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yagT yagT Rta_00240 Rta_00240 Rta_00250 Rta_00250 Rta_03670 Rta_03670 Rta_03680 Rta_03680 Rta_03690 Rta_03690 Rta_03930 Rta_03930 yagT-2 yagT-2 yagS yagS yagR yagR Rta_05485 Rta_05485 Rta_08040 Rta_08040 Rta_10020 Rta_10020 ppnP ppnP purF purF Rta_12460 Rta_12460 guaC guaC relA relA Rta_17850 Rta_17850 Rta_18440 Rta_18440 ndk ndk purA purA guaB guaB guaA guaA purL purL purD purD adk adk cysD cysD cysN cysN ppx ppx surE surE Rta_25120 Rta_25120 Rta_26280 Rta_26280 purM purM Rta_31420 Rta_31420 purN purN guaD guaD add add Rta_32380 Rta_32380 Rta_32390 Rta_32390 Rta_32640 Rta_32640 Rta_32650 Rta_32650 ureA ureA ureB ureB ureC ureC Rta_32920 Rta_32920 gmk gmk relA-2 relA-2 prs prs purH purH nrdA nrdA nrdB nrdB amn amn Rta_35070 Rta_35070 purK purK purE purE purC purC pykA pykA purB purB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yagTCandidate xanthine dehydrogenase yagT iron-sulfur binding subunit. (193 aa)
Rta_002404-hydroxybenzoyl-CoA reductase-like protein. (352 aa)
Rta_00250Xanthine dehydrogenase-like protein. (795 aa)
Rta_03670Candidate Xanthine dehydrogenase. (739 aa)
Rta_03680Candidate Xanthine dehydrogenase, FAD binding subunit. (333 aa)
Rta_03690Candidate Xanthine dehydrogenase, iron-sulfur binding subunit. (212 aa)
Rta_03930Conserved hypothetical protein. (329 aa)
yagT-2Candidate xanthine dehydrogenase yagT, iron-sulfur binding subunit. (208 aa)
yagSCandidate xanthine dehydrogenase yagS, FAD binding subunit. (325 aa)
yagRCandidate Xanthine dehydrogenase yagR, molybdenum binding subunit. (738 aa)
Rta_05485Adenylate cyclase-like protein. (194 aa)
Rta_08040Candidate deoxyguanosinetriphosphate triphosphohydrolase (dGTPase); Belongs to the dGTPase family. Type 2 subfamily. (383 aa)
Rta_10020Sugar kinase, ribokinase family-like protein. (296 aa)
ppnPConserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (105 aa)
purFCandidate amidophosphoribosyltransferase (Glutamine phosphoribosylpyrophosphate amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (508 aa)
Rta_12460Malate dehydrogenase-like protein; Belongs to the LDH2/MDH2 oxidoreductase family. (353 aa)
guaCGuanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (325 aa)
relACandidate GTP pyrophosphokinase (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (733 aa)
Rta_17850Adenylyl cyclase. (296 aa)
Rta_18440Allantoinase-like protein. (491 aa)
ndkCandidate nucleoside diphosphate kinase (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
purACandidate adenylosuccinate synthetase (IMP--aspartate ligase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa)
guaBCandidate Inosine-5 -monophosphate dehydrogenase (IMP dehydrogenase); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
guaACandidate GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (537 aa)
purLCandidate phosphoribosylformylglycinamidine synthase (FGAM synthase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa)
purDPhosphoribosylglycinamide synthetase; Belongs to the GARS family. (426 aa)
adkCandidate adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
cysDATP-sulfurylase small subunit. (310 aa)
cysNATP-sulfurylase large subunit. (415 aa)
ppxMetaphosphatase. (494 aa)
surECandidate acid phosphatase (Stationary-phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa)
Rta_25120Candidate response regulator, CyC-C. (393 aa)
Rta_26280(Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase). (198 aa)
purMCandidate phosphoribosylformylglycinamidine cyclo-ligase(Phosphoribosyl-aminoimidazole synthetase). (344 aa)
Rta_31420Guanylate kinase (GMP kinase)-like protein. (255 aa)
purN5 -phosphoribosylglycinamide transformylase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (196 aa)
guaDCandidate guanine deaminase (Guanase); Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (428 aa)
addCandidate adenosine deaminase (Adenosine aminohydrolase); Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (351 aa)
Rta_32380Candidate xanthine dehydrogenase small subunit. (499 aa)
Rta_32390Candidate xanthine dehydrogenase large subunit. (805 aa)
Rta_32640Candidate transthyretin protein precursor; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (140 aa)
Rta_32650GlcNAc deacetylase, Carbohydrate Esterase Family 4-like protein. (280 aa)
ureACandidate urease gamma subunit (Urea amidohydrolase gamma subunit); Belongs to the urease gamma subunit family. (100 aa)
ureBCandidate urease beta subunit (Urea amidohydrolase); Belongs to the urease beta subunit family. (101 aa)
ureCCandidate urease alpha subunit (Urea amidohydrolase). (572 aa)
Rta_32920Candidate HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (206 aa)
gmkCandidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (206 aa)
relA-2Candidate GTP pyrophosphokinase (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (753 aa)
prsCandidate ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)
purHCandidate bifunctional purine biosynthesis protein : Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase. (523 aa)
nrdACandidate ribonucleoside-diphosphate reductase, alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (968 aa)
nrdBCandidate ribonucleoside reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (406 aa)
amnCandidate AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (504 aa)
Rta_35070Conserved hypothetical protein. (298 aa)
purKCandidate phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa)
purECandidate phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa)
purCCandidate phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (302 aa)
pykACandidate pyruvate kinase II; Belongs to the pyruvate kinase family. (477 aa)
purBCandidate adenylosuccinate lyase (Adenylosuccinase); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (466 aa)
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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