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folD1 folD1 Smed_0483 Smed_0483 Smed_0484 Smed_0484 Smed_0536 Smed_0536 glyA glyA Smed_1037 Smed_1037 gcvP gcvP gcvH gcvH GcvT GcvT ilvA ilvA Smed_2019 Smed_2019 thyA thyA dsdA dsdA purU purU folD2 folD2 glyA-2 glyA-2 Smed_2197 Smed_2197 Smed_2198 Smed_2198 tdh tdh kbl kbl fhs fhs Smed_2430 Smed_2430 Smed_2712 Smed_2712 Smed_2749 Smed_2749 Smed_2750 Smed_2750 Smed_2751 Smed_2751 Smed_2752 Smed_2752 purU-2 purU-2 Smed_2880 Smed_2880 Smed_3240 Smed_3240 Smed_3286 Smed_3286 purU-3 purU-3 Smed_3311 Smed_3311 Smed_3316 Smed_3316
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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folD1Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa)
Smed_0483PFAM: Rieske [2Fe-2S] domain protein; KEGG: sme:SMc00982 putative dioxygenase protein. (414 aa)
Smed_0484PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: sme:SMc00981 putative ferredoxin protein. (364 aa)
Smed_0536TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sme:SMc00077 probable threonine synthase protein. (465 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
Smed_1037TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: sme:SMc01256 probable L-serine dehydratase protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (120 aa)
GcvTTIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc02047 probable aminomethyltransferase (glycine cleavage system T protein). (379 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa)
Smed_2019Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (187 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
dsdATIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ajs:Ajs_2250 D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (442 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (298 aa)
folD2Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
Smed_2197FAD dependent oxidoreductase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc01662 putative sarcosine dehydrogenase; Belongs to the GcvT family. (815 aa)
Smed_2198PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc01663 putative dimethylglycine dehydrogenase precursor; Belongs to the GcvT family. (815 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (344 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)
fhsPFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: sme:SMc02728 probable formate--tetrahydrofolate ligase protein; Belongs to the formate--tetrahydrofolate ligase family. (567 aa)
Smed_2430PFAM: FAD dependent oxidoreductase; glycine cleavage T protein (aminomethyl transferase); KEGG: sme:SMc01987 putative dehydrogenase protein; Belongs to the GcvT family. (853 aa)
Smed_2712Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (348 aa)
Smed_2749TIGRFAM: sarcosine oxidase, gamma subunit family; PFAM: Sarcosine oxidase gamma subunit; KEGG: sme:SMc03930 putative sarcosine oxidase gamma subunit protein. (184 aa)
Smed_2750TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase); FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Glycine cleavage T-protein barrel; KEGG: sme:SMc03931 putative sarcosine oxidase alpha subunit transmembrane protein. (997 aa)
Smed_2751TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase delta subunit heterotetrameric; KEGG: sme:SMc03932 putative sarcosine oxidase delta subunit protein. (113 aa)
Smed_2752TIGRFAM: sarcosine oxidase, beta subunit family; PFAM: FAD dependent oxidoreductase; KEGG: sme:SMc03933 putative sarcosine oxidase subunit B protein. (417 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
Smed_2880TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; aminotransferase class-III; KEGG: sme:SMc03104 probable 5-aminolevulinic acid synthase (delta-aminolevulinate synthase) (delta-ala synthetase) protein. (406 aa)
Smed_3240TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: sme:SMc02763 probable folc bifunctional protein (folylpolyglutamate synthase / dihydrofolate synthase); Belongs to the folylpolyglutamate synthase family. (447 aa)
Smed_3286PFAM: Sarcosine oxidase gamma subunit; KEGG: sme:SMc02605 putative sarcosine oxidase gamma subunit protein. (177 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
Smed_3311PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: rle:pRL110552 putative aminomethyltransferase/glycine cleavage protein; Belongs to the GcvT family. (377 aa)
Smed_3316PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: sme:SMc04148 putative aminomethyltransferase protein; Belongs to the GcvT family. (789 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
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