STRINGSTRING
Smed_0512 Smed_0512 Smed_0744 Smed_0744 Smed_0745 Smed_0745 Smed_0747 Smed_0747 fabH fabH Smed_0904 Smed_0904 Smed_0952 Smed_0952 Smed_0953 Smed_0953 Smed_1738 Smed_1738 Smed_1739 Smed_1739 Smed_1740 Smed_1740 accA accA Smed_2901 Smed_2901 Smed_3139 Smed_3139 Smed_3165 Smed_3165 Smed_3173 Smed_3173 accD accD Smed_3448 Smed_3448 Smed_3449 Smed_3449 fabA fabA Smed_3570 Smed_3570
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Smed_0512PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sme:SMc00005 putative enoyl-acyl-carrier-protein reductase NADH. (272 aa)
Smed_0744TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: sme:SMc00571 acyl-carrier-protein S-malonyltransferase. (314 aa)
Smed_07453-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
Smed_0747Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (421 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (323 aa)
Smed_0904TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: sme:SMc01928 probable biotin--[acetyl-CoA-carboxylase] synthetase protein. (255 aa)
Smed_0952acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
Smed_0953acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
Smed_1738PFAM: Beta-ketoacyl synthase; KEGG: sme:SMc04273 putative 3-oxoacyl-acyl-carrier-protein synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (427 aa)
Smed_1739PFAM: Beta-ketoacyl synthase; KEGG: sme:SMc04275 3-oxoacyl-(acyl carrier protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (400 aa)
Smed_1740PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: sme:SMc04277 putative (3R)-hydroxymyristoyl-[acyl carrier] dehydratase transmembrane protein. (158 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
Smed_2901PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: sme:SMc02522 putative oxidoreductase protein. (256 aa)
Smed_3139Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1184 aa)
Smed_3165PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: sme:SMc04391 3-ketoacyl-(acyl-carrier-protein) reductase. (257 aa)
Smed_3173Coenzyme A transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (539 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (304 aa)
Smed_3448PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sme:SMc00326 putative enoyl-acyl-carrier-protein reductase NADH. (268 aa)
Smed_3449PFAM: Beta-ketoacyl synthase; KEGG: sme:SMc00327 probable 3-oxoacyl-acyl-carrier-protein synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
fabABeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (171 aa)
Smed_3570PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sme:SMc01157 3-oxoacyl-[acyl-carrier protein] reductase. (259 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
Server load: medium (74%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.