STRINGSTRING
rac-1 rac-1 NCU00916 NCU00916 NCU00974 NCU00974 NCU01668 NCU01668 NCU06366 NCU06366 tcu-2 tcu-2 NCU02150 NCU02150 NCU16725 NCU16725 NCU08961 NCU08961 NCU06624 NCU06624 cax cax NCU02409 NCU02409 NCU00376 NCU00376 NCU08997 NCU08997 vma-11 vma-11 epp-1 epp-1 17E5.300 17E5.300 apg-10 apg-10 lcl2 lcl2 apg-6 apg-6 sec-61 sec-61 apg-13 apg-13 NCU00621 NCU00621 NCU03029 NCU03029 NCU08066 NCU08066 NCU00975 NCU00975 NCU02725 NCU02725 vma-13 vma-13 NCU02463 NCU02463 apg-11 apg-11 NCU00795 NCU00795 NCU08609 NCU08609 NCU00558 NCU00558 NCU02083 NCU02083 NCU02122 NCU02122 NCU03145 NCU03145 NCU02112 NCU02112 NCU02113 NCU02113 NCU08110 NCU08110 cln3 cln3 NCU05422 NCU05422 NCU06231 NCU06231 NCU07816 NCU07816 NCU06284 NCU06284 NCU06324 NCU06324 NCU07337 NCU07337 NCU07919 NCU07919 vma-9 vma-9 NCU07709 NCU07709 iml1 iml1 NCU08689 NCU08689 NCU04100 NCU04100 NCU05619 NCU05619 NCU05775 NCU05775 NCU05902 NCU05902 NCU06918 NCU06918 NCU09350 NCU09350 NCU09121 NCU09121 NCU07387 NCU07387 gh38-1 gh38-1 NCU00242 NCU00242 gpr-5 gpr-5 NCU00356 NCU00356 npc-2 npc-2 NCU00121 NCU00121 NCU00122 NCU00122 NCU00029 NCU00029 NCU00453 NCU00453 cpyA cpyA vac8 vac8 NCU01480 NCU01480 NCU03883 NCU03883 NCU04090 NCU04090 NCU05068 NCU05068 NCU04541 NCU04541 NCU03863 NCU03863 NCU04355 NCU04355 NCU02026 NCU02026 NCU06773 NCU06773 NCU05360 NCU05360 NCU01099 NCU01099 NCU04125 NCU04125 NCU04188 NCU04188 NCU04192 NCU04192 NCU03783 NCU03783 pho-2 pho-2 NCU04218 NCU04218 nca-2 nca-2 NCU01745 NCU01745 nca-3 nca-3 pep-4 pep-4 vph-1 vph-1 vma-4 vma-4 vma-6 vma-6 gla-1 gla-1 vma-1 vma-1 vma-8 vma-8 NCU01250 NCU01250 NCU03388 NCU03388 NCU01539 NCU01539 NCU11370 NCU11370 NCU11307 NCU11307 NCU10477 NCU10477 NCU11129 NCU11129
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rac-1Small GTPase RAC. (200 aa)
NCU00916Membrane bound cation transporter; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (794 aa)
NCU00974Glutaredoxin, variant. (254 aa)
NCU01668Uncharacterized protein. (871 aa)
NCU06366Vacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (504 aa)
tcu-2TCU-2. (200 aa)
NCU02150Ser/Thr protein phosphatase. (571 aa)
NCU16725Potassium ion channel Yvc1. (653 aa)
NCU08961Uncharacterized protein. (1047 aa)
NCU06624Chloride channel protein. (910 aa)
caxVacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (507 aa)
NCU02409Uncharacterized protein. (892 aa)
NCU00376GTR/RAG family GTPase Gtr2. (427 aa)
NCU08997Alkaline phosphatase. (587 aa)
vma-11V-type proton ATPase 16 kDa proteolipid subunit 2; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (167 aa)
epp-1Endopolyphosphatase; Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths. (731 aa)
17E5.300Probable Ras-related protein Rab7; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
apg-10Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa)
lcl2Long chronological lifespan protein 2; Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway. (132 aa)
apg-6Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With cpr-1/atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also in [...] (121 aa)
sec-61Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). (476 aa)
apg-13Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (678 aa)
NCU00621TORC1 growth control complex subunit Kog1. (1473 aa)
NCU03029Uncharacterized protein. (623 aa)
NCU08066Amino acid transporter. (549 aa)
NCU00975Uncharacterized protein. (331 aa)
NCU02725Uncharacterized protein. (984 aa)
vma-13V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa)
NCU02463Bax Inhibitor family protein; Belongs to the BI1 family. (287 aa)
apg-11Autophagy-related protein 22; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (737 aa)
NCU00795Membrane bound cation transporter; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (575 aa)
NCU08609Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (345 aa)
NCU00558Uncharacterized protein. (652 aa)
NCU020831-phosphatidylinositol-3-phosphate 5-kinase. (2558 aa)
NCU02122HCO3. (633 aa)
NCU03145Oxidative stress resistance. (522 aa)
NCU02112Uncharacterized protein. (1808 aa)
NCU02113Ubiquitin-conjugating enzyme E2 13; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
NCU08110Vacuolar transporter chaperone 4. (771 aa)
cln3Protein btn-1; Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity); Belongs to the battenin family. (464 aa)
NCU05422E3 ubiquitin-protein ligase PEP5. (1016 aa)
NCU06231Vacuolar amino acid transporter 1. (688 aa)
NCU07816Magnesium and cobalt transporter CorA. (650 aa)
NCU06284Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (881 aa)
NCU06324Zn(2)-C6 fungal-type domain-containing protein. (700 aa)
NCU07337Uncharacterized protein. (141 aa)
NCU07919Catechol O-methyltransferase. (262 aa)
vma-9Vacuolar ATPase subunit E. (75 aa)
NCU07709Cation efflux system protein czcD. (326 aa)
iml1Vacuolar membrane-associated protein iml1. (2004 aa)
NCU08689Polyphosphoinositide phosphatase Fig4. (1190 aa)
NCU04100Vacuolar sorting protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (706 aa)
NCU05619Uncharacterized protein. (94 aa)
NCU05775Amino acid transporter. (620 aa)
NCU05902Vacuolar assembly protein. (1359 aa)
NCU06918Purine permease. (613 aa)
NCU09350Aspartic-type endopeptidase; Belongs to the peptidase A1 family. (459 aa)
NCU09121Vacuolar sorting protein; Belongs to the STXBP/unc-18/SEC1 family. (666 aa)
NCU07387RING-type domain-containing protein. (547 aa)
gh38-1Alpha-mannosidase. (1089 aa)
NCU00242V-SNARE. (562 aa)
gpr-5PQ loop repeat protein. (538 aa)
NCU00356Nucleoside transporter. (524 aa)
npc-2Phosphatidylglycerol/phosphatidylinositol transfer protein; Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol; Belongs to the NPC2 family. (177 aa)
NCU00121CLC channel protein. (920 aa)
NCU00122Aspartyl aminopeptidase; Belongs to the peptidase M18 family. (537 aa)
NCU00029ZIP metal ion transporter. (514 aa)
NCU00453Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (663 aa)
cpyACarboxypeptidase Y homolog A; Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity). (554 aa)
vac8Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole; Belongs to the beta-catenin family. (559 aa)
NCU01480Anion exchange family protein. (618 aa)
NCU03883Vacuolar transporter chaperone 1. (127 aa)
NCU04090Niemann-Pick C1 protein. (1279 aa)
NCU05068Uncharacterized protein. (338 aa)
NCU04541SNF7 family protein. (218 aa)
NCU03863Uncharacterized protein. (456 aa)
NCU04355Phosphatidylinositol 4-kinase type II subunit alpha. (867 aa)
NCU02026Uncharacterized protein. (678 aa)
NCU06773Uncharacterized protein. (462 aa)
NCU05360Calcium permease; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1146 aa)
NCU01099GTP-binding protein GTR1. (409 aa)
NCU04125TGF beta receptor associated protein 1. (1266 aa)
NCU04188UPF0220 domain-containing protein. (173 aa)
NCU04192Vacuolar aspartyl aminopeptidase Lap4; Belongs to the peptidase M18 family. (535 aa)
NCU03783Transmembrane domain transporter. (772 aa)
pho-2Alkaline phosphatase; Belongs to the alkaline phosphatase family. (668 aa)
NCU04218RTA1 domain-containing protein. (328 aa)
nca-2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1449 aa)
NCU01745SPX domain-containing protein. (800 aa)
nca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1152 aa)
pep-4Vacuolar protease A. (396 aa)
vph-1V-type proton ATPase subunit a; Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (856 aa)
vma-4V-type proton ATPase subunit E; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (230 aa)
vma-6V-type proton ATPase subunit d; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (364 aa)
gla-1Glucoamylase. (626 aa)
vma-1V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (607 aa)
vma-8V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase D subunit family. (264 aa)
NCU01250Cystinosin. (297 aa)
NCU03388Stomatin family protein. (415 aa)
NCU01539Vacuolar morphogenesis protein AvaB. (1138 aa)
NCU113706-phosphogluconate dehydrogenase 2. (306 aa)
NCU11307CCC1. (307 aa)
NCU10477Ubiquitin-conjugating enzyme E2. (156 aa)
NCU11129Carboxypeptidase s. (596 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.