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| | Smed_0112 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sme:SMc02159 hypothetical protein. (221 aa) |
| | Smed_0117 | PFAM: protein of unknown function DUF344; KEGG: sme:SMc02148 hypothetical protein. (300 aa) |
| | Smed_0118 | PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: Phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: sme:SMc02147 probable phosphate regulon sensor histidine kinase transmembrane protein. (415 aa) |
| | Smed_0132 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sme:SMc02134 hypothetical protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (205 aa) |
| | Smed_0147 | PFAM: Peptidoglycan-binding domain 1 protein; Sel1 domain protein repeat-containing protein; KEGG: sme:SMc02230 hypothetical protein. (1226 aa) |
| | Smed_0165 | Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc02249 putative sensory transduction histidine kinase transmembrane protein. (1168 aa) |
| | Smed_0215 | HPr kinase; KEGG: sme:SMc02314 hypothetical protein. (366 aa) |
| | Smed_0230 | PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc03003 hypothetical protein. (463 aa) |
| | Smed_0235 | CheA signal transduction histidine kinase; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; KEGG: sme:SMc03007 chemotaxis protein (sensory transduction histidine kinase). (759 aa) |
| | Smed_0318 | TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc00776 putative sensor histidine kinase protein. (1138 aa) |
| | RibC | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; KEGG: sme:SMc00909 hypothetical protein; Belongs to the ribF family. (327 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (346 aa) |
| | Smed_0437 | PFAM: 2-keto-3-deoxy-galactonokinase; KEGG: sme:SMc00881 putative 2-dehydro-3-deoxygalactonokinase protein. (306 aa) |
| | Smed_0455 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (180 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (303 aa) |
| | Smed_0481 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (324 aa) |
| | thrB | TIGRFAM: homoserine kinase; PFAM: aminoglycoside phosphotransferase; KEGG: sme:SMc00017 putative homoserine kinase protein; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | Smed_0533 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; Diverse 7TM receptor extracellular region 2; Diverse 7TM receptor transmembrane region; PAS fold-3 domain protein; SMART: PAC repeat-containing protein; KEGG: sme:SMc00074 hypothetical transmembrane signal peptide protein. (970 aa) |
| | Smed_0548 | TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; KEGG: sme:SMc00025 putative pyruvate phosphate dikinase protein; Belongs to the PEP-utilizing enzyme family. (898 aa) |
| | cysN | Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (498 aa) |
| | cysD | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: sme:SMc00091 putative sulfate adenylate transferase subunit 2 cysteine biosynthesis protein. (317 aa) |
| | Smed_0574 | Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; KEGG: sme:SMc00038 hypothetical protein. (772 aa) |
| | selO | Protein of unknown function UPF0061; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family. (517 aa) |
| | Smed_0617 | Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc00059 putative sensor histidine kinase protein. (525 aa) |
| | Smed_0631 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc00129 probable sensor histidine kinase protein. (461 aa) |
| | Smed_0639 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc02367 putative sensor histidine kinase transmembrane protein. (465 aa) |
| | glnE | (Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (985 aa) |
| | Smed_0641 | Multi-sensor signal transduction histidine kinase; KEGG: sme:SMc02369 putative sensor histidine kinase transmembrane protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; SMART: PAC repeat-containing protein. (772 aa) |
| | Smed_0654 | PFAM: diacylglycerol kinase catalytic region; KEGG: sme:SMc02382 hypothetical protein. (308 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (135 aa) |
| | Smed_0677 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (741 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (139 aa) |
| | Smed_0724 | TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sme:SMc00552 putative CDP-diacylglycerol--serine O-phosphatidyltransferase transmembrane protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (295 aa) |
| | Smed_0758 | PFAM: YicC domain protein; domain of unknown function DUF1732; KEGG: sme:SMc00576 hypothetical protein. (295 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (219 aa) |
| | Smed_0767 | PFAM: DNA polymerase III chi subunit HolC; KEGG: sme:SMc00586 putative DNA polymerase III chi subunit. (149 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | Smed_0781 | TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sme:SMc00601 probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase transmembrane protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (195 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (736 aa) |
| | Smed_0854 | TIGRFAM: exopolysaccharide transport protein family; PFAM: lipopolysaccharide biosynthesis protein; KEGG: sme:SMc01795 putative polysaccharide synthesis/transport transmembrane protein. (709 aa) |
| | Smed_0871 | PFAM: phospholipase D/Transphosphatidylase; KEGG: sme:SMc04448 hypothetical protein. (520 aa) |
| | DnaE | KEGG: sme:SMc01375 probable DNA polymerase III, alpha chain protein; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1165 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (430 aa) |
| | PleD | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver; KEGG: sme:SMc01370 putative transcription regulator (with tandem N-terminal response regulator domains) protein. (455 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (257 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1380 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1401 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (336 aa) |
| | Smed_1027 | PFAM: PrkA serine kinase; PrkA AAA domain protein; KEGG: sme:SMc01267 serine protein kinase. (649 aa) |
| | ispDF | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (404 aa) |
| | Smed_1089 | Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; KEGG: sme:SMc01042 nitrogen regulation protein. (380 aa) |
| | Smed_1091 | Multi-sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc01044 probable nitrogen regulation transmembrane protein. (757 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | Smed_1136 | PFAM: phosphatidate cytidylyltransferase; KEGG: sme:SMc02096 probable phosphatidate cytidylyltransferase transmembrane protein; Belongs to the CDS family. (277 aa) |
| | Smed_1155 | PFAM: phospholipase D/Transphosphatidylase; KEGG: sme:SMc02076 putative cardiolipin synthetase transmembrane protein. (487 aa) |
| | Smed_1163 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sme:SMc02068 putative ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily. (372 aa) |
| | Smed_1223 | PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron maturase-specific domain protein; KEGG: sme:SMb21045 putative reverse transcriptasematurase protein. (419 aa) |
| | Smed_1244 | PFAM: aminoglycoside/hydroxyurea antibiotic resistance kinase; KEGG: sme:SMc01228 putative antibiotic resistance (kinase) protein. (272 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (181 aa) |
| | Smed_1279 | PFAM: type III effector Hrp-dependent outers; KEGG: sme:SMb20394 hypothetical protein. (432 aa) |
| | Smed_1291 | KEGG: sme:SMc01190 putative DNA polymerase III, delta' subunit protein. (343 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (234 aa) |
| | Smed_1305 | TIGRFAM: DNA polymerase LigD ligase region; PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMb20912 putative ATP-dependent DNA ligase protein. (343 aa) |
| | glmU | Nucleotidyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa) |
| | Smed_1420 | Phosphatidylcholine synthase; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (241 aa) |
| | Smed_1471 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sme:SMb20523 hypothetical protein transmembrane. (398 aa) |
| | anmK | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (382 aa) |
| | Smed_1525 | Multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc00471 putative sensor histidine kinase transmembrane protein. (872 aa) |
| | Smed_1532 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: sme:SMc00465 probable 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein. (174 aa) |
| | Smed_1537 | PFAM: Hpt domain protein; KEGG: sme:SMc00191 hypothetical protein. (122 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (219 aa) |
| | Smed_1600 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc04212 putative sensor histidine kinase transmembrane protein. (511 aa) |
| | Smed_1602 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (160 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (262 aa) |
| | Smed_1755 | KEGG: sme:SMc04301 putative regulator protein. (388 aa) |
| | CobU | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa) |
| | Smed_1795 | PFAM: response regulator receiver; KEGG: sme:SMc04170 putative two 2-component receiver domains protein. (274 aa) |
| | Smed_2015 | PFAM: amino acid-binding ACT domain protein; KEGG: sme:SMc01439 hypothetical protein. (128 aa) |
| | Smed_2027 | PFAM: protein of unknown function DUF1321; KEGG: sme:SMc01450 hypothetical protein. (171 aa) |
| | Smed_2046 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sme:SMc01464 hypothetical protein. (438 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (366 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (404 aa) |
| | Smed_2154 | PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc01618 putative carbohydrate kinase protein. (427 aa) |
| | Smed_2159 | PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc01623 putative erythritol kinase protein. (525 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (671 aa) |
| | Smed_2246 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc01595 putative sensor histidine kinase transmembrane protein. (472 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | Smed_2272 | PFAM: Polynucleotide adenylyltransferase region; KEGG: sme:SMc02700 tRNA nucleotidyltransferase (CCA-adding enzyme); Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (419 aa) |
| | Smed_2292 | PFAM: aminoglycoside phosphotransferase; KEGG: sme:SMc02722 putative aminoglycoside 3'-phosphotransferase protein; Belongs to the aminoglycoside phosphotransferase family. (273 aa) |
| | Smed_2321 | PFAM: PfkB domain protein; KEGG: sme:SMc01531 putative 2-dehydro-3-deoxygluconokinase protein. (310 aa) |
| | Smed_2344 | Signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: GAF domain protein; HWE histidine kinase; PAS fold-3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc01507 hypothetical protein. (500 aa) |
| | Smed_2351 | TIGRFAM: FGGY-family pentulose kinase; PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc01503 putative sugar kinase protein. (528 aa) |
| | Smed_2470 | PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc02334 putative pentose kinase transmembrane protein. (515 aa) |
| | Smed_2471 | PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc02335 putative pentose kinase protein. (509 aa) |
| | Smed_2478 | PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc02341 putative sugar kinase protein. (477 aa) |
| | Smed_2503 | PTSINtr with GAF domain, PtsP; TIGRFAM: phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilizing protein; GAF domain protein; PEP-utilising protein mobile region; PEP-utilising protein domain protein; KEGG: sme:SMc02437 phosphotransferase system, enzyme I; Belongs to the PEP-utilizing enzyme family. (755 aa) |
| | Smed_2504 | TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: sme:SMc02438 aspartate kinase; Belongs to the aspartokinase family. (424 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (192 aa) |
| | Smed_2608 | KEGG: sme:SMc00652 hypothetical protein. (220 aa) |
| | pal | Peptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (176 aa) |
| | Smed_2631 | TIGRFAM: DNA ligase D; DNA ligase D 3'-phosphoesterase domain; DNA polymerase LigD polymerase domain; DNA polymerase LigD ligase region; PFAM: DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMc03959 hypothetical protein. (865 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: sme:SMc03981 probable phosphoglycerate kinase protein; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | Smed_2676 | TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: sme:SMc04005 pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa) |
| | Smed_2687 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sme:SMc04015 hypothetical protein. (316 aa) |
| | Smed_2703 | PFAM: carbohydrate kinase FGGY; KEGG: ret:RHE_PA00020 xylulokinase protein; Belongs to the FGGY kinase family. (521 aa) |
| | Smed_2707 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: sme:SMc04023 probable UTP--glucose-1-phosphate uridylyltransferase protein. (295 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (419 aa) |
| | Smed_2761 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc03942 hypothetical protein. (788 aa) |
| | xylB | TIGRFAM: xylulokinase; PFAM: carbohydrate kinase FGGY; KEGG: sme:SMc03164 putative xylulose kinase protein. (484 aa) |
| | Smed_2805 | Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; CHASE domain protein; PAS fold-3 domain protein; KEGG: sme:SMc03178 hypothetical protein. (878 aa) |
| | Smed_2845 | PFAM: PfkB domain protein; KEGG: sme:SMc03138 putative sugar kinase protein. (270 aa) |
| | Smed_2873 | PFAM: ROK family protein; KEGG: sme:SMc03109 hypothetical protein. (298 aa) |
| | Smed_2951 | PFAM: ROK family protein; KEGG: sme:SMc02470 putative transcription regulator protein. (401 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (393 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (202 aa) |
| | rsfS | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (166 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1116 aa) |
| | Smed_3022 | KEGG: sme:SMc03789 hypothetical protein. (471 aa) |
| | Smed_3035 | PFAM: carbohydrate kinase FGGY; KEGG: pac:PPA2321 sugar kinase, putative xylulose kinase; Belongs to the FGGY kinase family. (502 aa) |
| | Smed_3047 | PFAM: protein of unknown function DUF343; KEGG: sme:SMc03803 hypothetical protein; Belongs to the UPF0434 family. (62 aa) |
| | Smed_3055 | PFAM: cyclic nucleotide-binding; KEGG: sme:SMc03819 hypothetical protein. (151 aa) |
| | Smed_3105 | TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: sme:SMc03867 hypothetical protein. (220 aa) |
| | Smed_3130 | PFAM: carbohydrate kinase FGGY; KEGG: atc:AGR_C_3493 glycerol kinase. (489 aa) |
| | Smed_3163 | Hydroxypyruvate reductase; PFAM: MOFRL domain protein; KEGG: sme:SMc04389 putative hydroxypyruvate reductase protein. (423 aa) |
| | Smed_3186 | TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: sme:SMc04084 pyridoxine kinase; Belongs to the pyridoxine kinase family. (293 aa) |
| | HolA | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: sme:SMc02802 putative DNA polymerase III, delta subunit. (343 aa) |
| | Smed_3209 | Protein of unknown function DUF299; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (273 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (194 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (242 aa) |
| | Smed_3244 | PFAM: Nucleotidyl transferase; KEGG: sme:SMc02758 putative nucleotidyl transferase protein. (243 aa) |
| | Smed_3246 | Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc02756 putative sensor histidine kinase protein. (826 aa) |
| | Smed_3249 | PFAM: PTS system fructose subfamily IIA component; KEGG: sme:SMc02753 putative IIA component of PTS system protein. (133 aa) |
| | Smed_3250 | HPr kinase; KEGG: sme:SMc02752 hypothetical protein. (161 aa) |
| | Smed_3251 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc04446 histidine kinase sensory transmembrane protein. (578 aa) |
| | coaA | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: sme:SMc02567 probable pantothenate kinase protein. (331 aa) |
| | Smed_3274 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc02585 sensor histidine kinase transmembrane protein. (433 aa) |
| | Smed_3279 | Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: sit:TM1040_3231 periplasmic sensor hybrid histidine kinase. (834 aa) |
| | glk | TIGRFAM: glucokinase; PFAM: Glucokinase; KEGG: sme:SMc02835 probable glucokinase transmembrane protein; Belongs to the bacterial glucokinase family. (339 aa) |
| | Smed_3378 | PFAM: PfkB domain protein; KEGG: sme:SMc02846 putative sugar kinase protein. (330 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1004 aa) |
| | Smed_3407 | PFAM: ATPase BadF/BadG/BcrA/BcrD type; KEGG: sme:SMc02875 hypothetical protein. (294 aa) |
| | Smed_3412 | PFAM: ROK family protein; KEGG: sme:SMc02880 hypothetical protein. (303 aa) |
| | slyX | PFAM: SlyX family protein; KEGG: sme:SMc02883 slyX protein, putative; Belongs to the SlyX family. (69 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (250 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (625 aa) |
| | Smed_3444 | PFAM: HWE histidine kinase; KEGG: sme:SMc00322 hypothetical protein. (572 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (714 aa) |
| | cmk | TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: sme:SMc00334 putative cytidylate kinase (CMP kinase) protein. (212 aa) |
| | Smed_3543 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | Smed_3562 | PFAM: PfkB domain protein; KEGG: sme:SMc01165 putative sugar kinase protein. (655 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (239 aa) |
| | Smed_0013 | TIGRFAM: PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: sme:SMc01141 probable nitrogen regulatory IIA protein. (154 aa) |
| | Smed_0015 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (513 aa) |
| | Smed_0027 | Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc01128 putative sensor histidine kinase transmembrane protein. (739 aa) |
| | glnD | Metal dependent phosphohydrolase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. (949 aa) |
| | rbsK | PfkB domain protein; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (306 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | Smed_0085 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc01716 putative sensor histidine kinase transmembrane protein. (493 aa) |
| | Smed_0098 | Putative transcriptional regulator, Crp/Fnr family; PFAM: cyclic nucleotide-binding; regulatory protein Crp; KEGG: sme:SMc02175 putative transcription regulator protein. (234 aa) |
| | FrcK | KEGG: sme:SMc02167 hypothetical protein. (206 aa) |
| | Smed_0108 | PFAM: PfkB domain protein; KEGG: sme:SMc02164 probable fructokinase protein. (310 aa) |
| | Smed_0114 | PFAM: phosphatidate cytidylyltransferase; KEGG: sme:SMc02157 hypothetical protein; Belongs to the CDS family. (313 aa) |
