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chl1 chl1 NCU01143 NCU01143 drh-11 drh-11 mus-8 mus-8 frh frh NCU01612 NCU01612 NCU01591 NCU01591 NCU03652 NCU03652 NCU08933 NCU08933 NCU08928 NCU08928 NCU04327 NCU04327 NCU03808 NCU03808 rad16 rad16 NCU01340 NCU01340 NCU01171 NCU01171 cyt-19 cyt-19 NCU06735 NCU06735 NCU08706 NCU08706 NCU02036 NCU02036 NCU06833 NCU06833 tif-1 tif-1 mus-25 mus-25 NCU09076 NCU09076 NCU04354 NCU04354 NCU07233 NCU07233 mus-52 mus-52 NCU01625 NCU01625 crf4-1 crf4-1 PIF1 PIF1 rrp-3 rrp-3 crf3-1 crf3-1 NCU00110 NCU00110 NCU06438 NCU06438 dbp-8 dbp-8 dbp-4 dbp-4 mak-5 mak-5 NCU09756 NCU09756 crf1-1 crf1-1 crf10-1 crf10-1 mus-41 mus-41 NCU08883 NCU08883 NCU09357 NCU09357 has-1 has-1 NCU09159 NCU09159 sad-3 sad-3 NCU05756 NCU05756 NCU05861 NCU05861 drh-10 drh-10 NCU05802 NCU05802 dbp-3 dbp-3 NCU09793 NCU09793 dbp-9 dbp-9 mus-50 mus-50 NCU04786 NCU04786 NCU05502 NCU05502 crf7-1 crf7-1 csa csa NCU04297 NCU04297 NCU01156 NCU01156 NCU01104 NCU01104 dbp-7 dbp-7 NCU06627 NCU06627 dcl-1 dcl-1 NCU08267 NCU08267 NCU05194 NCU05194 dbp-10 dbp-10 NCU06371 NCU06371 NCU06365 NCU06365 mus-51 mus-51 NCU06318 NCU06318 NCU08009 NCU08009 drh-1 drh-1 csb csb atrx atrx drh-15 drh-15 NCU05480 NCU05480 dcl-2 dcl-2 MCM7 MCM7 NCU02099 NCU02099 mph1 mph1 qde-3 qde-3 NCU01984 NCU01984 NCU00832 NCU00832 prp-28 prp-28 NCU09254 NCU09254 drh-16 drh-16 NCU09093 NCU09093 NCU02728 NCU02728 prp-5 prp-5 NCU02685 NCU02685 NCU01884 NCU01884 NCU01857 NCU01857 NCU02539 NCU02539 crf9-1 crf9-1 hel-2 hel-2 spb-4 spb-4 hel-1 hel-1 dbp-5 dbp-5 Prd-6 Prd-6 drh-9 drh-9 fal-1 fal-1 crf8-1 crf8-1 NCU07519 NCU07519 NCU04749 NCU04749 NCU04472 NCU04472 NCU03337 NCU03337 crf6-1 crf6-1 NCU07395 NCU07395
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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chl1ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (1068 aa)
NCU01143DEAD/DEAH box helicase. (1391 aa)
drh-11ATP-dependent RNA helicase drs1; ATP-binding RNA helicase involved in ribosome assembly. (829 aa)
mus-8Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
frhFRQ-interacting RNA helicase. (1106 aa)
NCU01612Pre-mRNA splicing factor ATP-dependent RNA helicase PRP43. (774 aa)
NCU01591Uncharacterized protein. (566 aa)
NCU03652SNF2 family helicase/ATPase. (1548 aa)
NCU08933Cellular nucleic acid-binding protein. (449 aa)
NCU08928ATP-dependent RNA helicase DHX8. (917 aa)
NCU04327DNA helicase; Belongs to the MCM family. (882 aa)
NCU03808Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16. (1258 aa)
rad16DNA repair protein RAD16. (1079 aa)
NCU01340Uncharacterized protein. (215 aa)
NCU01171DNA helicase; Belongs to the MCM family. (724 aa)
cyt-19ATP-dependent RNA helicase cyt-19, mitochondrial; Acts as an RNA chaperone to resolve non-native structures formed during RNA folding to promote mitochondrial group I, but also group II, intron splicing. Functions predominantly by disrupting accessible RNA secondary structure and depends on spontaneous openings in tightly packed RNAs to gain access to RNA helices. Belongs to the DEAD box helicase family. (626 aa)
NCU06735ATP dependent RNA helicase. (682 aa)
NCU08706AAA family ATPase. (622 aa)
NCU02036tRNA-splicing endonuclease. (2130 aa)
NCU06833UvrD_C_2 domain-containing protein. (722 aa)
tif-1ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (397 aa)
mus-25DNA repair and recombination protein RAD54. (835 aa)
NCU09076ATP-dependent RNA helicase. (434 aa)
NCU04354DEAD box family helicase. (684 aa)
NCU07233Uncharacterized protein. (361 aa)
mus-52ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
NCU01625DNA repair helicase RAD3. (806 aa)
crf4-1Chromatin remodelling complex ATPase chain ISW1. (1126 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (931 aa)
rrp-3ATP-dependent rRNA helicase rrp-3; Required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA (By similarity). (515 aa)
crf3-1SNF2-family ATP dependent chromatin remodeling factor snf21. (1482 aa)
NCU00110Uncharacterized protein. (721 aa)
NCU06438DNA repair helicase RAD25. (862 aa)
dbp-8ATP-dependent RNA helicase dbp-8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (626 aa)
dbp-4ATP-dependent RNA helicase dbp-4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (823 aa)
mak-5ATP-dependent RNA helicase mak-5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (805 aa)
NCU09756Uncharacterized protein; Belongs to the DEAD box helicase family. (784 aa)
crf1-1Helicase swr-1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1845 aa)
crf10-1Clockswitch protein CSW-1. (1011 aa)
mus-41DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein uvs-2/rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1228 aa)
NCU08883SNF2_N domain-containing protein. (355 aa)
NCU09357Stage V sporulation protein K. (2307 aa)
has-1ATP-dependent RNA helicase has-1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (578 aa)
NCU09159Uncharacterized protein. (749 aa)
sad-3Suppressor of ascus dominance-3 protein. (1160 aa)
NCU05756Peptidase M4. (449 aa)
NCU05861Uncharacterized protein. (1640 aa)
drh-10ATP-dependent RNA helicase dhh1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (569 aa)
NCU05802ATP-dependent RNA helicase A. (1491 aa)
dbp-3ATP-dependent RNA helicase dbp-3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (614 aa)
NCU09793DEAD/DEAH box DNA helicase. (1563 aa)
dbp-9ATP-dependent RNA helicase dbp-9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (676 aa)
mus-50UvrD/REP helicase. (1105 aa)
NCU04786SNF2 family helicase/ATPase. (1197 aa)
NCU05502Uncharacterized protein. (1563 aa)
crf7-1Chromodomain-helicase-DNA-binding protein 4. (1726 aa)
csaDNA excision repair protein. (1269 aa)
NCU04297Uncharacterized protein. (674 aa)
NCU01156Uncharacterized protein. (857 aa)
NCU01104ATP-dependent RNA helicase MSS116. (696 aa)
dbp-7ATP-dependent RNA helicase dbp-7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (814 aa)
NCU06627Uncharacterized protein. (1190 aa)
dcl-1ATP-dependent helicase dcl-1; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1584 aa)
NCU08267Activating signal cointegrator 1 complex subunit 3. (2066 aa)
NCU05194DNA helicase; Belongs to the MCM family. (972 aa)
dbp-10ATP-dependent RNA helicase dbp-10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (934 aa)
NCU06371Mitochondrial ATP-dependent RNA helicase Suv3. (796 aa)
NCU06365DEAD/DEAH box helicase. (1175 aa)
mus-51ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (645 aa)
NCU06318ATP-dependent RNA helicase DHX8. (1179 aa)
NCU08009DNA helicase; Belongs to the MCM family. (944 aa)
drh-1ATP-dependent RNA helicase dbp2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (562 aa)
csbDNA repair protein Rhp26/Rad26. (1173 aa)
atrxATRX. (1869 aa)
drh-15ATP-dependent RNA helicase mrh4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (625 aa)
NCU05480Uncharacterized protein. (242 aa)
dcl-2ATP-dependent helicase dcl-2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume. (1534 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
NCU02099Uncharacterized protein. (320 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1168 aa)
qde-3RecQ family helicase. (2330 aa)
NCU01984Uncharacterized protein. (1007 aa)
NCU00832Uncharacterized protein. (402 aa)
prp-28Pre-mRNA-splicing ATP-dependent RNA helicase prp-28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (728 aa)
NCU09254Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16. (840 aa)
drh-16ATP-dependent RNA helicase rok1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (781 aa)
NCU09093DEAD box RNA helicase-PL10B; Belongs to the DEAD box helicase family. (593 aa)
NCU02728Pre-mRNA splicing factor ATP-dependent RNA helicase prp16. (1005 aa)
prp-5Pre-mRNA-processing ATP-dependent RNA helicase prp-5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1194 aa)
NCU02685Pre-mRNA splicing helicase. (2209 aa)
NCU01884DUF2439 domain-containing protein. (1053 aa)
NCU01857DEAD/DEAH box RNA helicase. (1294 aa)
NCU02539DNA helicase; Belongs to the MCM family. (1013 aa)
crf9-1RING-13 protein. (1214 aa)
hel-2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (481 aa)
spb-4ATP-dependent rRNA helicase spb-4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (654 aa)
hel-1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
dbp-5ATP-dependent RNA helicase dbp-5; ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity). (483 aa)
Prd-6Regulator of nonsense transcripts 1 homolog; Eliminates the production of nonsense-containing RNAs. Belongs to the DNA2/NAM7 helicase family. (1093 aa)
drh-9ATP-dependent RNA helicase ded1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (688 aa)
fal-1ATP-dependent RNA helicase fal-1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (400 aa)
crf8-1TBP associated factor, variant. (1893 aa)
NCU07519ATP-dependent DNA helicase; Belongs to the helicase family. (813 aa)
NCU04749DNA replication helicase Dna2. (1727 aa)
NCU04472DEAD/DEAH box helicase. (1847 aa)
NCU03337ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa)
crf6-1Chromodomain helicase, variant. (1664 aa)
NCU07395DNA-binding protein SMUBP-2. (736 aa)
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 367110
Other names: N. crassa OR74A, Neurospora crassa 74-OR23-1V A, Neurospora crassa 74-OR23-1VA, Neurospora crassa FGSC 2489, Neurospora crassa FGSC 9013, Neurospora crassa N150, Neurospora crassa OR74A
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