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ppcK ppcK aceE aceE lpd lpd fumA fumA fumC fumC Rta_18430 Rta_18430 aceE-2 aceE-2 aceF aceF Rta_18700 Rta_18700 sucA sucA sucB sucB Rta_18810 Rta_18810 icdA icdA sdhB sdhB acnA acnA acnB acnB mdh mdh Rta_28080 Rta_28080 Rta_28090 Rta_28090 sdhA sdhA sdhB-2 sdhB-2 gltA gltA sucD sucD sucC sucC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ppcKCandidate Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (617 aa)
aceECandidate pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (877 aa)
lpdDihydrolipoamide dehydrogenase. (464 aa)
fumACandidate fumarate hydratase class I (Fumarase); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (517 aa)
fumCCandidate fumarate hydratase class II (Fumarase C); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (459 aa)
Rta_18430Succinate dehydrogenase, flavoprotein subunit (Fumarate reductase)-like protein. (426 aa)
aceE-2Candidate pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (901 aa)
aceFDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (567 aa)
Rta_18700Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). (598 aa)
sucACandidate 2-oxoglutarate dehydrogenase E1 component (Alpha- ketoglutarate dehydrogenase). (956 aa)
sucBDihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (427 aa)
Rta_18810Dihydrolipoamide dehydrogenase. (476 aa)
icdACandidate isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase). (417 aa)
sdhBCandidate succinate dehydrogenase iron-sulfur protein. (234 aa)
acnACandidate aconitase (aconitate hydratase). (952 aa)
acnBAconitase 2; Belongs to the aconitase/IPM isomerase family. (861 aa)
mdhCandidate malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
Rta_28080Succinate dehydrogenase cytochrome b-556 subunit-like protein. (148 aa)
Rta_28090Succinate dehydrogenase hydrophobic membrane anchor protein-like protein. (121 aa)
sdhACandidate succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (602 aa)
sdhB-2Candidate succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (234 aa)
gltACandidate citrate synthase; Belongs to the citrate synthase family. (436 aa)
sucDCandidate succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
sucCCandidate succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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