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Smed_0029 Smed_0029 rbsK rbsK pgi pgi edd edd pgl pgl zwf zwf AcnA AcnA Smed_0548 Smed_0548 tpiA tpiA eno eno pdhA pdhA Smed_1077 Smed_1077 Smed_1078 Smed_1078 Smed_1081 Smed_1081 GltA GltA Smed_1489 Smed_1489 Smed_1519 Smed_1519 Smed_1558 Smed_1558 rpiA rpiA fumC fumC Smed_1732 Smed_1732 pfp pfp prs prs Smed_2321 Smed_2321 pgiA pgiA Smed_2464 Smed_2464 Smed_2479 Smed_2479 Smed_2650 Smed_2650 Smed_2651 Smed_2651 pgk pgk Smed_2654 Smed_2654 Smed_2676 Smed_2676 Smed_2779 Smed_2779 Smed_2826 Smed_2826 Smed_2827 Smed_2827 Smed_2828 Smed_2828 Smed_2829 Smed_2829 tal tal Smed_2936 Smed_2936 Smed_2940 Smed_2940 SucA SucA sucD sucD sucC sucC mdh mdh SdhB SdhB SdhA SdhA Smed_2958 Smed_2958 Smed_2959 Smed_2959 Smed_2995 Smed_2995 Smed_3083 Smed_3083 Smed_3128 Smed_3128 Smed_3129 Smed_3129 pckA pckA glk glk gpmA gpmA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Smed_0029Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. (761 aa)
rbsKPfkB domain protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (306 aa)
pgiPFAM: phosphoglucose isomerase (PGI); KEGG: sme:SMc02163 probable glucose-6-phosphate isomerase protein; Belongs to the GPI family. (541 aa)
edd6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (606 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (231 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
AcnAAconitate hydratase domain protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (872 aa)
Smed_0548TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; KEGG: sme:SMc00025 putative pyruvate phosphate dikinase protein; Belongs to the PEP-utilizing enzyme family. (898 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
pdhADehydrogenase E1 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (348 aa)
Smed_1077Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (465 aa)
Smed_1078Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (457 aa)
Smed_1081TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: sme:SMc01035 dihydrolipoamide dehydrogenase. (481 aa)
GltATIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: sme:SMc02087 citrate synthase; Belongs to the citrate synthase family. (429 aa)
Smed_1489PFAM: ribulose-phosphate 3-epimerase; Orotidine 5'-phosphate decarboxylase; KEGG: sme:SMc00511 probable D-ribulose-5-phosphate 3-epimerase protein; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa)
Smed_1519TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: sme:SMc00480 isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
Smed_1558Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc00169 NAD-malic enzyme oxidoreductase protein. (770 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (482 aa)
Smed_17326-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (404 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa)
Smed_2321PFAM: PfkB domain protein; KEGG: sme:SMc01531 putative 2-dehydro-3-deoxygluconokinase protein. (310 aa)
pgiAPFAM: glucose-6-phosphate isomerase; KEGG: sme:SMc02042 glucose-6-phosphate isomerase; Belongs to the archaeal-type GPI family. (214 aa)
Smed_2464TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; KEGG: sme:SMc02043 probable KHG/KDPG aldolase (includes: 4-hydroxy-2-oxoglutarate aldolase, 2-dehydro-3-deoxyphosphogluconate aldolase) protein. (217 aa)
Smed_2479TIGRFAM: transketolase; PFAM: Transketolase domain protein; Transketolase central region; KEGG: sme:SMc02342 transketolase; Belongs to the transketolase family. (664 aa)
Smed_2650Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (651 aa)
Smed_2651TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: sme:SMc03979 glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: sme:SMc03981 probable phosphoglycerate kinase protein; Belongs to the phosphoglycerate kinase family. (399 aa)
Smed_2654PFAM: fructose-bisphosphate aldolase class-I; KEGG: sme:SMc03983 probable fructose-bisphosphate aldolase class I protein. (341 aa)
Smed_2676TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: sme:SMc04005 pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
Smed_2779TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; KEGG: sme:SMc03153 keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase. (212 aa)
Smed_28263-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); PFAM: dehydrogenase E1 component; KEGG: sme:SMc03201 probable 2-oxoisovalerate dehydrogenase alpha subunit protein. (410 aa)
Smed_2827PFAM: Transketolase central region; Transketolase domain protein; KEGG: sme:SMc03202 probable 2-oxoisovalerate dehydrogenase beta subunit protein. (337 aa)
Smed_2828PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: sme:SMc03203 probable lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex protein. (426 aa)
Smed_2829TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: sme:SMc03204 dihydrolipoamide dehydrogenase. (464 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
Smed_2936TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: sme:SMc02487 dihydrolipoamide dehydrogenase. (468 aa)
Smed_29402-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (415 aa)
SucATIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; Transketolase central region; KEGG: sme:SMc02482 probable 2-oxoglutarate dehydrogenase E1 component protein. (998 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
SdhBTIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: sme:SMc02466 probable succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
SdhATIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; KEGG: sme:SMc02465 probable succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (613 aa)
Smed_2958TIGRFAM: Succinate dehydrogenase hydrophobic membrane anchor; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: sme:SMc02464 probable succinate dehydrogenase membrane anchor subunit protein. (126 aa)
Smed_2959TIGRFAM: Succinate dehydrogenase cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: sme:SMc02463 probable succinate dehydrogenase cytochrome B-556 subunit transmembrane protein. (130 aa)
Smed_2995Phosphoketolase; PFAM: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; KEGG: rle:RL0066 putative xylulose-5-phosphate phosphoketolase. (790 aa)
Smed_3083Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa)
Smed_3128PFAM: Transketolase domain protein; KEGG: rle:RL2719 putative ferredoxin. (281 aa)
Smed_3129PFAM: Transketolase central region; Transketolase domain protein; KEGG: ret:RHE_CH02397 transketolase C-terminal subunit protein. (322 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa)
glkTIGRFAM: glucokinase; PFAM: Glucokinase; KEGG: sme:SMc02835 probable glucokinase transmembrane protein; Belongs to the bacterial glucokinase family. (339 aa)
gpmAPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
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