41 items (Cucumis sativus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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protein homology

Your Input:
	Csa_5G630860	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (553 aa)
	Csa_4G342570	Alpha-carbonic anhydrase domain-containing protein. (199 aa)
	Csa_4G062380	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (528 aa)
	Csa_4G197810	Uncharacterized protein. (357 aa)
	Csa_3G019900	Formyl_trans_N domain-containing protein. (326 aa)
	Csa_4G342560	Uncharacterized protein. (96 aa)
	Csa_4G377740	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (582 aa)
	Csa_3G129660	Adenosylhomocysteinase. (485 aa)
	Csa_3G354540	Mur_ligase_M domain-containing protein. (548 aa)
	Csa_3G151470	F-box domain-containing protein. (240 aa)
	Csa_3G122600	Uncharacterized protein. (363 aa)
	Csa_3G221750	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (585 aa)
	Csa_3G742880	Alpha-carbonic anhydrase domain-containing protein. (275 aa)
	Csa_3G742870	Alpha-carbonic anhydrase domain-containing protein. (280 aa)
	Csa_3G743390	Alpha-carbonic anhydrase domain-containing protein. (280 aa)
	Csa_3G776970	Alpha-carbonic anhydrase domain-containing protein. (273 aa)
	Csa_3G743380	Alpha-carbonic anhydrase domain-containing protein. (84 aa)
	Csa_3G823100	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (558 aa)
	Csa_2G149470	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (638 aa)
	Csa_2G145880	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	Csa_2G372170	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (515 aa)
	Csa_2G140370	Adenosylhomocysteinase. (485 aa)
	Csa_2G248730	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (527 aa)
	Csa_1G007880	Uncharacterized protein. (337 aa)
	Csa_1G120410	Alpha-carbonic anhydrase domain-containing protein. (254 aa)
	Csa_1G120470	Alpha-carbonic anhydrase domain-containing protein. (276 aa)
	Csa_1G120420	Alpha-carbonic anhydrase domain-containing protein. (275 aa)
	Csa_1G604600	Uncharacterized protein. (636 aa)
	Csa_1G597110	VWFA domain-containing protein. (755 aa)
	Csa_1G120450	Alpha-carbonic anhydrase domain-containing protein. (275 aa)
	Csa_1G123480	Alpha-carbonic anhydrase domain-containing protein. (100 aa)
	Csa_4G001540	Uncharacterized protein. (373 aa)
	Csa_5G604090	Uncharacterized protein. (469 aa)
	Csa_6G497310	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (519 aa)
	Csa_6G446560	Alpha-carbonic anhydrase domain-containing protein. (276 aa)
	Csa_6G446510	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (390 aa)
	Csa_6G091300	Uncharacterized protein. (213 aa)
	Csa_6G091310	Uncharacterized protein. (226 aa)
	Csa_6G091320	Uncharacterized protein. (204 aa)
	Csa_7G448860	VWFA domain-containing protein. (754 aa)
	Csa_7G419610	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (393 aa)

Your Current Organism:

Cucumis sativus

NCBI taxonomy Id: 3659
Other names: C. sativus, Cucumis sativus L., cucumber, cucumbers

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Csa_1G007880	Csa_1G604600	A0A0A0LRK4	A0A0A0LX21	Uncharacterized protein.	Uncharacterized protein.	0.798
Csa_1G007880	Csa_2G145880	A0A0A0LRK4	A0A0A0LKC8	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.562
Csa_1G007880	Csa_2G248730	A0A0A0LRK4	A0A0A0LPA5	Uncharacterized protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.700
Csa_1G007880	Csa_2G372170	A0A0A0LRK4	A0A0A0LLE7	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.562
Csa_1G007880	Csa_3G019900	A0A0A0LRK4	A0A0A0L1I1	Uncharacterized protein.	Formyl_trans_N domain-containing protein.	0.484
Csa_1G007880	Csa_3G122600	A0A0A0LRK4	A0A0A0L8Y4	Uncharacterized protein.	Uncharacterized protein.	0.596
Csa_1G007880	Csa_3G221750	A0A0A0LRK4	A0A0A0LAD1	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.562
Csa_1G007880	Csa_3G354540	A0A0A0LRK4	A0A0A0L7A4	Uncharacterized protein.	Mur_ligase_M domain-containing protein.	0.557
Csa_1G007880	Csa_3G823100	A0A0A0LRK4	A0A0A0LHM9	Uncharacterized protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.420
Csa_1G007880	Csa_4G001540	A0A0A0LRK4	A0A0A0KWH1	Uncharacterized protein.	Uncharacterized protein.	0.681
Csa_1G007880	Csa_4G062380	A0A0A0LRK4	A0A0A0KYS6	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.562
Csa_1G007880	Csa_4G197810	A0A0A0LRK4	A0A0A0L1G2	Uncharacterized protein.	Uncharacterized protein.	0.653
Csa_1G007880	Csa_4G377740	A0A0A0LRK4	A0A0A0L3A9	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.562
Csa_1G007880	Csa_5G630860	A0A0A0LRK4	A0A0A0KTX7	Uncharacterized protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.420
Csa_1G007880	Csa_6G091300	A0A0A0LRK4	A0A0A0KF68	Uncharacterized protein.	Uncharacterized protein.	0.572
Csa_1G007880	Csa_6G091310	A0A0A0LRK4	A0A0A0KDE7	Uncharacterized protein.	Uncharacterized protein.	0.572
Csa_1G007880	Csa_6G091320	A0A0A0LRK4	A0A0A0KAA8	Uncharacterized protein.	Uncharacterized protein.	0.572
Csa_1G007880	Csa_6G497310	A0A0A0LRK4	A0A0A0KLP6	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.562
Csa_1G123480	Csa_3G743380	A0A0A0LSQ8	A0A0A0LGE2	Alpha-carbonic anhydrase domain-containing protein.	Alpha-carbonic anhydrase domain-containing protein.	0.522
Csa_1G123480	Csa_3G743390	A0A0A0LSQ8	A0A0A0LEA7	Alpha-carbonic anhydrase domain-containing protein.	Alpha-carbonic anhydrase domain-containing protein.	0.542