STRINGSTRING
uvs-2 uvs-2 mus-8 mus-8 tsn tsn NCU01771 NCU01771 rpa-1 rpa-1 NCU06782 NCU06782 mei-3 mei-3 NCU01248 NCU01248 uvs-6 uvs-6 mus-38 mus-38 NCU05006 NCU05006 NCU03985 NCU03985 NCU00103 NCU00103 NCU04378 NCU04378 NCU05986 NCU05986 drc-4 drc-4 NCU02402 NCU02402 NCU07078 NCU07078 mus-44 mus-44 NCU04738 NCU04738 NCU05517 NCU05517 NCU06572 NCU06572 NCU06627 NCU06627 pim1 pim1 NCU06585 NCU06585 NCU07735 NCU07735 NCU06345 NCU06345 NCU08009 NCU08009 NCU06222 NCU06222 NCU07870 NCU07870 NCU09065 NCU09065 NCU09259 NCU09259 mus-40 mus-40 NCU02661 NCU02661 5F3.150 5F3.150 rpc-82 rpc-82 Prd-6 Prd-6 NCU00137 NCU00137 NCU05800 NCU05800 NCU12087 NCU12087 NCU12100 NCU12100 NCU16387 NCU16387
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uvs-2Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (501 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
tsnRecombination hotspot-binding protein. (239 aa)
NCU01771DNA repair protein rhp57. (510 aa)
rpa-1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (610 aa)
NCU06782Zinc metalloproteinase. (404 aa)
mei-3DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
NCU01248Telo_bind domain-containing protein. (735 aa)
uvs-6UVS6. (1314 aa)
mus-38MUS38. (960 aa)
NCU05006Cytochrome P450. (461 aa)
NCU03985DUF159 domain-containing protein. (479 aa)
NCU00103Uncharacterized protein. (292 aa)
NCU04378DNA replication initiation factor Cdc45. (874 aa)
NCU05986Sucrase/ferredoxin domain-containing protein. (381 aa)
drc-4DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (610 aa)
NCU02402SMC_N domain-containing protein. (1167 aa)
NCU07078Uncharacterized protein. (326 aa)
mus-44Mating-type switching protein swi10. (405 aa)
NCU04738Zf-primase domain-containing protein. (977 aa)
NCU05517Mitochondrial genome maintenance protein MGM101. (337 aa)
NCU06572zf-C2HE domain-containing protein. (299 aa)
NCU06627Uncharacterized protein. (1190 aa)
pim1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1107 aa)
NCU06585Rad4 family protein. (1040 aa)
NCU07735Grp1p. (354 aa)
NCU06345Tyrosyl-DNA phosphodiesterase. (661 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
NCU06222Tyrosyl-DNA phosphodiesterase domain-containing protein. (691 aa)
NCU07870DNA polymerase. (1479 aa)
NCU09065SMC_N domain-containing protein. (1138 aa)
NCU09259Uncharacterized protein. (625 aa)
mus-40DNA excision repair protein Rad2. (1269 aa)
NCU02661DNA-directed RNA polymerase II polypeptide. (171 aa)
5F3.150Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (513 aa)
rpc-82DNA-directed RNA polymerase III subunit rpc-3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity). (624 aa)
Prd-6Regulator of nonsense transcripts 1 homolog; Eliminates the production of nonsense-containing RNAs. Belongs to the DNA2/NAM7 helicase family. (1093 aa)
NCU00137SsDNA binding protein. (222 aa)
NCU05800Zinc knuckle domain-containing protein, variant. (225 aa)
NCU12087Nitrilase. (897 aa)
NCU12100Uncharacterized protein. (84 aa)
NCU16387XPGI domain-containing protein. (226 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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