(41 nodes) Valine, leucine and isoleucine degradation network (Ramlibacter tataouinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rta_00980	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase). (701 aa)
	bcat	Candidate Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (311 aa)
	Rta_02980	Candidate NAD-dependent aldehyde dehydrogenase. (513 aa)
	Rta_04750	2-hydroxy-3-oxopropionate reductase-like protein. (300 aa)
	Rta_05640	Candidate Isovaleryl-CoA dehydrogenase. (392 aa)
	Rta_05680	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
	Rta_05720	Unsaturated acyl-CoA reductaseButyryl dehydrogenase. (375 aa)
	Rta_05920	3-hydroxyisobutyrate dehydrogenase-like protein. (296 aa)
	Rta_06610	Candidate Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (573 aa)
	Rta_06620	Candidate Long chain acyl-CoA dehydrogenase. (382 aa)
	Rta_06630	Unsaturated acyl-CoA hydratase. (261 aa)
	Rta_06650	Candidate Acetyl/propionyl-CoA carboxylase, alpha subunit. (676 aa)
	Rta_06670	Candidate Hydroxymethylglutaryl-CoA lyase. (306 aa)
	fadA	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	bkdA1	Candidate 2-oxoisovalerate dehydrogenase, alpha subunit. (412 aa)
	bkdA2	Candidate 2-oxoisovalerate dehydrogenase, beta subunit. (357 aa)
	bkdB	Candidate Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (435 aa)
	lpd	Dihydrolipoamide dehydrogenase. (464 aa)
	Rta_14140	Butyryl-CoA dehydrogenase (Short-chain-acyl-CoA dehydrogenase)-like protein; (Unsaturated acyl-CoA reductase) (Butyryl dehydrogenase). (387 aa)
	Rta_14210	acyl-CoA dehydrogenase-like protein. (401 aa)
	Rta_14260	hydroxymethylglutaryl-CoA lyase (3-hydroxy-3-methylglutarate-CoA lyase)-like protein. (312 aa)
	Rta_14810	Candidate succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (Succinyl CoA:3-oxoacid CoA-transferase). (232 aa)
	Rta_14820	Candidate succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (Succinyl CoA:3-oxoacid CoA-transferase). (211 aa)
	Rta_16200	long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase)-like protein. (509 aa)
	Rta_16630	acyl-CoA dehydrogenase-like protein. (389 aa)
	Rta_18100	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
	Rta_18160	Butyryl-CoA dehydrogenase (Short-chain-acyl-CoA dehydrogenase)-like protein; (Unsaturated acyl-CoA reductase) (Butyryl dehydrogenase). (389 aa)
	Rta_18230	Candidate methylmalonyl-CoA mutase. (717 aa)
	Rta_18250	Candidate propionyl-CoA carboxylase. (510 aa)
	accA-2	Candidate Acetyl or propionyl-CoA carboxylase subunit. (682 aa)
	Rta_18700	Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). (598 aa)
	Rta_18810	Dihydrolipoamide dehydrogenase. (476 aa)
	Rta_20040	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
	Rta_21710	hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase)-like protein; (HL) (3- hydroxy-3-methylglutarate-CoA lyase). (305 aa)
	Rta_22080	Acyl dehydrogenase. (424 aa)
	Rta_23090	Aldehyde dehydrogenase (NAD+)-like protein; Belongs to the aldehyde dehydrogenase family. (477 aa)
	Rta_30045	Conserved hypothetical protein. (187 aa)
	Rta_33880	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	Rta_34370	Unsaturated acyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
	Rta_36460	Unsaturated acyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (264 aa)
	Rta_36600	Beta-alanine--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)

Your Current Organism:

Ramlibacter tataouinensis

NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Rta_00980	Rta_05680	Rta_00980	Rta_05680	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.929
Rta_00980	Rta_06670	Rta_00980	Rta_06670	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	Candidate Hydroxymethylglutaryl-CoA lyase.	0.933
Rta_00980	Rta_14260	Rta_00980	Rta_14260	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	hydroxymethylglutaryl-CoA lyase (3-hydroxy-3-methylglutarate-CoA lyase)-like protein.	0.931
Rta_00980	Rta_14810	Rta_00980	Rta_14810	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	Candidate succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (Succinyl CoA:3-oxoacid CoA-transferase).	0.908
Rta_00980	Rta_14820	Rta_00980	Rta_14820	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	Candidate succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (Succinyl CoA:3-oxoacid CoA-transferase).	0.909
Rta_00980	Rta_16200	Rta_00980	Rta_16200	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase)-like protein.	0.426
Rta_00980	Rta_18100	Rta_00980	Rta_18100	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.929
Rta_00980	Rta_20040	Rta_00980	Rta_20040	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.929
Rta_00980	Rta_21710	Rta_00980	Rta_21710	Candidate acetoacetate--CoA ligase (Acetoacetyl-CoA synthetase).	hydroxymethylglutaryl-CoA lyase (HMG-CoA lyase)-like protein; (HL) (3- hydroxy-3-methylglutarate-CoA lyase).	0.928
Rta_02980	Rta_04750	Rta_02980	Rta_04750	Candidate NAD-dependent aldehyde dehydrogenase.	2-hydroxy-3-oxopropionate reductase-like protein.	0.929
Rta_02980	Rta_05680	Rta_02980	Rta_05680	Candidate NAD-dependent aldehyde dehydrogenase.	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.911
Rta_02980	Rta_05720	Rta_02980	Rta_05720	Candidate NAD-dependent aldehyde dehydrogenase.	Unsaturated acyl-CoA reductaseButyryl dehydrogenase.	0.912
Rta_02980	Rta_05920	Rta_02980	Rta_05920	Candidate NAD-dependent aldehyde dehydrogenase.	3-hydroxyisobutyrate dehydrogenase-like protein.	0.926
Rta_02980	Rta_18100	Rta_02980	Rta_18100	Candidate NAD-dependent aldehyde dehydrogenase.	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.911
Rta_02980	Rta_18250	Rta_02980	Rta_18250	Candidate NAD-dependent aldehyde dehydrogenase.	Candidate propionyl-CoA carboxylase.	0.911
Rta_02980	Rta_20040	Rta_02980	Rta_20040	Candidate NAD-dependent aldehyde dehydrogenase.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.911
Rta_02980	Rta_23090	Rta_02980	Rta_23090	Candidate NAD-dependent aldehyde dehydrogenase.	Aldehyde dehydrogenase (NAD+)-like protein; Belongs to the aldehyde dehydrogenase family.	0.923
Rta_02980	Rta_33880	Rta_02980	Rta_33880	Candidate NAD-dependent aldehyde dehydrogenase.	Acetyl-CoA C-acetyltransferase-like protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.911
Rta_02980	Rta_36600	Rta_02980	Rta_36600	Candidate NAD-dependent aldehyde dehydrogenase.	Beta-alanine--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.937
Rta_02980	accA-2	Rta_02980	Rta_18270	Candidate NAD-dependent aldehyde dehydrogenase.	Candidate Acetyl or propionyl-CoA carboxylase subunit.	0.907

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