STRINGSTRING
csm-3 csm-3 NCU02683 NCU02683 NCU03190 NCU03190 MCM7 MCM7 NCU04738 NCU04738 NCU05433 NCU05433 mus-27 mus-27 NCU01171 NCU01171 pold-1 pold-1 NCU06788 NCU06788 NCU06395 NCU06395 NCU02232 NCU02232 cac-2 cac-2 slx4 slx4 NCU00897 NCU00897 NCU05194 NCU05194 rpa-2 rpa-2 NCU07893 NCU07893 mrc1 mrc1 NCU04327 NCU04327 NCU06787 NCU06787 mei-3 mei-3 NCU03517 NCU03517 NCU00424 NCU00424 uvs-6 uvs-6 NCU04548 NCU04548 NCU03461 NCU03461 ctc-1 ctc-1 NCU00070 NCU00070 NCU00444 NCU00444 NCU00423 NCU00423 snf5 snf5 crc-2 crc-2 NCU00118 NCU00118 set-4 set-4 NCU04378 NCU04378 yaf9 yaf9 NCU07554 NCU07554 NCU07364 NCU07364 NCU10155 NCU10155 crf1-1 crf1-1 NCU07568 NCU07568 NCU05979 NCU05979 tof-1 tof-1 slx1 slx1 NCU00470 NCU00470 crf8-1 crf8-1 NCU00401 NCU00401 NCU07519 NCU07519 qde-2 qde-2 NCU04729 NCU04729 NCU03820 NCU03820 NCU16971 NCU16971 NCU10346 NCU10346 NCU08700 NCU08700 NCU01534 NCU01534 NCU10788 NCU10788 fsd-1 fsd-1 NCU02796 NCU02796 NCU09240 NCU09240 NCU10376 NCU10376 NCU16423 NCU16423 NCU16422 NCU16422 NCU02121 NCU02121 NCU09813 NCU09813 NCU07395 NCU07395 spo11 spo11 NCU03763 NCU03763 rpa-1 rpa-1 NCU03597 NCU03597 NCU01370 NCU01370 NCU01410 NCU01410 NCU01362 NCU01362 sms-2 sms-2 NCU01599 NCU01599 hat-2 hat-2 drc-3 drc-3 arp-6 arp-6 pcn pcn hda-3 hda-3 NCU03291 NCU03291 NCU03073 NCU03073 polh polh drc-1 drc-1 msh4 msh4 vib-1 vib-1 hh2a hh2a hel-1 hel-1 5F3.150 5F3.150 hH2Az hH2Az hel-2 hel-2 crf2-1 crf2-1 crc-1 crc-1 arp-5 arp-5 NCU08317 NCU08317 drc-2 drc-2 NCU08039 NCU08039 NCU08009 NCU08009 NCU07998 NCU07998 arp-8 arp-8 NCU07870 NCU07870 NCU02539 NCU02539 arp-4 arp-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
csm-3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (409 aa)
NCU02683Uncharacterized protein. (738 aa)
NCU03190Rec8. (763 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
NCU04738Zf-primase domain-containing protein. (977 aa)
NCU05433Uncharacterized protein. (412 aa)
mus-27Chromosome segregation protein. (879 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
pold-1DNA polymerase. (1104 aa)
NCU06788Chromo domain-containing protein. (145 aa)
NCU06395YL1_C domain-containing protein. (210 aa)
NCU02232DNA primase; Belongs to the eukaryotic-type primase small subunit family. (576 aa)
cac-2Chromatin assembly factor 1 protein. (732 aa)
slx4Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (1013 aa)
NCU00897Sin3 complex subunit. (924 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
rpa-2Replication protein A-2. (284 aa)
NCU07893RSC complex subunit Sfh1. (591 aa)
mrc1MRC1. (1464 aa)
NCU04327DNA helicase; Belongs to the MCM family. (882 aa)
NCU06787MRG domain-containing protein. (366 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
NCU03517Ski8. (342 aa)
NCU00424Spo76 protein. (1595 aa)
uvs-6UVS6. (1314 aa)
NCU04548DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2259 aa)
NCU03461Chromatin modification-related protein. (824 aa)
ctc-1FACT complex subunit ctc-1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (565 aa)
NCU00070PHD-type domain-containing protein. (888 aa)
NCU00444Transcription initiation factor TFIID subunit 14. (226 aa)
NCU00423PHD-type domain-containing protein. (1413 aa)
snf5SWI-SNF complex subunit. (732 aa)
crc-2SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (342 aa)
NCU00118RRM domain-containing protein. (713 aa)
set-4SET-4. (948 aa)
NCU04378DNA replication initiation factor Cdc45. (874 aa)
yaf9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (309 aa)
NCU07554Structural maintenance of chromosomes protein. (1204 aa)
NCU07364Uncharacterized protein. (381 aa)
NCU10155DNA polymerase epsilon subunit B. (851 aa)
crf1-1Helicase swr-1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1845 aa)
NCU07568HMG box domain-containing protein. (353 aa)
NCU05979RXT2_N domain-containing protein. (580 aa)
tof-1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1235 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (402 aa)
NCU00470DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (484 aa)
crf8-1TBP associated factor, variant. (1893 aa)
NCU00401Uncharacterized protein. (458 aa)
NCU07519ATP-dependent DNA helicase; Belongs to the helicase family. (813 aa)
qde-2Post-transcriptional silencing protein QDE-2. (1089 aa)
NCU04729NDT80 domain-containing protein. (726 aa)
NCU03820Checkpoint protein; Belongs to the HUS1 family. (371 aa)
NCU16971Uncharacterized protein. (236 aa)
NCU10346Uncharacterized protein. (2592 aa)
NCU08700Uncharacterized protein. (1043 aa)
NCU01534PAPA-1 domain-containing protein. (430 aa)
NCU10788Uncharacterized protein. (386 aa)
fsd-1Female sexual development-1 protein. (626 aa)
NCU02796Chromatin modification-related protein. (663 aa)
NCU09240Vezatin domain-containing protein. (658 aa)
NCU10376Uncharacterized protein. (441 aa)
NCU16423Uncharacterized protein. (378 aa)
NCU16422Uncharacterized protein. (79 aa)
NCU02121Transcriptional regulator. (633 aa)
NCU09813SMT3, variant 1. (99 aa)
NCU07395DNA-binding protein SMUBP-2. (736 aa)
spo11Meiosis-specific topoisomerase Spo11. (466 aa)
NCU03763DNA polymerase delta subunit 2. (525 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU03597DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (667 aa)
NCU01370Uncharacterized protein. (603 aa)
NCU01410DUF1711 domain-containing protein. (291 aa)
NCU01362INO80 chromatin remodeling complex. (750 aa)
sms-2Meiotic silencing suppressor 2; Belongs to the argonaute family. (989 aa)
NCU01599Uncharacterized protein. (570 aa)
hat-2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. (446 aa)
drc-3DNA replication complex GINS protein psf3; The GINS complex plays an essential role in the initiation of DNA replication. (218 aa)
arp-6Actin-related protein 6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (446 aa)
pcnProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
hda-3Histone deacetylase RPD3. (658 aa)
NCU03291Double-strand-break repair protein rad21. (658 aa)
NCU03073CBFD_NFYB_HMF domain-containing protein. (397 aa)
polhSister chromatid cohesion protein Eso1. (672 aa)
drc-1DNA replication complex GINS protein psf1; The GINS complex plays an essential role in the initiation of DNA replication. (216 aa)
msh4MutS ortholog 4 protein. (1318 aa)
vib-1Transcription factor vib-1; Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death. (670 aa)
hh2aHistone H2A; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
hel-1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
5F3.150Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (513 aa)
hH2AzHistone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (143 aa)
hel-2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (481 aa)
crf2-1Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1997 aa)
crc-1SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (733 aa)
arp-5Chromatin remodeling complex subunit; Belongs to the actin family. (762 aa)
NCU08317PHD-type domain-containing protein. (1021 aa)
drc-2DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (273 aa)
NCU08039RING-type domain-containing protein. (359 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
NCU07998Uncharacterized protein. (441 aa)
arp-8Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (748 aa)
NCU07870DNA polymerase. (1479 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
arp-4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosome [...] (469 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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