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| | Smed_2804 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMc03177 DNA ligase. (537 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (302 aa) |
| | Smed_2889 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc03093 hypothetical protein. (159 aa) |
| | Smed_2882 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: sme:SMc03102 putative carbon monoxide dehydrogenase large subunit transmembrane protein. (781 aa) |
| | Smed_2880 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; aminotransferase class-III; KEGG: sme:SMc03104 probable 5-aminolevulinic acid synthase (delta-aminolevulinate synthase) (delta-ala synthetase) protein. (406 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) |
| | Smed_2819 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. (256 aa) |
| | CobH | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: sme:SMc03192 probable precorrin-8X methylmutase protein. (210 aa) |
| | Smed_2816 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03191 probable precorrin-2 C20-methyltransferase protein; Belongs to the precorrin methyltransferase family. (257 aa) |
| | Smed_2815 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03190 probable precorrin-3B C17-methyltransferase protein. (254 aa) |
| | CbiJ | TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; KEGG: sme:SMc03189 probable precorrin-6X reductase protein. (266 aa) |
| | Smed_2813 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03188 probable precorrin-6Y C5,15-methyltransferase (decarboxylating) protein. (413 aa) |
| | Smed_2812 | TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03187 probable precorrin-4 C11-methyltransferase protein; Belongs to the precorrin methyltransferase family. (266 aa) |
| | Smed_2767 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: sme:SMc02978 hypothetical protein. (369 aa) |
| | Smed_2766 | PFAM: Creatininase; KEGG: sme:SMc02977 putative creatinine amidohydrolase. (263 aa) |
| | Smed_2756 | Putative adenylate/guanylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: sme:SMc03937 putative adenylate/guanylate cyclase protein. (406 aa) |
| | Smed_2730 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc04051 putative RNA polymerase sigma-E factor (sigma-24) protein; Belongs to the sigma-70 factor family. ECF subfamily. (174 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (345 aa) |
| | Smed_2685 | TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: sme:SMc04013 putative para-aminobenzoate synthase component I protein. (385 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (349 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (154 aa) |
| | Smed_2667 | PFAM: thiamine monophosphate synthase; KEGG: sme:SMc03996 thiamine-phosphate pyrophosphorylase. (217 aa) |
| | Smed_2646 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: sme:SMc03974 hypothetical protein. (193 aa) |
| | Smed_2635 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: sme:SMc03963 sulfolipid biosynthesis protein. (301 aa) |
| | Smed_2633 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: sme:SMc03961 sulfolipid (UDP-sulfoquinovose) biosynthesis protein. (406 aa) |
| | Smed_2631 | TIGRFAM: DNA ligase D; DNA ligase D 3'-phosphoesterase domain; DNA polymerase LigD polymerase domain; DNA polymerase LigD ligase region; PFAM: DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMc03959 hypothetical protein. (865 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (301 aa) |
| | Smed_2571 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: sme:SMc00684 hypothetical protein. (382 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | Smed_2562 | PFAM: BolA family protein; KEGG: sme:SMc00698 putative transcription regulator protein; Belongs to the BolA/IbaG family. (93 aa) |
| | Smed_2559 | Cobalt chelatase, pCobT subunit; KEGG: sme:SMc00701 probable cobalamin biosynthesis protein; TIGRFAM: cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase CobT subunit; SMART: von Willebrand factor type A. (631 aa) |
| | Smed_2557 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (212 aa) |
| | Smed_2541 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: sme:SMc00719 hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | Smed_2530 | TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: sme:SMc00731 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa) |
| | Smed_2522 | PFAM: AMP-dependent synthetase and ligase; KEGG: sme:SMc00741 putative fatty-acid-CoA ligase protein. (547 aa) |
| | Smed_2367 | TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; KEGG: sme:SMc01821 dihydropyrimidinase. (484 aa) |
| | Smed_2364 | Putative adenylate/guanylate cyclase; PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: sme:SMc01818 putative adenylate cyclase transmembrane protein. (558 aa) |
| | Smed_2361 | TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sme:SMc01815 dihydropyrimidine dehydrogenase. (437 aa) |
| | Smed_2345 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc01506 putative RNA polymerase sigma-E factor (sigma-24) protein; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa) |
| | Smed_2317 | PFAM: aminotransferase class-III; KEGG: sme:SMc01534 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa) |
| | Smed_2295 | Anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: sme:SMc02725 anthranilate synthase includes: glutamine amidotransferase protein. (729 aa) |
| | queF | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (154 aa) |
| | Smed_2284 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc02713 putative RNA polymerase sigma-E factor (sigma-24) protein; Belongs to the sigma-70 factor family. ECF subfamily. (189 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | Smed_2234 | KEGG: sme:SMc01580 hypothetical protein. (65 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: sme:SMc01569 probable carbamoyl-phosphate synthetase, glutamine-hydrolyzing protein; Belongs to the CarA family. (401 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (671 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (684 aa) |
| | Smed_2218 | PFAM: protein of unknown function DUF1486; KEGG: sme:SMc01558 hypothetical protein. (134 aa) |
| | Smed_2204 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc01667 hypothetical protein. (119 aa) |
| | ribH-2 | 67-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (175 aa) |
| | folD2 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (298 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (463 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | Smed_2019 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (187 aa) |
| | Smed_1997 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc01419 probable RNA polymerase sigma factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa) |
| | Smed_1991 | SMART: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: sme:SMc01491 conserved hypothetical protein. (1023 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (250 aa) |
| | Smed_1960 | KEGG: sme:SMc04343 putative adenylate/guanylate cyclase transmembrane protein. (317 aa) |
| | Smed_1945 | TIGRFAM: HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: sme:SMc04299 hypothetical protein. (250 aa) |
| | Smed_1797 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: sme:SMc04173 hypothetical protein. (219 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (484 aa) |
| | Smed_1763 | Putative Chase2 sensor protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: sme:SMc04307 putative adenylate/guanylate cyclase transmembrane protein. (725 aa) |
| | CobU | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa) |
| | Smed_1760 | TIGRFAM: cobalamin biosynthesis protein CobW; PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: sme:SMc04304 probable cobalamine biosynthesis protein. (354 aa) |
| | CobN | TIGRFAM: cobaltochelatase, CobN subunit; PFAM: CobN/magnesium chelatase; KEGG: sme:SMc04303 probable cobalamin biosynthesis protein. (1273 aa) |
| | Smed_1758 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (214 aa) |
| | Smed_1747 | KEGG: sme:SMc04285 probable cobalamin biosynthesis protein. (145 aa) |
| | Smed_1746 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc04284 probable uroporphyrin-III C-methyltransferase protein; Belongs to the precorrin methyltransferase family. (279 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (429 aa) |
| | Smed_1744 | PFAM: aminotransferase class I and II; KEGG: sme:SMc04281 probable cobalamin biosynthesis protein pyridoxal-phosphate-dependent aminotransferase. (333 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (317 aa) |
| | Smed_1683 | Sterile alpha motif SAM protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; sterile alpha motif SAM protein; Sterile alpha motif homology 2; KEGG: sme:SMa1591 putative adenylate cyclase. (1122 aa) |
| | Smed_1663 | PFAM: transcription antitermination protein NusG; KEGG: atc:AGR_C_797 transcription antitermination protein NusG. (219 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (262 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (338 aa) |
| | Smed_1591 | PFAM: Usg family protein; KEGG: sme:SMc00137 hypothetical protein. (88 aa) |
| | Smed_1585 | TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: sme:SMc00142 probable molybdopterin-guanine dinucleotide biosynthesis protein. (174 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (219 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (349 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (560 aa) |
| | Smed_1562 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. (231 aa) |
| | hemF | Coproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (303 aa) |
| | Smed_1534 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa) |
| | Smed_1533 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa) |
| | Smed_1532 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: sme:SMc00465 probable 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein. (174 aa) |
| | Smed_1506 | PFAM: BolA family protein; KEGG: sme:SMc00487 hypothetical protein; Belongs to the BolA/IbaG family. (77 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (743 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: sme:SMc00495 probable phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) protein. (254 aa) |
| | Smed_1492 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: sme:SMc00508 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | Smed_1481 | PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; molybdopterin binding domain; KEGG: sme:SMc00519 hypothetical protein. (538 aa) |
| | Smed_1411 | Molybdenum cofactor synthesis domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (406 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (164 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: sme:SMc00236 probable indole-3-glycerol phosphate synthase (IGPS) tryptophan biosynthesis lyase decarboxylase protein; Belongs to the TrpC family. (271 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | glmU | Nucleotidyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) |
| | Smed_1385 | PFAM: molybdopterin binding domain; KEGG: sme:SMc00944 hypothetical protein. (253 aa) |
| | Smed_1346 | KEGG: mag:amb0358 hypothetical protein. (793 aa) |
| | Smed_1305 | TIGRFAM: DNA polymerase LigD ligase region; PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMb20912 putative ATP-dependent DNA ligase protein. (343 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (234 aa) |
| | Smed_1291 | KEGG: sme:SMc01190 putative DNA polymerase III, delta' subunit protein. (343 aa) |
| | Smed_1283 | PFAM: Usg family protein; KEGG: sme:SMb21568 hypothetical conserved hyothetical protein, in Caulobacter crescentus located in trpFBA operon. (90 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (376 aa) |
| | queA | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (360 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (181 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: sme:SMc01215 probable carbamoyl-phosphate synthase large chain (ammonia chain arginine biosynthesis) protein; Belongs to the CarB family. (1163 aa) |
| | Smed_1233 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1263 aa) |
| | Smed_1223 | PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron maturase-specific domain protein; KEGG: sme:SMb21045 putative reverse transcriptasematurase protein. (419 aa) |
| | Smed_1210 | Ketosteroid isomerase-related protein-like protein; KEGG: ret:RHE_CH02036 hypothetical protein. (167 aa) |
| | Smed_1208 | PFAM: protein of unknown function DUF336; KEGG: ret:RHE_CH02038 hypothetical protein. (137 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | Smed_1099 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (484 aa) |
| | Smed_1086 | PFAM: CinA domain protein; KEGG: sme:SMc01039 putative competence-damage protein; Belongs to the CinA family. (165 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (323 aa) |
| | Smed_1077 | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (465 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | folE | PFAM: GTP cyclohydrolase I; KEGG: sme:SMc01005 probable GTP cyclohydrolase I protein. (205 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (336 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1401 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1380 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (176 aa) |
| | Smed_0971 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: sme:SMc01324 putative oxidoreductase protein. (297 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (257 aa) |
| | Smed_0952 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: sme:SMc01360 probable aspartate carbamoyltransferase catalytic chain protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | Smed_0935 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: sme:SMc01361 putative dihydropyrimidinase protein. (430 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (430 aa) |
| | DnaE | KEGG: sme:SMc01375 probable DNA polymerase III, alpha chain protein; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1165 aa) |
| | ctaA | Cytochrome oxidase assembly; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (367 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (160 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa) |
| | Smed_0819 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sme:SMc01773 probable riboflavin synthase alpha chain protein. (206 aa) |
| | Smed_0818 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (398 aa) |
| | Smed_0812 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sme:SMc01766 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (337 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: sme:SMc00615 phosphoribosylaminoimidazole synthetase. (356 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (220 aa) |
| | Smed_0780 | TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein; KEGG: sme:SMc00600 probable molybdopterin MPT converting factor, subunit 1 protein. (86 aa) |
| | Smed_0779 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: sme:SMc00599 probable molybdopterin MPT converting factor, subunit 2 protein. (156 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | Smed_0767 | PFAM: DNA polymerase III chi subunit HolC; KEGG: sme:SMc00586 putative DNA polymerase III chi subunit. (149 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (342 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (219 aa) |
| | Smed_0750 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: pfl:PFL_5026 cobalamin synthesis protein/P47K family protein. (320 aa) |
| | Smed_0734 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (499 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (496 aa) |
| | Smed_0705 | KEGG: sme:SMc02559 hypothetical protein. (201 aa) |
| | Smed_0701 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; KEGG: sme:SMc02598 probable nicotinate-nucleotide pyrophosphorylase carboxylating protein; Belongs to the NadC/ModD family. (299 aa) |
| | Smed_0700 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (532 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (359 aa) |
| | Smed_0689 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: sme:SMc02640 UDP-glucuronic acid epimerase protein. (341 aa) |
| | Smed_0688 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: sme:SMc02641 UDP-glucose 6-dehydrogenase protein. (437 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (135 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (500 aa) |
| | Smed_0580 | PFAM: aldo/keto reductase; KEGG: sme:SMc00101 putative oxidoreductase protein. (275 aa) |
| | Smed_0532 | PFAM: protein of unknown function DUF179; KEGG: sme:SMc00019 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (201 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (316 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (366 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (206 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (637 aa) |
| | purD | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; KEGG: sme:SMc00993 probable phosphoribosylamine--glycine ligase protein; Belongs to the GARS family. (423 aa) |
| | Smed_0455 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (180 aa) |
| | atpF1 | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (161 aa) |
| | atpF2 | H+transporting two-sector ATPase B/B' subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). (204 aa) |
| | atpE | H+transporting two-sector ATPase C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (250 aa) |
| | Smed_0435 | PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: sme:SMc00883 hypothetical protein. (294 aa) |
| | RibC | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; KEGG: sme:SMc00909 hypothetical protein; Belongs to the ribF family. (327 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa) |
| | Smed_0367 | KEGG: sme:SMa1630 hypothetical protein. (106 aa) |
| | Smed_0315 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: sme:SMc00774 acetoacetyl-CoA synthetase protein. (650 aa) |
| | folD1 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (299 aa) |
| | FliI | TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase; KEGG: sme:SMc03025 flagellum-specific ATP synthase protein. (467 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (430 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (434 aa) |
| | Smed_0199 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: sme:SMc02275 probable pyrazinamidase/nicotinamidase (includes: pyrazinamidase, nicotinamidase) protein. (199 aa) |
| | Smed_0196 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sme:SMc02272 acyl-transferase transferase protein. (470 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (362 aa) |
| | apaG | PFAM: ApaG domain protein; KEGG: sme:SMc02135 ApaG protein. (130 aa) |
| | Smed_0117 | PFAM: protein of unknown function DUF344; KEGG: sme:SMc02148 hypothetical protein. (300 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (232 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (347 aa) |
| | Smed_0097 | Putative Chase2 sensor protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: sme:SMc02176 putative adenylate cyclase transmembrane protein. (635 aa) |
| | Smed_0057 | Putative Chase2 sensor protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: sme:SMb20776 putative adenylate cyclase protein. (650 aa) |
| | Smed_0015 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (513 aa) |
| | Smed_0007 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (381 aa) |
| | Smed_0004 | Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc01150 putative RNA polymerase sigma-70 factor, ECF subfamily. (427 aa) |
| | Smed_3566 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (160 aa) |
| | Smed_3543 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa) |
| | queG | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (387 aa) |
| | Smed_3520 | PFAM: TspO/MBR family protein; KEGG: atc:AGR_C_485 mitochondrial benzodiazepine receptor/sensory transduction protein. (177 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | Smed_3502 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; KEGG: sme:SMc04051 putative RNA polymerase sigma-E factor (sigma-24) protein. (220 aa) |
| | cmk | TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: sme:SMc00334 putative cytidylate kinase (CMP kinase) protein. (212 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (552 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (625 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (250 aa) |
| | Smed_3396 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: sme:SMc02864 putative thiamine biosynthesis transmembrane protein. (258 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1004 aa) |
| | Smed_3377 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc02845 putative antibiotic resistance protein. (141 aa) |
| | Smed_3344 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (324 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | Smed_3341 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (265 aa) |
| | Smed_3322 | PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: sme:SMc04142 hypothetical protein. (294 aa) |
| | purU-3 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) |
| | coaA | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: sme:SMc02567 probable pantothenate kinase protein. (331 aa) |
| | Smed_3240 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: sme:SMc02763 probable folc bifunctional protein (folylpolyglutamate synthase / dihydrofolate synthase); Belongs to the folylpolyglutamate synthase family. (447 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (304 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: sme:SMc02767 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (215 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (242 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (194 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (343 aa) |
| | Smed_3207 | PFAM: conserved hypothetical protein 701; KEGG: sme:SMc02795 hypothetical protein. (180 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (421 aa) |
| | HolA | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: sme:SMc02802 putative DNA polymerase III, delta subunit. (343 aa) |
| | Smed_3196 | PFAM: AMP-dependent synthetase and ligase; KEGG: sme:SMc04095 putative acyl-CoA synthetase protein. (635 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | purH | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: sme:SMc04088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (536 aa) |
| | Smed_3186 | TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: sme:SMc04084 pyridoxine kinase; Belongs to the pyridoxine kinase family. (293 aa) |
| | Smed_3162 | PFAM: aminotransferase class-III; KEGG: sme:SMc04388 putative omega-amino acid--pyruvate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | RpoH2 | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (288 aa) |
| | Smed_3105 | TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: sme:SMc03867 hypothetical protein. (220 aa) |
| | PhhB | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: sme:SMc03834 putative pterin-4-alpha-carbinolamine dehydratase protein. (105 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1116 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (202 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (393 aa) |
| | Smed_2983 | TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; KEGG: pde:Pden_4616 dihydropyrimidinase. (477 aa) |
| | Smed_2967 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (238 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (330 aa) |
| | Smed_2931 | KEGG: sme:SMc02491 hypothetical protein. (382 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (734 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (188 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (291 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
