STRINGSTRING
Smed_0029 Smed_0029 pgi pgi Smed_0548 Smed_0548 tpiA tpiA eno eno Smed_1489 Smed_1489 Smed_1558 Smed_1558 fumC fumC pfp pfp Smed_2479 Smed_2479 Smed_2650 Smed_2650 Smed_2651 Smed_2651 pgk pgk Smed_2654 Smed_2654 Smed_2676 Smed_2676 tal tal mdh mdh Smed_2995 Smed_2995 Smed_3128 Smed_3128 Smed_3129 Smed_3129 pckA pckA gpmA gpmA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Smed_0029Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. (761 aa)
pgiPFAM: phosphoglucose isomerase (PGI); KEGG: sme:SMc02163 probable glucose-6-phosphate isomerase protein; Belongs to the GPI family. (541 aa)
Smed_0548TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; KEGG: sme:SMc00025 putative pyruvate phosphate dikinase protein; Belongs to the PEP-utilizing enzyme family. (898 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
Smed_1489PFAM: ribulose-phosphate 3-epimerase; Orotidine 5'-phosphate decarboxylase; KEGG: sme:SMc00511 probable D-ribulose-5-phosphate 3-epimerase protein; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa)
Smed_1558Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc00169 NAD-malic enzyme oxidoreductase protein. (770 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (482 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (404 aa)
Smed_2479TIGRFAM: transketolase; PFAM: Transketolase domain protein; Transketolase central region; KEGG: sme:SMc02342 transketolase; Belongs to the transketolase family. (664 aa)
Smed_2650Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (651 aa)
Smed_2651TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: sme:SMc03979 glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: sme:SMc03981 probable phosphoglycerate kinase protein; Belongs to the phosphoglycerate kinase family. (399 aa)
Smed_2654PFAM: fructose-bisphosphate aldolase class-I; KEGG: sme:SMc03983 probable fructose-bisphosphate aldolase class I protein. (341 aa)
Smed_2676TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: sme:SMc04005 pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
Smed_2995Phosphoketolase; PFAM: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; KEGG: rle:RL0066 putative xylulose-5-phosphate phosphoketolase. (790 aa)
Smed_3128PFAM: Transketolase domain protein; KEGG: rle:RL2719 putative ferredoxin. (281 aa)
Smed_3129PFAM: Transketolase central region; Transketolase domain protein; KEGG: ret:RHE_CH02397 transketolase C-terminal subunit protein. (322 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa)
gpmAPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
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