(57 nodes) Mixed, incl. Fructose metabolism, and Alcohol dehydrogenase (NAD+) activity network (Neurospora crassa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	xyk-1	D-xylulose kinase. (590 aa)
	cfp	Pyruvate decarboxylase. (570 aa)
	NCU01704	NADP:D-xylose dehydrogenase. (392 aa)
	NCU09685	Uncharacterized protein. (150 aa)
	NCU01424	DUF636 domain-containing protein. (137 aa)
	NCU06652	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (380 aa)
	NCU03755	Flavin dependent monooxygenase. (477 aa)
	NCU03803	Sorbitol utilization protein SOU2. (292 aa)
	NCU01072	Class II aldolase/adducin domain-containing protein. (331 aa)
	NCU01071	Uncharacterized protein. (388 aa)
	NCU01056	Uncharacterized protein. (356 aa)
	NCU02850	Alcohol dehydrogenase. (408 aa)
	NCU00054	Fungal_trans domain-containing protein. (627 aa)
	NCU07242	Short-chain dehydrogenase/oxidoreductase. (271 aa)
	NCU04092	N-acylethanolamine amidohydrolase. (625 aa)
	NCU04342	Uncharacterized protein. (321 aa)
	NCU00173	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (368 aa)
	NCU00088	4-nitrophenylphosphatase. (306 aa)
	NCU00378	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (546 aa)
	NCU04078	NAD-dependent methanol dehydrogenase. (501 aa)
	NCU09429	Flavin-containing monooxygenase. (666 aa)
	NCU09648	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
	NCU09406	Amine oxidase. (823 aa)
	NCU09391	Phenylalanine ammonia-lyase; Belongs to the PAL/histidase family. (762 aa)
	NCU09538	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (462 aa)
	NCU04613	HAD superfamily hydrolase. (287 aa)
	NCU09041	L-xylulose reductase. (340 aa)
	NCU09022	Uncharacterized protein. (546 aa)
	NCU08222	Uncharacterized protein. (607 aa)
	NCU08174	Clr5 domain-containing protein. (603 aa)
	ilv-5	Pyruvate decarboxylase. (576 aa)
	NCU06072	Clr5 domain-containing protein. (755 aa)
	NCU05518	Amine oxidase. (703 aa)
	NCU08882	NAD binding Rossmann fold oxidoreductase. (370 aa)
	NCU08275	Aromatic-L-amino-acid decarboxylase. (508 aa)
	NCU07022	Sorbitol dehydrogenase. (437 aa)
	NCU06400	Amidohydrolase. (440 aa)
	NCU07919	Catechol O-methyltransferase. (262 aa)
	NCU07623	2,2-dialkylglycine decarboxylase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (535 aa)
	NCU05687	Clr5 domain-containing protein. (508 aa)
	NCU09231	DUF1275 domain-containing protein. (361 aa)
	xr	Xylose reductase. (322 aa)
	NCU03081	Uncharacterized protein. (236 aa)
	NCU00715	Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (518 aa)
	NCU00891	Xylitol dehydrogenase. (383 aa)
	NCU00877	Uncharacterized protein. (118 aa)
	NCU00866	DUF1275 domain-containing protein. (314 aa)
	NCU02476	Alcohol dehydrogenase III. (411 aa)
	NCU01905	Sorbitol dehydrogenase. (434 aa)
	NCU02931	Uncharacterized protein. (662 aa)
	ard-1	L-arabinitol 4-dehydrogenase; Catalyzes the NAD-dependent oxidation of L-arabinitol to L- xylulose in the fungal L-arabinose catabolic pathway. L-arabinose catabolism is important for using plant material as a carbon source. Not active on D-arabinitol, D-sorbitol and D-mannitol. Belongs to the zinc-containing alcohol dehydrogenase family. (363 aa)
	adh-1	Alcohol dehydrogenase 1. (353 aa)
	NCU00326	Calcium homeostasis protein Regucalcin, variant. (305 aa)
	NCU05822	Uncharacterized protein. (375 aa)
	NCU05586	Malate/L-lactate dehydrogenase. (436 aa)
	NCU06538	Uncharacterized protein. (492 aa)
	NCU16599	C6 zinc finger domain-containing protein. (559 aa)

Your Current Organism:

Neurospora crassa

NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NCU00054	NCU00173	Q7RW44	Q7RXB4	Fungal_trans domain-containing protein.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.848
NCU00054	NCU00877	Q7RW44	Q7SFF4	Fungal_trans domain-containing protein.	Uncharacterized protein.	0.623
NCU00054	NCU04078	Q7RW44	Q7RZE2	Fungal_trans domain-containing protein.	NAD-dependent methanol dehydrogenase.	0.623
NCU00088	xyk-1	Q7RYN9	A7UWY8	4-nitrophenylphosphatase.	D-xylulose kinase.	0.572
NCU00173	NCU00054	Q7RXB4	Q7RW44	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Fungal_trans domain-containing protein.	0.848
NCU00173	NCU02850	Q7RXB4	Q7RV37	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Alcohol dehydrogenase.	0.891
NCU00173	NCU03081	Q7RXB4	Q7SDS9	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein.	0.848
NCU00173	NCU06652	Q7RXB4	Q1K6M8	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.999
NCU00326	NCU00891	U9WGW9	Q7SFE0	Calcium homeostasis protein Regucalcin, variant.	Xylitol dehydrogenase.	0.408
NCU00326	NCU01704	U9WGW9	Q1K5G9	Calcium homeostasis protein Regucalcin, variant.	NADP:D-xylose dehydrogenase.	0.547
NCU00326	NCU01905	U9WGW9	Q7SHA1	Calcium homeostasis protein Regucalcin, variant.	Sorbitol dehydrogenase.	0.408
NCU00326	NCU05687	U9WGW9	Q7SBQ1	Calcium homeostasis protein Regucalcin, variant.	Clr5 domain-containing protein.	0.408
NCU00326	NCU06072	U9WGW9	Q7S4X8	Calcium homeostasis protein Regucalcin, variant.	Clr5 domain-containing protein.	0.408
NCU00326	NCU07022	U9WGW9	Q7S9B3	Calcium homeostasis protein Regucalcin, variant.	Sorbitol dehydrogenase.	0.408
NCU00326	NCU08174	U9WGW9	Q7S4B9	Calcium homeostasis protein Regucalcin, variant.	Clr5 domain-containing protein.	0.408
NCU00326	NCU08882	U9WGW9	Q7S754	Calcium homeostasis protein Regucalcin, variant.	NAD binding Rossmann fold oxidoreductase.	0.537
NCU00326	ard-1	U9WGW9	Q7SI09	Calcium homeostasis protein Regucalcin, variant.	L-arabinitol 4-dehydrogenase; Catalyzes the NAD-dependent oxidation of L-arabinitol to L- xylulose in the fungal L-arabinose catabolic pathway. L-arabinose catabolism is important for using plant material as a carbon source. Not active on D-arabinitol, D-sorbitol and D-mannitol. Belongs to the zinc-containing alcohol dehydrogenase family.	0.408
NCU00326	xyk-1	U9WGW9	A7UWY8	Calcium homeostasis protein Regucalcin, variant.	D-xylulose kinase.	0.593
NCU00378	NCU00877	Q7RYT1	Q7SFF4	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein.	0.449
NCU00378	NCU02476	Q7RYT1	Q7SG88	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Alcohol dehydrogenase III.	0.922

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