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Smed_3230 Smed_3230 Smed_0029 Smed_0029 Smed_0144 Smed_0144 hisD hisD zwf zwf guaB guaB Smed_0580 Smed_0580 Smed_0584 Smed_0584 Smed_0688 Smed_0688 pdxA pdxA Smed_0768 Smed_0768 Smed_0818 Smed_0818 Smed_0849 Smed_0849 Smed_1024 Smed_1024 Smed_1258 Smed_1258 Smed_1453 Smed_1453 Smed_1519 Smed_1519 Smed_1558 Smed_1558 Smed_1595 Smed_1595 hisD-2 hisD-2 Smed_1732 Smed_1732 ilvC ilvC murB murB Smed_2128 Smed_2128 Smed_2158 Smed_2158 lcdH lcdH tdh tdh Smed_2232 Smed_2232 Smed_2353 Smed_2353 Smed_2354 Smed_2354 Smed_2390 Smed_2390 Smed_2461 Smed_2461 Smed_2465 Smed_2465 Smed_2466 Smed_2466 Smed_2486 Smed_2486 Smed_2487 Smed_2487 Smed_2534 Smed_2534 Smed_2575 Smed_2575 Smed_2618 Smed_2618 Smed_2692 Smed_2692 Smed_2695 Smed_2695 Smed_2747 Smed_2747 Smed_2763 Smed_2763 dxr dxr mdh mdh gpsA gpsA Smed_2996 Smed_2996 Smed_3163 Smed_3163 Smed_3165 Smed_3165 leuB leuB aroE aroE Smed_3319 Smed_3319 Smed_3380 Smed_3380
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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Smed_3230PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sme:SMc02771 putative zinc-type alcohol dehydrogenase protein. (338 aa)
Smed_0029Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc01126 NADP-dependent malic enzyme protein. (761 aa)
Smed_0144PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: sme:SMc02227 putative fatty oxidation complex alpha subunit includes: enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, 3-hydroxybutyryl-CoA epimerase transmembrane protein. (736 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
Smed_0580PFAM: aldo/keto reductase; KEGG: sme:SMc00101 putative oxidoreductase protein. (275 aa)
Smed_0584PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sme:SMc00105 putative oxidoreductase transmembrane protein. (346 aa)
Smed_0688PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: sme:SMc02641 UDP-glucose 6-dehydrogenase protein. (437 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (342 aa)
Smed_0768Galactose 1-dehydrogenase; PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: sme:SMc00588 putative D-galactose 1-dehydrogenase protein. (308 aa)
Smed_0818Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (398 aa)
Smed_0849PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: rle:pRL110382 putative D-xylulose reductase. (344 aa)
Smed_1024TIGRFAM: Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sme:SMc01270 probable alcohol dehydrogenase class III + glutathione-dependent formaldehyde dehydrogenase protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
Smed_1258PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sme:SMc01214 putative zinc-containing alcohol dehydrogenase protein. (344 aa)
Smed_1453PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: sme:SMc00293 homoserine dehydrogenase. (440 aa)
Smed_1519TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: sme:SMc00480 isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
Smed_1558Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: sme:SMc00169 NAD-malic enzyme oxidoreductase protein. (770 aa)
Smed_1595PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: sme:SMc00133 putative oxidoreductase protein. (289 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
Smed_17326-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (324 aa)
Smed_2128PFAM: iron-containing alcohol dehydrogenase; KEGG: sme:SMc01582 putative alcohol dehydrogenase protein. (381 aa)
Smed_2158PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc01622 putative phosphoglycerate dehydrogenase. (345 aa)
lcdH3-hydroxyacyl-CoA dehydrogenase NAD-binding; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine. (496 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (344 aa)
Smed_2232PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: sme:SMc01572 putative oxidoreductase protein. (288 aa)
Smed_2353PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: sme:SMc01501 probable mannitol 2-dehydrogenase protein. (494 aa)
Smed_2354PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sme:SMc01500 sorbitol dehydrogenase. (257 aa)
Smed_2390PFAM: 6-phosphogluconate dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc01943 2-hydroxyacid dehydrogenase. (324 aa)
Smed_2461PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: sme:SMc02039 putative oxidoreductase protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (242 aa)
Smed_2465KEGG: sme:SMc02044 hypothetical protein. (317 aa)
Smed_2466PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02045 putative oxidoreductase protein. (310 aa)
Smed_2486PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: sme:SMa0241 hypothetical protein. (327 aa)
Smed_2487PFAM: NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: sme:SMa0237 putative D-threonine. (288 aa)
Smed_2534PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: sme:SMc00727 3-hydroxybutyryl-CoA dehydrogenase. (290 aa)
Smed_2575PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sme:SMc00680 putative zinc-type alcohol dehydrogenase protein. (347 aa)
Smed_2618TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc00641 putative D-3-phosphoglycerate dehydrogenase protein. (531 aa)
Smed_2692PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: ret:RHE_PA00028 putative glycerol-3-phosphate dehydrogenase (NAD(P)+) protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa)
Smed_2695PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ret:RHE_PA00025 probable oxidoreductase protein, short-chain dehydrogenase-reductase family. (241 aa)
Smed_2747PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sme:SMc03929 putative zinc-type alcohol dehydrogenase transmembrane protein. (403 aa)
Smed_2763PFAM: 6-phosphogluconate dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc04462 glycerate dehydrogenase. (321 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (391 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
gpsAPFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: sme:SMc03229 probable glycerol-3-phosphate dehydrogenase protein. (331 aa)
Smed_2996PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: atc:AGR_C_1112 alcohol dehydrogenase. (344 aa)
Smed_3163Hydroxypyruvate reductase; PFAM: MOFRL domain protein; KEGG: sme:SMc04389 putative hydroxypyruvate reductase protein. (423 aa)
Smed_3165PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: sme:SMc04391 3-ketoacyl-(acyl-carrier-protein) reductase. (257 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
Smed_3319PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: sme:SMc04145 hypothetical protein. (261 aa)
Smed_3380Glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sme:SMc02849 2-hydroxyacid dehydrogenase. (357 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
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