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argB argB argD argD Smed_0128 Smed_0128 Smed_0169 Smed_0169 hisD hisD Smed_0342 Smed_0342 hisS hisS hisZ hisZ hisG hisG aroC aroC Smed_0665 Smed_0665 dapA dapA argC argC hisI hisI Smed_1061 Smed_1061 Smed_1094 Smed_1094 trpD trpD trpC trpC Smed_1453 Smed_1453 Smed_1570 Smed_1570 hisD-2 hisD-2 Smed_2012 Smed_2012 Smed_2013 Smed_2013 dadA dadA Smed_2233 Smed_2233 Smed_2295 Smed_2295 Smed_2504 Smed_2504 argJ argJ argH argH lysA lysA Smed_2549 Smed_2549 hisC hisC aroB aroB aroK aroK Smed_2684 Smed_2684 Smed_2685 Smed_2685 Smed_2686 Smed_2686 argG argG dapF dapF Smed_3096 Smed_3096 hisC-2 hisC-2 Smed_3160 Smed_3160 Smed_3176 Smed_3176 asd asd aroE aroE trpF trpF trpB trpB trpA trpA hisE hisE hisF hisF hisA hisA hisH hisH hisB hisB dapB dapB Smed_3428 Smed_3428 aroA aroA Smed_3509 Smed_3509
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: sme:SMc02138 putative acetylornithine aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
Smed_0128Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (303 aa)
Smed_0169TIGRFAM: chorismate mutase related enzymes; PFAM: Chorismate mutase; KEGG: sme:SMc02253 putative salicylate biosynthesis protein. (103 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
Smed_0342PFAM: FAD dependent oxidoreductase; KEGG: sme:SMc00797 putative oxidoreductase protein. (417 aa)
hisSTIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; KEGG: sme:SMc00919 probable histidyl-tRNA synthetase protein. (507 aa)
hisZtRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (377 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (231 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
Smed_0665PFAM: aminotransferase class I and II; KEGG: sme:SMc02393 histidinol-phosphate aminotransferase. (373 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (151 aa)
Smed_1061PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01017 putative acetyltransferase protein. (158 aa)
Smed_1094PFAM: aminotransferase class IV; KEGG: sme:SMc01047 putative aminotransferase protein. (287 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: sme:SMc00236 probable indole-3-glycerol phosphate synthase (IGPS) tryptophan biosynthesis lyase decarboxylase protein; Belongs to the TrpC family. (271 aa)
Smed_1453PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: sme:SMc00293 homoserine dehydrogenase. (440 aa)
Smed_1570TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II; KEGG: sme:SMc00155 phospho-2-dehydro-3-deoxyheptonate aldolase. (457 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
Smed_2012TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: sme:SMc01494 putative phosphoserine phosphatase protein. (295 aa)
Smed_2013PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01437 putative acetyl transferase protein. (191 aa)
dadAD-amino-acid dehydrogenase; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. (416 aa)
Smed_2233PFAM: aminotransferase class I and II; KEGG: sme:SMc01578 aspartate aminotransferase A (transaminase) protein. (400 aa)
Smed_2295Anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: sme:SMc02725 anthranilate synthase includes: glutamine amidotransferase protein. (729 aa)
Smed_2504TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: sme:SMc02438 aspartate kinase; Belongs to the aspartokinase family. (424 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00725 probable argininosuccinate lyase ASAL protein. (467 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa)
Smed_2549PFAM: Prephenate dehydrogenase; NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: sme:SMc00711 cyclohexadienyl dehydrogenase / prephenate dehydrogenase. (308 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: sme:SMc00710 putative histidinol-phosphate aminotransferase protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (380 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (192 aa)
Smed_2684TIGRFAM: oligoendopeptidase, pepF/M3 family; PFAM: peptidase M3A and M3B thimet/oligopeptidase F; Oligopeptidase F; KEGG: sme:SMc04012 putative oligoendopeptidase F protein. (627 aa)
Smed_2685TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: sme:SMc04013 putative para-aminobenzoate synthase component I protein. (385 aa)
Smed_2686KEGG: sme:SMc04014 4-amino-4-deoxychorismate lyase. (208 aa)
argGPFAM: argininosuccinate synthase; KEGG: sme:SMc03826 probable argininosuccinate synthase protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (292 aa)
Smed_3096TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: sme:SMc03858 putative chorismate mutase protein. (111 aa)
hisC-2TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: sme:SMc03885 putative histidinol-phosphate aminotransferase protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa)
Smed_3160PFAM: aminotransferase class I and II; KEGG: sme:SMc04386 aspartate aminotransferase B protein. (410 aa)
Smed_3176PFAM: protein of unknown function DUF993; KEGG: sme:SMc04402 hypothetical protein. (389 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: sme:SMc02767 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (215 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa)
hisEPFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: sme:SMc02568 probable phosphoribosyl-ATP pyrophosphatase protein. (107 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. (248 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sme:SMc02574 probable imidazoleglycerol-phosphate dehydratase protein. (202 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (272 aa)
Smed_3428PFAM: prephenate dehydratase; KEGG: sme:SMc02899 putative prephenate dehydratase protein. (284 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (456 aa)
Smed_3509Tyrosine transaminase; PFAM: aminotransferase class I and II; KEGG: sme:SMc00387 tyrosine aminotransferase protein. (389 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
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