STRINGSTRING
Smed_0028 Smed_0028 Smed_0038 Smed_0038 lnt lnt dapD dapD Smed_0125 Smed_0125 Smed_0145 Smed_0145 Smed_0196 Smed_0196 Smed_0414 Smed_0414 Smed_0499 Smed_0499 Smed_0512 Smed_0512 Smed_0534 Smed_0534 Smed_0592 Smed_0592 Smed_0744 Smed_0744 Smed_0747 Smed_0747 Smed_0769 Smed_0769 Smed_0820 Smed_0820 plsX plsX fabH fabH Smed_0855 Smed_0855 plsY plsY Smed_0947 Smed_0947 lipB lipB Smed_1035 Smed_1035 Smed_1061 Smed_1061 Smed_1078 Smed_1078 Smed_1080 Smed_1080 Smed_1113 Smed_1113 lpxD lpxD fabZ fabZ lpxA lpxA Smed_1243 Smed_1243 Smed_1366 Smed_1366 Smed_1377 Smed_1377 Smed_1403 Smed_1403 glmU glmU Smed_1439 Smed_1439 Smed_1560 Smed_1560 Smed_1738 Smed_1738 Smed_1739 Smed_1739 Smed_1740 Smed_1740 Smed_1772 Smed_1772 Smed_1981 Smed_1981 Smed_2013 Smed_2013 Smed_2044 Smed_2044 Smed_2214 Smed_2214 kbl kbl Smed_2279 Smed_2279 Smed_2280 Smed_2280 Smed_2291 Smed_2291 Smed_2370 Smed_2370 Smed_2515 Smed_2515 argJ argJ Smed_2521 Smed_2521 Smed_2603 Smed_2603 Smed_2771 Smed_2771 Smed_2777 Smed_2777 Smed_2828 Smed_2828 Smed_2880 Smed_2880 Smed_2940 Smed_2940 tsaD tsaD Smed_2975 Smed_2975 Smed_3007 Smed_3007 Smed_3008 Smed_3008 metAA metAA Smed_3037 Smed_3037 Smed_3077 Smed_3077 Smed_3117 Smed_3117 Smed_3165 Smed_3165 Smed_3448 Smed_3448 Smed_3449 Smed_3449 fabA fabA Smed_3472 Smed_3472 Smed_3521 Smed_3521
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Smed_0028KEGG: sme:SMc01127 hypothetical protein. (296 aa)
Smed_0038PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01117 putative acetyltransferase protein. (167 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (543 aa)
dapDTIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; KEGG: sme:SMc01732 probable 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase protein; Belongs to the transferase hexapeptide repeat family. (285 aa)
Smed_0125GCN5-related N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring. (158 aa)
Smed_0145TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: sme:SMc02228 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
Smed_01968-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sme:SMc02272 acyl-transferase transferase protein. (470 aa)
Smed_0414PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc00906 putative acetyltransferase protein. (159 aa)
Smed_0499TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: sme:SMc00966 putative acetyl-CoA acyltransferase protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
Smed_0512PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sme:SMc00005 putative enoyl-acyl-carrier-protein reductase NADH. (272 aa)
Smed_0534PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc00075 probable ribosomal-protein-alanine acetyltransferase. (203 aa)
Smed_0592PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc00108 putative acetyltransferase protein. (167 aa)
Smed_0744TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: sme:SMc00571 acyl-carrier-protein S-malonyltransferase. (314 aa)
Smed_0747Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (421 aa)
Smed_0769PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc00589 hypothetical protein. (308 aa)
Smed_0820PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01775 putative acetyltransferase protein. (180 aa)
plsXFatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (347 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (323 aa)
Smed_0855KEGG: sme:SMc01796 hypothetical protein. (416 aa)
plsYProtein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (203 aa)
Smed_0947PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01349 hypothetical protein. (167 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (262 aa)
Smed_1035PFAM: protein of unknown function DUF1624; KEGG: sme:SMc01258 hypothetical protein. (365 aa)
Smed_1061PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01017 putative acetyltransferase protein. (158 aa)
Smed_1078Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (457 aa)
Smed_1080PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01034 hypothetical protein. (193 aa)
Smed_1113TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; serine acetyltransferase domain protein; KEGG: sme:SMc02113 probable serine acetyltransferase protein. (275 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (354 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa)
lpxAacyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (270 aa)
Smed_1243PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01229 putative acetyltransferase (antibiotic resistance) protein. (169 aa)
Smed_1366PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01171 hypothetical protein. (187 aa)
Smed_1377KEGG: sme:SMc01789 hypothetical signal peptide protein. (72 aa)
Smed_1403PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc00230 putative acetyltransferase. (165 aa)
glmUNucleotidyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa)
Smed_1439Propanoyl-CoA C-acyltransferase; PFAM: Thiolase; KEGG: sme:SMc00262 putative 3-ketoacyl-CoA thiolase protein; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
Smed_1560PFAM: autoinducer synthesis protein; KEGG: sme:SMc00168 putative autoinducer synthase protein. (214 aa)
Smed_1738PFAM: Beta-ketoacyl synthase; KEGG: sme:SMc04273 putative 3-oxoacyl-acyl-carrier-protein synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (427 aa)
Smed_1739PFAM: Beta-ketoacyl synthase; KEGG: sme:SMc04275 3-oxoacyl-(acyl carrier protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (400 aa)
Smed_1740PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: sme:SMc04277 putative (3R)-hydroxymyristoyl-[acyl carrier] dehydratase transmembrane protein. (158 aa)
Smed_1772PFAM: acyltransferase 3; KEGG: rde:RD1_B0055 acyltransferase family protein. (683 aa)
Smed_1981PFAM: acyltransferase 3; KEGG: hch:HCH_02732 predicted acyltransferase. (671 aa)
Smed_2013PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01437 putative acetyl transferase protein. (191 aa)
Smed_2044PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01462 putative acetyltransferase protein. (153 aa)
Smed_2214PFAM: aminoglycoside 3-N-acetyltransferase; KEGG: sme:SMc02813 probable aminoglycoside N3'-acetyltransferase protein. (263 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)
Smed_2279PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01545 hypothetical protein. (163 aa)
Smed_2280PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc02707 hypothetical protein. (186 aa)
Smed_2291PFAM: GCN5-related N-acetyltransferase; KEGG: rle:RL2080 putative acetyltransferase. (168 aa)
Smed_2370PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01824 hypothetical protein. (161 aa)
Smed_2515PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc02449 putative acetyltransferase protein. (270 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa)
Smed_2521KEGG: sme:SMc00742 hypothetical protein. (424 aa)
Smed_2603KEGG: sme:SMc00656 hypothetical protein. (93 aa)
Smed_2771PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc02982 hypothetical protein. (196 aa)
Smed_2777PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc03151 hypothetical protein. (232 aa)
Smed_2828PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: sme:SMc03203 probable lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex protein. (426 aa)
Smed_2880TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; aminotransferase class-III; KEGG: sme:SMc03104 probable 5-aminolevulinic acid synthase (delta-aminolevulinate synthase) (delta-ala synthetase) protein. (406 aa)
Smed_29402-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (415 aa)
tsaDPutative metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (360 aa)
Smed_2975PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc03241 hypothetical protein. (168 aa)
Smed_3007PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc03773 hypothetical protein. (221 aa)
Smed_3008PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc03774 hypothetical protein. (200 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (323 aa)
Smed_3037PFAM: alpha/beta hydrolase fold; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: vei:Veis_2228 alpha/beta hydrolase fold. (437 aa)
Smed_3077PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc03840 putative acetyltransferase (antibiotic resistance) protein. (185 aa)
Smed_3117TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: sme:SMc03879 acetyl-CoA acetyltransferase protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Smed_3165PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: sme:SMc04391 3-ketoacyl-(acyl-carrier-protein) reductase. (257 aa)
Smed_3448PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sme:SMc00326 putative enoyl-acyl-carrier-protein reductase NADH. (268 aa)
Smed_3449PFAM: Beta-ketoacyl synthase; KEGG: sme:SMc00327 probable 3-oxoacyl-acyl-carrier-protein synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
fabABeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (171 aa)
Smed_3472PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc00352 putative acetyltransferase protein. (173 aa)
Smed_3521PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc00397 hypothetical protein. (182 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
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