate amino-acid acetyltransferase (N-acetylglutamate synthase); Belongs to the acetyltransferase family. ArgA subfamily. (469 aa) |
| | Rta_20980 | Aminotransferases-like protein. (398 aa) |
| | dapD | Tetrahydropicolinate succinylase; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | dapE | Candidate succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (389 aa) |
| | Rta_21220 | Threonine dehydratase catabolic (Threonine deaminase)-like protein. (321 aa) |
| | Rta_21420 | Conserved hypothetical protein. (361 aa) |
| | Rta_21560 | Dihydrodipicolinate synthase-like protein; Belongs to the DapA family. (310 aa) |
| | leuD-3 | Alpha-IPM isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (208 aa) |
| | leuC-3 | Alpha-IPM isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (465 aa) |
| | Rta_21670 | Candidate carboxyvinyl-carboxyphosphonate phosphorylmutase (Carboxyphosphonoenolpyruvate phosphonomutase). (288 aa) |
| | Rta_22600 | Ferredoxin--nitrite reductase-like protein. (608 aa) |
| | cysH | 3 - phosphoadenylylsulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (246 aa) |
| | leuA1 | Alpha-IPM synthetase 1; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa) |
| | ilvC | Alpha-keto-beta-hydroxylacil reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | metX | Homoserine transacetylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (376 aa) |
| | Rta_37720 | Carboxyvinyl-carboxyphosphonate phosphorylmutase (Carboxyphosphonoenolpyruvate phosphonomutase)-like protein. (272 aa) |
| | Rta_37590 | Glutamine synthetase (Glutamate--ammonia ligase)-like protein. (455 aa) |
| | argC-2 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (305 aa) |
| | Rta_36600 | Beta-alanine--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa) |
| | proC | Candidate pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | Rta_36030 | Acetyltransferase-like protein. (162 aa) |
| | gph-2 | Candidate phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (237 aa) |
| | trpE | Candidate anthranilate synthase component I. (506 aa) |
| | trpD1 | Candidate anthranilate phosphoribosyltransferase 1; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (343 aa) |
| | trpC | Candidate indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (263 aa) |
| | ilvA | Candidate threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | Rta_34230 | Candidate asparagine synthetase (glutamine-hydrolyzing). (595 aa) |
| | Rta_33780 | Conserved hypothetical protein. (264 aa) |
| | selD | Selenium donor protein; Synthesizes selenophosphate from selenide and ATP. (357 aa) |
| | ilvD-4 | Candidate dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (585 aa) |
| | Rta_32670 | N-acetylornithinase. (408 aa) |
| | cysM | O- acetylserine (Thiol)-lyase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | nudB | Candidate dATP pyrophosphohydrolase. (160 aa) |
| | nadA | Candidate quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (371 aa) |
| | Rta_30420 | MelG protein (non-ribosomal peptide synthetase)-like protein. (1519 aa) |
| | Rta_30410 | Polyketide synthase-like protein. (2108 aa) |
| | Rta_30300 | Threonine dehydratase biosynthetic (Threonine deaminase)-like protein. (312 aa) |
| | serS | Candidate seryl-tRNA synthetase (Serine--tRNA ligase); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | Rta_29550 | Conserved hypothetical protein. (206 aa) |
| | leuC-5 | Alpha-IPM isomerase. (416 aa) |
| | leuD-5 | Alpha-IPM isomerase; Belongs to the LeuD family. (164 aa) |
| | proB | Candidate glutamate 5-kinase (Gamma-glutamyl kinase); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (389 aa) |
| | argH | Candidate argininosuccinate lyase (Arginosuccinase). (471 aa) |
| | plsX | Candidate fatty acid/phospholipid synthesis protein plsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (341 aa) |
| | fabH | Candidate 3-oxoacyl-[acyl-carrier-protein] synthase (Beta-ketoacyl-ACP synthase); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like sup [...] (325 aa) |
| | fabD | Candidate [Acyl-carrier-protein] S-malonyltransferase. (301 aa) |
| | acpP | Candidate Acyl-carrier-protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | fabF | Candidate 3-oxoacyl-[acyl-carrier-protein] synthase (Beta-ketoacyl-ACP synthase); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | acpS | 4-phosphopantetheinyltransferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (135 aa) |
| | accD | Candidate Acetyl-CoA carboxylase carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | hisF | Candidate Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | trpA | Candidate tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | trpB | Candidate tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (415 aa) |
| | Rta_01290 | Candidate Threonine dehydratase catabolic (Threonine deaminase). (402 aa) |
| | ilvH | Candidate acetolactate synthase small subunit (Acetohydroxy-acid synthase small subunit). (163 aa) |
| | ilvI | Candidate acetolactate synthase large subunit (Acetohydroxy-acid synthase large subunit). (592 aa) |
| | Rta_23720 | Acetolactate synthase large subunit (Acetohydroxy-acid synthase large subunit)-like protein; Belongs to the TPP enzyme family. (544 aa) |
| | Rta_23760 | Conserved hypothetical protein. (395 aa) |
| | Rta_23800 | Conserved hypothetical protein. (303 aa) |
| | thrC | Candidate threonine synthase. (473 aa) |
| | thrA | Candidate homoserine dehydrogenase. (444 aa) |
| | Rta_24470 | Candidate tartrate dehydrogenase. (361 aa) |
| | Rta_24720 | Glutamate carboxypeptidase. (440 aa) |
| | Rta_24930 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (Cobalamin-independent methionine synthase)-like protein. (370 aa) |
| | dapA-2 | Candidate dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (281 aa) |
| | Rta_25720 | Conserved hypothetical protein. (257 aa) |
| | kdsA | Candidate 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (285 aa) |
| | Rta_26220 | Neomycin-kanamycin phosphotransferase, type V. (319 aa) |
| | Rta_26460 | Zeta- crystallin. (328 aa) |
| | Rta_26640 | Similar to anthranilate phosphoribosyltransferase 2 of Ralstonia solanacearum (Pseudomonas solanacearum)-like protein. (301 aa) |
| | cysE | Candidate serine acetyltransferase. (257 aa) |
| | Rta_26940 | Pyruvate dehydrogenase-like protein; Belongs to the TPP enzyme family. (606 aa) |
| | Rta_26990 | Candidate membrane protein GlpM. (116 aa) |
| | hisD-2 | Candidate histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa) |
| | folK | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. (164 aa) |
| | argD | Candidate acetylornithine aminotransferase (acetylornithine transaminase); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | arcB | Candidate ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (315 aa) |
| | kynU | Kynureninase (L-kynurenine hydrolase)-like protein; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (448 aa) |
| | serC | Candidate phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (335 aa) |
| | acnB | Aconitase 2; Belongs to the aconitase/IPM isomerase family. (861 aa) |
| | leuC-4 | Candidate 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (483 aa) |
| | leuD-4 | Candidate 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa) |
| | leuB | Candidate 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (365 aa) |
| | asd | Candidate aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (382 aa) |
| | trpF | Candidate N-(5 -phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (248 aa) |
| | phhA | Candidate phenylalanine 4-monooxygenase (Phenylalanine-4-hydroxylase). (286 aa) |
| | Rta_05340 | Threonine deaminase. (323 aa) |
| | Rta_04890 | Candidate 3-oxoacyl-[acyl-carrier-protein] synthase (Beta-ketoacyl-ACP synthase). (339 aa) |
| | Rta_04820 | Conserved hypothetical protein. (95 aa) |
| | putA | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1019 aa) |
| | Rta_04120 | Candidate 3-oxoacyl-[acyl-carrier-protein] synthase (Beta-ketoacyl-ACP synthase). (648 aa) |
| | Rta_03950 | Hypothetical protein. (356 aa) |
| | lipA | Candidate lipoic acid synthetase (Lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (327 aa) |
| | Rta_02620 | Conserved hypothetical protein. (274 aa) |
| | fabB | Candidate 3-oxoacyl-[acyl-carrier-protein] synthase I (Beta-ketoacyl-ACP synthase); Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (414 aa) |
| | Rta_02540 | Candidate acyl-coenzyme A synthetases/AMP-(fatty) acid ligase. (558 aa) |
| | Rta_02520 | Candidate Acyl carrier protein. (101 aa) |
| | metE | Candidate Methylcobalamin:homocysteine methyltransferase (Methionine synthase). (341 aa) |
| | proA | Candidate Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | dapB | Candidate Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (279 aa) |
| | mtnN | Candidate adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (217 aa) |
| | bcat | Candidate Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (311 aa) |
| | ilvD | Candidate Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (566 aa) |
| | panE | Candidate 2-dehydropantoate 2-reductase. (324 aa) |
| | alr2 | Candidate Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (376 aa) |
| | Rta_01520 | Conserved hypothetical protein. (329 aa) |
| | metH-2 | Candidate methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (911 aa) |
| | hisA | Candidate 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (225 aa) |
| | hisH | Candidate Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa) |
| | hisB | Candidate Imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisC | Candidate Histidinol-phosphate aminotransferase 1; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | hisD | Candidate Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | hisG | Candidate ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (216 aa) |
| | gltB | Candidate Ferredoxin-dependent glutamate synthase. (1573 aa) |
| | aroB | Candidate 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (322 aa) |
| | aroK | Candidate shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | lysA | Candidate Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (423 aa) |
| | dapA | Candidate dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | metF | Candidate 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (272 aa) |
| | Rta_06610 | Candidate Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (573 aa) |
| | Rta_05970 | NADPH:quinone reductase (Quinone oxidoreductase)-like protein. (328 aa) |
| | ttuC | Candidate Tartrate dehydrogenase. (359 aa) |
| | hisF-2 | Candidate Phosphoribosyl-ATP pyrophosphatase. (124 aa) |
| | Rta_08490 | Delta-ALA synthetase. (418 aa) |
