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Smed_0196 Smed_0196 RibC RibC Smed_0435 Smed_0435 dxs dxs pdxH pdxH ribB ribB Smed_0580 Smed_0580 Smed_0750 Smed_0750 pdxA pdxA Smed_0818 Smed_0818 Smed_0819 Smed_0819 ribH ribH Smed_1099 Smed_1099 Smed_1208 Smed_1208 purC purC Smed_1532 Smed_1532 Smed_1533 Smed_1533 Smed_1534 Smed_1534 Smed_1562 Smed_1562 cobT cobT cobS cobS cobD cobD Smed_1744 Smed_1744 cobB cobB Smed_1747 Smed_1747 Smed_1758 Smed_1758 CobN CobN Smed_1760 Smed_1760 CobU CobU cobQ cobQ Smed_1945 Smed_1945 pdxJ pdxJ panB panB panC panC ribH-2 ribH-2 Smed_2204 Smed_2204 kbl kbl Smed_2317 Smed_2317 Smed_2530 Smed_2530 Smed_2559 Smed_2559 Smed_2571 Smed_2571 Smed_2667 Smed_2667 Smed_2766 Smed_2766 Smed_2767 Smed_2767 Smed_2812 Smed_2812 Smed_2813 Smed_2813 CbiJ CbiJ Smed_2815 Smed_2815 Smed_2816 Smed_2816 CobH CobH Smed_2819 Smed_2819 Smed_2880 Smed_2880 Smed_2889 Smed_2889 Smed_3105 Smed_3105 Smed_3162 Smed_3162 Smed_3186 Smed_3186 Smed_3240 Smed_3240 Smed_3322 Smed_3322 Smed_3377 Smed_3377
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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Smed_01968-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: sme:SMc02272 acyl-transferase transferase protein. (470 aa)
RibCTIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; KEGG: sme:SMc00909 hypothetical protein; Belongs to the ribF family. (327 aa)
Smed_0435PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: sme:SMc00883 hypothetical protein. (294 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (637 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (206 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (366 aa)
Smed_0580PFAM: aldo/keto reductase; KEGG: sme:SMc00101 putative oxidoreductase protein. (275 aa)
Smed_0750PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: pfl:PFL_5026 cobalamin synthesis protein/P47K family protein. (320 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (342 aa)
Smed_0818Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (398 aa)
Smed_0819TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sme:SMc01773 probable riboflavin synthase alpha chain protein. (206 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa)
Smed_1099uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (484 aa)
Smed_1208PFAM: protein of unknown function DUF336; KEGG: ret:RHE_CH02038 hypothetical protein. (137 aa)
purCTIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: sme:SMc00495 probable phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) protein. (254 aa)
Smed_1532TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: sme:SMc00465 probable 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein. (174 aa)
Smed_1533Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa)
Smed_1534Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (289 aa)
Smed_1562TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: sme:SMc00166 putative oxidoreductase NAD protein. (231 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (338 aa)
cobSCobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (262 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (317 aa)
Smed_1744PFAM: aminotransferase class I and II; KEGG: sme:SMc04281 probable cobalamin biosynthesis protein pyridoxal-phosphate-dependent aminotransferase. (333 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (429 aa)
Smed_1747KEGG: sme:SMc04285 probable cobalamin biosynthesis protein. (145 aa)
Smed_1758cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (214 aa)
CobNTIGRFAM: cobaltochelatase, CobN subunit; PFAM: CobN/magnesium chelatase; KEGG: sme:SMc04303 probable cobalamin biosynthesis protein. (1273 aa)
Smed_1760TIGRFAM: cobalamin biosynthesis protein CobW; PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: sme:SMc04304 probable cobalamine biosynthesis protein. (354 aa)
CobUAdenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (484 aa)
Smed_1945TIGRFAM: HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: sme:SMc04299 hypothetical protein. (250 aa)
pdxJPyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (250 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (291 aa)
ribH-267-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (175 aa)
Smed_2204PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc01667 hypothetical protein. (119 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)
Smed_2317PFAM: aminotransferase class-III; KEGG: sme:SMc01534 beta alanine-pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa)
Smed_2530TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; KEGG: sme:SMc00731 hypothetical protein; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa)
Smed_2559Cobalt chelatase, pCobT subunit; KEGG: sme:SMc00701 probable cobalamin biosynthesis protein; TIGRFAM: cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase CobT subunit; SMART: von Willebrand factor type A. (631 aa)
Smed_2571PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: sme:SMc00684 hypothetical protein. (382 aa)
Smed_2667PFAM: thiamine monophosphate synthase; KEGG: sme:SMc03996 thiamine-phosphate pyrophosphorylase. (217 aa)
Smed_2766PFAM: Creatininase; KEGG: sme:SMc02977 putative creatinine amidohydrolase. (263 aa)
Smed_2767PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: sme:SMc02978 hypothetical protein. (369 aa)
Smed_2812TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03187 probable precorrin-4 C11-methyltransferase protein; Belongs to the precorrin methyltransferase family. (266 aa)
Smed_2813TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03188 probable precorrin-6Y C5,15-methyltransferase (decarboxylating) protein. (413 aa)
CbiJTIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; KEGG: sme:SMc03189 probable precorrin-6X reductase protein. (266 aa)
Smed_2815TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03190 probable precorrin-3B C17-methyltransferase protein. (254 aa)
Smed_2816TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sme:SMc03191 probable precorrin-2 C20-methyltransferase protein; Belongs to the precorrin methyltransferase family. (257 aa)
CobHPFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: sme:SMc03192 probable precorrin-8X methylmutase protein. (210 aa)
Smed_2819precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. (256 aa)
Smed_2880TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; aminotransferase class-III; KEGG: sme:SMc03104 probable 5-aminolevulinic acid synthase (delta-aminolevulinate synthase) (delta-ala synthetase) protein. (406 aa)
Smed_2889PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc03093 hypothetical protein. (159 aa)
Smed_3105TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: sme:SMc03867 hypothetical protein. (220 aa)
Smed_3162PFAM: aminotransferase class-III; KEGG: sme:SMc04388 putative omega-amino acid--pyruvate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
Smed_3186TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: sme:SMc04084 pyridoxine kinase; Belongs to the pyridoxine kinase family. (293 aa)
Smed_3240TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: sme:SMc02763 probable folc bifunctional protein (folylpolyglutamate synthase / dihydrofolate synthase); Belongs to the folylpolyglutamate synthase family. (447 aa)
Smed_3322PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: sme:SMc04142 hypothetical protein. (294 aa)
Smed_3377PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc02845 putative antibiotic resistance protein. (141 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
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