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tca-4 tca-4 dnr-8 dnr-8 NCU08771 NCU08771 NCU01127 NCU01127 cfp cfp leu-1 leu-1 cr-1 cr-1 NCU01786 NCU01786 uvs-3 uvs-3 NCU08888 NCU08888 NCU03818 NCU03818 NCU03607 NCU03607 NCU08703 NCU08703 ipp-1 ipp-1 dut-1 dut-1 emp-7 emp-7 ace-8 ace-8 NCU03858 NCU03858 NCU05076 NCU05076 NCU03564 NCU03564 NCU06497 NCU06497 NCU00352 NCU00352 NCU00293 NCU00293 pan-2 pan-2 ilv-5 ilv-5 NCU05750 NCU05750 Ad-8 Ad-8 NCU04718 NCU04718 NCU07115 NCU07115 NCU07064 NCU07064 NCU03590 NCU03590 NCU03592 NCU03592 NCU06281 NCU06281 NCU05254 NCU05254 NCU05302 NCU05302 utr4 utr4 NCU10058 NCU10058 his-2 his-2 rgt-1 rgt-1 isn-1 isn-1 NCU07443 NCU07443 NCU02004 NCU02004 NCU00781 NCU00781 tca-6 tca-6 NCU02734 NCU02734 lys-7 lys-7 B12J7.040 B12J7.040 NCU01870 NCU01870 NCU02937 NCU02937 NCU00581 NCU00581 tca-9 tca-9 tca-5 tca-5 NCU06970 NCU06970 NCU17026 NCU17026 NCU07982 NCU07982 rpd rpd NCU04364 NCU04364
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tca-4Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (379 aa)
dnr-8Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (394 aa)
NCU08771Acetolactate synthase; Belongs to the TPP enzyme family. (608 aa)
NCU01127DUF636 domain-containing protein. (137 aa)
cfpPyruvate decarboxylase. (570 aa)
leu-13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (368 aa)
cr-1Adenylate cyclase; Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP. (2300 aa)
NCU01786Ribose-phosphate pyrophosphokinase II. (412 aa)
uvs-3UVS-3. (969 aa)
NCU08888Phenylalanyl-tRNA synthetase subunit beta. (608 aa)
NCU03818Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1331 aa)
NCU03607Threonine dehydratase catabolic. (388 aa)
NCU08703Inorganic pyrophosphatase. (301 aa)
ipp-1Inorganic pyrophosphatase. (290 aa)
dut-1Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (165 aa)
emp-7Enolase. (438 aa)
ace-8Pyruvate kinase. (527 aa)
NCU03858Uncharacterized protein. (419 aa)
NCU05076Uncharacterized protein. (131 aa)
NCU03564Flap structure-specific endonuclease. (1037 aa)
NCU06497Cell division cycle protein 123. (488 aa)
NCU00352Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1360 aa)
NCU00293NADH pyrophosphatase. (511 aa)
pan-23-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. (383 aa)
ilv-5Pyruvate decarboxylase. (576 aa)
NCU05750Ribonuclease H. (498 aa)
Ad-8Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (430 aa)
NCU04718DUF1752 domain-containing protein. (573 aa)
NCU07115HET domain-containing protein. (622 aa)
NCU07064L-galactonate dehydratase. (451 aa)
NCU03590Uncharacterized protein. (456 aa)
NCU03592Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1743 aa)
NCU06281Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1486 aa)
NCU05254Ribose-phosphate pyrophosphokinase. (485 aa)
NCU05302GTP-binding protein Obg. (591 aa)
utr4Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (234 aa)
NCU10058Phosphoglucomutase 2; Belongs to the phosphohexose mutase family. (554 aa)
his-2ATP phosphoribosyltransferase. (337 aa)
rgt-1tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (293 aa)
isn-1IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation; Belongs to the ISN1 family. (431 aa)
NCU07443Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1562 aa)
NCU02004Phosphoserine phosphatase. (496 aa)
NCU00781Uncharacterized protein. (89 aa)
tca-6Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
NCU02734Citrate lyase beta subunit. (319 aa)
lys-7Homoisocitrate dehydrogenase. (402 aa)
B12J7.040Probable acetate kinase. (469 aa)
NCU01870Eno3 protein. (441 aa)
NCU02937Uncharacterized protein. (203 aa)
NCU00581Phosphopantetheinyl transferase. (348 aa)
tca-9Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (447 aa)
tca-5Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (462 aa)
NCU06970Ribose-phosphate pyrophosphokinase II, variant. (323 aa)
NCU17026HET domain-containing protein. (153 aa)
NCU07982Acetolactate synthase. (689 aa)
rpdRibose-phosphate pyrophosphokinase II. (501 aa)
NCU04364PAP-associated domain-containing protein. (1187 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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