(38 nodes) Mixed, incl. Fatty acid beta-oxidation, and Leucine catabolic process network (Neurospora crassa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	fox-2	Peroxisomal hydratase-dehydrogenase-epimerase; Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3- ketoacyl-CoA. (894 aa)
	NCU01378	Acetoacetyl-CoA synthase. (708 aa)
	NCU03618	Integral membrane protein. (658 aa)
	NCU05419	Hydroxymethylglutaryl-CoA lyase. (399 aa)
	NCU08004	Electron transfer flavoprotein alpha-subunit. (348 aa)
	NCU00055	Catechol 1,2-dioxygenase 1. (323 aa)
	NCU00446	Acetoacetyl-CoA synthase. (689 aa)
	NCU06448	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	NCU04393	3-hydroxyacyl-CoA dehydrogenase. (323 aa)
	NCU04072	Catechol dioxygenase. (297 aa)
	NCU00299	Peroxisomal D3,D2-enoyl-CoA isomerase. (279 aa)
	NCU10016	Thermophilic desulfurizing enzyme family protein. (454 aa)
	NCU09058	Enoyl-CoA hydratase. (343 aa)
	NCU09646	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (415 aa)
	NCU09553	3-hydroxybutyryl CoA dehydrogenase. (316 aa)
	NCU06881	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (516 aa)
	NCU08145	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (557 aa)
	NCU02291	Glutaryl-CoA dehydrogenase. (436 aa)
	acd-1	Acyl-CoA dehydrogenase. (546 aa)
	NCU06120	Uncharacterized protein. (166 aa)
	NCU04768	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (645 aa)
	NCU04796	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)
	NCU05559	Uncharacterized protein. (594 aa)
	NCU05558	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	NCU04231	Uncharacterized protein. (697 aa)
	NCU07733	Electron transfer flavoprotein beta-subunit. (256 aa)
	NCU06543	Acyl-CoA dehydrogenase. (433 aa)
	NCU06346	ACB domain-containing protein. (101 aa)
	NCU06960	Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (427 aa)
	NCU02127	Methylcrotonoyl-CoA carboxylase subunit beta. (623 aa)
	NCU02126	Isovaleryl-CoA dehydrogenase. (482 aa)
	NCU09732	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	NCU08058	3-hydroxyacyl-CoA dehydrogenase. (622 aa)
	NCU02571	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
	NCU00580	Acyl-CoA thioesterase. (362 aa)
	NCU16336	3-hydroxyacyl-CoA dehydrogenase. (616 aa)
	NCU09885	Acyl-CoA dehydrogenase, variant. (438 aa)
	NCU00591	Methylcrotonoyl-CoA carboxylase subunit alpha, variant. (743 aa)

Your Current Organism:

Neurospora crassa

NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NCU00055	NCU00299	Q7RW43	Q7RZR5	Catechol 1,2-dioxygenase 1.	Peroxisomal D3,D2-enoyl-CoA isomerase.	0.549
NCU00055	NCU00591	Q7RW43	V5IR53	Catechol 1,2-dioxygenase 1.	Methylcrotonoyl-CoA carboxylase subunit alpha, variant.	0.613
NCU00055	NCU02127	Q7RW43	Q7SE48	Catechol 1,2-dioxygenase 1.	Methylcrotonoyl-CoA carboxylase subunit beta.	0.648
NCU00055	NCU02571	Q7RW43	Q7SHP4	Catechol 1,2-dioxygenase 1.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.545
NCU00055	NCU03618	Q7RW43	Q1K7R4	Catechol 1,2-dioxygenase 1.	Integral membrane protein.	0.527
NCU00055	NCU04072	Q7RW43	Q7RZE7	Catechol 1,2-dioxygenase 1.	Catechol dioxygenase.	0.905
NCU00055	NCU04393	Q7RW43	Q7RZ80	Catechol 1,2-dioxygenase 1.	3-hydroxyacyl-CoA dehydrogenase.	0.527
NCU00055	NCU04768	Q7RW43	Q7S640	Catechol 1,2-dioxygenase 1.	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	0.475
NCU00055	NCU04796	Q7RW43	Q7S6N9	Catechol 1,2-dioxygenase 1.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.521
NCU00055	NCU05558	Q7RW43	Q7S705	Catechol 1,2-dioxygenase 1.	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.521
NCU00055	NCU05559	Q7RW43	Q7S704	Catechol 1,2-dioxygenase 1.	Uncharacterized protein.	0.521
NCU00055	NCU06346	Q7RW43	Q7S9W0	Catechol 1,2-dioxygenase 1.	ACB domain-containing protein.	0.460
NCU00055	NCU06448	Q7RW43	Q7RYW9	Catechol 1,2-dioxygenase 1.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.579
NCU00055	NCU06881	Q7RW43	Q7S3H2	Catechol 1,2-dioxygenase 1.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.448
NCU00055	NCU06960	Q7RW43	Q7SAI9	Catechol 1,2-dioxygenase 1.	Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.579
NCU00055	NCU07733	Q7RW43	Q7S8Q8	Catechol 1,2-dioxygenase 1.	Electron transfer flavoprotein beta-subunit.	0.766
NCU00055	NCU08004	Q7RW43	Q7RVY2	Catechol 1,2-dioxygenase 1.	Electron transfer flavoprotein alpha-subunit.	0.768
NCU00055	NCU08058	Q7RW43	Q7SGM5	Catechol 1,2-dioxygenase 1.	3-hydroxyacyl-CoA dehydrogenase.	0.527
NCU00055	NCU08145	Q7RW43	Q7S4A2	Catechol 1,2-dioxygenase 1.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.448
NCU00055	NCU09058	Q7RW43	Q7S1U1	Catechol 1,2-dioxygenase 1.	Enoyl-CoA hydratase.	0.626

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