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NCU11252 NCU11252 chl1 chl1 NCU03909 NCU03909 NCU01447 NCU01447 NCU03464 NCU03464 NCU01580 NCU01580 NCU01551 NCU01551 NCU01831 NCU01831 NCU01706 NCU01706 NCU01515 NCU01515 NCU07775 NCU07775 prk-3 prk-3 NCU04206 NCU04206 NCU04136 NCU04136 NCU01322 NCU01322 NCU01067 NCU01067 NCU04770 NCU04770 NCU04363 NCU04363 ctc-1 ctc-1 NCU01625 NCU01625 NCU00448 NCU00448 NCU04495 NCU04495 NCU05120 NCU05120 NCU00095 NCU00095 NCU06470 NCU06470 NCU06446 NCU06446 NCU06438 NCU06438 NCU03956 NCU03956 NCU04984 NCU04984 NCU07757 NCU07757 trf-3 trf-3 NCU06889 NCU06889 NCU02223 NCU02223 NCU05809 NCU05809 NCU04761 NCU04761 NCU05523 NCU05523 trf-2 trf-2 MED5 MED5 NCU07013 NCU07013 NCU08560 NCU08560 NCU08553 NCU08553 NCU08729 NCU08729 NCU00806 NCU00806 NCU09378 NCU09378 NCU03096 NCU03096 NCU03095 NCU03095 NCU03047 NCU03047 NCU02103 NCU02103 NCU09748 NCU09748 NCU03315 NCU03315 NCU09259 NCU09259 NCU02615 NCU02615 NCU02661 NCU02661 NCU01899 NCU01899 NCU02950 NCU02950 NCU02587 NCU02587 NCU02563 NCU02563 hat-2-2 hat-2-2 iws-1 iws-1 stk-1 stk-1 spt-6 spt-6 rtf-1 rtf-1 ctc-2 ctc-2 tcf-29 tcf-29 NCU03782 NCU03782 NCU09300 NCU09300 stk-47 stk-47 NCU07289 NCU07289 NCU16790 NCU16790 NCU02052 NCU02052
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCU11252Cyclin Pch1; Belongs to the cyclin family. (547 aa)
chl1ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (1068 aa)
NCU03909Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (302 aa)
NCU01447Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (138 aa)
NCU03464Transcription factor TFIID complex subunit Taf13. (215 aa)
NCU01580Transcription factor TFIIH subunit Tfb4. (439 aa)
NCU01551Uncharacterized protein. (312 aa)
NCU01831General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa)
NCU01706MYB DNA-binding domain-containing protein. (438 aa)
NCU01515DNA-directed RNA polymerase II polypeptide. (337 aa)
NCU07775TAFII28 domain-containing protein. (410 aa)
prk-3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (407 aa)
NCU04206Uncharacterized protein. (329 aa)
NCU04136Transcription initiation factor TFIID subunit. (801 aa)
NCU01322Transcription factor TFIIE complex alpha subunit. (353 aa)
NCU01067CYCLIN domain-containing protein. (427 aa)
NCU04770TATA-binding protein. (257 aa)
NCU04363Uncharacterized protein. (690 aa)
ctc-1FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa)
NCU01625DNA repair helicase RAD3. (806 aa)
NCU00448DUF4211 domain-containing protein. (726 aa)
NCU04495C-type cyclin. (442 aa)
NCU05120DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1287 aa)
NCU00095Tetratricopeptide repeat protein 1. (1279 aa)
NCU06470CID domain-containing protein. (373 aa)
NCU06446Uncharacterized protein. (489 aa)
NCU06438DNA repair helicase RAD25. (862 aa)
NCU03956Plus3 domain-containing protein. (601 aa)
NCU04984Uncharacterized protein. (339 aa)
NCU07757Transcription initiation factor TFIID complex 60 kDa subunit. (465 aa)
trf-3Transcription elongation factor spt5; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (1054 aa)
NCU06889Uncharacterized protein. (532 aa)
NCU02223TFIID_20kDa domain-containing protein. (836 aa)
NCU05809Uncharacterized protein. (377 aa)
NCU04761Uncharacterized protein. (568 aa)
NCU05523RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa)
trf-2Transcription elongation factor spt4; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (120 aa)
MED5Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1154 aa)
NCU07013RTR1-type domain-containing protein. (365 aa)
NCU08560Acyl_transf_3 domain-containing protein. (481 aa)
NCU08553DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (130 aa)
NCU08729Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (245 aa)
NCU00806Uncharacterized protein. (238 aa)
NCU09378DNA-directed RNA polymerase II polypeptide. (146 aa)
NCU03096Bromodomain associated domain-containing protein. (231 aa)
NCU03095Transcription initiation factor TFIID subunit 7. (563 aa)
NCU03047Uncharacterized protein. (345 aa)
NCU02103DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1761 aa)
NCU09748Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (115 aa)
NCU03315Uncharacterized protein. (407 aa)
NCU09259Uncharacterized protein. (625 aa)
NCU02615Uncharacterized protein. (421 aa)
NCU02661DNA-directed RNA polymerase II polypeptide. (171 aa)
NCU01899Uncharacterized protein. (650 aa)
NCU02950Uncharacterized protein. (451 aa)
NCU02587RNA polymerase II transcription factor B subunit 3. (362 aa)
NCU02563Transcription elongation factor S-II. (298 aa)
hat-2-2Histone acetyl transferase-2. (1116 aa)
iws-1Transcription factor iws-1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. (430 aa)
stk-1Serine/threonine-protein kinase bur1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the mus-8/ubc2 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). (559 aa)
spt-6Transcription elongation factor spt-6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1402 aa)
rtf-1General transcription and DNA repair factor IIH subunit rtf-1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has b [...] (72 aa)
ctc-2FACT complex subunit ctc-2; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1032 aa)
tcf-29General transcription and DNA repair factor IIH subunit tcf-29; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has [...] (663 aa)
NCU03782DNA-directed RNA polymerase II subunit RPB11. (133 aa)
NCU09300RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (868 aa)
stk-47Protein kinase. (1250 aa)
NCU07289Transcription initiation factor IIB, variant. (348 aa)
NCU16790CDC73_C domain-containing protein. (409 aa)
NCU02052Transcription initiation factor TFIId 127kD subunit, variant. (1870 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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