STRINGSTRING
Smed_0004 Smed_0004 Smed_0027 Smed_0027 mutS mutS Smed_0051 Smed_0051 Smed_0057 Smed_0057 Smed_0073 Smed_0073 Smed_0082 Smed_0082 Smed_0095 Smed_0095 Smed_0097 Smed_0097 Smed_0099 Smed_0099 Smed_0118 Smed_0118 Smed_0124 Smed_0124 Smed_0125 Smed_0125 apaG apaG Smed_0150 Smed_0150 Smed_0153 Smed_0153 Smed_0155 Smed_0155 Smed_0165 Smed_0165 Smed_0215 Smed_0215 Smed_0232 Smed_0232 Smed_0234 Smed_0234 Smed_0235 Smed_0235 Smed_0236 Smed_0236 cheB cheB Smed_0239 Smed_0239 cheD cheD Smed_0243 Smed_0243 Smed_0244 Smed_0244 FliG FliG Smed_0248 Smed_0248 Smed_0249 Smed_0249 Smed_0250 Smed_0250 Smed_0254 Smed_0254 Smed_0263 Smed_0263 MotB MotB Smed_0273 Smed_0273 Smed_0275 Smed_0275 Smed_0305 Smed_0305 Smed_0318 Smed_0318 Smed_0320 Smed_0320 Smed_0337 Smed_0337 Smed_0354 Smed_0354 Smed_0383 Smed_0383 Smed_0399 Smed_0399 mutL mutL Smed_0429 Smed_0429 Smed_0430 Smed_0430 Smed_0452 Smed_0452 Smed_0472 Smed_0472 Smed_0489 Smed_0489 Smed_0504 Smed_0504 Smed_0530 Smed_0530 Smed_0543 Smed_0543 Smed_0566 Smed_0566 Smed_0574 Smed_0574 Smed_0577 Smed_0577 Smed_0587 Smed_0587 Smed_0594 Smed_0594 Smed_0603 Smed_0603 Smed_0617 Smed_0617 Smed_0622 Smed_0622 Smed_0629 Smed_0629 Smed_0630 Smed_0630 Smed_0631 Smed_0631 Smed_0638 Smed_0638 Smed_0639 Smed_0639 Smed_0641 Smed_0641 Smed_0657 Smed_0657 recO recO Smed_0697 Smed_0697 Smed_0702 Smed_0702 Smed_0711 Smed_0711 Smed_0714 Smed_0714 Smed_0715 Smed_0715 Smed_0716 Smed_0716 radA radA lptD lptD uvrC uvrC Smed_0840 Smed_0840 Smed_0841 Smed_0841 Smed_0843 Smed_0843 lon lon DnaE DnaE dinB dinB Smed_0925 Smed_0925 PleD PleD Smed_0955 Smed_0955 Smed_0960 Smed_0960 Smed_1016 Smed_1016 Smed_1021 Smed_1021 Smed_1029 Smed_1029 Smed_1089 Smed_1089 ntrC ntrC Smed_1091 Smed_1091 Smed_1092 Smed_1092 Smed_1103 Smed_1103 Smed_1112 Smed_1112 Smed_1145 Smed_1145 Smed_1154 Smed_1154 Smed_1205 Smed_1205 Smed_1216 Smed_1216 uvrA uvrA Smed_1236 Smed_1236 Smed_1245 Smed_1245 Smed_1248 Smed_1248 Smed_1277 Smed_1277 Smed_1305 Smed_1305 lexA lexA Smed_1358 Smed_1358 Smed_1360 Smed_1360 Smed_1361 Smed_1361 Smed_1390 Smed_1390 mfd mfd recG recG ku ku ku-2 ku-2 Smed_1452 Smed_1452 Smed_1460 Smed_1460 Smed_1467 Smed_1467 Smed_1475 Smed_1475 Smed_1480 Smed_1480 recA recA Smed_1525 Smed_1525 Smed_1537 Smed_1537 Smed_1546 Smed_1546 Smed_1550 Smed_1550 Smed_1559 Smed_1559 Smed_1560 Smed_1560 Smed_1569 Smed_1569 Smed_1571 Smed_1571 Smed_1586 Smed_1586 Smed_1598 Smed_1598 Smed_1600 Smed_1600 Smed_1613 Smed_1613 uvrB uvrB Smed_1619 Smed_1619 Smed_1636 Smed_1636 Smed_1677 Smed_1677 Smed_1679 Smed_1679 Smed_1683 Smed_1683 Smed_1709 Smed_1709 Smed_1748 Smed_1748 Smed_1763 Smed_1763 Smed_1764 Smed_1764 Smed_1787 Smed_1787 Smed_1790 Smed_1790 Smed_1795 Smed_1795 Smed_1799 Smed_1799 Smed_1801 Smed_1801 Smed_1802 Smed_1802 Smed_1808 Smed_1808 Smed_1835 Smed_1835 Smed_1840 Smed_1840 Smed_1914 Smed_1914 Smed_1942 Smed_1942 Smed_1960 Smed_1960 Smed_1980 Smed_1980 Smed_1991 Smed_1991 Smed_1997 Smed_1997 Smed_2036 Smed_2036 Smed_2045 Smed_2045 Smed_2050 Smed_2050 Smed_2051 Smed_2051 ligA ligA Smed_2071 Smed_2071 Smed_2128 Smed_2128 Smed_2166 Smed_2166 Smed_2176 Smed_2176 Smed_2213 Smed_2213 Smed_2214 Smed_2214 Smed_2216 Smed_2216 Smed_2226 Smed_2226 Smed_2245 Smed_2245 Smed_2246 Smed_2246 Smed_2254 Smed_2254 ychF ychF Smed_2284 Smed_2284 Smed_2292 Smed_2292 Smed_2328 Smed_2328 Smed_2342 Smed_2342 Smed_2344 Smed_2344 Smed_2345 Smed_2345 Smed_2347 Smed_2347 Smed_2364 Smed_2364 Smed_2380 Smed_2380 Smed_2381 Smed_2381 Smed_2399 Smed_2399 Smed_2402 Smed_2402 Smed_2403 Smed_2403 Smed_2434 Smed_2434 Smed_2437 Smed_2437 Smed_2496 Smed_2496 clpB clpB Smed_2509 Smed_2509 Smed_2514 Smed_2514 Smed_2525 Smed_2525 Smed_2540 Smed_2540 Smed_2561 Smed_2561 Smed_2588 Smed_2588 Smed_2596 Smed_2596 Smed_2605 Smed_2605 Smed_2607 Smed_2607 Smed_2608 Smed_2608 Smed_2631 Smed_2631 ruvB ruvB ruvA ruvA ruvC ruvC Smed_2656 Smed_2656 Smed_2666 Smed_2666 Smed_2683 Smed_2683 Smed_2709 Smed_2709 Smed_2719 Smed_2719 Smed_2721 Smed_2721 Smed_2724 Smed_2724 Smed_2730 Smed_2730 Smed_2756 Smed_2756 Smed_2761 Smed_2761 Smed_2768 Smed_2768 Smed_2798 Smed_2798 Smed_2804 Smed_2804 Smed_2805 Smed_2805 ung ung Smed_2885 Smed_2885 Smed_2886 Smed_2886 Smed_2892 Smed_2892 Smed_2893 Smed_2893 Smed_2931 Smed_2931 Smed_2953 Smed_2953 msrA msrA Smed_2968 Smed_2968 dnaE2 dnaE2 Smed_3022 Smed_3022 Smed_3023 Smed_3023 Smed_3036 Smed_3036 Smed_3054 Smed_3054 Smed_3056 Smed_3056 Smed_3100 Smed_3100 Smed_3106 Smed_3106 Smed_3112 Smed_3112 Smed_3114 Smed_3114 Smed_3115 Smed_3115 Smed_3223 Smed_3223 Smed_3242 Smed_3242 Smed_3246 Smed_3246 Smed_3250 Smed_3250 Smed_3251 Smed_3251 Smed_3252 Smed_3252 Smed_3255 Smed_3255 Smed_3256 Smed_3256 actR actR Smed_3274 Smed_3274 Smed_3279 Smed_3279 Smed_3280 Smed_3280 Smed_3313 Smed_3313 Smed_3373 Smed_3373 nth nth polA polA Smed_3384 Smed_3384 dnaJ dnaJ recF recF msrA-2 msrA-2 Smed_3423 Smed_3423 Smed_3433 Smed_3433 recR recR Smed_3466 Smed_3466 Smed_3468 Smed_3468 Smed_3491 Smed_3491 Smed_3502 Smed_3502 Smed_3511 Smed_3511 uppP uppP Smed_3558 Smed_3558 Smed_3568 Smed_3568 mutM mutM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Smed_0004Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc01150 putative RNA polymerase sigma-70 factor, ECF subfamily. (427 aa)
Smed_0027Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc01128 putative sensor histidine kinase transmembrane protein. (739 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (915 aa)
Smed_0051PFAM: histidine kinase HAMP region domain protein; Cache domain protein; chemotaxis sensory transducer; KEGG: sme:SMc01104 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein. (796 aa)
Smed_0057Putative Chase2 sensor protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: sme:SMb20776 putative adenylate cyclase protein. (650 aa)
Smed_0073TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: Ada metal-binding domain protein; Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; SMART: helix-turn-helix- domain containing protein AraC type; KEGG: sme:SMc01728 putative transcription regulator protein. (370 aa)
Smed_0082PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: sme:SMc01719 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein. (665 aa)
Smed_0095PFAM: Sel1 domain protein repeat-containing protein; KEGG: sme:SMc02178 hypothetical protein. (187 aa)
Smed_0097Putative Chase2 sensor protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: sme:SMc02176 putative adenylate cyclase transmembrane protein. (635 aa)
Smed_0099PFAM: DoxX family protein; KEGG: sme:SMc02174 hypothetical protein. (145 aa)
Smed_0118PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: Phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: sme:SMc02147 probable phosphate regulon sensor histidine kinase transmembrane protein. (415 aa)
Smed_0124Two component transcriptional regulator, winged helix family; TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sme:SMc02140 phosphate regulon transcriptional regulatory protein. (227 aa)
Smed_0125GCN5-related N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring. (158 aa)
apaGPFAM: ApaG domain protein; KEGG: sme:SMc02135 ApaG protein. (130 aa)
Smed_0150PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMa0112 hypothetical protein. (135 aa)
Smed_0153PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; DEAD/H associated domain protein; SMART: DEAD-like helicases; KEGG: sme:SMc02237 putative ATP-dependent helicase protein. (884 aa)
Smed_0155Alkylhydroperoxidase like protein, AhpD family; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (153 aa)
Smed_0165Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc02249 putative sensory transduction histidine kinase transmembrane protein. (1168 aa)
Smed_0215HPr kinase; KEGG: sme:SMc02314 hypothetical protein. (366 aa)
Smed_0232PFAM: chemotaxis sensory transducer; KEGG: sme:SMc03004 putative chemoreceptor (methyl-accepting chemotaxis protein). (532 aa)
Smed_0234PFAM: response regulator receiver; KEGG: sme:SMc03006 chemotaxis regulator protein. (121 aa)
Smed_0235CheA signal transduction histidine kinase; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; KEGG: sme:SMc03007 chemotaxis protein (sensory transduction histidine kinase). (759 aa)
Smed_0236PFAM: CheW domain protein; KEGG: sme:SMc03008 chemotaxis protein. (158 aa)
cheBResponse regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
Smed_0239PFAM: response regulator receiver; KEGG: sme:SMc03011 chemotaxis regulator protein. (129 aa)
cheDCheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family. (183 aa)
Smed_0243PFAM: regulatory protein LuxR; Bacterio-opsin activator HTH domain protein; KEGG: sme:SMc03015 putative transcription regulator protein. (245 aa)
Smed_0244PFAM: regulatory protein LuxR; KEGG: sme:SMc03016 putative transcription regulator protein. (247 aa)
FliGPFAM: flagellar motor switch protein FliG; KEGG: sme:SMc03019 flagellar motor switch protein. (345 aa)
Smed_0248Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (215 aa)
Smed_0249PFAM: surface presentation of antigens (SPOA) protein; KEGG: sme:SMc03021 flagellar motor switch transmembrane protein. (315 aa)
Smed_0250PFAM: MotA/TolQ/ExbB proton channel; KEGG: sme:SMc03022 chemotaxis (motility protein A) transmembrane. (292 aa)
Smed_0254KEGG: sme:SMc03026 hypothetical protein. (190 aa)
Smed_0263Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (163 aa)
MotBPFAM: OmpA/MotB domain protein; KEGG: sme:SMc03042 chemotaxis (motility protein B) transmembrane. (397 aa)
Smed_0273KEGG: sme:SMc03044 chemotaxis protein (motility protein D). (471 aa)
Smed_0275Two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; KEGG: sme:SMc03046 putative transcription regulator protein. (223 aa)
Smed_0305PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: sme:SMc00765 probable methyl-accepting chemotaxis protein. (841 aa)
Smed_0318TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc00776 putative sensor histidine kinase protein. (1138 aa)
Smed_0320PFAM: regulatory protein LuxR; KEGG: pde:Pden_3582 response regulator receiver protein. (275 aa)
Smed_0337RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: response regulator receiver; Sigma-70 region 4 type 2; KEGG: sme:SMc00794 two-component response regulator. (265 aa)
Smed_0354KEGG: sme:SMc00804 hypothetical protein. (413 aa)
Smed_0383PFAM: Catalase domain protein; KEGG: sme:SMc00819 catalase hydroperoxidase HPII(III) protein. (494 aa)
Smed_0399PFAM: methyladenine glycosylase; KEGG: sme:SMc00923 probable DNA-3-methyladenine glycosylase I protein. (211 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (605 aa)
Smed_0429TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc00888 putative contains A 2-component receiver domain protein. (579 aa)
Smed_0430TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; KEGG: sme:SMc00887 hypothetical protein. (449 aa)
Smed_0452PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: sme:SMc00866 hypothetical protein. (385 aa)
Smed_0472TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; KEGG: sme:SMc00992 hypothetical protein. (742 aa)
Smed_0489PFAM: histidine kinase HAMP region domain protein; Cache domain protein; chemotaxis sensory transducer; KEGG: sme:SMc00975 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein. (698 aa)
Smed_0504PFAM: protein of unknown function DUF1006; KEGG: sme:SMc00961 hypothetical protein. (399 aa)
Smed_0530Redoxin domain protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (161 aa)
Smed_0543A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (370 aa)
Smed_0566KEGG: sme:SMc00032 hypothetical protein. (182 aa)
Smed_0574Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; KEGG: sme:SMc00038 hypothetical protein. (772 aa)
Smed_0577PFAM: OsmC family protein; KEGG: sme:SMc00040 hypothetical protein. (140 aa)
Smed_0587Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (200 aa)
Smed_0594PFAM: beta-lactamase; KEGG: sme:SMc00047 putative beta-lactamase signal peptide protein. (296 aa)
Smed_0603PFAM: UspA domain protein; KEGG: sme:SMc00048 hypothetical protein. (164 aa)
Smed_0617Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc00059 putative sensor histidine kinase protein. (525 aa)
Smed_0622KEGG: sme:SMc00063 hypothetical protein. (100 aa)
Smed_0629KEGG: sme:SMc00065 conserved hypothetical signal peptide protein. (83 aa)
Smed_0630Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sme:SMc00458 probable transcription regulator protein. (223 aa)
Smed_0631Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc00129 probable sensor histidine kinase protein. (461 aa)
Smed_0638Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sme:SMc02366 putative transcription regulator protein. (233 aa)
Smed_0639Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc02367 putative sensor histidine kinase transmembrane protein. (465 aa)
Smed_0641Multi-sensor signal transduction histidine kinase; KEGG: sme:SMc02369 putative sensor histidine kinase transmembrane protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; SMART: PAC repeat-containing protein. (772 aa)
Smed_0657KEGG: sme:SMc02385 hypothetical protein. (316 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (249 aa)
Smed_0697PFAM: MOSC domain containing protein; MOSC domain protein beta barrel domain protein; KEGG: sme:SMc02631 hypothetical protein. (283 aa)
Smed_0702Superoxide dismutase copper/zinc binding; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (172 aa)
Smed_0711PFAM: protein of unknown function DUF159; KEGG: sme:SMc02553 hypothetical protein; Belongs to the SOS response-associated peptidase family. (256 aa)
Smed_0714PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc02550 hypothetical protein. (160 aa)
Smed_0715PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc02549 hypothetical protein. (159 aa)
Smed_0716PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc02548 hypothetical protein. (166 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (467 aa)
lptDOrganic solvent tolerance protein; Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane; Belongs to the LptD family. (781 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (674 aa)
Smed_0840PFAM: Antibiotic biosynthesis monooxygenase; KEGG: sme:SMa0558 hypothetical protein. (129 aa)
Smed_0841PFAM: Antibiotic biosynthesis monooxygenase; KEGG: atu:Atu0206 hypothetical protein. (137 aa)
Smed_0843PFAM: Carboxymuconolactone decarboxylase; KEGG: sme:SMa0559 4-carboxymuconolactone decarboxylase, putative. (259 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (806 aa)
DnaEKEGG: sme:SMc01375 probable DNA polymerase III, alpha chain protein; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1165 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (430 aa)
Smed_0925PFAM: response regulator receiver; KEGG: sme:SMc01371 putative 2-component receiver domain protein. (123 aa)
PleDTIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver; KEGG: sme:SMc01370 putative transcription regulator (with tandem N-terminal response regulator domains) protein. (455 aa)
Smed_0955PFAM: DSBA oxidoreductase; KEGG: sme:SMc01342 putative outer membrane protein. (255 aa)
Smed_0960TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: sme:SMc01334 probable penicillin-binding 1A transmembrane protein. (817 aa)
Smed_1016PFAM: small multidrug resistance protein; KEGG: sme:SMc01278 probable chaperone homologue transmembrane protein. (104 aa)
Smed_1021S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (277 aa)
Smed_1029PFAM: SpoVR family protein; KEGG: sme:SMc01265 hypothetical protein. (513 aa)
Smed_1089Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; KEGG: sme:SMc01042 nitrogen regulation protein. (380 aa)
ntrCNitrogen metabolism transcriptional regulator, NtrC, Fis Family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (484 aa)
Smed_1091Multi-sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc01044 probable nitrogen regulation transmembrane protein. (757 aa)
Smed_1092Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; SMART: AAA ATPase; KEGG: sme:SMc01045 probable nitrogen regulation protein. (454 aa)
Smed_1103PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: sme:SMc02122 probable ferredoxin--NADP reductase protein. (270 aa)
Smed_1112PFAM: alpha/beta hydrolase fold; KEGG: sme:SMc02114 hypothetical protein. (261 aa)
Smed_1145PFAM: ComEC/Rec2-related protein; KEGG: sme:SMc02086 hypothetical protein. (799 aa)
Smed_1154TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: sme:SMc02077 putative exodeoxyribonuclease III protein. (263 aa)
Smed_1205TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; KEGG: rle:RL1932 putative modification methylase. (632 aa)
Smed_1216PFAM: metallophosphoesterase; KEGG: rle:RL1938 putative phosphatase. (291 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (973 aa)
Smed_1236Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (170 aa)
Smed_1245PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: sme:SMc01227 putative glycerol trinitrate (GTN) reductase protein. (373 aa)
Smed_1248TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sme:SMc01224 probable thioredoxin reductase protein. (324 aa)
Smed_1277PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: pde:Pden_2817 glutathione-dependent formaldehyde-activating, GFA. (130 aa)
Smed_1305TIGRFAM: DNA polymerase LigD ligase region; PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMb20912 putative ATP-dependent DNA ligase protein. (343 aa)
lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (238 aa)
Smed_1358PFAM: beta-lactamase domain protein; KEGG: aba:Acid345_3957 beta-lactamase-like. (687 aa)
Smed_1360PFAM: small multidrug resistance protein; KEGG: sme:SMc01179 putative multidrug transmembrane resistance signal peptide protein. (114 aa)
Smed_1361PFAM: small multidrug resistance protein; KEGG: sme:SMc01178 putative multidrug transmembrane resistance signal peptide protein. (108 aa)
Smed_1390TIGRFAM: hemimethylated DNA binding protein; PFAM: Hemimethylated DNA-binding region; KEGG: sme:SMc00949 hypothetical protein. (109 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1171 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (701 aa)
kuKu family containing protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (294 aa)
ku-2Ku family containing protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (271 aa)
Smed_1452TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: sme:SMc00292 probable single-stranded-DNA-specific exonuclease protein. (600 aa)
Smed_1460PFAM: beta-lactamase; KEGG: sme:SMa1953 putative beta-lactamase. (334 aa)
Smed_1467TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sme:SMc00531 putative ABC transporter ATP-binding protein. (251 aa)
Smed_1475PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: sme:SMc00524 putative bacterioferritin comigratory protein. (155 aa)
Smed_1480PFAM: TfoX domain protein; KEGG: sme:SMc00520 hypothetical protein. (105 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (361 aa)
Smed_1525Multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc00471 putative sensor histidine kinase transmembrane protein. (872 aa)
Smed_1537PFAM: Hpt domain protein; KEGG: sme:SMc00191 hypothetical protein. (122 aa)
Smed_1546Putative transcriptional regulator, MerR family; TIGRFAM: redox-sensitive transcriptional activator SoxR; PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; KEGG: sme:SMc00182 putative transcription regulator protein. (161 aa)
Smed_1550PFAM: transport-associated; KEGG: sme:SMc00179 hypothetical/unknown protein. (92 aa)
Smed_1559PFAM: regulatory protein LuxR; Autoinducer-binding domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc00170 putative transcription regulator HSL-dependent protein. (246 aa)
Smed_1560PFAM: autoinducer synthesis protein; KEGG: sme:SMc00168 putative autoinducer synthase protein. (214 aa)
Smed_1569PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc00156 hypothetical protein. (135 aa)
Smed_1571Glutathione-disulfide reductase; Maintains high levels of reduced glutathione. (463 aa)
Smed_1586PFAM: Sel1 domain protein repeat-containing protein; KEGG: mgm:Mmc1_2003 Sel1 domain protein repeat-containing protein. (380 aa)
Smed_1598PFAM: Uracil-DNA glycosylase superfamily; KEGG: sme:SMc04210 hypothetical protein. (217 aa)
Smed_1600Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc04212 putative sensor histidine kinase transmembrane protein. (511 aa)
Smed_1613PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; Cache type 2 domain protein; KEGG: sme:SMc04227 probable chemoreceptor (methyl-accepting chemotaxis) transmembrane protein. (603 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (978 aa)
Smed_1619PFAM: heat shock protein DnaJ domain protein; KEGG: sme:SMc04233 hypothetical DnaJ domain protein. (205 aa)
Smed_1636KEGG: sme:SMc04183 putative transmembrane protein. (271 aa)
Smed_1677KEGG: pde:Pden_0257 hypothetical protein. (123 aa)
Smed_1679Hypothetical protein; KEGG: mkm:Mkms_2959 HNH endonuclease. (121 aa)
Smed_1683Sterile alpha motif SAM protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; sterile alpha motif SAM protein; Sterile alpha motif homology 2; KEGG: sme:SMa1591 putative adenylate cyclase. (1122 aa)
Smed_1709KEGG: sme:SMc04246 hypothetical transmembrane signal peptide protein. (134 aa)
Smed_1748PFAM: protein of unknown function DUF81; KEGG: sme:SMc04286 hypothetical transmembrane protein. (261 aa)
Smed_1763Putative Chase2 sensor protein; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: sme:SMc04307 putative adenylate/guanylate cyclase transmembrane protein. (725 aa)
Smed_1764PFAM: alpha/beta hydrolase fold; KEGG: sme:SMc04308 putative oxidoreductase protein. (271 aa)
Smed_1787PFAM: Chloramphenicol phosphotransferase family protein; KEGG: sme:SMc04451 putative chloramphenicol phosphotransferase protein. (220 aa)
Smed_1790PFAM: alpha/beta hydrolase fold; KEGG: sme:SMc04165 putative oxidoreductase protein. (287 aa)
Smed_1795PFAM: response regulator receiver; KEGG: sme:SMc04170 putative two 2-component receiver domains protein. (274 aa)
Smed_1799PFAM: Integral membrane protein TerC; KEGG: sme:SMc04175 putative transmembrane protein. (212 aa)
Smed_1801PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc04177 hypothetical protein. (153 aa)
Smed_1802PFAM: protein of unknown function DUF924; KEGG: sme:SMc04178 hypothetical protein. (187 aa)
Smed_1808KEGG: sme:SMc04183 putative transmembrane protein. (269 aa)
Smed_1835KEGG: nfa:nfa27910 hypothetical protein. (230 aa)
Smed_1840PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc04188 hypothetical protein. (113 aa)
Smed_1914KEGG: nar:Saro_2694 hypothetical protein. (255 aa)
Smed_1942PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: sme:SMc04292 probable adenylate/guanylate cyclase protein. (626 aa)
Smed_1960KEGG: sme:SMc04343 putative adenylate/guanylate cyclase transmembrane protein. (317 aa)
Smed_1980Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; Sigma-70 region 4 type 2; KEGG: sme:SMb20468 putative sensory transduction DNA-binding response regulator protein. (226 aa)
Smed_1991SMART: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: sme:SMc01491 conserved hypothetical protein. (1023 aa)
Smed_1997RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc01419 probable RNA polymerase sigma factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa)
Smed_2036Alkylhydroperoxidase like protein, AhpD family; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (143 aa)
Smed_2045PFAM: phosphoribosyltransferase; KEGG: sme:SMc01463 hypothetical protein. (223 aa)
Smed_2050PFAM: CheW domain protein; KEGG: sme:SMc01468 probable chemotaxis protein. (154 aa)
Smed_2051PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: sme:SMc01469 probable methyl accepting chemotaxis transmembrane protein. (717 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (717 aa)
Smed_2071DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (557 aa)
Smed_2128PFAM: iron-containing alcohol dehydrogenase; KEGG: sme:SMc01582 putative alcohol dehydrogenase protein. (381 aa)
Smed_2166PFAM: regulatory protein LuxR; KEGG: sme:SMc01630 putative transcription regulator protein. (247 aa)
Smed_2176PFAM: CoA-binding domain protein; KEGG: sme:SMc01640 putative acyl-CoA synthetase protein. (687 aa)
Smed_2213Transcriptional regulator, SARP family; KEGG: sme:SMc01543 hypothetical protein. (612 aa)
Smed_2214PFAM: aminoglycoside 3-N-acetyltransferase; KEGG: sme:SMc02813 probable aminoglycoside N3'-acetyltransferase protein. (263 aa)
Smed_2216PFAM: protein of unknown function DUF541; KEGG: sme:SMc01556 hypothetical protein. (264 aa)
Smed_2226TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: sme:SMc01566 probable ATP-dependent DNA helicase protein. (647 aa)
Smed_2245Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sme:SMc01593 putative transcription regulator protein. (233 aa)
Smed_2246Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc01595 putative sensor histidine kinase transmembrane protein. (472 aa)
Smed_2254PFAM: protein of unknown function DUF152; KEGG: sme:SMc02683 conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. (264 aa)
ychFGTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (367 aa)
Smed_2284RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc02713 putative RNA polymerase sigma-E factor (sigma-24) protein; Belongs to the sigma-70 factor family. ECF subfamily. (189 aa)
Smed_2292PFAM: aminoglycoside phosphotransferase; KEGG: sme:SMc02722 putative aminoglycoside 3'-phosphotransferase protein; Belongs to the aminoglycoside phosphotransferase family. (273 aa)
Smed_2328PFAM: small multidrug resistance protein; KEGG: sme:SMc01523 putative methyl viologen/ethidium resistance transmembrane protein. (113 aa)
Smed_2342KEGG: sme:SMc01509 hypothetical protein. (120 aa)
Smed_2344Signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: GAF domain protein; HWE histidine kinase; PAS fold-3 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc01507 hypothetical protein. (500 aa)
Smed_2345RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc01506 putative RNA polymerase sigma-E factor (sigma-24) protein; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa)
Smed_2347RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: response regulator receiver; Sigma-70 region 4 type 2; KEGG: sme:SMc01504 two-component response regulator. (264 aa)
Smed_2364Putative adenylate/guanylate cyclase; PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: sme:SMc01818 putative adenylate cyclase transmembrane protein. (558 aa)
Smed_2380PFAM: Antibiotic biosynthesis monooxygenase; KEGG: sme:SMc01833 hypothetical protein. (98 aa)
Smed_2381Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (179 aa)
Smed_2399KEGG: sme:SMc01953 putative 2-component receiver domain protein. (128 aa)
Smed_2402PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sme:SMc01956 hypothetical protein. (518 aa)
Smed_2403PFAM: NADPH-dependent FMN reductase; KEGG: sme:SMc01960 putative oxidoreductase protein. (185 aa)
Smed_2434KEGG: jan:Jann_2415 hypothetical protein. (178 aa)
Smed_2437KEGG: sme:SMc02026 putative beta-lactamase precursor protein. (290 aa)
Smed_2496PFAM: Siderophore-interacting protein; FAD-binding 9 siderophore-interacting domain protein; KEGG: pde:Pden_4240 FAD-binding 9, siderophore-interacting domain protein. (333 aa)
clpBATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (868 aa)
Smed_2509Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (85 aa)
Smed_2514PFAM: NUDIX hydrolase; KEGG: sme:SMc02448 putative mutator protein 7,8-dihydro-8-oxoguanine-triphosphatase. (135 aa)
Smed_2525PFAM: HhH-GPD family protein; KEGG: sme:SMc00736 putative DNA-3-methyladenine glycosidase II protein. (215 aa)
Smed_2540PFAM: response regulator receiver; KEGG: sme:SMc00720 putative 2-component receiver domain protein. (119 aa)
Smed_2561PFAM: heat shock protein DnaJ domain protein; KEGG: sme:SMc00699 hypothetical protein. (211 aa)
Smed_2588PFAM: protein of unknown function DUF886; KEGG: sme:SMc00667 hypothetical protein. (197 aa)
Smed_2596Transcriptional regulator, TetR family; PFAM: regulatory protein TetR; Tetracyclin repressor domain protein; KEGG: sme:SMc01715 hypothetical protein. (257 aa)
Smed_2605Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sme:SMc00654 response regulator,controls chromosomal replication initiation protein. (233 aa)
Smed_2607PFAM: response regulator receiver; KEGG: sme:SMc00653 putative 2-component receiver domain protein. (120 aa)
Smed_2608KEGG: sme:SMc00652 hypothetical protein. (220 aa)
Smed_2631TIGRFAM: DNA ligase D; DNA ligase D 3'-phosphoesterase domain; DNA polymerase LigD polymerase domain; DNA polymerase LigD ligase region; PFAM: DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMc03959 hypothetical protein. (865 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (346 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (205 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (167 aa)
Smed_2656PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: sme:SMc03985 probable adenylate/guanylate cyclase protein. (634 aa)
Smed_2666PFAM: Sel1 domain protein repeat-containing protein; KEGG: sme:SMc03995 hypothetical protein. (381 aa)
Smed_2683Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver; sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: sme:SMc04011 putative sigma-54-dependent transcription regulator protein. (549 aa)
Smed_2709PFAM: protein of unknown function DUF459; KEGG: sme:SMc04025 hypothetical protein. (416 aa)
Smed_2719PFAM: response regulator receiver; KEGG: sme:SMc04044 putative 2-component receiver domain protein. (120 aa)
Smed_2721PFAM: Sel1 domain protein repeat-containing protein; KEGG: pcu:pc0710 hypothetical protein. (128 aa)
Smed_2724PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc04046 hypothetical protein. (134 aa)
Smed_2730RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: sme:SMc04051 putative RNA polymerase sigma-E factor (sigma-24) protein; Belongs to the sigma-70 factor family. ECF subfamily. (174 aa)
Smed_2756Putative adenylate/guanylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: sme:SMc03937 putative adenylate/guanylate cyclase protein. (406 aa)
Smed_2761Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; SMART: PAS domain containing protein; KEGG: sme:SMc03942 hypothetical protein. (788 aa)
Smed_2768SMART: WD-40 repeat protein; KEGG: sme:SMc02979 hypothetical protein. (329 aa)
Smed_2798PFAM: Integral membrane protein TerC; KEGG: sme:SMc03171 hypothetical protein. (251 aa)
Smed_2804PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: sme:SMc03177 DNA ligase. (537 aa)
Smed_2805Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; CHASE domain protein; PAS fold-3 domain protein; KEGG: sme:SMc03178 hypothetical protein. (878 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (241 aa)
Smed_2885PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: sme:SMc03099 putative adenylate cyclase protein. (588 aa)
Smed_2886PFAM: alpha/beta hydrolase fold; KEGG: sme:SMc03098 hypothetical protein. (290 aa)
Smed_2892PFAM: CheW domain protein; KEGG: sme:SMc03090 putative chemotaxis protein. (159 aa)
Smed_2893TIGRFAM: PAS sensor protein; PFAM: chemotaxis sensory transducer; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein; KEGG: sme:SMc03087 probable chemoreceptor (methyl-accepting chemotaxis protein). (589 aa)
Smed_2931KEGG: sme:SMc02491 hypothetical protein. (382 aa)
Smed_2953KEGG: sme:SMc02468 hypothetical protein. (213 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (198 aa)
Smed_2968KEGG: sme:SMc03233 hypothetical protein. (462 aa)
dnaE2DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1116 aa)
Smed_3022KEGG: sme:SMc03789 hypothetical protein. (471 aa)
Smed_3023KEGG: sme:SMc03790 hypothetical protein. (318 aa)
Smed_3036Alkylhydroperoxidase like protein, AhpD family; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (111 aa)
Smed_3054TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: sme:SMc03818 putative exodeoxyribonuclease III protein. (268 aa)
Smed_3056Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sme:SMc03820 putative transcription regulator protein. (253 aa)
Smed_3100PFAM: protein of unknown function DUF81; KEGG: sme:SMc03862 hypothetical transmembrane protein. (248 aa)
Smed_3106KEGG: sme:SMc03868 hypothetical protein. (161 aa)
Smed_3112PFAM: transcription factor CarD; KEGG: sme:SMc03874 CarD family transcriptional regulator. (189 aa)
Smed_3114PFAM: RNA-binding S4 domain protein; KEGG: sme:SMc03876 hypothetical heat shock-like protein. (137 aa)
Smed_3115PFAM: helicase domain protein; KEGG: sme:SMc03877 hypothetical protein. (1026 aa)
Smed_3223PFAM: HpcH/HpaI aldolase; KEGG: sme:SMc02778 putative hydroxyacid aldolase protein; Belongs to the HpcH/HpaI aldolase family. (266 aa)
Smed_3242TIGRFAM: Double-strand break repair helicase AddA; PFAM: UvrD/REP helicase; KEGG: sme:SMc02760 putative ATP-dependent nuclease/helicase protein; Belongs to the helicase family. UvrD subfamily. (1189 aa)
Smed_3246Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc02756 putative sensor histidine kinase protein. (826 aa)
Smed_3250HPr kinase; KEGG: sme:SMc02752 hypothetical protein. (161 aa)
Smed_3251Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: sme:SMc04446 histidine kinase sensory transmembrane protein. (578 aa)
Smed_3252Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sme:SMc02560 transcriptional regulatory protein. (240 aa)
Smed_3255PFAM: Peptidoglycan-binding LysM; transport-associated; SMART: Transport-associated and nodulation region; KEGG: sme:SMc02564 hypothetical protein. (157 aa)
Smed_3256PFAM: 2OG-Fe(II) oxygenase; KEGG: sme:SMc02566 probable DNA repair system specific for alkylated DNA protein. (203 aa)
actRTwo component transcriptional regulator, Fis family; Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response. (194 aa)
Smed_3274Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sme:SMc02585 sensor histidine kinase transmembrane protein. (433 aa)
Smed_3279Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: sit:TM1040_3231 periplasmic sensor hybrid histidine kinase. (834 aa)
Smed_3280Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: sit:TM1040_3232 two component transcriptional regulator, winged helix family. (241 aa)
Smed_3313PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: sme:SMc04151 putative ferredoxin protein. (321 aa)
Smed_3373TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: helix-turn-helix- domain containing protein AraC type; Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; KEGG: sme:SMc02841 putative methylated-DNA--protein-cysteine methyltransferase transcription regulator. (290 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (236 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1004 aa)
Smed_3384KEGG: sme:SMc02853 hypothetical transmembrane protein. (315 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (375 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (409 aa)
msrA-2Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (217 aa)
Smed_3423PFAM: transport-associated; KEGG: sme:SMc02894 hypothetical protein. (119 aa)
Smed_3433Conserved hypothetical protein 103; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (107 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
Smed_3466PFAM: DoxX family protein; KEGG: sme:SMc00346 hypothetical protein. (150 aa)
Smed_3468PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: mmr:Mmar10_0575 glutathione-dependent formaldehyde-activating, GFA. (163 aa)
Smed_3491PFAM: protein of unknown function DUF892; KEGG: sme:SMc00371 hypothetical protein. (163 aa)
Smed_3502RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; KEGG: sme:SMc04051 putative RNA polymerase sigma-E factor (sigma-24) protein. (220 aa)
Smed_3511PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: ret:RHE_CH01077 hypothetical protein. (138 aa)
uppPPutative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (268 aa)
Smed_3558PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: sme:SMc00431 hypothetical protein. (134 aa)
Smed_3568PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sme:SMc01159 putative oxidoreductase protein. (301 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (306 aa)
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.