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NCU10477 NCU10477 NCU11053 NCU11053 rpt-2 rpt-2 NCU01090 NCU01090 ubi ubi mus-8 mus-8 scon-2 scon-2 rpn-6 rpn-6 NCU03437 NCU03437 NCU04024 NCU04024 NCU04618 NCU04618 NCU04608 NCU04608 NCU04607 NCU04607 NCU03652 NCU03652 pca-6 pca-6 NCU04302 NCU04302 NCU04256 NCU04256 NCU03649 NCU03649 NCU03623 NCU03623 NCU03610 NCU03610 NCU03714 NCU03714 NCU03704 NCU03704 NCU03668 NCU03668 NCU01225 NCU01225 NCU05363 NCU05363 rpn-10 rpn-10 NCU02967 NCU02967 rpt-3 rpt-3 NCU02289 NCU02289 NCU04370 NCU04370 NCU03356 NCU03356 csn-1 csn-1 csn-5 csn-5 NCU04513 NCU04513 NCU06484 NCU06484 NCU06483 NCU06483 NCU00400 NCU00400 rpt-5 rpt-5 rpn-7 rpn-7 NCU04049 NCU04049 cul-4 cul-4 rpn-12 rpn-12 pca-1 pca-1 NCU10046 NCU10046 pcb-7 pcb-7 rpn-2 rpn-2 NCU09846 NCU09846 csn-4 csn-4 pcb-1 pcb-1 NCU09302 NCU09302 pca-3 pca-3 NCU05939 NCU05939 NCU07387 NCU07387 rpt-4 rpt-4 upl-1 upl-1 rad23 rad23 NCU09196 NCU09196 NCU06882 NCU06882 NCU02382 NCU02382 rpn-3 rpn-3 rpn-9 rpn-9 NCU04800 NCU04800 NCU05592 NCU05592 sip-5 sip-5 NCU05579 NCU05579 NCU01268 NCU01268 csn-3 csn-3 NCU06648 NCU06648 NCU03736 NCU03736 NCU01188 NCU01188 csn-6 csn-6 rpn-1 rpn-1 pca-5 pca-5 ddi-1 ddi-1 NCU07264 NCU07264 dim-8 dim-8 sem-1 sem-1 NCU07342 NCU07342 NCU07994 NCU07994 NCU08523 NCU08523 NCU05716 NCU05716 pcb-6 pcb-6 pcb-5 pcb-5 pcb-2 pcb-2 NCU00537 NCU00537 NCU02113 NCU02113 rpt-1 rpt-1 NCU03146 NCU03146 rpn-11 rpn-11 NCU00734 NCU00734 NCU03309 NCU03309 pcb-3 pcb-3 NCU02151 NCU02151 NCU00723 NCU00723 NCU02043 NCU02043 NCU00869 NCU00869 NCU00770 NCU00770 NCU02498 NCU02498 NCU02493 NCU02493 NCU02490 NCU02490 csn-7a csn-7a ubr1 ubr1 NCU03028 NCU03028 rpn-5 rpn-5 NCU01919 NCU01919 NCU02535 NCU02535 un-7 un-7 NCU00595 NCU00595 csn-2 csn-2 scon-3 scon-3 rpn-8 rpn-8 pca-2 pca-2 B11B22.010 B11B22.010 pcb-4 pcb-4 pca-4 pca-4 NCU09006 NCU09006 NCU06213 NCU06213 NCU02431 NCU02431 NCU08875 NCU08875 NCU09866 NCU09866 NCU06372 NCU06372 NCU03526 NCU03526 NCU03406 NCU03406 NCU05620 NCU05620 NCU08040 NCU08040 cul-1 cul-1 NCU05393 NCU05393 NCU01679 NCU01679 NCU02688 NCU02688 NCU02634 NCU02634 NCU02532 NCU02532 NCU09813 NCU09813
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU10477Ubiquitin-conjugating enzyme E2. (156 aa)
NCU1105326S proteasome non-ATPase regulatory subunit 9. (229 aa)
rpt-226S protease regulatory subunit 4; Belongs to the AAA ATPase family. (459 aa)
NCU01090Uncharacterized protein. (656 aa)
ubiPolyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...] (305 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
scon-2Probable E3 ubiquitin ligase complex SCF subunit scon-2; Component of the SCF(scon-2) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor; Belongs to the WD repeat MET30/SCONB/SCON-2 family. (650 aa)
rpn-626S proteasome non-ATPase regulatory subunit 11. (424 aa)
NCU03437Uncharacterized protein. (995 aa)
NCU04024HECT domain-containing protein. (1466 aa)
NCU04618Uncharacterized protein. (1110 aa)
NCU04608Uncharacterized protein. (514 aa)
NCU04607Uncharacterized protein. (441 aa)
NCU03652SNF2 family helicase/ATPase. (1548 aa)
pca-6Proteasome subunit alpha type. (265 aa)
NCU04302Ubiquitin-conjugating enzyme E; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
NCU04256IFRD domain-containing protein. (466 aa)
NCU03649Uncharacterized protein. (608 aa)
NCU03623Ubiquitin-conjugating enzyme E; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
NCU03610NEDD8-conjugating enzyme UBC12; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
NCU03714Thioredoxin. (580 aa)
NCU03704Ubiquitin carboxyl-terminal hydrolase. (331 aa)
NCU03668WD domain-containing protein. (792 aa)
NCU01225Ubiquitin conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (235 aa)
NCU0536326S protease regulatory subunit 8; Belongs to the AAA ATPase family. (389 aa)
rpn-1026S proteasome regulatory subunit S5A. (303 aa)
NCU02967Ankyrin repeat domain-containing protein. (237 aa)
rpt-326S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (421 aa)
NCU02289Ubiquitin-conjugating enzyme E2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
NCU04370Ubiquitin-activating enzyme E1 1; Belongs to the ubiquitin-activating E1 family. (1035 aa)
NCU03356Uncharacterized protein. (611 aa)
csn-1COP9 signalosome complex subunit 1; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex. (425 aa)
csn-5COP9 signalosome complex subunit 5; Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex; Belongs to the peptidase M67A family. CSN5 subfamily. (336 aa)
NCU04513Ubiquitin conjugating enzyme Ubc14. (204 aa)
NCU06484Uncharacterized protein. (1955 aa)
NCU06483F-box and WD repeat-containing protein. (650 aa)
NCU00400Uncharacterized protein. (1007 aa)
rpt-5Regulatory particle, ATPase-like-5 protein; Belongs to the AAA ATPase family. (460 aa)
rpn-7Proteasome regulatory particle. (492 aa)
NCU04049Uncharacterized protein. (548 aa)
cul-4Ubiquitin ligase subunit CulD; Belongs to the cullin family. (1039 aa)
rpn-1226S proteasome non-ATPase regulatory subunit 8. (289 aa)
pca-1Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (254 aa)
NCU10046Ubiquitin conjugating enzyme Ubc8; Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
pcb-7Proteasome subunit beta; Belongs to the peptidase T1B family. (268 aa)
rpn-226S proteasome regulatory subunit RPN2; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1188 aa)
NCU09846SP-RING-type domain-containing protein. (1231 aa)
csn-4COP9 signalosome complex subunit 4; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex. (440 aa)
pcb-1Proteasome subunit beta. (229 aa)
NCU09302DNA damage-binding protein cmr1; DNA-binding protein that binds to both single- and double- stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes. (521 aa)
pca-3Proteasome subunit alpha type. (251 aa)
NCU05939Cell division control protein 4. (1046 aa)
NCU07387RING-type domain-containing protein. (547 aa)
rpt-4Proteasome 26S subunit; Belongs to the AAA ATPase family. (390 aa)
upl-1E3 ubiquitin-protein ligase bre1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (724 aa)
rad23Rad23-like protein. (383 aa)
NCU09196Uncharacterized protein. (866 aa)
NCU06882RBR-type E3 ubiquitin transferase. (537 aa)
NCU02382Ubiquitin carboxyl-terminal hydrolase. (522 aa)
rpn-326S proteasome non-ATPase regulatory subunit 3. (552 aa)
rpn-9Proteasome regulatory particle subunit. (381 aa)
NCU04800E3 ubiquitin-protein ligase. (1145 aa)
NCU05592Ubiquitin-conjugating enzyme. (264 aa)
sip-5Protein sip-5; May negatively regulate the snf-1 kinase; Belongs to the SIP5 family. (857 aa)
NCU05579Uncharacterized protein. (714 aa)
NCU01268Ubiquitin-conjugating enzyme E2 6. (317 aa)
csn-3COP9 signalosome complex subunit 3; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex. (497 aa)
NCU06648Polarized growth protein Boi2. (945 aa)
NCU03736Uncharacterized protein. (338 aa)
NCU01188Ubiquitin conjugating enzyme. (238 aa)
csn-6COP9 signalosome complex subunit 6; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex. (497 aa)
rpn-126S proteasome regulatory subunit rpn-1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (902 aa)
pca-5Proteasome subunit alpha type. (245 aa)
ddi-1DNA damage-inducible protein 1; Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. (439 aa)
NCU07264Ubiquitin-conjugating enzyme E2 15; Belongs to the ubiquitin-conjugating enzyme family. (175 aa)
dim-8DNA damage-binding protein 1. (1158 aa)
sem-1Putative 26S proteasome complex subunit sem-1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis; Belongs to the DSS1/SEM1 family. (91 aa)
NCU07342Uncharacterized protein. (607 aa)
NCU07994Uncharacterized protein. (375 aa)
NCU08523Uncharacterized protein. (325 aa)
NCU05716Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (300 aa)
pcb-6Proteasome component C5. (265 aa)
pcb-5Proteasome subunit beta. (291 aa)
pcb-2Proteasome subunit beta type 7. (275 aa)
NCU00537Uncharacterized protein. (346 aa)
NCU02113Ubiquitin-conjugating enzyme E2 13; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
rpt-126S protease regulatory subunit 7; Belongs to the AAA ATPase family. (439 aa)
NCU03146F-box protein pof7. (583 aa)
rpn-1126S proteasome regulatory subunit RPN11. (338 aa)
NCU00734Ulp1 protease. (257 aa)
NCU03309Nedd8-like protein. (78 aa)
pcb-3Proteasome subunit beta. (205 aa)
NCU02151WD repeat containing protein 23. (677 aa)
NCU00723Znf1p. (304 aa)
NCU02043UPF0326 protein hag1. (312 aa)
NCU00869Uncharacterized protein. (991 aa)
NCU00770Uncharacterized protein. (1845 aa)
NCU02498Cullin-3; Belongs to the cullin family. (838 aa)
NCU02493Proteasome subunit alpha type. (297 aa)
NCU02490DnaJ domain-containing protein. (461 aa)
csn-7aCOP9 signalosome complex subunit 7a; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex. (417 aa)
ubr1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2156 aa)
NCU03028Deubiquitination-protection protein dph1. (431 aa)
rpn-526S proteasome non-ATPase regulatory subunit 12. (494 aa)
NCU01919Ubiquitin carboxyl-terminal hydrolase. (548 aa)
NCU02535Uncharacterized protein. (533 aa)
un-7Protein png-1; Belongs to the transglutaminase-like superfamily. PNGase family. (412 aa)
NCU00595Ubiquitin thiolesterase. (666 aa)
csn-2COP9 signalosome complex subunit 2; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex. (490 aa)
scon-3E3 ubiquitin ligase complex SCF subunit scon-3; Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor (By similarity). (171 aa)
rpn-826S proteasome regulatory subunit rpn-8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (352 aa)
pca-2Probable proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (249 aa)
B11B22.010E3 ubiquitin-protein ligase TOM1-like; Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins; Belongs to the UPL family. TOM1/PTR1 subfamily. (4076 aa)
pcb-4Probable proteasome subunit beta type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (203 aa)
pca-4Proteasome subunit alpha type. (269 aa)
NCU09006NEDD8-activating enzyme E1 regulatory subunit, variant. (477 aa)
NCU06213MIZ zinc finger protein. (525 aa)
NCU02431RING-14 protein, variant. (436 aa)
NCU08875Cullin binding protein CanA, variant 1. (1348 aa)
NCU09866Thyroid hormone receptor interactor 12. (2020 aa)
NCU06372Ubiquitin carboxyl-terminal hydrolase. (253 aa)
NCU03526Ubiquitin-activating enzyme E1 3. (662 aa)
NCU03406Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (109 aa)
NCU05620Proteasome activator subunit 4, variant. (1955 aa)
NCU08040NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. (548 aa)
cul-1Cullin 1, variant; Belongs to the cullin family. (776 aa)
NCU05393Uncharacterized protein. (708 aa)
NCU01679Uncharacterized protein. (624 aa)
NCU02688Ubiquitin-conjugating enzyme E2Z. (451 aa)
NCU02634RPN13_C domain-containing protein. (393 aa)
NCU02532NEDD8-activating enzyme E1 catalytic subunit. (435 aa)
NCU09813SMT3, variant 1. (99 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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