STRINGSTRING
mus-9 mus-9 NCU10467 NCU10467 NCU01771 NCU01771 uvs-2 uvs-2 NCU03924 NCU03924 mei-3 mei-3 NCU06833 NCU06833 mus-25 mus-25 uvs-6 uvs-6 NCU05006 NCU05006 NCU00081 NCU00081 PIF1 PIF1 mus-21 mus-21 NCU09503 NCU09503 mus-41 mus-41 NCU09439 NCU09439 NCU06049 NCU06049 mus-50 mus-50 NCU08879 NCU08879 NCU08806 NCU08806 mus-81 mus-81 mph1 mph1 qde-3 qde-3 NCU00517 NCU00517 mus-23 mus-23 mus-11 mus-11 NCU00470 NCU00470 NCU04749 NCU04749 NCU03820 NCU03820 NCU03337 NCU03337 NCU16423 NCU16423 NCU16422 NCU16422
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mus-9Phosphatidyl inositol 3-kinase; Belongs to the PI3/PI4-kinase family. (2492 aa)
NCU10467Replication factor C subunit 4. (357 aa)
NCU01771DNA repair protein rhp57. (510 aa)
uvs-2Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (501 aa)
NCU03924DNA repair protein Rtt107. (847 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
NCU06833UvrD_C_2 domain-containing protein. (722 aa)
mus-25DNA repair and recombination protein RAD54. (835 aa)
uvs-6UVS6. (1314 aa)
NCU05006Cytochrome P450. (461 aa)
NCU00081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (695 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (931 aa)
mus-21Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2939 aa)
NCU09503Uncharacterized protein. (1048 aa)
mus-41DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein uvs-2/rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1228 aa)
NCU09439RecQ mediated genome instability protein Rmi1. (284 aa)
NCU06049DNA damage response protein RcaA. (912 aa)
mus-50UvrD/REP helicase. (1105 aa)
NCU08879BRCT domain-containing protein. (1160 aa)
NCU08806RECA_2 domain-containing protein. (442 aa)
mus-81Crossover junction endonuclease mus-81; Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (645 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
qde-3RecQ family helicase. (2330 aa)
NCU00517Cell cycle checkpoint protein RAD17. (944 aa)
mus-23Double-strand break repair protein mus-23; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (739 aa)
mus-11DNA repair and recombination protein mus-11; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the mei-3/rad51 recombinase (By similarity). (600 aa)
NCU00470DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (484 aa)
NCU04749DNA replication helicase Dna2. (1727 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
NCU16423Uncharacterized protein. (378 aa)
NCU16422Uncharacterized protein. (79 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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